Tetrabutylammonium hydrogen sulfate(TBAHS) tuaj yeem siv ua surfactant, catalyst, emulsifier, tshuaj tua kab mob, kab mob, tshuaj tiv thaiv kab mob, thiab lwm yam. qee qhov sib xyaw ua ke nrog cov qauv tshwj xeeb thiab nyuaj rau kev sib cais. Nws daim ntawv thov piv txwv yog raws li nram no:
1) Kev txhaj tshuaj moxifloxacin hydrochloride ua piv txwv, cov ntsiab lus tseem ceeb muaj xws li: N-methyl impurity, impurity A, impurity B, impurity C, impurity D, thiab impurity E. Cov txheej txheem analytical ntawm cov khoom muaj feem xyuam uas Suav Pharmacopoeia, European Pharmacopoeia thiab American Pharmacopoeia muab yog thim rov qab-theem kua chromatography, yog muab tub lim nrog phenyl bonded silica gel, thiab theem mobile yog acetonitrile- ntsev tov (tau tetrabutylammonium bisulfate 0.5g, Potassium dihydrogen phosphate 1g, ntxiv dej ntxiv 500sphomL, acid 2mL, dilute nrog dej mus rau 1000mL) (ntim piv 30:70), nrhiav kom tau wavelength yog 293nm, txaus tus nqi yog 1.3mL / min, kem kub yog 30 degree, txhaj ntim yog 20μL. Lub sijhawm txawb tuaj yeem cais cov moxifloxacin thiab nws cov impurities.
2) Siv hauv kev tshawb nrhiav cov ntsiab lus carboplatin thiab cov khoom muaj feem xyuam hauv kev txhaj tshuaj carboplatin thiab carboplatin, siv cov kua chromatography siab, siv octadecylsilane bonded silica gel kem, thiab siv cov theem A thiab mobile theem B Gradient elution, tus nqi ntws yog {{1 } }. lub xov tooj ntawm tes A yog tetrabutylammonium bisulfate buffer, 20mL yog diluted nrog dej rau 1000mL; The mobile theem B yog tetrabutylammonium hydrogensulfate buffer, tau 20mL thiab ntxiv dej kom dilute rau 750mL, ntxiv acetonitrile 240-260mL; piav qhia tetrabutylammonium hydrogensulfate tsis yog 8.5g tetrabutylammonium hydrogensulfate, Ntxiv 80mL dej kom yaj, ces ntxiv 3.4mL ntawm phosphoric acid, thiab thaum kawg kho tus nqi pH rau 7.3-7.7 nrog 10mol / mL sodium hydroxide tov; gradient elution yog ua nrog mobile theem A thiab mobile theem B, lub sij hawm (min) / ntws theem B (v feem pua): 0/0; 10/0; 35/100; 40/100; 41/0; 55/0. Piv nrog rau kev kos duab ua ntej, txoj kev tshawb pom saum toj no pom tseeb txhim kho kev tuav pov hwm kev ua haujlwm, thiab muaj cov yam ntxwv ntawm kev muaj zog tshwj xeeb, siab rhiab heev thiab raug zoo.
3) Nws yog siv rau kev txiav txim siab ntawm ammonium acetoacetamide sulfamate nyob rau hauv zus tau tej cov acesulfame-K, cov kauj ruam tseem ceeb yog: (1) Xaiv cov analytical chromatographic tej yam kev mob: ODS kem (4.6mm × 25cm) los yog lwm yam sib npaug chromatographic kab, wavelength 25 0nm, ntws tus nqi 1ml / min, kem kub 25 degree, txhaj ntim 20ul; (2) Npaj tetrabutylammonium hydrogensulfate tov nrog dej deionized mus rau molar concentration ntawm 1.0~2.0mmol/L, thiab npaj tetrabutylammonium hydrogensulfate tov thiab chromatographic qib methanol nyob rau hauv ib tug volume ratio ntawm 60: 40 los ua ib theem mobile; (3) dilute cov qauv mus kuaj nrog cov organic hnyav mus rau ib qho concentration ntawm 0.5 feem pua rau 2.0 feem pua los ntawm ntim los npaj cov tshuaj ntsuam xyuas; (4) siv cov kab Syringe rub cov tshuaj ntsuam xyuas, txhaj tshuaj ua kua chromatograph, soj ntsuam nrog thaj tsam sab nraud tus qauv; (5) sau cov ntsiab lus ntawm ammonium acetoacetylsulfame hauv cov qauv los ntsuas. Cov txheej txheem tuaj yeem txiav txim siab cov ntsiab lus ntawm ammonium acetoacetamide sulfamate kom raug thiab nrawm.
4) Catalysts rau cov synthesis ntawm benzyl alkyl disulfide, siv thiourea thiab benzyl thiocyanide li sulfur qhov chaw, alkyl halides li raw cov ntaub ntawv, poov tshuaj iodide thiab tetrabutylammonium bisulfate li catalysts, poov tshuaj phosphate as base, Reaction in water. Cov txheej txheem ntawm kev tsim khoom tam sim no zam kev siv mercaptan nrog pungent tsw raws li cov leej faj, thiab siv cov cuab yeej siv hluav taws xob microwave thiab "ib lub lauj kaub" uas tsis tsuas yog tuaj yeem ua tiav lub hom phiaj ntawm kev tiv thaiv ib puag ncig, tab sis kuj ua kom yooj yim rau kev ua haujlwm thiab ntxiv. txo cov synthesis thiab scale nqi ntawm ntau lawm.
5) Nws yog siv los npaj cov tshuaj trivalent chromium electroplating, uas yog tsim los ntawm cov khoom siv raw hauv qab no: 10-15 qhov chaw ntawm hydroxychromium sulfate, 8-10 qhov chaw ntawm chromium trichloride, 5-8 qhov chaw ntawm cobalt nitrate, 3-5 qhov chaw Aluminium sulfate, 3-5 qhov chaw ntawm poov tshuaj carbonate, 5-8 qhov chaw ntawm poov tshuaj nitrate, 3-5 qhov chaw ntawm ammonium chloride, 2-3 qhov chaw ntawm octadecyl dimethyl benzyl ammonium chloride, 1-2 qhov chaw ntawm tetrabutyl Ammonium bromide, 2-3 qhov chaw ntawm tetrabutylammonium bisulfate, 8-10 qhov chaw ntawm hydrochloric acid, 5-8 qhov chaw ntawm oxalic acid, {{13} } qhov chaw ntawm sodium pyrophosphate, 2-3 qhov chaw ntawm disodium dihydrogen pyrophosphate, 2-3 qhov chaw Glycine, 3-4 qhov chaw ntawm aminocaproic acid, 80-100 qhov chaw ntawm deionized dej.
Lub trivalent chromium electroplating tov tsuas yog precipitates oxygen thaum lub sij hawm chromium plating txheej txheem, yog huv si thiab tsis muaj kuab paug, muaj ib tug kaj tsos, ob peb kab nrib pleb, zoo bonding quab yuam, nplua nuj los ntawm raw cov ntaub ntawv, tsis tshua muaj nqi, zoo heev nqi kev ua tau zoo, thiab zoo stability ntawm cov tshuaj electroplating. rau nws industrialization.
Tetrabutyl quaternary ammonium ntsev yog ib theem hloov catalyst nrog kev ua tau zoo dua. Tetrabutylammonium bisulfate tsis siv ntsev system feem ntau yog siv los ua aqueous mobile theem nyob rau hauv reversed-theem kua chromatography nrhiav kom tau, tab sis, nrog rau kev loj hlob ntawm tetrabutylammonium bisulfate concentration, kev ruaj ntseg ntawm tetrabutylammonium bisulfate tsis ntsev system maj mam txo. Tetrabutylammonium bisulfate buffered saline tov yuav tsum tau npaj tam sim ntawd ua ntej siv, thiab lub sij hawm siv yuav tsum tsis txhob ntau tshaj 6 teev (pom tseeb turbidity yuav pom tom qab 8 teev nyob rau hauv chav tsev kub), txwv tsis pub nws yuav ua rau chromatographic ncov drift los yog txawm ntsev nyob rau hauv lub twj tso kua mis los yog kem. Cov dej nag ua rau lub twj tso kua mis thiab kab puas.
Kev tsim cov txheej txheem ntawm tetrabutylammonium bisulfate suav nrog cov txheej txheem ziab, vim tias tetrabutylammonium bisulfate yog cov dej-soluble heev, thiab nws yog ib qho tsim nyog los xyuas kom meej tias qhov chaw khaws cia qhuav, txias thiab deb ntawm cov khoom sib xws thaum khaws cia. Ua ntej ziab, nws yuav tsum tau lees tias yuav qhuav tsis muaj dej, yog li cov txheej txheem ziab kom qhuav muaj kev cuam tshuam zoo ntawm tetrabutylammonium bisulfate.
Kev ziab ntawm tetrabutylammonium bisulfate feem ntau yog nqa tawm hauv lub tshuab ziab khaub ncaws, thiab feem ntau ntawm cov tshuab ziab khaub ncaws yog ob lub khob zoo li lub tog raj kheej kom qhuav. Txhawm rau tiv thaiv tetrabutylammonium bisulfate los ntawm kev sib cuag nrog ib puag ncig sab nraud thiab ua rau muaj kuab paug, lub tog raj kheej kom qhuav yog feem ntau teem rau kaw. Cov dej vapor evaporated los ntawm cov khoom thaum lub sij hawm ziab qhuav tsis tuaj yeem tawm hauv lub sijhawm, thiab cov dej kub kub hauv lub tog raj kheej, uas tsis tsuas yog cuam tshuam rau kev ziab, tab sis kuj yooj yim ua rau muaj kev nyab xeeb yog tias lub siab nyob hauv lub tog raj kheej. siab dhau lawm.