Cov antiiviral antiviral kev kho mob tau muab cov tswv cuab tshiab thiab kev cia siab rau kev ua kom muaj kev sib kis feline exceritis (FIP), uas yog ib zaug xav ua ib tug mob uas tuag taus. Lub nucleoside analog GS-441524 yog coj tus nqi hauv qhov kev hloov kho no vim nws qhov kev ua tau zoo hauv kev kho fip. Cov ntawv no tshawb nrhiav cov laj thawj rau kev txhawb nqa kev txhawb nqa ntawmGS-441524 txhajKev kho mob ntawm FIP cov neeg tshawb fawb thiab yuav ua li cas nws muaj peev xwm daws cov kev saib xyuas feline.
GS-441524 txhaj
1.Txoj kev tshwj xeeb (hauv Tshuag)
(1) kev txhaj tshuaj
20mg, 6ml; 30Mg, 8ml; 40mg, 10ml
(2) Ntsiav tshuaj
25/45 / 60/0mg
(3) API (hmoov ntshiab)
(4) ntsiav tshuaj xovxwm tshuab
https://www.achievechn.com/pillsés22 rov hais
2.Customization:
Peb yuav sib tham ntawm tus kheej, OEM / ODM, tsis muaj hom, rau kev tshawb nrhiav kev ua haujlwm nkaus xwb.
Intern Code: BM-3-001
GS-441524 CAS 1191237-69-0
Kev tsom xam: HPLC, LC - ms, hnmr
Kev Txhawb Nqa Tshuab: R & Dept.-4
Peb muabGS-441524 txhaj, thov saib mus rau lub vev xaib txuas ntxiv no kom cov ncauj lus kom ntxaws thiab cov ntaub ntawv.
Khoom:https://www.bloomteechz.com/Oemixat0002222 }oadm/GS-441524-Qhov khoom muag khoom.HTML
Mechanism ntawm kev ua txhaum Felie Coronavirus
GS-441524(https://en.wikipedia.org/wiki/gs-441524) Tau mus ua kom zoo siab saib xyuas vim nws tshwj xeeb mechanism ntawm kev nqis tes ua rau lub corine coronavirus, tus neeg sawv cev ntawm FIP. Qhov kev ua haujlwm tshiab no los ntawm kev sib tw kis tus kab mob kis, siv tau rau tus kab mob kis hauv Miv lub cev.
Kev txwv tsis pub tus kab mob RNA synthesis
Thawj hom kev ua ntawm gs - 441524 cuam tshuam nrog kev txwv ntawm tus kab mob RNAles synthesis. Los ntawm cuam tshuam nrog RNA-dependent RNA Polymerase Enzyme, cov tshuaj tiv thaiv tus kab mob los ntawm kev sib txawv nws cov caj ces. Qhov kev cuam tshuam loj no nyob hauv lub neej muaj kev cuam tshuam, ua rau muaj kev txo qis hauv cov kis rau tus mob fip.
Broad -} spectrum antiviral kev ua si
GS-441524 txhajtau pom tseeb dav -} spectrum antiviral kev ua si tiv thaiv ntau yam ntawm feline corine coronavirus. Cov versatility no yog qhov tshwj xeeb yog qhov tseem ceeb uas tau muab cov tshuaj tiv thaiv ntawm RNA cov kab mob sib hloov sai. Cov tshuaj muaj peev xwm tsom cov cheeb tsam muaj kev xaiv ntawm tus genrome ua rau nws xaiv cov kev kho mob ntawm FIP, yog suav nrog cov hom ntub, thiab cov hom paj ntoo qhuav, thiab cov duab paj nruag neurological, thiab neurological cov kab mob.
Tsawg Cytotoxicity Profile
Ib qho ntawm cov ntsiab lus zoo ntawm GS-441524 yog nws cov lus qhia tsawg cytopoxicity profile. Tsis zoo li qee cov tshuaj tiv thaiv kab mob uas tuaj yeem ua rau cov kev mob tshwm sim tseem ceeb, GS-441524 cov khoom ua pov thawj tsawg heev rau cov hauv hlwb. Cov xeeb ceem no tso cai rau kev tswj hwm ntawm kev kho cov tshuaj uas tsis muaj kev cuam tshuam tag nrho kev noj qab haus huv ntawm cov miv kho mob. Cov txiaj ntsig kev nyab xeeb profile tau yog qhov tseem ceeb heev hauv kev nkag mus sistre ntawm GS-441524 kev kho mob FIP cov kev tshawb fawb thiab cov kws kho tsiaj.
Ntev - lub sij hawm remission cov nqi hauv kev tshawb fawb
Qhov ua tau zoo ntawm gs - 44152524 Hauv kev kho cov FIP tau muaj los ntawm kev tshawb fawb ntau cov lus qhia kev pom zoo ntev. Cov kev tshawb nrhiav no tau txhawb kev ntseeg siab ntawm FIP cov kws tshaj lij hauv kev pom zoo GS-441524 ua qhov kev xaiv ua ntej.
Kev Tshawb Fawb Chaw Tshawb Fawb
Ob peb qhov chaw tshawb nrhiav tau sim ua kom pom tau qhov zoo tshaj plaws ntawm GS-441524 hauv kev kho fip. Hauv ib qho kev kawm piv, miv nrog ntau hom fip tau kho nrogGS 441524 TshuajTshaj li 12 {-} lub lim tiam. Cov txiaj ntsig tau tsis muaj dab tsi luv luv ntawm astounding, nrog ntau dua 80% ntawm kev kho miv ua tiav kev zam mus ntev. Qhov kev ua tau zoo no nce siab tshaj txhua txoj kev kho mob yav dhau los rau FIP, uas yog palliative nyob rau hauv qhov.
Kev txhawb nqa kev kho mob hauv kev kho miv
Tej zaum qhov feem ntau yog tshaj tawm ntawm gs - 441524 txoj kev kho yog qhov kev kho mob tau pom hauv cov miv. Ua raws li {-} Kev tshawb fawb tau pom tias kev ua ntu zus uas ua tiav cov tshuaj kho mob uas ua tiav cov kab mob sib txuas, feem ntau tshaj 12 lub hlis. Qhov kev ua tau zoo no ntawm cov lus teb tsis tau pom nyob hauv kev kho FIP thiab tau hloov kho lub sij hawm ntev tau txais cov miv uas cuam tshuam.
Kev ua tau zoo hla sib txawv FIP govifestations
Gs - 441524 tau pom tias kev ua tau zoo thoob plaws ntau yam FIP, suav nrog cov lus tsis muaj tseeb- ua rau-kho cov ntawv neurological. Cov kev tshawb fawb tau pom tias muaj kev hloov kho kom haum, txawm tias miv nrog ocular lossis nurological kev koom tes tuaj yeem ua tiav kev kho mob. Cov versatility no hauv kev kho FIP sib txawv tau ua GS-441524 ib qho cuab yeej muaj txiaj ntsig hauv cov kws kho tsiaj ua lwm yam kab mob nyuaj.
{- Cov ntaub ntawv pov thawj ntiaj teb txhawb kev ua tau zoo
Tshaj dhau kev tswj hwm kev sim, tiag - Cov tswv yim ntiaj teb los ntawm gs {}} 441524 raws li kev kho mob FIP zoo heev. Anecdotal Cov Ntawv Tshaj Tawm thiab Kev Tshawb Xyuas muaj xwm yeem qhia tau zoo ib yam, nrog ntau tus miv ua kom rov zoo dua los ntawm dab tsi yog ib zaug yog ib zaug yog ib zaug suav tias yog kev kuaj mob davhlau ya nyob twg. Qhov kev sib txuam ntawm cov ntaub ntawv tiag tiag-ntiaj teb tau ua Instrumental tau txais kev lees paub ntawm GS-441524 kev kho hauv FIP cov neeg tshawb fawb thiab cov kws qhia.
Cov ntawv thov muaj peev xwm tshaj FIP kho
Thaum GS-441524 tau ua kom zoo nkauj saib xyuas feem ntau rau cov FIP, cov kws tshawb nrhiav tau tshawb txog cov kev pab cuam lwm yam feline thiab qee cov kab mob cuam tshuam rau lwm hom tsiaj.
Lwm yam feline coronavirus -}} associatediatediatediatediated.
Qhov kev vam meej ntawm gs - 441524 hauv kev tshawb nrhiav tau tshawb xyuas nws cov kab mob feline coronavirus {5} {5} {5} {begoriated kab mob. Kev tshawb fawb tab tom tshawb xyuas qhov ua tau zoo ntawm gs {}} 441524 hauv kev kho mob belonavirus cov tsos mob me me hauv miv. Qhov dav-spectrum antiviral kev ua si ntawm GS-441524 ua rau nws muaj kev sib tw rau kev tswj hwm ntau yam Coronavirus ntsig txog cov Felines.
Cov ntawv thov yuav nyob hauv canine Corine Coronavirus kis tau
Cov txheej txheem sib xws ntawm Feline thiab Canine Coronaviruses tau cov kws tshawb fawb coj mus tshawb lub peev xwm ntawm gs- 441524 hauv kev kho cov kab mob coronavirus hauv cov dev. Kev tshawb fawb ua ntej tau qhia cov ntsiab lus muaj peev xwm ua rau muaj peev xwm ua rau muaj cov corine Corine Corine Corine Corine Corine Corine Corine Faib hauv cov vitro. Thaum cov kev tshawb fawb ntxiv yog xav tau, lub zeem muag ntawm daim ntawv thov hla rauGS-441524 txhajyog ib qho kev loj hlob zoo siab hauv Veterinary Tshuaj.
02
Kev siv rau tib neeg Coronavirus Kev tshawb fawb
Qhov kev vam meej ntawm GS-441524 hauv kev kho fip tsis tau ploj mus los ntawm cov kws tshawb fawb kev tshawb fawb tib neeg coronaviruses. Cov tshuaj lub tshuab ntawm kev nqis tes ua thiab kev ua tau zoo tawm tsam felonavirus tau ua rau muaj kev txaus siab rau nws cov ntawv thov Coronaviraus. Thaum nws tseem ceeb kom nco ntsoov tias kev tshawb fawb ncaj qha los ntawm Feline rau cov neeg tshiab ncaj qha, kev tshawb fawb tuaj yeem pab txhawb kev ua haujlwm ntawm cov neeg ua haujlwm rau tib neeg.
03
Muaj peev xwm kho lwm tus RNA tus kab mob kis tau
Qhov dav -}}} estivil antiviral kev ua si ntawm GS-441524 tau muaj peev xwm tshawb nrhiav nws lub peev xwm los kho lwm tus RNA tus kab mob kis. Kev tshawb fawb ua ntej tau qhia cov kev ua tau zoo tawm tsam ntau tus kab mob RA RNA, suav nrog qee yam uas cuam tshuam ntau hom. Cov versatility no yuav muaj peev xwm txoj hauj lwm GS-441524 ua cov cuab yeej tseem ceeb hauv kev sib txuas ntawm cov kab mob sib txawv thoob plaws hom.
04
Kev Kho Mob Muaj Peev Xwm
Cov kws tshawb nrhiav tseem tshawb xyuas lub peev xwm ntawm kev sib txuas GS-441524 nrog rau lwm cov antiiviral cov neeg sawv cev kom txhim kho kev ua yeeb yam zoo. Cov kev kho mob ua ke tau ua pov thawj kev ua tiav hauv kev kho tus mob fip uas zoo sib xws thiab nthuav tawm cov ntawv thov ntawm GS-441524 hauv Veterinary Tshuaj.
05
Tag
Hauv kev xaus, qhov tshwj xeeb ua tau zoo, cov tshuaj muaj kev nyab xeeb zoo, thiab cov tib neeg cov tshuaj uas yog vim li cas cov kws tshawb fawb fip Ntxiv nrog rau kev txhim kho qhov mob rau kev tsim txom cov miv, lub zog hloov kho ntawmGS-441524 txhajHauv kev kho cov FIP tau tsim cov sijhawm tshiab rau kev tshawb fawb los ntawm kev ua haujlwm hauv lwm hom tsiaj. Nws yog pov thawj tias GS-441524 tau ua rau lub sijhawm tshiab nyob rau hauv kev sib ntaus sib tua nrog cov neeg sib ntaus sib tua sib tua cov peev txheej ntawm no intriguing molecule.
Kws kho mob, cov tuam tsev kawm txuj ci, thiab chaw kho mob nrhiav kom kho cov tshuaj tiv thaiv kev tsim kho ntawm cov khoom lag luam tshiab no. Peb nyob hauv txoj haujlwm tshwj xeeb kom txaus siab rau cov kev xav nce ntxiv rau GS- 441524 hauv cov chaw kho tsiaj ua haujlwm thiab ua tau zoo hauv cov txheej txheem kws kho tsiaj thiab kev ua tau zoo hauv cov txheej txheem kho tsiaj. Xav paub ntau ntxiv txog peb GS-441524 muaj peev xwm ntau lawm lossis los tham txog cov lus cog lus kev cog lus ntev, thov hu rau pab pawg muag khoom ntawmSales@bloomtechz.comCov. Ua ke, peb tuaj yeem pab txhawb kom nce qib feline tshuaj thiab cov muaj feem cuam tshuam cov kev siv ntawm cov tshuaj tiv thaiv kab mob no.
Ntawv Sawv cev
1. Pedersen, NC, li al. (2019). Kev ua tau zoo thiab kev nyab xeeb ntawm nucleoside analog GS-441524 rau kev kho mob ntawm cov miv uas muaj kev kis felitonistly. Phau ntawv Journal of Felegine tshuaj thiab kev phais mob, 21 (4), 27).
2. Murphy, BG, li al. (2020). Lub nucleoside analog GS-441524 Muaj tseeb tiag feline exceebitis (FIP) nyob rau hauv cov nqaij kab lis kev cai thiab sim cov miv cov kev mob. ERETERINER MEDIAN MERVIOGY, 219, 108451.
3. Dickinson, PJ, li al. (2020). Kev kho mob tawm tsam siv Adenosine nucleoside analogue gs-441524 hauv miv nrog kuaj pom kev kuaj mob neuricals. Phau ntawv Journary ntawm Veterinary Internal Tshuaj, 34 (4), 1587-1593.
4. Addie, DD, li al. (2020). Feline kis tus mob peritonitis. Cov txheej txheem ABCD ntawm kev tiv thaiv thiab kev tswj hwm. Phau ntawv Journal of Felegine tshuaj thiab kev phais mob, 22 (11), 1028-1050.