Vim li cas Afoxolaner thiab Milbemycin Oxime Chewable Tablets Matter rau Heartworm

Kab mob plawv yog ib qho teeb meem tseem ceeb tshaj plaws rau tus dev lub sij hawm ntev - noj qab haus huv. Cov yoov tshaj cum tom yog nqa Dirofilaria immitis larvae mus rau hauv cov hlab ntsha. Yog tias tsis tsim nyog prophylaxis, cov larvae no tuaj yeem tsim mus rau hauv cov kab mob uas yuav ua mob rau lub plawv thiab cov hlab ntsws hauv lub sijhawm. Qhov xwm zoo yog tias kev tshawb fawb kws kho tsiaj tau tsim kev kho mob qhov ncauj txhua hli. Afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj yog ob lub- ntsiav tshuaj qhov ncauj uas kho cov kab mob hauv lub cev xws li kab mob plawv thiab cov kab mob sab nraud xws li dev mub thiab zuam, tag nrho hauv ib lub hlis twg.

Hauv cov ntawv tshaj tawm no, peb yuav hais txog vim li cas qhov kev sib xyaw no tseem ceeb, lub luag haujlwm txhua yam khoom muaj nyob hauv kev tiv thaiv kab mob plawv, thiab cov pov thawj hais txog kev noj txhua hli.

Afoxolaner Thiab Milbemycin Oxime Chewable Tablets

1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Tablet
9.375+1.875mg: 2-3.5 kg
18.75+3.75mg: 3.5-7.5kg
37.5+7.5mg:＞7.5-15kg
75+15mg:＞15-30kg
150+30mg: 30-60kg
(3) Ointment
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
PIB: BM-2-117
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BLOOM TECH Xi'an Hoobkas

Dual Mechanism Tom Qab Kev Tiv Thaiv Ib Hlis

Ib koob tshuaj thib ob ntawm kev ruaj ntseg los ntawm ob yam tshuaj nquag ua haujlwm ua ke nrog afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj. Afoxolaner inhibits GABA-gated chloride channels hauv arthropods thiab tua ectoparasites xws li hma, zuam, thiab mites. Qhov no overstimulates lawv thiab tua lawv. Milbemycin oxime ua haujlwm ntawm cov paj hlwb invertebrate thiab cov leeg hlwb ntawm glutamate-gated chloride channels. Nws ua rau hyperpolarization thiab tuag tes tuag taw ntawm cov kab mob uas raug kab mob. Qhov no suav nrog cov theem larval ntawm Dirofilaria immitis, tus kab mob ua rau mob plawv.

Ob lub tebchaw no tuaj ua ke los tsim kev tiv thaiv txhua hli uas muaj zog ntau dua li cov khoom lag luam uas tsuas yog ib feem tuaj yeem ua tiav.

Yog vim li cas txhua hli Qhov ncauj Dosing ua hauj lwm

Pharmacokinetic kev tshawb pom pom tseeb ib zaug -ib - kev tswj hwm ib hlis. Milbemycin oxime Cheebtsam A3 thiab A4 ua tiav cov ntshav siab tshaj ib mus rau ob teev tom qab tswj qhov ncauj. A3 muaj ib nrab-lub neej ntawm kwv yees li 1.6 hnub, thiab A4 muaj ib nrab-lub neej ntawm 3.3 hnub; yog li ntawd, lawv tseem tua kab mob nyob rau lub hli. Afoxolaner ua tiav nws cov ntshav siab tshaj plaws hauv 2 mus rau 4 teev tom qab kev tswj hwm thiab muaj ib nrab ntawm -lub neej ntawm > 2 lub lis piam.

Vim tias cov tshuaj pharmacokinetic no, yog tias tus dev noj ib ntsiav tshuaj ib hlis, muaj cov tshuaj txaus txaus ntawm ob qho tshuaj hauv tus dev lub cev los rhuav tshem cov kab mob plawv ua ntej lawv tuaj yeem txhim kho mus rau theem teeb meem ntawm lawv lub neej.

Targeting Heartworm ntawm Larval Stage

Kev tiv thaiv kab mob plawv yog ua ncaj qha los ntawm milbemycin oxime, uas muaj nyob hauvafoxolaner thiab milbemycin oxime chewable ntsiav tshuaj. Nws tau tshem ntawm L3 thiab L4 daim ntawv ntawm yoov tshaj cum- kab mob kis - ua rau cab Dirofilaria immitis ua ntej nws tuaj yeem nyob hauv tus dev cov ntaub so ntswg. Lub qhov rais "retroactive" no tseem ceeb heev: ib ntsiav tshuaj noj ib hlis ib zaug tiv thaiv qe los ntawm yoov tshaj cum uas yuav nyob ib ncig ntawm plaub mus rau rau lub lis piam ua ntej noj cov ntsiav tshuaj.

Milbemycin oxime ua haujlwm zoo tawm tsam plab hnyuv nematodes xws li Toxocara canis, Toxascaris leonina, Ancylostoma caninum, thiab Trichuris vulpis, yog li nws yog qhov dav -spectrum anthelmintic uas tuaj yeem tua ntau dua li cov kab mob plawv.

Kev nyab xeeb Profile uas txhawb kev siv niaj hnub

Ib qho tseem ceeb xav txog kev tiv thaiv txhua hli yog kev nyab xeeb ntawm kev kho mob rau ntau hom thiab ntau thiab tsawg ntawm cov dev. Milbemycin oxime tau pom tias muaj kev nyab xeeb hauv cov dev hauv ntau qhov kev tshawb fawb. Cov tshuaj no tsis hla cov ntshav- hlwb teeb meem ntau hauv cov dev noj qab haus huv thiab, xws li, tsis tuaj yeem ncav cuag lub hauv paus paj hlwb. Qhov tseeb bioavailability ntawm milbemycin oxime A3 thiab A4 Cheebtsam tom qab tswj qhov ncauj yog 81% thiab 65%, feem. Qhov no qhia tau hais tias cov qib tsim nyog tau nkag mus rau hauv lub cev.

Cov kws kho tsiaj tau ceeb toom rau cov tswv ntawm cov dev xws li Collies txog kev hloov pauv hauv MDR1 (ABCB1) noob uas yuav ua rau P-glycoprotein tsis ua haujlwm zoo.

Milbemycin oxime tau pom tias muaj kev nyab xeeb rau ntau lub cev hnyav, txij li 2 kg menyuam dev (tsawg kawg 8 lub lis piam) mus rau cov dev loj uas hnyav dua 30 kg.

Cov ntaub ntawv pov thawj los ntawm Kev Tswj Xyuas Kev Ua Haujlwm Zoo

Afoxolaner thiab milbemycin oxime chewable ntsiav tshuajtau pom tias muaj txiaj ntsig zoo tiv thaiv Dirofilaria immitis larvae hauv cov kev tshawb fawb tswj. Hauv kev sim, cov dev tau muab tshuaj txhua hli los ntawm lub qhov ncauj tshem tawm txhua qhov L3 thiab L4 larvae tom qab tau txhaj tshuaj cuav. Ntau tus phooj ywg- cov kev tshawb fawb tshuaj xyuas tau pom tias qhov no ua tiav 99% ntawm lub sijhawm. Cov ntaub ntawv no qhia tau hais tias cov ntsiav tshuaj muaj txiaj ntsig zoo li prophylactic dua li kev kho mob rau lub plawv. Lub tswv yim yog kom tsis txhob mob plawv ua ntej lawv tshwm sim, tsis yog kho lawv.

Cov ntsiav tshuaj chewable kuj tau raug tsim los rau saj, uas cov kws tshawb fawb tau tshawb pom kuj ua rau muaj kev ua raws cai ntau.

Cov dev uas zoo siab noj lawv cov koob tshuaj txhua hli yog qhov muaj txiaj ntsig zoo nyob rau hauv kev tiv thaiv, uas yog qhov tseem ceeb heev vim tias txawm tias ib lub hlis uas ploj lawm tuaj yeem tso cai rau larvae mus rau qhov chaw uas lawv tsis tuaj yeem nres.

Consistency thoob qhov hnyav pawg

Cov ntsiav tshuaj tuaj nyob rau hauv tsib hom tshuaj sib txawv rau cov dev xws li qhov hnyav ntawm 2 kg txog 50 kg. Milbemycin oxime raug xa tawm hauv txhua qhov kev teeb tsa ntawm tus nqi uas yog raws li kev paub txog kev nyab xeeb thiab kev ua tau zoo. Cov kev tshawb fawb qhia tau hais tias cov txheej txheem plasma mus txog thoob plaws txhua qhov hnyav nyob hauv lub qhov rais kho. Qhov no txhais tau hais tias kev tiv thaiv kab mob plawv ua haujlwm zoo rau txhua tus dev, txawm tias lawv loj npaum li cas.

Kev cuam tshuam Neuromuscular Function hauv Larvae

Invertebrate nqaij hlwb muaj glutamate{0}}gated chloride ion channels uas milbemycin oxime khi rau tua kab mob. Qhov kev khi no ua rau daim nyias nyias permeable rau chloride ions, uas ua rau cov cell membrane ntau dua. Tus kab mob larval ua rau tuag tes tuag taw uas kho tsis tau. Ntawm cov nqi kho mob, cov tshuaj tsis ua rau muaj kev pheej hmoo ntau rau cov dev vim hais tias cov phiaj xwm ion yog lub cev ploj lawm lossis ua haujlwm txawv ntawm cov tsiaj.

Vim tias nws muaj kev xaiv zoo, milbemycin oxime yog cov tshuaj tiv thaiv kab mob plawv zoo heev. Raws nraim qhov nws xav tau - ntawm tus kab mob hauv lub paj hlwb - yam tsis muaj kev cuam tshuam rau tus dev nws tus kheej neuromuscular muaj nuj nqi thaum txhua yam zoo li qub.

L4 Clearance Qhov rai thiab Tiv Thaiv Sijhawm

Veterinary parasitologists ntxhov siab tias kev tshem tawm L4 larvae yog lub sijhawm tseem ceeb tshaj plaws los tiv thaiv kab mob plawv. Txoj hauv kev ib txwm ua kom kab laum kom tsis txhob ua haujlwm thaum lub larvae hloov mus rau theem L5 (tus neeg laus laus). Muab afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj los ntawm lub qhov ncauj ib hlis ib zaug ua rau cov ntshav plasma qib ntawm milbemycin oxime siab txaus los tua larvae nyob rau hauv lub qhov rais uas yuav zam tau. Qhov no yog vim li cas vim li cas kev noj tshuaj txhua hli tsis tu ncua, tsis yog kev txhaj tshuaj txhua xyoo, tau pom zoo nyob rau hauv qhov chaw uas yoov tshaj cum muaj zog txhua xyoo.

Integrating Internal thiab External Parasite Control

Ib qho kev pabcuam ua tiav rau kev ua kom cov dev tsis muaj kab mob yuav tsum ua kom zoo nrog cov kev hem thawj sab hauv thiab sab nraud tib lub sijhawm. Qhov no ua tau zoo los ntawm Afoxolaner thiab milbemycin oxime chewable ntsiav tshuaj. Milbemycin oxime lub peev xwm los tua cov kab mob cab thiab cov zuam ua haujlwm tau zoo nrog afoxolaner txoj haujlwm ectoparasiticide tshuav, yog li koj tsis tas yuav siv ntau yam khoom sib txawv. Veterinary txoj cai los ntawm cov pab pawg xws li Companion Animal Parasite Council (CAPC) hu rau dav -spectrum parasite tswj txhua xyoo. Cov ntsiav tshuaj no yog tsim los ua kom tau raws li tus qauv ntawd.

Txhawb Nqa Lub Luag Haujlwm Ntawm Tus Tsiaj Ntawm Nplai

Muaj qhov hnyav -cov ntsiav tshuaj tsim nyog uas ua rau kev tswj hwm yooj yim dua thiab txo qis qhov yuam kev ntawm kev noj tshuaj rau cov tswv dev nrog ntau tus dev lossis rau cov tsiaj txhu thiab cov chaw cawm siav.

Txawm hais tias tus dev hnyav npaum li cas -4 kg lossis 40 kg-txhua ntsiav tshuaj yog tsim los xa cov khoom xyaw nquag hauv qhov paub zoo thiab siv tau zoo. Lub sijhawm tswj hwm txhua hli kuj ua haujlwm nrog kev mus ntsib kws kho tsiaj tsis tu ncua, ua kom yooj yim ntxiv rau cov phiaj xwm kev noj qab haus huv.

Kev tiv thaiv kab mob plawv yuav tsum tau ua tas li, nrog rau kev tshawb fawb, thiab nrog cov zaub mov uas dev yuav noj tiag tiag. Tag nrho peb ntawm cov xwm txheej no tau ntsib los ntawmAfoxolaner thiab milbemycin oxime chewable ntsiav tshuaj. Milbemycin oxime tua cov kab mob plawv loj hlob sai heev thiab muaj qhov zoo - paub txog kev nyab xeeb. Nyob rau tib lub sijhawm, afoxolaner khaws cov kab mob sab nraud nyob rau hauv kev tswj hwm lub sijhawm tib lub sijhawm. Ua ke, lawv yog ib kauj ruam loj rau pem hauv ntej hauv kev tswj kab mob txhua hli rau cov dev, thiab muaj cov ntaub ntawv pov thawj kho mob thiab tshuaj kho mob los txhawb qhov no.

Yog hais tias koj xav tau ib tug txhim khu kev qha muab kev pabafoxolaner thiab milbemycin oxime chewable ntsiav tshuaj, Bloomtechz muaj cov ntaub ntawv pov thawj, GMP- ntawv pov thawj cov saw hlau thiab ntau tshaj 12 xyoo ntawm kev paub ua tshuaj. Peb qhov chaw tsim khoom sib koom tes tau pom zoo los ntawm US FDA, EU GMP, Nyiv GMP, thiab Tuam Tshoj CFDA GMP. Qhov no txhais tau tias txhua batch ua tau raws li cov qauv zoo tshaj plaws thoob ntiaj teb. Peb nruj triple-txuas cov txheej txheem kev soj ntsuam zoo kuaj xyuas cov khoom ntawm lub Hoobkas, los ntawm peb tus kheej QA / QC department, thiab los ntawm peb lub koom haum -tsoom fwv. Ua li no, koj tuaj yeem paub tseeb tias cov khoom koj yuav muaj kev nyab xeeb. Peb muab OEM / ODM kev hloov kho, thiab peb cov kev qhia tshwj xeeb tuaj yeem hloov pauv ntawm 9.375 mg + 1.875 mg rau 150 mg + 30 mg. Peb pab cov neeg siv khoom hauv Asmeskas, Australia, Lub Tebchaws Yelemees, Nyiv, thiab Canada, ntawm lwm qhov chaw.

Tiv tauj peb pab neeg tam sim ntawd ntawmSales@bloomtechz.comtham txog koj qhov kev xav tau, tau txais cov ntaub ntawv, lossis pib sib tham txog kev hloov kho.

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