Valerophenone, tseem hu ua 1-Phenyl-1-pentanone los yog 2-Phenylacetone, yog ib qho organic compound nrog cov tshuaj formula C₁₀H₁₂O. Nws yog nyob rau hauv chav kawm ntawm ketones thiab yog structurally tsim los ntawm ib pawg phenyl (-C₆H₅) txuas mus rau ib tug pentanone saw (-C₅H₁₁CO-).
Cov tshuaj no yog siv nyob rau hauv ntau yam tshuaj syntheses thiab tuaj yeem pom nyob rau hauv kev tsim tshuaj, tshuaj tsw qab, thiab ua tus thawj coj hauv kev sib txuas ntawm lwm cov organic tebchaw. Nws yog ib qho tseem ceeb nyob rau hauv cov organic chemistry vim nws muaj ntau yam reactivity thiab lub luag hauj lwm raws li lub tsev thaiv nyob rau hauv synthesis pathways.This blog delves rau hauv nws ntau haiv neeg siv, teb ib co ntawm cov nquag nug cov lus nug txog cov tshuaj no compound.
Synthesis thiab Chemical Properties
Valerophenone tuaj yeem ua ke los ntawm ntau txoj hauv kev, tab sis ib txoj hauv kev muaj feem cuam tshuam nrog Friedel-Crafts acylation ntawm benzene nrog valeroyl chloride nyob rau hauv lub xub ntiag ntawm ib tug Lewis acid catalyst xws li txhuas chloride (AlCl3). Cov tshuaj tiv thaiv no qhia cov pab pawg pentanoyl mus rau lub nplhaib benzene, tsim valerophenone.
Cov khoom siv tshuaj lom neeg ntawm valerophenone suav nrog nws lub peev xwm ua rau muaj kev cuam tshuam ketone. Nws tuaj yeem koom nrog cov tshuaj tiv thaiv nucleophilic ntxiv, qhov twg cov nucleophile tawm tsam cov carbonyl carbon, thiab nws tuaj yeem raug txo qis rau cov cawv uas siv cov tshuaj txo qis xws li lithium aluminium hydride (LiAlH4) lossis sodium borohydride (NaBH4). Tsis tas li ntawd, valerophenone tuaj yeem koom nrog cov tshuaj tiv thaiv condensation, xws li aldol condensations, uas muaj txiaj ntsig zoo hauv cov organic synthesis rau kev tsim cov molecules complex.
Dab tsi yog Pharmaceutical Applications ntawm Valerophenone?
Valerophenoneplays lub luag haujlwm tseem ceeb hauv kev lag luam kws tshuaj raws li qhov nruab nrab hauv cov tshuaj synthesis. Nws ua hauj lwm raws li lub tsev thaiv rau zus tau tej cov ntau yam tshuaj tebchaw. Tshwj xeeb, nws cov qauv tso cai rau kev hloov kho uas ua rau kev txhim kho cov tshuaj sib txawv, uas yog qhov tseem ceeb rau kev kho mob ntau yam.
Ib qho tseem ceeb ntawm kev siv valerophenone hauv cov tshuaj yog nws txoj kev koom tes hauv kev sib txuas ntawm amines los ntawm Leuckart-Wallach cov tshuaj tiv thaiv. Cov tshuaj tiv thaiv no hloov cov ketones rau hauv amines, uas yog cov khoom tseem ceeb hauv ntau cov tshuaj. Lub versatility ntawm valerophenone cov tshuaj cov qauv ua rau nws tsim nyog los tsim ib tug ntau yam ntawm cov tshuaj tebchaw, xws li sedatives thiab anticonvulsants.
Tsis tas li ntawd, valerophenone tau pom muaj peev xwm hauv kev siv tshuaj tua kab mob thiab tshuaj tiv thaiv kab mob. Kev tshawb fawb qhia tias qhov sib xyaw no muaj cov khoom siv uas tuaj yeem siv los tsim cov tshuaj tua kab mob tshiab thiab tshuaj tiv thaiv kab mob. Nws muaj peev xwm inhibit cov kab mob loj hlob thiab txo qhov mob opens muaj peev xwm rau nws suav nrog hauv kev kho mob rau cov kab mob thiab cov kab mob inflammatory.
Valerophenone kuj tseem siv rau hauv kev tshawb fawb los ua tus qauv rau kev tsom xam. Hauv kev tshawb fawb forensic, nws ua haujlwm raws li cov khoom siv hauv cov pa roj chromatography-mass spectrometry (GC-MS) rau kev kuaj pom cov tshuaj amphetamines hauv cov qauv tshuaj lom neeg. Daim ntawv thov no qhia txog nws qhov tseem ceeb hauv kev txhim kho thiab kev lees paub ntawm txoj hauv kev rau kev kuaj tshuaj thiab tshuaj toxicological.
Valerophenone siv li cas hauv Organic Synthesis?
Hauv cov organic synthesis, valerophenone yog ib qho tseem ceeb nruab nrab. Nws cov khoom siv tshuaj ua rau nws pib cov khoom siv rau kev sib txuas cov organic molecules. Organic chemists nquag siv valerophenone hauv cov tshuaj tiv thaiv uas yuav tsum tau tsim cov carbon-carbon bonds tshiab, uas yog qhov tseem ceeb hauv kev tsim ntau cov organic tebchaw.
Ib qho tshuaj tiv thaiv tseem ceeb cuam tshuam nrog valerophenone yog tsim ntawm imines. Cov txheej txheem no suav nrog cov tshuaj tiv thaiv ntawm valerophenone nrog thawj amine los tsim ib qho imine, uas tuaj yeem raug txo qis ntxiv lossis hloov kho los tsim lwm cov tshuaj. Imines yog cov nruab nrab tseem ceeb hauv kev sib txuas ntawm cov tshuaj, agrochemicals, thiab dyes.
Valerophenone kuj koom nrog hauv kev tsim cov hemiketals. Cov tshuaj tiv thaiv no cuam tshuam nrog kev sib cuam tshuam ntawm cawv thiab valerophenone, ua rau hemiketal. Hemiketals yog precursors rau ketals, uas yog cov pab pawg tiv thaiv siv nyob rau hauv cov organic synthesis los tiv thaiv rhiab functional pab pawg neeg thaum lub sij hawm tshuaj tiv thaiv.
Ntxiv mus,valerophenoneyog koom nrog hauv keto-enol tautomerism, ib qho tshwm sim uas muaj nyob rau hauv qhov sib npaug ntawm nws daim ntawv keto (valerophenone) thiab nws daim ntawv enol. Qhov no tautomerism yog qhov tseem ceeb hauv ntau cov tshuaj tiv thaiv, vim tias daim ntawv enol tuaj yeem koom nrog cov tshuaj sib txawv piv rau keto daim ntawv, yog li nthuav dav ntau yam kev hloov pauv tshuaj.
Dab tsi yog kev lag luam thiab kev lag luam siv Valerophenone?
Tshaj li cov tshuaj thiab cov organic synthesis, valerophenone muaj ntau daim ntawv thov kev lag luam thiab kev lag luam. Nws siv nyob rau hauv kev lag luam tshuaj tsw qab yog qhov tseem ceeb, qhov twg nws pab rau kev tsim cov naj hoom thiab flavors. Valerophenone imparts qab zib, floral aroma, ua rau nws xav tau ib feem ntawm ntau yam khoom tsw qab.
Hauv kev lag luam zaub mov thiab dej haus, valerophenone yog siv los txhim kho aromas, ntxiv qhov tob thiab nyuaj rau cov tsw. Daim ntawv thov no qhia txog nws lub luag haujlwm hauv kev tsim cov kev paub txog kev xav uas txaus siab rau cov neeg siv khoom.
Valerophenonekuj tseem siv rau hauv kev tsim cov kua siv lead ua kua. Cov kua ua kua yog cov khoom siv tseem ceeb hauv kev siv tshuab, xws li siv hauv cov ntxaij vab tshaus LCD. Lub compound ua raws li qhov nruab nrab hauv kev sib txuas ntawm cov khoom siv ua kua siv lead ua, ua rau kev nce qib ntawm cov khoom siv thev naus laus zis.
Hauv kev tshawb fawb forensic, valerophenone lub luag haujlwm txuas ntxiv dhau nws qhov kev siv raws li tus qauv rau kev kuaj pom amphetamine. Nws kuj yog siv rau hauv ntau yam kev tshuaj ntsuam xyuas los txheeb xyuas thiab txheeb xyuas lwm yam khoom. Nws cov khoom siv tshuaj ruaj khov ua rau nws muaj kev ntseeg siab cov ntaub ntawv hauv kev tshawb nrhiav forensic.
Valerophenone cov ntawv thov sib txawv qhia txog nws qhov tseem ceeb hauv ntau qhov kev lag luam. Los ntawm cov kws tshuaj thiab cov organic synthesis mus rau cov tshuaj tsw qab thiab forensic science, qhov sib xyaw ua ke no txuas ntxiv mus rau kev tsim kho tshiab thiab kev loj hlob thoob plaws ntau yam.
Xaus
Valerophenoneyog ib tug multifaceted compound nrog daim ntaub ntawv uas span pharmaceuticals, organic synthesis, thiab industrial siv. Nws lub luag haujlwm ua ib qho nruab nrab hauv kev sib xyaw tshuaj, tus neeg koom nrog cov tshuaj tiv thaiv tseem ceeb, thiab cov khoom siv hauv cov tshuaj tsw qab thiab cov kua muaju qhia txog nws qhov tseem ceeb hauv kev tshawb fawb tshawb fawb thiab cov khoom lag luam. Raws li kev tshawb fawb txuas ntxiv mus, valerophenone lub peev xwm siv tau tuaj yeem nthuav dav ntxiv, ua kom nws txoj haujlwm ua cov tshuaj muaj txiaj ntsig zoo hauv ntau qhov kev lag luam.
Cov ntaub ntawv
1. Safrole.com - Valerophenone: Synthesis Methods thiab Physico-Chemical Characterization
2. Thermo Fisher Scientific - Valerophenone, 99%
3. Starsky Chemical - Dab tsi yog kev siv ntawm Valerophenone?
4. Cocentech Chemicals Blog - Kev Siv Valerophenone
5. PubChem - Valerophenone Compound Summary
6. Organic Syntheses - Leuckart-Wallach Reaction
7. Tshuaj Tiv Thaiv Kev Nyab Xeeb - Valerophenone
8. ScienceDirect - Valerophenone Kev Tshawb Fawb Cov Ntawv
9. American Chemical Society - Kev siv Valerophenone
10. Forensic Science International - Valerophenone hauv Kev Tshawb Fawb Chemistry