Selank(link:https://www.bloomtechz.com/synthetic-chemical/peptide/selank-peptide-cas-129954-34-3.html) yog polypeptide compound nrog molecular mis C33H57N11O9 thiab CAS 129954-34-3. Dawb crystal hmoov. Solubility hauv dej yog 3.36 mg / mL thiab ntawm pH 7. 0, 37 degree, nws yog 2.56 mg / mL. Tsis tas li ntawd, Selank kuj tuaj yeem yaj hauv cov kuab tshuaj organic, piv txwv li, solubility hauv methanol tuaj yeem ncav cuag 19.8 mg / mL.
1. Selank qhov kev tshawb pom:
Selank tau pom thawj zaug hauv xyoo 1982 los ntawm Lavxias tus kws tshawb fawb EV Radionova li al. thaum lawv kawm txog peptides hauv cov kua cerebrospinal ntawm nas. Lawv pom xya amino acid peptide hauv nas cerebrospinal kua thiab hu ua Selank (Sеlеnсеrin).
2. Kev tshawb fawb pib ntawm Selank:
Txij li thaum Selank tau muaj npe, cov kws tshawb fawb tau pib tshawb fawb txog nws cov tshuaj thiab tshuaj kho mob. Hauv cov kev tshawb fawb yav dhau los, cov kws tshawb fawb pom tias Selank muaj ntau yam kev ua haujlwm lom neeg, xws li kev tiv thaiv kev ntxhov siab, tiv thaiv kev nyuaj siab, txhim kho kev nco thiab txhim kho kev tiv thaiv.
Ntawm lawv, cov tshuaj tiv thaiv kev ntxhov siab thiab kev tiv thaiv kev ntxhov siab yog ib qho ntawm qhov kub ntawm Selank txoj kev tshawb fawb dav dav. Ntau cov kev tshawb fawb sim tau pom tias Selank tuaj yeem txo qhov kev xav zoo li tus cwj pwm tsis zoo thiab kev nyuaj siab zoo li tus cwj pwm hauv nas, thiab nws kuj muaj qee yam cuam tshuam rau tib neeg kev nyuaj siab.
Tsis tas li ntawd, Selank tseem tuaj yeem txhim kho kev tiv thaiv kab mob, txhawb kev sib txawv thiab kev loj hlob ntawm lub cev tiv thaiv kab mob, yog li txhim kho lub cev tiv thaiv kab mob, thiab muaj cov txiaj ntsig ntawm kev kho mob, txo cov ntshav siab thiab txhim kho kev pw tsaug zog. Cov kev tshawb pom no me ntsis qhia txog cov tshuaj pharmacological ntawm Selank.
3. Kev kho mob ntawm Selank:
Raws li Selank txoj kev tshawb fawb txog tshuaj kho mob ntau thiab muaj peev xwm siv tshuaj kho mob, qee qhov kev tshawb fawb soj ntsuam ntsig txog Selank tau ua tiav. Ib qho ntawm cov kev tshawb fawb ntxov tshaj plaws tau ua nyob rau xyoo 2000, uas tau sim tshuaj Selank rau cov neeg noj qab haus huv thiab cov neeg mob kev nyuaj siab, thiab pom tias nws tuaj yeem txhim kho kev txawj ntse ntawm cov neeg noj qab haus huv thiab lub hlwb ntawm cov neeg mob kev nyuaj siab.
Tsis tas li ntawd, qee qhov kev tshawb fawb ua ntej ntawm daim ntawv thov kev kho mob ntawm Selank tab tom pib. Piv txwv li, qee cov kws tshawb fawb tab tom kawm txog kev kho mob ntawm Selank rau cov neeg mob autism thiab Alzheimer's disease, nrog rau nws cov kev tiv thaiv ntawm neurons thiab lub plawv puas.
4. Synthesis method of Selank:
Txhawm rau txhim kho cov khoom siv tshuaj zoo dua qub thiab kev siv tshuaj kho mob ntawm Selank, cov kws tshawb fawb tau ntxiv cov txheej txheem ntau lawm ntawm Selank. Niaj hnub no, muaj ob lub ntsiab synthesis txoj kev rau Selank: solid-phase synthesis thiab kua-theem synthesis.
4.1 Cov txheej txheem sib xyaw ua ke yog ib txoj hauv kev siv ntau tshaj plaws, vim tias nws tuaj yeem ua cov khoom sib txuas siab thiab tuaj yeem zam kev cuam tshuam ntawm thermodynamics thiab kinetics ntawm peptides hauv cov tshuaj aqueous. Txawm li cas los xij, vim qhov qeeb ntawm cov tshuaj tiv thaiv ntawm cov txheej txheem txheej txheem, ntau cov kauj ruam ntawm kev ntxiv reactants thiab dissolving yuav tsum tau, uas ua rau cov txheej txheem synthesis ntau cumbersome.
4.2 Txoj kev ua kua-theem synthesis yog tsim rau me me-scale synthesis tshua, nrog rau kev ua haujlwm yooj yim thiab ceev cov tshuaj tiv thaiv. Qhov tsis zoo yog tias nws tsis yooj yim los tswj qhov tshwm sim ntawm qhov tshwm sim, thiab kev nyob ntev ntawm polypeptide hauv kev daws teeb meem yuav ua rau muaj kev cuam tshuam ntawm thermodynamic thiab kinetic.
5. Kev lag luam zeem muag ntawm Selank:
Nrog rau kev tshawb fawb dav dav thiab kev siv tshuaj kho mob ntawm Selank, nws muaj kev lag luam dav heev. Tshwj xeeb tshaj yog nyob rau hauv kev tiv thaiv kev ntxhov siab thiab kev nyuaj siab, Selank tau dhau los ua ib qho ntawm cov khoom muag zoo tshaj plaws hauv cov khw muag tshuaj hauv ntau lub teb chaws. Tsis tas li ntawd, kev tshawb fawb txog cov peev txheej thov xws li autism, Alzheimer's disease, thiab neuronal puas tsuaj kuj tseem yuav ua rau Selank txoj kev lag luam zeem muag.
Feem ntau hais lus, kev txhim kho keeb kwm ntawm Selank pib nrog kev tshawb pom ntawm cov kws tshawb fawb thiab xav tau los daws cov teeb meem tswv yim. Tom qab xyoo ntawm kev tshawb fawb thiab kev xyaum, Selank tau ua tiav cov txiaj ntsig tseem ceeb heev thiab kev siv tshuaj kho mob. Nyob rau yav tom ntej, nrog kev txhim kho txuas ntxiv ntawm Selank cov thev naus laus zis ntau lawm thiab txuas ntxiv txuas ntxiv ntawm cov ntawv thov cuam tshuam, nws ntseeg tau tias Selank txoj kev lag luam kev cia siab yuav dhau los ua ntau thiab ntau haiv neeg. Nkag siab txog cov tshuaj lom neeg ntawm Selank yog qhov tseem ceeb rau nws daim ntawv thov thiab kev tshawb fawb.
1. Molecular qauv:
Selank muaj 7 amino acid residues, suav nrog 5 fatty amide pawg, 1 glycine thiab 1 alanine. Cov amino acid residues yog txuas los ntawm amide bonds los tsim ib tug polypeptide saw. Selank muaj cov qauv molecular ntawm C33H57N11O9 thiab molecular hnyav ntawm 751.9. Cov molecule ntawm Selank muaj ntau pawg amino pawg thiab carboxyl pawg, thiab ntau hom kev cuam tshuam xws li hydrogen bonds, condensation tshua, thiab oxidation cov tshuaj tiv thaiv tuaj yeem tshwm sim ntawm cov pab pawg ua haujlwm, yog li cuam tshuam rau nws cov tshuaj lom neeg thiab cov tshuaj pharmacological.
2. Solubility:
Selank yog hydrophilic molecule uas tuaj yeem yaj hauv cov kuab tshuaj xws li dej, ethanol, thiab methanol. Selank molecules muaj ntau yam amino acid residues, ntawm cov pab pawg fatty amide muaj ntau dua solubility hauv cov kuab tshuaj tsis-polar. Hauv chav kuaj thiab daim ntawv thov, cov kuab tshuaj xws li dej lossis buffers feem ntau yog siv los npaj thiab siv Selank.
3. Acid-base khoom:
Lub molecule ntawm Selank muaj ntau yam amino thiab carboxyl pawg, yog li nws muaj acid-base zog. Hauv cov pH li niaj zaus, pawg carboxyl ntawm Selank yog qhov tsis zoo ion, thiab pawg amino yog ib qho zoo ion. Thaum pH ntawm cov tshuaj yog qis dua Selank lub isoelectric point, nws cov amino pawg zoo yuav hnov mob yooj yim dua nrog cov tsis zoo nqi molecules. Thaum pH ntawm cov tshuaj nyob rau saum toj ntawm lub isoelectric point, nws cov pa phem carboxyl pawg yuav hnov mob yooj yim dua nrog cov txiaj ntsig zoo. Cov cuab yeej ntawm cov kua qaub no tuaj yeem cuam tshuam kev cuam tshuam thiab kev cuam tshuam ntawm Selank thiab lwm yam molecules.
4. Kev ruaj ntseg:
Kev ruaj ntseg ntawm Selank cuam tshuam los ntawm ntau yam, xws li kub, lub teeb, oxygen, enzymes, thiab lwm yam. Hauv lub xeev qhuav, Selank tuaj yeem khaws cia rau lub sijhawm ntev. Txawm li cas los xij, nyob rau hauv cov av noo lossis kub kub, nws raug cuam tshuam los ntawm oxidation thiab hydrolysis, ua rau poob ntawm stability. Tsis tas li ntawd, hauv tib neeg lub cev, Selank tau yooj yim hydrolyzed los ntawm enzymes xws li proteolytic enzymes, yog li cuam tshuam rau nws cov tshuaj pharmacological. Yog li ntawd, kev khaws cia thiab siv cov txheej txheem tsim nyog feem ntau yuav tsum muaj nyob rau hauv cov chaw soj nstuam thiab cov ntawv thov kom muaj kev ruaj ntseg thiab cov tshuaj siv tshuaj ntawm Selank.
5. Lwm yam tshuaj lom neeg:
Selank tseem muaj ntau yam tshuaj lom neeg, xws li nws lub peev xwm los ua kom muaj kev sib koom tes nrog lwm cov molecules thiab tsim cov complexes nrog hlau ions. Tsis tas li ntawd, cov molecules ntawm Selank muaj ntau cov sulfur oxides, thiab cov pab pawg ua haujlwm no muaj kev cuam tshuam oxidation thiab alkylation, yog li cuam tshuam rau nws cov tshuaj pharmacological. Thaum ua ntawv thov thiab tshawb fawb Selank, nws yog ib qho tsim nyog yuav tsum xav txog cov khoom siv tshuaj lom neeg thiab lawv cov kev cuam tshuam, thiab kho cov kev mob tshwm sim thiab cov txheej txheem kom ntseeg tau tias nws cov tshuaj pharmacological thiab zoo.