GABApab cov nroj tsuag tiv thaiv cov yeeb ncuab sab nraud. Thaum kab noj, cell rupture thiab cov ntaub so ntswg raug mob yog tshwm sim los ntawm cov nroj tsuag raug mob. Qhov kev txiav tshuab no yuav txhawb nqa qhov nce ntawm Ca2 ntxiv rau hauv cov nroj tsuag. Nroj tsuag zais GABA raws li kev txhawb nqa ntawm Ca2 ntxiv rau kev ntsuas los tiv thaiv kab noj. Nyob rau hauv cov txheej txheem no, tsis muaj jasmonate teeb liab koom nrog rau tsub zuj zuj ntawm GABA. Muaj ionic GABA receptors hauv kab. GABA gated chloride channel subunit RDL (tiv taus dieldrin) ntawm Drosophila yog lub hom phiaj ntawm ntau yam tshuaj tua kab. GABA induction txo qhov tam sim no ntawm GABA receptor. Tshwj xeeb, GABA ua los ntawm GABA receptor gated chloride channels hauv invertebrates. Zoo li feem ntau cov tshuaj tua kab, los ntawm GABA receptor chloride channels, Cl-downstream tsav los ntawm electrochemical gradients, ua rau plasma membrane hyperpolarization thiab inhibiting kab noj. Nyob rau hauv cov nroj tsuag luam yeeb overexpressing GABA, thaum inoculated nrog qaum teb nematodes, nws tau pom tias lub peev xwm ntawm cov poj niam laus nematodes poob tag nrho. Txoj kev no tuaj yeem ua rau cov nroj tsuag ua tiav cov txiaj ntsig ntawm kev tiv thaiv cov yeeb ncuab ntuj. Nyob rau hauv tus txheej txheem ntawm pub Ligustrum lucidum los ntawm herbivorous poj niam e larvae, nws tau pom tias Ligustrum lucidum yuav txo nws cov lysine kev ua si thiab ua protein ntau noj, thaum poj niam e larvae yuav secrete glycine - Alanine, amine thiab lwm yam molecules inhibit qhov txo ntawm cov nroj tsuag lysine. Cov txheej txheem kev sib txuas lus ntawm cov nroj tsuag thiab herbivores kuj ua pov thawj txoj haujlwm ntawm GABA raws li lub teeb liab molecule.
Lub luag haujlwm hauv cov txheej txheem ntawm kev tiv thaiv oxidation thiab oxidation: GABA shunt, raws li ib qho khoom nruab nrab ntawm cov ceg ntawm txoj kev ntawm tricarboxylic acid voj voog, yog ze ze rau lub zog voj voog. Nyob rau tib lub sijhawm, GABA plays lub luag haujlwm ua tus tswj hwm ntawm oxidative metabolites. Thaum Arabidopsis SSADH mutant raug rau qhov kub thiab txias, nws tau pom tias nws cov reactive oxygen intermediate (ROI) accumulated, ua rau cov nroj tsuag tuag. ua pov thawj tias muaj kev sib raug zoo ntawm ROI thiab GABA. Ib yam li ntawd, cov mutants ntawm SSADH thiab GABA-T noob muaj ntau ntawm ROI ntawm qhov kub thiab txias －Phenylnitrone (PBN) tuaj yeem khaws tau ntau ntawm GABA thiab txhim kho cov ciaj sia ntawm cov poov xab. Yog li, nws tau txiav txim siab tias GABA shunt txoj hauv kev ua lub luag haujlwm hauv inhibiting ROI ntawm qhov kub thiab txias. Hauv cov txheej txheem ntawm GABA shunt, SSA tuaj yeem hloov pauv mus rau GHB los ntawm GlyR / ssar, thiab GHB muaj feem cuam tshuam nrog ROI. Muaj ntau qhov sib txuam ntawm GHB thiab ROI hauv SSADH tshem tawm mutant, thiab guabatrin tuaj yeem cuam tshuam cov tsub zuj zuj ntawm GHB thiab ROI thiab inhibit peroxidation tuag. GABA shunting txheej txheem tuaj yeem txo qhov sib xyaw ntawm ROI thiab tiv thaiv kab mob los ntawm kev puas tsuaj oxidative thiab peroxide lwj los ntawm qhov kub thiab txias.
Muaj ob txoj hauv kev ntawm GABA synthesis thiab kev hloov pauv hauv cov nroj tsuag: ib qho yog tias glutamic acid decarboxylase (GAD) catalyzes decarboxylation ntawm glutamic acid rau synthesize GABA, uas yog hu ua GABA shunt; Lwm qhov yog GABA tsim los ntawm kev hloov pauv ntawm polyamine degradation khoom, uas yog hu ua polyamine degradation txoj kev.
Nws tseem tuaj yeem tswj cov pa roj carbon thiab oxygen sib npaug: cov pa roj carbon thiab nitrogen metabolic sib npaug koom nrog ntau cov txheej txheem physiological, suav nrog lub zog metabolism, amino acid metabolism thiab lwm yam. Vim hais tias GABA synthesis thiab shunt txoj kev koom nrog nitrogen metabolism, GABA kuj yog ib feem tseem ceeb ntawm tricarboxylic acid voj voog nyob rau hauv lub zog voj voog. GABA shunt txoj kev sib tw nrog cov kab mob ua pa rau SSADH. Yog li ntawd, GABA tau raug suav hais tias yog qhov tseem ceeb txuas ntawm carbon thiab nitrogen metabolism rau lub sijhawm ntev. GABA txoj hauv kev ntawm glutamate synthesis nyob rau hauv ceg ntawm tricarboxylic acid voj voog yog ib qho tseem ceeb rau cov nroj tsuag teb sai sai rau sab nraud stimuli. Feem ntau NH3 ntxiv yog tsim los ntawm glutamine synthetase / glutamate synthetase txoj hauv kev, uas yog suav tias yog txoj hauv kev tseem ceeb ntawm cov amino acids. Feem ntau ntawm cov dawb amino molecules yog kho los ntawm glutamine. Glutamate yog suav tias yog lub ntsiab tsub zuj zuj ntawm nitrogen hauv cov hauv paus hniav qub ntawm cov nroj tsuag. Nitrogen khaws cia hauv cov amino acids xws li arginine. Nyob rau tib lub sijhawm, arginine kuj tuaj yeem siv rau kev thauj mus los kom tau raws li nitrogen xav tau ntawm cov kab mob. Ib yam li ntawd, cov amino acids kuj koom nrog hauv lub zog metabolism los ntawm kev hloov mus rau precursors lossis intermediates ntawm lub voj voog tricarboxylic acid. Hauv kev tshawb fawb ntawm spinach, nws tau pom tias proline suav txog 8.1 feem pua ~ 36 feem pua ntawm tag nrho cov amino acids dawb, GABA suav txog 12.8 feem pua ~ 22.2 feem pua, glutamate suav txog 5.6 feem pua ~ 21.5 feem pua. Glutamate yog qhov ua ntej ntawm GABA thiab proline. Nyob rau hauv qis kub, cov nroj tsuag yuav hloov cov nitrogen ntawm glutamate mus rau hauv txoj kev metabolic ntawm nitrogen tswj los ntawm GABA thiab proline. Tsis tas li ntawd, hauv Arabidopsis kab lis kev cai qis dua 50mmol / L GABA, tshwj tsis yog NADP ntxiv rau citrate dehydrogenase, glutamine synthetase hauv paus thiab paj thiab phosphoenolpyruvate carboxylase hauv paj, yuav luag tag nrho cov enzyme kev ua ub no cuam tshuam rau thawj nitrogen metabolism thiab nitrate nqus tau cuam tshuam. Hauv Arabidopsis kab lis kev cai raws li NaCl cov xwm txheej, nws tau pom tias GABA tsub zuj zuj coj mus rau qhov nce ntawm tag nrho cov amino acids hauv Arabidopsis. Nyob rau hauv Arabidopsis nplooj kab lis kev cai nrog sib txawv nitrogen tebchaw (10mmol / L NH4Cl, 5mmol / L NH4NO3, 5mmol / L glutamate thiab 5mmol / L glutamine) raws li ib tug tsuas yog nitrogen qhov chaw, lawv cov kev ua ntawm GAD thiab protein theem sib txawv, qhia tias GAD plays lub luag hauj lwm. nyob rau hauv nitrogen metabolism.
Qhov nce ntawm GAD kev ua si thiab GABA thiab dopamine kuj pom nyob rau hauv txiv tsawb nyob rau hauv tsis muaj kev ntxhov siab. Nyob rau hauv kev nyuaj siab ntsev, glutamate dehydrogenase kev ua si thiab GAD qhia tau nce sai sai, thiab tom qab ntawd ntxiv cov flux ntawm GABA shunt thiab lwm txoj hauv kev los tswj cov pa roj carbon thiab nitrogen. Hauv kev ntxhov siab, qhov piv ntawm NADH: NAD ntxiv thiab ADP: ATP tuaj yeem cuam tshuam GABA-T, ua rau GABA tsub zuj zuj. Hauv qab ntsev ntsev, cov nroj tsuag siv ntau dua C / N sib npaug txoj hauv kev los txo kev ntxhov siab.
Tsis tas li ntawd, GABA kuj muaj cov nyhuv ripening. GABA tuaj yeem txhawb nqa ethylene biosynthesis los ntawm stimulating cov transcriptional abundance ntawm 1-aminocyclopropane-1-carboxylic acid (ACC) synthase. Ethylene tuaj yeem muab cov pa oxygen rau cov nroj tsuag los ntawm kev txhawb nqa kev loj hlob ntawm cov cag ntoo hauv qab dej nkag. Cov ntsiab lus siab ntawm GABA tuaj yeem cuam tshuam kev loj hlob ntawm cov nroj tsuag thiab cov kab mob GABA aminotransferase (GABA-T, gabt) mutants, thiab cov concentration siab tuaj yeem cuam tshuam kev loj hlob ntawm cov kab mob hauv cov nroj tsuag. Qhov inhibition ntawm GABA-T nyob rau hauv txiv lws suav yuav ua rau tsub zuj zuj ntawm GABA thiab tshwm sim ntawm dwarfism nyob rau hauv txiv lws suav.