Cov mis mos molecular ntawm5-Methoxytryptamine(link:https://www.bloomtechz.com/synthetic-chemical/api-researching-only/5-methoxytryptamine-cas-608-07-1.html) yog C13H16N2O, thiab qhov txheeb ze molecular hnyav yog 220.28 g / mol. Nws muaj ib lub nplhaib indole, ib pawg ethylamine thiab ib pawg methoxy. Ethylamino thiab methoxy pawg tau txuas rau txoj haujlwm 3 thiab 5 ntawm lub nplhaib indole, raws li. Nws muaj zoo solubility nyob rau hauv cov organic solvents, xws li ethanol, dimethylformamide (DMF) thiab acetonitrile. Nws solubility tseem cuam tshuam los ntawm cov qauv molecular thiab ib puag ncig. Nws yog chiral molecule nrog kev ua haujlwm kho qhov muag. Nws tuaj yeem muaj nyob ua ob enantiomers, levorotatory (S) thiab dextrorotatory (R). Cov enantiomers no tuaj yeem tau txais los ntawm chiral hluavtaws cov txheej txheem lossis cov txheej txheem sib cais. Cov ntaub ntawv uas tsis muaj xim rau daj ntseg daj crystalline khoom, los yog dawb rau beige crystalline hmoov. Nws cov tsos tuaj yeem sib txawv nyob ntawm txoj kev npaj, purity thiab crystallization.
Ib txoj hauv kev zoo sib xws ntawm 5-Methoxytryptamine yog raws li hauv qab no:
Kauj ruam 1: Synthesis ntawm 5-Methoxytryptohol
Tshuaj formula:
C10H11TSIS MUAJ2ntxiv rau C5H6ClCrNO3 → C11H13TSIS MUAJ2ntxiv by-products
Cov tshuaj tiv thaiv kab mob: substrate 5-Hydroxytryptohol, oxidant PCC (pyridinium chlorochromate), hnyav THF (tetrahydrofuran) thiab chav tsev kub.
cov txheej txheem tshuaj tiv thaiv:
1. Muab 5-Hydroxytryptohol thiab PCC nyob rau hauv ib lub vial qhuav substrate.
2. Ntxiv qhov tsim nyog ntawm THF hnyav kom yaj cov sib tov.
3. Muab cov tshuaj tiv thaiv sib tov nyob rau hauv chav tsev kub, feem ntau rau ob peb teev mus rau hmo ntuj.
4. Tom qab paub meej tias cov tshuaj tiv thaiv tiav, siv txoj kev sib cais thiab purification, xws li extraction, crystallization los yog kem chromatography, los ntxuav cov khoom 5-Methoxytryptohol.
Kauj ruam 2: Synthesis ntawm 5-Methoxytryptamine
Tshuaj formula:
C11H13TSIS MUAJ2 ntxiv rau catalyst ntxiv tus neeg saib xyuas → C11H14N2O plus by-products
Cov tshuaj tiv thaiv kab mob: substrate 5-Methoxytryptohol, catalyst, hloov tus neeg sawv cev, hnyav thiab qhov kub thiab txias.
cov txheej txheem tshuaj tiv thaiv:
1. Muab 5-Methoxytryptohol thiab tsim nyog catalyst, hloov tus neeg sawv cev mus rau hauv cov tshuaj tiv thaiv hlab ntsha.
2. Ntxiv qhov tsim nyog ntawm cov kuab tshuaj kom yaj cov sib tov.
3. Teem qhov ntsuas kub kom tsim nyog raws li qhov yuav tsum tau muaj cov tshuaj tiv thaiv, feem ntau yog chav sov lossis cov tshuaj tiv thaiv cua sov.
4. Cov tshuaj tiv thaiv yuav tshwm sim nyob rau hauv ib lub sij hawm cov tshuaj tiv thaiv, qhov kev kawm ntawm uas yuav tsum tau soj ntsuam los ntawm tsim nyog analytical txoj kev.
5. Tom qab cov tshuaj tiv thaiv, purify cov khoom 5-Methoxytryptamine siv ib tug tsim nyog sib cais thiab purification txoj kev.
Reductive Amination (reductive amination) yog ib txoj kev siv hluavtaws, uas tuaj yeem tau txais cov khoom sib txuas amine los ntawm kev ua haujlwm aldehydes lossis ketones nrog amines nyob rau hauv qhov tsim nyog. Rau cov synthesis ntawm 5-Methoxytryptamine, txoj kev Reductive Amination tuaj yeem siv los ua 5-Methoxyindole nrog rau cov khoom tsim nyog aldehyde lossis ketone los tsim cov khoom lag luam.
Tshuaj formula:
C9H9Tsis muaj ntxiv aldehyde / C14H16O3ntxiv H2 → C11H14N2O plus H2O
Cov kauj ruam yooj yim ntawm Reductive Amination yog raws li hauv qab no:
Kauj Ruam 1: Npaj cov tshuaj tiv thaiv kab mob:
Muab cov substrate 5-Methoxyndole thiab tus nqi tsim nyog ntawm cov khoom tsim nyog aldehyde lossis ketone rau hauv cov hlab ntsha cov tshuaj tiv thaiv raws li qhov tsim nyog molar piv ntawm cov tshuaj.
Kauj Ruam 2: Ntxiv tus neeg sawv cev txo qis thiab catalyst:
Ntxiv cov nyiaj tsim nyog ntawm hydrogen (H2) thiab cov khoom tsim nyog xws li platinum lossis palladium. Hydrogen thiab catalyst yog tus yuam sij kom paub qhov txo qis Amination.
Kauj Ruam 3: Cov xwm txheej tshwm sim:
Cov tshuaj tiv thaiv yog nqa tawm ntawm qhov tsim nyog kub thiab hydrogen siab. Kev xaiv ntawm qhov kub thiab txias thiab hydrogen siab yuav tsum tau txiav txim siab raws li tus yam ntxwv ntawm cov reactants thiab tus nqi ntawm cov tshuaj tiv thaiv.
Kauj Ruam 4: Lub Sijhawm Tawm Tsam:
Tom qab cov tshuaj tiv thaiv tiav lawm, cov khoom lag luam 5-Methoxytryptamine yog huv si los ntawm kev sib cais thiab kev ua kom huv, xws li crystallization lossis kem chromatography. Kev xaiv ntawm kev sib cais thiab kev ua kom huv yuav tsum tau txiav txim siab raws li cov khoom ntawm cov khoom thiab cov yam ntxwv ntawm lwm cov tshuaj tiv thaiv.
Enzymatic Transamination (enzymatic transamination) yog ib txoj kev siv hluavtaws, uas siv cov enzyme tshwj xeeb catalysts los ua kom tiav cov kev hloov pauv ntawm pawg amine. Rau kev sib txuas ntawm 5-Methoxytryptamine, txoj kev Enzymatic Transamination tuaj yeem siv tau kom tau txais cov khoom lag luam los ntawm cov tshuaj tiv thaiv enzyme-catalyzed ntawm ib qho chaw tsim nyog thiab tus neeg pub amine.
Tshuaj formula:
5-Methoxyndole precursor ntxiv rau amine pub ntxiv rau enzyme → hloov khoom ntawm C11H14N2O plus substrate
Cov kauj ruam yooj yim ntawm Enzymatic Transamination yog raws li hauv qab no:
Kauj Ruam 1: Npaj cov tshuaj tiv thaiv kab mob:
Muab cov substrate thiab cov amine-raws li pub rau hauv cov tshuaj tiv thaiv kab mob raws li qhov tsim nyog molar ratio ntawm cov tshuaj. Lub substrate tuaj yeem yog qhov sib xyaw ua ntej ntawm 5-Methoxyndole thiab cov amine pub tuaj yeem yog qhov tsim nyog amine compound.
Kauj Ruam 2: Ntxiv qhov tsim nyog enzyme catalyst:
Raws li kev xaiv enzyme catalyst, nws ntxiv rau hauv cov tshuaj tiv thaiv kab mob hauv qhov tsim nyog. Kev xaiv ntawm enzyme catalyst yuav tsum tau txiav txim siab raws li cov yam ntxwv ntawm cov tshuaj tiv thaiv substrate thiab cov khoom xav tau.
Kauj Ruam 3: Kho cov tshuaj tiv thaiv kab mob:
Raws li qhov yuav tsum tau ua ntawm cov enzyme catalyst, kho cov xwm txheej xws li pH tus nqi, qhov kub thiab txias lub sijhawm ntawm cov tshuaj tiv thaiv. Cov xwm txheej no tseem ceeb heev rau kev ua haujlwm thiab kev ruaj ntseg ntawm enzyme.
Kauj Ruam 4: Lub Sijhawm Tawm Tsam:
Ua qhov tshuaj tiv thaiv tsis pub dhau lub sij hawm tsim nyog. Kev xaiv lub sijhawm tshuaj tiv thaiv yuav tsum tau txiav txim siab raws li cov yam ntxwv ntawm cov tshuaj tiv thaiv substrate thiab tus nqi catalytic ntawm enzyme.
Kauj Ruam 5: Sib cais thiab ntxuav:
Thaum cov tshuaj tiv thaiv ua tiav, cov khoom lag luam 5-Methoxytryptamine yog huv si los ntawm kev sib cais thiab kev ua kom huv, xws li kab chromatography lossis crystallization. Kev xaiv ntawm kev sib cais thiab kev ua kom huv yuav tsum tau txiav txim siab raws li cov khoom ntawm cov khoom thiab cov yam ntxwv ntawm lwm cov tshuaj tiv thaiv.
Mannich cov tshuaj tiv thaiv yog ib qho tseem ceeb organic synthesis cov tshuaj tiv thaiv rau cov synthesis ntawm cov tebchaw uas muaj amine pawg. Rau kev sib txuas ntawm 5-Methoxytryptamine, Mannich cov tshuaj tiv thaiv tuaj yeem siv los ua haujlwm 5-Methoxyndole nrog formaldehyde thiab methineamine los tsim cov khoom xav tau.
Tshuaj formula:
C9H9TSIS plus H2O plus methineamine → C11H14N2O plus H2O
Cov kauj ruam yooj yim ntawm Mannich cov tshuaj tiv thaiv yog raws li nram no:
Kauj Ruam 1: Npaj cov tshuaj tiv thaiv kab mob:
Muab cov substrate 5-Methoxyndole, formaldehyde thiab methineamine rau hauv cov hlab ntsha cov tshuaj tiv thaiv raws li qhov tsim nyog molar piv ntawm cov tshuaj.
Kauj Ruam 2: Ntxiv acid catalyst:
Ib qho tsim nyog ntawm acidic catalyst xws li hydrochloric acid lossis sulfuric acid ntxiv. Acid catalysts tuaj yeem txhawb cov tshuaj tiv thaiv.
Kauj Ruam 3: Cov xwm txheej tshwm sim:
Cov tshuaj tiv thaiv yog nqa tawm nyob rau hauv qhov tsim nyog qhov kub thiab txias, feem ntau yog chav tsev kub lossis cua sov. Kev xaiv ntawm qhov kub thiab txias yuav tsum tau txiav txim siab raws li tus yam ntxwv ntawm cov reactants thiab tus nqi ntawm cov tshuaj tiv thaiv.
Kauj Ruam 4: Lub Sijhawm Tawm Tsam:
Cov tshuaj tiv thaiv tshwm sim nyob rau hauv ib lub sij hawm cov tshuaj tiv thaiv thiab qhov kev nce qib ntawm cov tshuaj tiv thaiv tuaj yeem raug saib xyuas los ntawm cov kev ntsuas tsim nyog. Kev xaiv lub sijhawm tshuaj tiv thaiv yuav tsum tau txiav txim siab raws li tus nqi ntawm cov tshuaj tiv thaiv thiab cov txiaj ntsig ntawm cov khoom.
Kauj Ruam 5: Sib cais thiab ntxuav:
Thaum cov tshuaj tiv thaiv ua tiav, cov khoom lag luam 5-Methoxytryptamine yog huv si los ntawm kev sib cais thiab kev ua kom huv, xws li crystallization lossis kem chromatography. Kev xaiv ntawm kev sib cais thiab kev ua kom huv yuav tsum tau txiav txim siab raws li cov khoom ntawm cov khoom thiab cov yam ntxwv ntawm lwm cov tshuaj tiv thaiv.
Cov saum toj no yog ib qho ntawm ntau txoj hauv kev sim ua ke, thiab peb lub tuam txhab cov kws tshawb fawb tshawb fawb tau ua cov ntsiab lus luv luv. Yeej muaj lwm txoj hau kev. Txhawm rau kom tau txais cov ncauj lus ntxaws ntxaws ntxiv thiab cov tshuaj sib npaug, thov xa mus rau cov ntaub ntawv tshawb fawb ntsig txog, phau ntawv qhia txog kev ua haujlwm chemistry lossis phau ntawv qhia txog cov organic chemistry, lossis xa email rau peb, thiab peb yuav teb koj tom qab sab laj cov kws tshawb fawb. Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias thaum ua haujlwm hauv chav kuaj, thov ua raws li kev kuaj xyuas kev nyab xeeb thiab ua raws li cov cai thiab cov cai.