Paeonol(2'-hydroxy-4'-methoxyacetophenone) (txuas:https://www.bloomtechz.com/synthetic-chemical/api-researching-only/paeonol-powder-cas-552-41-0.html) yog ib qho organic compound nrog cov tshuaj formula C9H10O3. Peony bark yog cov cag ntoo qhuav ntawm Ranunculaceae cog Paeonia suffruticosa Andr. Nws yog ib qho ntawm feem ntau siv tshuaj suav tshuaj hauv kev kho mob. Paeonol, raws li cov tshuaj tseem ceeb ntawm Paeonia, tau txais kev saib xyuas ntau ntxiv nyob rau xyoo tas los no, nrog kev tshawb fawb ntau ntxiv hauv nws cov khoom siv hluav taws xob, tshuaj siv tshuaj, thiab tshawb nrhiav thiab tshem tawm.
pharmacological kev txiav txim
Paeonol muaj qee yam muaj txiaj ntsig hauv kev txhim kho thiab kev siv cov khoom noj qab haus huv, tab sis tseem tsis muaj cov ntaub ntawv soj ntsuam txog kev nyab xeeb ntawm kev nyab xeeb thiab qhov tob. Txoj kev tshawb no tshuaj xyuas qhov mob toxicity ntawm paeonol rau nematodes, nrog rau cov kev cuam tshuam ntawm cov ntsuas xws li kev coj cwj pwm, kev noj zaub mov, thiab kev muaj peev xwm ntawm kev yug me nyuam, txhawm rau muab cov ntaub ntawv tshuaj ntsuam xyuas kev nyab xeeb rau kev loj hlob thiab kev siv cov khoom noj qab haus huv ntsig txog paeonol. . Cov cwj pwm txav ntawm nematodes yog qhov qhia tau hais tias qhia txog cov haujlwm tseem ceeb ntawm lawv lub cev, uas yooj yim rau kev khiav lag luam, rhiab heev, yooj yim rau kev soj ntsuam, tsis tshua muaj nqi, thiab luv luv hauv lub voj voog. Lub taub hau viav vias zaus thiab lub cev dabtsi yog khoov zaus ntawm nematodes feem ntau yog siv los ntsuas lawv tus cwj pwm txav; Kev coj tus cwj pwm tuaj yeem cuam tshuam txog seb qhov kev pub mis ntawm nematodes puas cuam tshuam los ntawm cov tshuaj exogenous, thiab kev hloov pauv hauv kev muaj peev xwm ua rau muaj peev xwm cuam tshuam txog kev cuam tshuam ntawm cov tshuaj exogenous ntawm kev ua me nyuam lub cev ntawm nematodes.
Qhov kev sim tau pom tias tom qab 24 teev ntawm kev kho mob nrog 100 thiab 200mg / L concentrations ntawm paeonol ntawm nematodes, tsis muaj qhov mob hnyav heev; Paeonol tuaj yeem txhim kho lub taub hau viav vias thiab lub cev khoov lub peev xwm ntawm nematodes, txhim khu kev ua haujlwm ntawm lub cev, thiab 100 mg / L ntawm Paeonol muaj cov txiaj ntsig zoo tshaj plaws. Paeonol tsis muaj kev cuam tshuam rau lub zog noj ntawm nematodes, uas tuaj yeem tshem tawm qhov ua tau tias Paeonol tuaj yeem txo qhov nqos ntau zaus ntawm nematodes, yog li txo qis zog ntawm kev noj zaub mov kom tsawg thiab cuam tshuam rau kev ua haujlwm ntawm lub cev. Paeonol tsis muaj kev cuam tshuam rau kev muaj peev xwm ua me nyuam, qhia tias nematodes tseem nyob hauv lub xeev noj qab haus huv thaum nws ua. Tsis muaj tshuaj lom ntawm paeonol ntawm nematodes tau pom, thiab nws tuaj yeem txhim kho lub peev xwm txav ntawm nematodes. Nws muaj qee yam peev txheej ntawm daim ntawv thov hauv kev txhim kho thiab siv cov khoom siv kho mob.
Xwm
Nws muaj analgesic, anti-inflammatory, antipyretic, thiab tiv thaiv tsis haum. Paeonol muaj cov nyhuv analgesic tseem ceeb ntawm qhov mob tshwm sim los ntawm lub cev lossis tshuaj lom neeg xws li tus Tsov tus tw siab thiab acetic acid. Paeonol muaj cov nyhuv inhibitory tseem ceeb ntawm kev mob tshwm sim los ntawm carrageenan, qe dawb, formaldehyde, histamine, 5-hydroxytryptamine, bradykinin, xylene, thiab endotoxin. Paeonol muaj cov nyhuv antipyretic tseem ceeb ntawm kev nce hauv lub cev kub los ntawm cov tshuaj tiv thaiv kab mob typhoid, tshuaj tiv thaiv triple, thiab lwm yam. Nws muaj cov nyhuv inhibitory ntawm hom II, III, thiab IV kev ua xua.
Txoj Cai ntawm Kev Ua
Nws muaj sedative, hypnotic, antibacterial, anti-inflammatory, antioxidant, thiab ntshav siab txo cov teebmeem. Hais txog tshuaj pleev ib ce; Paeonol tuaj yeem tiv thaiv kev tsim cov O2- dawb radicals hauv cov hlwb, ua kom tawv nqaij, txo thiab ua kom cov pigments tso rau hauv daim tawv nqaij, tshem tawm stasis thiab pob, txo qis qhov mob, txo qhov o thiab mob, tiv thaiv kev ua xua, thiab kab mob. Nws muaj cov txiaj ntsig zoo thiab kev noj qab haus huv ntawm pigmentation, mob nqaij, khaus tawv nqaij, psoriasis, pob khaus pob khaus, thiab eczema. Tsis tas li ntawd, nws muaj cov txiaj ntsig zoo hauv cov tshuaj txhuam hniav, tshuaj ntxuav qhov ncauj, cov hmoov txhuam hniav, thiab dej txhuam hniav.
Keeb kwm Discovery:
1. Keeb kwm tshuaj ntsuab:
Paeonol yog thawj zaug siv hauv tshuaj suav tshuaj. Nyob rau hauv Tuam Tshoj thaum ub, Chuanxiong tau dav siv los kho cov tsos mob xws li dysmenorrhea, vasodilation, thiab rheumatism. Txawm hais tias tib neeg tau paub ntev txog cov txiaj ntsig tshuaj ntawm Ligusticum chuanxiong, kev nce qib tseem ceeb tsis tau ua nyob rau hauv txoj kev tshawb fawb ntawm nws cov khoom xyaw nquag mus txog rau xyoo pua 20th.
2. Kev rho tawm thiab kev txheeb xyuas:
Thaum pib ntawm lub xyoo pua 20th, cov kws tshawb fawb tau pib tshawb nrhiav qhov tob ntawm Chuanxiong los txiav txim siab nws cov khoom xyaw nquag. Raws li cov lus ceeb toom, xyoo 1939, cov kws tshawb fawb Nyij Pooj tau ua tiav Paeonol los ntawm Ligusticum chuanxiong thawj zaug thiab txheeb xyuas nws cov qauv tshuaj. Lawv hu ua cov khoom 'Peonol'.
3. Kev tshawb fawb tshuaj:
Hauv kaum xyoo tom ntej, cov kws tshawb fawb tau tshawb fawb txog tshuaj lom neeg ntawm Paeonol. Lawv tsis tu ncua delve rau hauv cov khoom, qauv, thiab kev ua ntawm Paeonol los ntawm txoj kev xws li synthesis, extraction, thiab sib cais.
4. Pharmacology thiab pharmacodynamics tshawb fawb:
Pharmacological thiab pharmacological kev tshawb fawb ntawm Paeonol tau pom tias nws muaj ntau yam kev ua haujlwm lom neeg, suav nrog tshuaj tua kab mob, tshuaj tiv thaiv kab mob, tshuaj tua kab mob, thiab tshuaj tiv thaiv qog. Cov kev tshawb fawb no muab cov hauv paus kev tshawb fawb rau kev kho mob ntawm Paeonol.
5. Kev tshawb fawb thiab kev siv tshuaj kho mob:
Daim ntawv thov kev kho mob ntawm Paeonol maj mam tau txais kev saib xyuas. Kev tshawb fawb tau pom tias Paeonol tuaj yeem siv los kho cov kab mob plawv, kab mob inflammatory, thiab kab mob neurological. Tsis tas li ntawd, Paeonol kuj tau tsim los ua raw khoom rau cov tshuaj pleev ib ce thiab cov khoom noj qab haus huv.
Txawm hais tias qhov kev tshawb pom keeb kwm ntawm Paeonol yog luv luv, kev tshawb fawb ntawm nws tseem tab tom ua vim nws txoj haujlwm lom neeg thiab muaj peev xwm siv tshuaj kho mob.
Molecular Structure Analysis ntawm Paeonol:
1. Cov yam ntxwv zoo:
Paeonol belongs rau chav kawm acetophenone ntawm cov tebchaw, nrog lub nplhaib benzene thiab pawg acetone. Nws cov mis molecular yog C9H10O3, nrog tus txheeb ze molecular hnyav ntawm 166.17 g / mol.
2. Molecular qauv:
Cov yam ntxwv tseem ceeb ntawm Paeonol yog raws li hauv qab no:
-Benzene nplhaib: Paeonol molecule muaj rau lub nplhaib benzene, uas yog tsim los ntawm 6 carbon atoms thiab 5 hydrogen atoms. Cov haujlwm 2 'thiab 4' ntawm lub nplhaib benzene txuas nrog pawg hydroxyl thiab pawg methoxy, raws li.
-Acetone pawg: Paeonol molecule muaj ib pawg acetone, uas yog kev sib xyaw ntawm ib pawg ketone thiab ob pawg methyl. Cov pab pawg no txuas nrog txoj haujlwm 1 ntawm lub nplhaib benzene.
3. Cov pab pawg ua haujlwm:
Cov pab pawg ua haujlwm hauv Paeonol molecules suav nrog hydroxyl (- OH) thiab methoxy (- OCH3). Lub xub ntiag ntawm hydroxyl thiab methoxy pawg endows Paeonol nrog ntau yam ntawm nws cov haujlwm thiab cov khoom siv tshuaj.
4. Kev ua haujlwm kho qhov muag:
Paeonol yog ib tug chiral molecule uas tej zaum yuav muaj stereoisomers. Nws qhov kev ua haujlwm kho qhov muag tuaj yeem txiav txim siab los ntawm kev ntsuas qhov kho qhov muag.
5. X-ray siv lead ua qauv:
Kev kawm X-ray diffraction ntawm Paeonol qhia tau hais tias nws cov qauv siv lead ua yog monoclinic.
6. Molecular qauv:
Los ntawm kev siv cov txheej txheem chemistry suav nrog, tus qauv peb-dimensional molecular ntawm Paeonol tuaj yeem tsim. Cov qauv no tuaj yeem siv los kawm txog lawv cov kev sib cuam tshuam thiab cov tshuaj pharmacological nrog rau lwm cov molecules.
Zuag qhia tag nrho, cov qauv molecular ntawm Paeonol feem ntau yog cov yam ntxwv ntawm benzene thiab acetone pawg, nrog cov pab pawg ua haujlwm xws li hydroxyl thiab methoxy pawg. Cov yam ntxwv ntawm cov qauv no endow Paeonol nrog ntau yam tshuaj lom neeg lom zem thiab ua haujlwm lom neeg.