Sodium Triacetylborohydride(link:https://www.bloomtechz.com/synthetic-chemical/organic-intermediates/sodium-triacetoxyborohydride-cas-56553-60-7.html) yog cov hmoov dawb nrog cov tshuaj formula NaBH (OAc)₃ thiab nws qhov hnyav molecular yog li 252.06 g / mol. Lub compound muaj ntau yam ntawm lub cev, nrog rau qhov taw tes ntawm 150-155 degree, kuj lub teeb ntom thiab zoo solubility. Qhov ceev yog li 1.18 g / cm³. Qhov no txhais tau hais tias qhov sib xyaw ua ke yog lub teeb thiab, nyob rau hauv qee qhov xwm txheej, tuaj yeem ntab ntawm ntau cov kuab tshuaj. Cov cuab yeej no ua rau Sodium Triacetoxyborohydride yooj yim siv hauv chav kuaj. Cov khoom ntawm lub cev no ua rau nws yog ib qho tseem ceeb txo tus neeg sawv cev thiab ua lub luag haujlwm tseem ceeb hauv cov organic synthesis.
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Hauv qab no yog cov lus qhia luv luv txog cov khoom tseem ceeb ntawm cov tshuaj lom neeg:
1. Kev txo qis:
Sodium Triacetylborohydride yog ib qho muaj zog txo tus neeg sawv cev uas tuaj yeem txo ntau cov organic tebchaw kom txo qis oxidation xeev. Rau cov tebchaw uas muaj cov pa oxygen ua haujlwm, xws li aldehydes, ketones, acids thiab esters, Sodium Triacetoxyborohydride feem ntau yuav raug xaiv txo qis rau cov cawv sib xws lossis hydroxyl compounds. Rau cov tebchaw uas muaj leej faj ua haujlwm pab pawg, xws li mercaptans thiab disulfides, tus neeg sawv cev txo qis kuj muaj zog txo cov khoom.
2. Reactivity:
Hauv ntau cov organic syntheses, Sodium Triacetoxyborohydride kuj tseem siv los ua cov khoom siv rau kev txo qis. Nyob rau hauv cov tshuaj tiv thaiv no, cov compound feem ntau yog ntxiv rau cov tshuaj tiv thaiv kom hnov mob nrog lwm yam tshuaj. Piv txwv li, nws tuaj yeem hnov mob nrog carboxylic acid anhydrides los tsim cov cawv sib xws, lossis hnov mob nrog cov ketones uas muaj ntxhiab los tsim cov ntxhiab tsw ntxhiab, thiab lwm yam. Tsis tas li ntawd, Sodium Triacetoxyborohydride kuj tseem siv tau los ua cov tshuaj tiv thaiv condensation, xws li condensation tshua ntawm carboxylic. acids thiab amines.
3. Kev ruaj ntseg:
Txawm hais tias Sodium Triacetoxyborohydride yog ib qho muaj zog txo tus neeg sawv cev, nws ruaj khov dua li lwm cov tshuaj txo qis xws li sodium borohydride. Thaum lub sij hawm cia thiab siv, lub compound tsis yooj yim cuam tshuam los ntawm tej yam kev mob xws li huab cua, noo noo thiab kub. Nyob rau tib lub sijhawm, nws yuav tsum tau muab sau tseg tias Sodium Triacetoxyborohydride yuav tsum tsis txhob muaj kev sib cuag nrog cov neeg ua haujlwm oxidizing, xws li hydrogen peroxide lossis potassium permanganate, txwv tsis pub muaj kev phom sij txaus ntshai yuav tshwm sim.
4. Reversibility:
Kev txo cov tshuaj tiv thaiv ntawm Sodium Triacetoxyborohydride yog thim rov qab, yog li qee cov tshuaj hloov pauv tuaj yeem xaiv tau los ntawm kev tswj cov tshuaj tiv thaiv. Piv txwv li, los ntawm kev tswj hwm txoj haujlwm ntawm cov khoom siv hluav taws xob cuam tshuam, pawg carbonyl hauv cov ketones aromatic tuaj yeem raug xaiv kom txo qis yam tsis muaj kev cuam tshuam cov tshuaj tiv thaiv ntawm lwm txoj haujlwm.
5. Specification:
5.1. Efficiency: Sodium Triacetoxyborohydride yog ib qho kev txo qis heev, nws tuaj yeem txo tau ntau yam kev ua haujlwm, xws li nitro, aldehyde, ketone, ester, thiab lwm yam. , Lithium Aluminium Hydride thiab lwm yam yog sai dua.
5.2. Kev xaiv: Sodium Triacetoxyborohydride muaj kev xaiv zoo txo qis ntawm cov pab pawg sib txawv, piv txwv li, nws tuaj yeem xaiv txo ketones yam tsis muaj kev cuam tshuam rau pawg ua haujlwm xws li enol thiab carboxylic acid, uas ua rau nws nyiam txo tus neeg sawv cev rau ntau tus kws tshuaj hluavtaws.
5.3. Kev nyab xeeb: Piv nrog rau lwm cov tshuaj txo qis, xws li lithium aluminium hydride, sodium bisulfite, thiab lwm yam, kev siv Sodium Triacetoxyborohydride muaj kev nyab xeeb dua vim tias nws yuav tsis tso cov pa roj hydrogen hauv dej los yog acidic, thiab nws txoj kev siv kuj tseem muaj kev tiv thaiv tsis zoo. xav tau.
5.4. Yooj yim: Sodium Triacetoxyborohydride yog ib qho yooj yim los npaj, muaj lub neej cia ntev, thiab tuaj yeem khaws cia thiab siv hauv chav tsev kub. Tsis tas li ntawd, Sodium Triacetoxyborohydride kuj tuaj yeem sib xyaw nrog lwm cov tshuaj txo qis los txhim kho nws lub peev xwm txo qis lossis kho cov tshuaj tiv thaiv.
5.5. Kev siv ntau yam: Sodium Triacetoxyborohydride ua lub luag haujlwm tseem ceeb hauv ntau cov organic synthesis, xws li kev npaj cov organic tebchaw xws li cawv, ethers, amines, thiab alkenes. Tsis tas li ntawd, nws tseem tuaj yeem siv los npaj thiab tiv thaiv cov pab pawg ua haujlwm xws li hydroxyl, amino, thiab amine pawg, thiab txo cov organic ntau dhau thiab cov kua dej pov tseg hauv cov txheej txheem tsim khoom.
Sodium Triacetylborohydride muaj qhov tshwj xeeb hauv kev txo cov tshuaj tiv thaiv. Piv txwv li, nyob rau hauv polyfunctional carboxylic acids los yog ketones, tsuas yog ib pab neeg ua hauj lwm yuav raug txo kom raug cov cawv los yog hydroxyl compound, thaum lwm pab pawg neeg ua hauj lwm tsis cuam tshuam. Qhov no ua rau Sodium Triacetoxyborohydride muaj kev xaiv ntau hauv cov organic synthesis thiab tuaj yeem txo cov tiam ntawm lwm cov kev tawm tsam.
Hauv kev xaus, Sodium Triacetoxyborohydride, ua ib qho tseem ceeb txo tus neeg sawv cev, muaj zog txo qis thiab ruaj khov. Nws muaj qhov tshwj xeeb thiab kev xaiv hauv cov tshuaj lom neeg, yog li nws tau siv dav hauv kev siv tshuaj synthesis, organic synthesis thiab cov khoom siv science.
Nyob rau hauv chav tsev kub, Sodium Triacetoxyborohydride muaj cov thermal thiab tshuaj lom neeg ruaj khov, thiab tuaj yeem khaws cia thiab siv tau raws li kev sim ib txwm muaj.
1. Molecular qauv:
Cov qauv molecular ntawm Sodium Triacetoxyborohydride yog tsim los ntawm peb pawg acetoxy thiab borohydride ion. Cov qauv ntawm borohydride ion zoo ib yam li cov tetrahedron li niaj zaus, uas B atom nyob rau hauv qhov chaw, thiab peb pawg OAc tau faib equidistantly thiab equiangularly nyob ib ncig ntawm nws, thiab txhua H atom txuas nrog OAc pawg los tsim ib daim ntawv cog lus. nrog B atom. Ntxiv nrog rau borohydride ions, sodium ions kuj ua lub luag haujlwm tseem ceeb hauv kev ruaj ntseg hauv cov lattice.
2. Crystal qauv:
Cov qauv siv lead ua ntawm Sodium Triacetylborohydride tau txais xyoo 1973 los ntawm GW Parshall li al. Nws yog monoclinic nrog qhov chaw pab pawg P21 / c. Chav tsev cell parameters yog a=13.236 Å, b=16.145 Å, c=9.048 Å, thiab=96.74 degree . Chav tsev cell muaj plaub lub molecules, txhua qhov sib cuam tshuam nrog lwm cov molecules los ntawm hydrogen bonds, tsim cov qauv peb-dimensional network. Nyob rau hauv lub lattice, lub borohydride ion tsim hydrogen bonds nrog peb pawg OAc sib txawv los ntawm H atoms, ua qhov kev ncua deb ntawm lawv txog 1.2 Å. Cov sodium ion tsim ib daim ntawv cog lus ionic nrog ib qho ntawm peb pawg OAc.
3. Spectroscopy khoom:
Sodium Triacetylborohydride muaj ntau yam ntxwv spectral zog, uas tuaj yeem siv rau nws qhov kev soj ntsuam zoo thiab ntau yam. Piv txwv li, muaj qhov pom tseeb C=O stretching vibration ncov ntawm txog 1700 cm-1 hauv nws IR spectrum. Lub caij no, kuj tseem muaj qhov nqus tau los ntawm BH thiab CH daim ntawv cog lus. Hauv nws cov 1H NMR spectrum, H atoms ntawm hydride ion ua rau muaj kev hloov pauv tshuaj lom neeg ntawm kwv yees li -4 ppm. Tsis tas li ntawd, nyob ib ncig ntawm boron ions (piv txwv li, OAc thiab H atoms), kuj tseem muaj cov nyhuv magnetic hauv zos uas ua rau kev sib cais thiab kev hloov pauv tshuaj lom neeg.
4. Solubility khoom:
Sodium Triacetoxyborohydride muaj qhov zoo solubility hauv dej, txog 1.5 g tuaj yeem yaj hauv 100 mL dej. Nws solubility yog siab dua hauv cov kuab tshuaj organic xws li ethanol, methanol thiab dimethylformamide. Vim nws muaj zog alkalinity, nws tsis ruaj khov nyob rau hauv acidic tov thiab yooj yim decomposes los tsim hydrogen.
Hauv kev xaus, Sodium Triacetoxyborohydride muaj cov qauv molecular tshwj xeeb thiab cov yam ntxwv spectroscopic. Cov khoom no muaj feem xyuam rau nws daim ntawv thov dav, piv txwv li, nws tuaj yeem siv los txo cov tebchaw xws li ketones, aldehydes thiab enones, thiab tseem tuaj yeem siv los ua ke los ua ke boron-muaj heterocyclic compounds. Kev nkag siab txog nws cov yam ntxwv zoo yog qhov tseem ceeb rau kev nkag siab txog nws txoj kev siv tshuab, qhov zoo thiab qhov tsis zoo. Nws muaj qhov zoo ntawm kev ua haujlwm siab, kev nyab xeeb, yooj yim, thiab kev xaiv zoo, thiab tau siv dav hauv kev tsim cov organic synthesis.