Letrozolehmoovyog ib qho hluavtaws benzotriazole derivative.it txo cov tshuaj estrogen los ntawm inhibiting aromatase, yog li tshem tawm cov nyhuv stimulating estrogen ntawm qog loj hlob. Rau kev kho mob qog noj ntshav mis thiab radiotherapy. Nws yog ib tiam tshiab ntawm kev xaiv aromatase inhibitors. Nws yog cov khoom siv benzylriazole. Los ntawm inhibiting aromatase, qib estrogen yog txo, yog li tshem tawm cov nyhuv stimulating estrogen ntawm qog loj hlob.
Cov kev ua hauv vivo yog 150-250 lub sij hawm muaj zog dua thawj tiam aromatase inhibitor aminolutamide. Vim nws qhov kev xaiv siab, nws tsis cuam tshuam rau kev ua haujlwm ntawm glucocorticoids, ntxhia corticosteroids, thiab thyroid. Kev siv cov koob tshuaj ntau tsis cuam tshuam qhov tso tawm ntawm adrenal corticosteroids, yog li nws muaj qhov ntsuas kev kho mob siab. General Chat Chat Lounge Ntau yam kev tshawb fawb ua ntej qhia tau hais tias letrozole tsis yog ib qho tshuaj lom rau lub cev thiab lub hom phiaj ntawm lub cev, thiab nws tsis yog cov nyhuv mutagenic lossis carcinogenic. Thiab muaj kev phiv me me ntau dua thiab zoo zam. Piv nrog rau cov tshuaj estrogen, cov khoom tiv thaiv qog nqaij hlav muaj zog dua. Nws yog qhov tsim nyog rau cov neeg mob postmenopausal nrog mob qog noj ntshav siab siab uas tsis muaj txiaj ntsig hauv kev kho cov tshuaj tiv thaiv estrogen thiab mob qog noj ntshav thaum ntxov.
Thaum Lub Kaum Ob Hlis 2005, Lub Chaw Haujlwm Saib Xyuas Tshuaj thiab Khoom Noj Noj Qab Haus Huv tau pom zoo nws tsim los ntawm Novartis hauv Switzerland los kho cov neeg mob qog noj ntshav mis, tso cai rau nws siv rau kev phais mob postmenopausal kho cov tshuaj hormone-zoo thaum ntxov invasive mob cancer mis. Qhov no yog qhov thib ob aromatase inhibitor pom zoo hauv UK tom qab kev pom zoo ntawm AstraZeneca's Arimidex thaum Lub Rau Hli 2005. Ob cov tshuaj tau pom nyob rau hauv kev sim tshuaj tiv thaiv kom tsis txhob muaj kev pheej hmoo ntawm mob qog noj ntshav ntawm lub mis zoo dua li tamoxifen txoj kev kho tam sim no.
Tom qab qhov ncauj tswj hwm ntawmletrozolehmoov, cov tshuaj tau sai thiab tag nrho absorbed nyob rau hauv lub plab hnyuv ib ntsuj av, mus txog lub siab tshaj plaws cov ntshav concentration nyob rau hauv 1 teev, thiab tam sim ntawd muab faib mus rau hauv cov ntaub so ntswg. Cov piam thaj hauv cov protein khi yog tsawg, tsuas yog 60 feem pua, thiab ib nrab-lub neej ntawm cov hlab ntsha tshem tawm theem yog txog 2d. Nws tshem tawm tsuas yog los ntawm cov metabolism hauv hydroxy metabolites uas tsis muaj cov tshuaj pharmacological. Lub raum tso tawm yuav luag tag nrho cov metabolites thiab txog 5 feem pua ntawm cov tshuaj qub.