Atropine sulfateyog ib cov tshuaj muab tau los ntawm cov nroj tsuag belladonna thiab yog siv rau ntau yam kev kho mob lub hom phiaj, nrog rau kev kho mob ntawm bradycardia, organophosphate lom, thiab raws li ib tug preanesthetic neeg sawv cev. Nws cov txheej txheem ntawm kev ua haujlwm cuam tshuam nrog kev thaiv cov teebmeem ntawm neurotransmitter acetylcholine hauv lub paj hlwb.
Nkag siab txog Atropine Sulfate: Ib qho Txheej Txheem
Atropine sulfateyog ib qho anticholinergic sedate uas ua haujlwm los ntawm kev thaiv cov haujlwm ntawm acetylcholine ntawm cholinergic receptors hauv lub cev. Acetylcholine yog ib qho neurotransmitter uas muaj kev vam meej rau kev taw qhia ntawm cov paj hlwb thiab cov leeg. Atropine sulfate squares cov receptors, cia siab tias cov acetylcholine los ntawm kev tso cai thiab ua rau cov leeg cog lus. Qhov no los txog rau hauv kev nthuav dav ntawm cov teebmeem, suav qhov nthuav dav ntawm cov menyuam kawm ntawv, nthuav lub plawv dhia, thiab lub qhov ncauj qhuav.
Atropine sulfate yog ib tug kws tshuaj cais raws li ib tug anticholinergic neeg teb xov tooj, uas implies nws squares cov kev ua ntawm acetylcholine, ib tug neurotransmitter nyob rau hauv lub apprehensive moj khaum. Acetylcholine nco ntsoov rau kev xa cov hlab ntsha tsav tsheb thiab ua ib feem tseem ceeb hauv cov peev txheej sib txawv, suav cov leeg tshem tawm, tswj lub plawv dhia, thiab qog nqaij hlav.
Pharmacological cuam tshuam ntawm Atropine Sulfate
Atropine sulfateua los ntawm kev sib tw tso cai rau muscarinic acetylcholine receptors, tom qab ntawd cia siab tias acetylcholine los ntawm kev tso cai rau cov receptors. Qhov kev ua ub no los txog hauv kev nthuav dav ntawm cov tshuaj pharmacological, suav nrog:
Nce Heart Rate:
Atropine sulfatesiv nws qhov cuam tshuam rau lub plawv los ntawm kev thaiv cov hlab ntsha vagus incitement. Tsis tu ncua, cov hlab ntsha vagus tso tawm acetylcholine, uas txo qis lub plawv dhia. Los ntawm kev txwv qhov kev ua no, atropine sulfate cia siab tias yuav ua haujlwm ntawm acetylcholine rau nws cov receptors, tom qab ntawd txo qis parasympathetic tone thiab nthuav lub plawv dhia. Cov cuab yeej no ua rau atropine sulfate tshwj xeeb tshaj yog muaj txiaj ntsig hauv kev kho mob ntawm bradycardia, lossis lub plawv dhia qis, xws li mob plawv lossis qee yam ntawm lub plawv.
Bronchodilation:
Hauv cov txheej txheem ua pa, atropine sulfate ua raws li bronchodilator. Nws ua tiav qhov no los ntawm kev tawm tsam qhov cuam tshuam ntawm acetylcholine ntawm cholinergic receptors pom nyob rau hauv cov leeg du ntawm txoj kev dav hlau. Acetylcholine tsis tu ncua ua rau bronchoconstriction, tsav mus rau nqaim ntawm txoj kev dav hlau. Los ntawm kev thaiv cov acetylcholine los ntawm cov neeg ua haujlwm rau cov receptors, atropine sulfate txo qhov kev nqaim no, tuaj txog ntawm cov leeg nqaij bronchial du thiab nthuav dav ntawm bronchioles. Cov cuab yeej no yog siv tsis raug rau hauv kev kho mob ua pa xws li mob hawb pob thiab mob ntsws tsis tu ncua (COPD), qhov twg bronchodilation tuaj yeem muab kev pab cuam kom pom tseeb thiab ua rau cov cua ntws mus tas li.
Txo Glandular Discharges:
Atropine sulfateIb yam nkaus thiab muaj kev cuam tshuam los tiv thaiv lub cev ntawm lub cev. Nws tuaj yeem txo qis tiam ntawm nti thiab tawm hws los ntawm kev thaiv cov haujlwm ntawm acetylcholine ntawm glandular cholinergic receptors. Acetylcholine feem ntau invigoates lub emission ntawm cov kua. Thaum tswj hwm atropine sulfate, nws cia siab tias qhov kev tshoov siab no, tsav mus rau qhov txo qis hauv kev ua kom zais cia. Cov cuab yeej no muaj txiaj ntsig zoo hauv qee qhov xwm txheej kho dua tshiab, xws li kev phais mob, qhov uas txo qis emissions nyob rau hauv txoj kev aviation tuaj yeem ua rau kev nkag siab zoo rau tus kws tshaj lij thiab txo qis txoj kev xav.
Kev nthuav dav menyuam kawm ntawv:
Ib qho kev cuam tshuam tsis zoo tshaj plaws ntawm atropine sulfate yog kev nthuav dav, ntxiv rau lub npe hu ua mydriasis. Qhov no tshwm sim txij li thaum atropine sulfate squares cov kev ua ntawm acetylcholine ntawm cov leeg sphincter ntawm iris, uas yog nco ntsoov rau choking cov understudy. Los ntawm kev txwv acetylcholine los ntawm cov neeg ua haujlwm rau cov muscarinic receptors, cov leeg sphincter unwinds, tsav tsheb mus rau kev nthuav dav ntawm kev kawm. Qhov kev cuam tshuam no feem ntau yog siv hauv ophthalmology los txhawb kev kuaj lub qhov muag thiab nws cov qauv thaum lub sijhawm kuaj qhov muag thiab kev phais. Mydriasis pib los ntawm atropine sulfate tso cai rau cov kws kho mob kom zoo dua pom cov retina, focal point, thiab lwm qhov ntawm lub qhov muag, txhawb kev txiav txim siab thiab kho qhov muag sib txawv.
Kev siv tshuaj kho mob thiab kev txiav txim siab
Bradycardia: Atropine sulfateyog siv rau hauv kev kho mob ntawm bradycardia, ib qho mob uas lub plawv dhia qeeb qeeb. Tus mob no tuaj yeem tshwm sim los ntawm ntau yam ua rau, suav nrog kab mob, tshuaj phiv tshuaj, lossis kev puas tsuaj rau lub plawv hluav taws xob. Atropine sulfate ua haujlwm los ntawm kev thaiv cov hlab ntsha vagus stimulation, uas ib txwm tso tawm acetylcholine kom qeeb lub plawv dhia. Los ntawm inhibiting cov nyhuv acetylcholine, atropine sulfate txo cov suab nrov parasympathetic thiab ua kom lub plawv dhia, yog li kho lub plawv dhia qeeb cuam tshuam nrog bradycardia.
Organophosphate Poisoning:Nyob rau hauv cov ntaub ntawv ntawm organophosphate lom, atropine sulfate ua hauj lwm raws li ib tug tseem ceeb tshuaj tiv thaiv. Organophosphates yog cov tebchaw uas tuaj yeem pom hauv qee cov tshuaj tua kab thiab cov paj hlwb; Lawv tawm tsam lawv cov tshuaj lom los ntawm irreversibly inhibiting lub enzyme acetylcholinesterase, ua rau ib tug tsub zuj zuj ntawm acetylcholine ntawm cholinergic synapses thiab ntau stimulation ntawm muscarinic receptors thoob plaws hauv lub cev. Atropine sulfate sib tw antagonizes acetylcholine ntawm cov muscarinic receptors, pab tiv thaiv cov cholinergic stimulation ntau dhau thiab txo cov tsos mob xws li bradycardia, bronchospasm, thiab nce secretions. Nws yog ib qho tseem ceeb rau kev tswj cov theem mob ntawm organophosphate raug thiab tuaj yeem cawm txoj sia thaum noj tam sim.
Cov tshuaj Preanesthetic:Ua ntej qee cov txheej txheem phais, atropine sulfate yuav siv tau los ua tshuaj preanesthetic. Nws lub hom phiaj tseem ceeb yog kom txo qis cov qaub ncaug thiab bronchial secretions, uas tuaj yeem cuam tshuam nrog kev ua pa thiab ua rau muaj kev pheej hmoo ntawm kev nqhis dej thaum siv tshuaj loog. Tsis tas li ntawd, atropine sulfate pab tiv thaiv bradycardia uas yuav tshwm sim raws li cov lus teb rau cov tshuaj loog los yog raws li ib tug reflex thaum phais, tshwj xeeb tshaj yog cov txheej txheem uas txhawb lub vagus paj. Los ntawm kev tswj hwm atropine sulfate ua ntej kev siv tshuaj loog, cov kws kho mob tuaj yeem pab tswj lub plawv dhia thiab txhim kho tag nrho cov ntaub ntawv kev nyab xeeb thaum lub sijhawm phais.
Nws yog ib qho tseem ceeb kom nco ntsoov tiasatropine sulfateyuav tsum tau siv nrog ceev faj, vim nws tuaj yeem ua rau muaj kev phiv xws li qhov ncauj qhuav, qhov muag tsis pom kev, tso zis tso tseg, thiab ua rau lub plawv dhia. Nws yuav tsum tau siv raws li kev saib xyuas ntawm tus kws kho mob thiab ua raws li cov lus qhia.
Yog xav paub ntxiv txog atropine sulfate thiab nws daim ntawv thov kev kho mob, thov hu rau Sales@bloomtechz.com.
Cov ntaub ntawv:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646265/
https://pubchem.ncbi.nlm.nih.gov/compound/Atropine-sulfate