Taw qhia
Linaclotide, ib daim ntawv tshuaj siv los kho cov teeb meem plab hnyuv tshwj xeeb, tau txais qhov tseem ceeb thaum lig. Txawm li cas los xij, zoo li txhua yam tshuaj, tsis yog txhua tus yuav tsum tau noj.
Peb muabLinaclotide, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia tshwj xeeb thiab cov ntaub ntawv khoom.
Khoom siv:https://www.bloomtechz.com/synthetic-chemical/peptide/linaclotide-cas-851199-59-2.html
Nkag siab Linaclotide
Yuav ua li cas hais txog peb pib paub dab tsi cov khoom yog thiab txoj kev uas nws ua hauj lwm ua ntej nkag mus rau hauv lub contraindications. Cov neeg laus uas muaj kev cuam tshuam tsis tu ncua idiopathic (CIC) thiab touchy hauv kev tsis sib haum xeeb nrog kev txhaws (IBS-C) tau pom zoo. Nws ua haujlwm los ntawm kev ua kom cov kua dej tso rau hauv cov hnyuv, uas yuav pab ua kom cov quav mos thiab ua kom cov plab zom mov ntau zaus.
Nws muaj ib qho chaw nrog chav kawm ntawv tshuaj hu ua guanylate cyclase-C agonists. Nws txhawb kev tsim ntawm cyclic guanosine monophosphate (cGMP) los ntawm kev ua kom lub guanylate cyclase-C receptor nyob rau hauv plab hnyuv epithelium. Vim tias qhov nce hauv cGMP, qhov tso tawm ntawm cov tshuaj chloride thiab bicarbonate rau hauv cov hnyuv lumen ua rau muaj kev thauj mus los thiab ua rau cov kua hauv plab.
Contraindications tseem ceeb rau kev siv Linaclotide
Thaumlinaclotidetuaj yeem ua tau zoo rau ntau tus neeg mob, muaj qee yam xwm txheej thiab qhov xwm txheej uas nws siv yuav raug contraindicated. Ntawm no yog cov thawj contraindications kom paub txog:
1. Mechanical Gastrointestinal Obstruction
Cov khoom no yuav tsum tsis txhob siv rau cov neeg mob uas paub lossis xav tias muaj kev cuam tshuam txog kev ua rau lub plab zom mov. Qhov xwm txheej no tshwm sim thaum muaj qhov cuam tshuam tiag tiag hauv lub plab zom mov, cuam tshuam cov ntu ntawm cov zaub mov thiab dej. Kev siv nws hauv cov xwm txheej zoo li no tuaj yeem rhuav tshem qhov cuam tshuam lossis ua rau muaj teeb meem.
Cov tsos mob ntawm mechanical gastrointestinal obstruction yuav muaj xws li:
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mob hnyav hauv plab.
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Queasiness thiab regurgitating.
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Tsis muaj zog kom kis tau roj los yog defecation.
·
Lub plab loj los yog bulging.
Yog tias koj xav tias koj muaj mob plab hnyuv, nws tseem ceeb heev kom nrhiav kev kho mob tam sim ntawd tsis yog sim kho nws nrog cov tshuaj zoo li nws.
2. Hypersensitivity rau Linaclotide los yog nws cov Cheebtsam
Raws li nrog rau txhua yam tshuaj, cov tib neeg uas muaj kev paub tsis meej lossis tsis haum rau nws lossis ib qho ntawm nws cov khoom yuav tsum tsis txhob siv cov tshuaj no.
Kev tsis haum tshuaj tuaj yeem muaj txij li mob me mus rau qhov hnyav thiab tuaj yeem suav nrog cov tsos mob xws li:
· Cov tawv nqaij ua pob khaus lossis khaus khaus.
· Khaus khaus.
· Kev nthuav dav, tshwj xeeb ntawm lub ntsej muag, tus nplaig, lossis caj pas.
· Teeb meem so.
· Discombobulation lossis blacking tawm.
Yog tias koj muaj cov tsos mob no tom qab noj cov khoom, tsum tsis txhob siv cov tshuaj tam sim ntawd thiab nrhiav kev pab kho mob.
3. Cov neeg mob menyuam yaus
Linaclotidetsis pom zoo siv rau cov neeg mob menyuam yaus, tshwj xeeb tshaj yog cov hnub nyoog qis dua 18 xyoo. Kev txhawj xeeb txog kev nyab xeeb thiab qhov tsis muaj peev xwm txhais tau hauv cov neeg no ua rau muaj qhov tsis txaus ntseeg.
Nyob rau hauv qhov tseeb, kev siv ntawm nws nyob rau hauv cov tub ntxhais hluas cov neeg mob tau raug ib lub thawv ceeb toom los ntawm FDA. Kev tsom mus rau hauv cov tsiaj muaj zog tau pom tias nws tuaj yeem ua rau muaj kev npau taws heev, uas tuaj yeem ua rau tuag taus. Thaum cov kev ntsuam xyuas no tau sib koom ua ke ntawm cov tsiaj hluas, qhov qub thawj koom ruam rau tib neeg cov menyuam yaus tau pom tias yog qhov yooj yim txaus los lav thaj chaw ruaj khov rau qhov no.
Yog tias koj yog leej niam leej txiv lossis tus saib xyuas ntawm tus menyuam uas muaj IBS-C lossis tsis muaj qhov thaiv tsis tu ncua, nws yog ib qho tseem ceeb uas yuav tsum tau sab laj nrog kws kho mob plab menyuam txog kev kho mob uas tsim nyog, nyab xeeb, thiab muaj txiaj ntsig.
Lwm yam kev txiav txim siab tseem ceeb thaum siv Linaclotide
Thaum tsis nruj contraindications, muaj ob peb lwm yam yuav tsum tau xav txog thaum siv nws:
Kev nyab xeeb ntawm cov khoom thaum cev xeeb tub tsis tau tshawb xyuas kom meej. Tsis muaj cov ntaub ntawv hais txog nws txoj kev siv rau cov poj niam cev xeeb tub, thiab cov tsiaj tsom rau tsis tau pom tias cov hatchling raug mob. Txawm li cas los xij, nws yuav tsum tsis txhob siv thaum cev xeeb tub tshwj tsis yog tias qhov txiaj ntsig zoo cuam tshuam qhov kev phom sij rau tus menyuam hauv plab vim tias tsis muaj tib neeg cov ntaub ntawv.
Yog li, nws yog qhov tsaus ntuj seb tib neeg cov mis nyuj muaj cov khoom. Kev saib xyuas yuav tsum tau muab ntxuav kom huv thaum saib xyuas cov khoom rau cov niam laus. Ua ntej yuav siv nws, nws yog ib qho tseem ceeb uas yuav tau soj ntsuam qhov zoo thiab kev phom sij nrog koj tus neeg muab kev pab kho mob, tshwj xeeb yog tias koj cev xeeb tub lossis pub niam mis.
Txawm hais tias tsis muaj contraindications, nws yog ib qho tseem ceeb uas yuav tsum tau saib xyuas tias qhov kev khiav yog qhov kev pom dav dav tshaj plaws rau nws. Hauv kev kho mob ua ntej, 2% ntawmlinaclotide-kho cov neeg mob tau ntsib kev ua haujlwm hnyav. Yog tias koj noj cov tshuaj no thiab ua haujlwm hnyav, koj yuav tsum tau txiav nws thiab tham nrog koj tus PCP.
Nws yog cov khoom, tshwj xeeb tshaj yog kev twv txiaj ntawm kev xoob ntawm lub plab, tej zaum yuav pom tau ntau dua hauv cov neeg tsim. Txawm tias muaj tseeb hais tias ua ntau seasoned tsis yog ib qho contraindication, cov neeg mob laus yuav tsum tau xyuas kom ruaj khov rau cov teebmeem thib ob thaum noj cov tshuaj no.
Xaus
Txawm tias muaj tseeb hais tias cov khoom muaj peev xwm kho mob idiopathic clogging thiab phem tempered entrail teeb meem nrog stoppage, tsis yog txhua txhua tus neeg yog ib tug dlej muaj peev xwm rau nws. Mechanical gastrointestinal deterrent, heev touchiness rau cov tshuaj los yog nws qhov chaw, thiab siv nyob rau hauv cov me nyuam yog cov feem ntau dav lees paub contraindications.
Txawm li cas los xij, qhov tsim nyog ntawm nws rau txhua tus neeg mob yog nyob ntawm ntau yam, suav nrog tus neeg mob kev noj qab haus huv tag nrho, lwm yam tshuaj uas lawv yuav noj, thiab cov ntsiab lus tshwj xeeb ntawm lawv cov teeb meem plab hnyuv. Ua ntej pib lossis nres ib qho tshuaj, suav nroglinaclotide, nws yog ib qho tseem ceeb rau kev sab laj nrog ib tus kws kho mob.
Koj tus PCP tuaj yeem muab cov kev hloov pauv hloov los txiav txim siab txog koj qhov kev vam meej tshwj xeeb, pab nrog xyuas kom koj tau txais kev kho mob uas tsim nyog thiab tsim nyog tshaj plaws rau koj tus mob thaum txwv kev pheej hmoo. Nco ntsoov, thaum cov ntaub ntawv hais txog contraindications thiab tej zaum yuav tshwm sim tshwm sim yog loj, nws yuav tsum tsis tu ncua pom raws li kev cob cog rua nrog muaj peev xwm cov lus qhia.
Cov ntaub ntawv
US Food and Drug Administration. (2012). Linzess (linaclotide) capsules, rau kev siv qhov ncauj. Tau txais los ntawm https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/202811lbl.pdf
Chey, WD, Lembo, AJ, Lavins, BJ, Shiff, SJ, Kurtz, CB, Currie, MG, ... & Johnston, JM (2012). Linaclotide rau kev chim siab plob tsis so tswj nrog cem quav: ib 26-lub lim tiam, randomized, ob-dig muag, placebo-tswj sim los ntsuas kev ua tau zoo thiab kev nyab xeeb. American Journal of Gastroenterology, 107(11), 1702-1712.
Lacy, BE, Levenick, JM, & Crowell, MD (2012). Linaclotide: kev kho tshiab rau cem quav thiab cem quav-predominant irritable plob tsis so tswj syndrome. Gastroenterology & hepatology, 8(10), 653.
Quigley, EM, Tack, J., Chey, WD, Rao, SS, Fortea, J., Falques, M., ... & Johnston, JM (2013). Randomized soj ntsuam kev sim: linaclotide theem 3 kev tshawb fawb hauv IBS-C-ib qho kev tsom xam ntxiv raws li European Medicines Agency-cov ntsiab lus xaus. Alimentary Pharmology & Therapeutics, 37(1), 49-61.
Rao, S., Lembo, AJ, Shiff, SJ, Lavins, BJ, Currie, MG, Jia, XD, ... & Johnston, JM (2012). Ib 12-lub lim tiam, randomized, tswj kev sim nrog rau 4-lub lim tiam randomized tshem tawm lub sij hawm los soj ntsuam kev ua tau zoo thiab kev nyab xeeb ntawm linaclotide nyob rau hauv chim siab plob tsis so tswj syndrome nrog cem quav. American Journal of Gastroenterology, 107(11), 1714-1724.