Thaum lub sij hawm kev yuav khoom ntawmGS-4415 24raw cov ntaub ntawv los ntawm Activet Pharma Chr Olesen, txhawm rau kom ua raws li cov txheej txheem thiab kev ntseeg siab ntawm qhov zoo, lawv muab peb cov ntaub ntawv ntxaws ntxaws thiab cov ntaub ntawv zoo. Cov ntsiab lus tsis yog tsuas yog suav nrog cov ntawv pov thawj tsim nyog thiab cov ntawv pov thawj zoo, tab sis kuj tseem txuas ntxiv mus rau tag nrho -cov ntaub ntawv keeb kwm ntawm cov ntaub ntawv raw los ntawm kev tshawb fawb, txheej txheem tsim khoom, kev soj ntsuam purity mus rau lub sijhawm ntev - kev tshawb fawb kev ruaj ntseg. Ob tog tau ua ntau qhov kev sib txuas lus sau kom ntxaws thiab kev pom zoo ntawm cov teeb meem xws li cov ntaub ntawv tshuaj, kev tswj xyuas qhov tsis huv, kev npaj thauj mus los, thiab cov qauv tshuaj ntsuam xyuas tom ntej. Tau ntsib cov ntaub ntawv nyuaj thiab kev ua raws cai, peb pab neeg tau teb thiab txhawb nrog kev tshaj lij thiab kev sib koom tes zoo, thaum kawg ua kom muaj kev vam meej ntawm qhov kev sib pauv no. Qhov kev koom tes no tsis yog tsuas yog qhia tau hais tias Activet Pharma Chr Olesen txoj kev nruj thiab lub luag haujlwm ntawm kev tswj hwm kev pheej hmoo, tab sis kuj tau tsim lub hauv paus ruaj khov ntawm kev ntseeg siab rau yav tom ntej kev koom tes sib sib zog nqus.
Thawj qhov kev sib txuas lus
Qhia meej txog kev yuav khoom thiab kos npe rau cov ntaub ntawv cuam tshuam xws li cov ntawv cog lus.
Client Profile
Khoom Specification
Cov neeg siv khoom xav tau siab -purity (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile, feem ntau hu ua GS-441524 Qhov kev sib xyaw no ua haujlwm tseem ceeb hauv nruab nrab hauv kev txhim kho tshuaj tiv thaiv kab mob, xav tau kev tswj hwm nruj thiab cov ntaub ntawv cov qauv kom ua tau raws li European txoj cai.
Kev npaj cov ntaub ntawv
Muab COA, MOA, flow- daim ntawv thiab lwm yam ntaub ntawv raws li tus neeg siv khoom xav tau.
Qhov Kev Sib Tw
Cov txheej txheem kev yuav khoom rau cov kws kho mob - cov ntaub ntawv qib siab rau kev lag luam nyob sab Europe suav nrog kev ua raws li kev tswj hwm. Pab neeg ua haujlwm tau txais kev lees paub zoo tau ua tiav cov ntaub ntawv pov thawj suav nrog:
Batch List(Olesen Pharma tshwj xeeb hom)
Certificate of Analysis (COA)nrog tag nrho cov ntaub ntawv txheeb xyuas
Certificate of Conformitypaub meej tias ua raws li specifications
Txheej Txheem Flow Chartpiav qhia txog cov txheej txheem tsim khoom
Method of Analysis (MOA)cov ntaub ntawv
GMO tshaj tawmthiab lwm daim ntawv pov thawj kev ua raws cai
Cov ntaub ntawv pov thawj zoo ntxiv raws li cov neeg siv khoom xav tau
Tsis tas li ntawd, cov khoom ntim tshwj xeeb yuav tsum muaj kev tiv thaiv dual - txheej: thawj ntim hauv PE hnab nrog cov desiccant tsim nyog, ua raws li kev ntim khoom thib ob hauv cov hnab ntawv aluminium nrog cov khoom tsis muaj dej noo. Kev xa khoom zaum kawg yuav tsum tau npaj los ntawm FedEx nthuav qhia xa nrog lub qhov rooj - mus rau - qhov rooj kev pabcuam kom ntseeg tau tias xa khoom raws sijhawm thiab kev saib xyuas.
Shaanxi Achieve Chem-Tech's Solution
Raws li lub tuam txhab kev lag luam thev naus laus zis uas tau koom nrog hauv kev lag luam tshuaj intermediates thiab cov ntaub ntawv raw rau ntau xyoo, peb lub tuam txhab, nrog rau nws cov kev tshawb fawb thiab kev loj hlob tsub zuj zuj thiab nruj ntau lawm kev tswj system, tau tsim ib tug paub tab, saj zawg zog thiab heev customized kev pab cuam system. Lub tuam txhab tsis tsuas yog tsom mus rau kev sib txuas thiab kev ua kom zoo ntawm cov pa nruab nrab, tab sis kuj qhia tau zoo heev cov lus teb thiab kev ua raws kev sib koom ua ke muaj peev xwm thaum ntsib kev xav tau kev lag luam thoob ntiaj teb nyuaj. Nws lub peev xwm npog tag nrho cov saw hlau los ntawm kilogram- qib kev tshawb fawb txog ton- theem kev lag luam tsim khoom, thiab tuaj yeem muab cov neeg siv khoom kawg - mus rau - cov kev pabcuam kawg suav nrog kev tsim qauv, txheej txheem kev tsim kho, kev tshuaj xyuas thiab kev sim, thiab cov ntaub ntawv tswj hwm kev txhawb nqa, pab cov neeg siv khoom nrawm cov txheej txheem tsim khoom thiab tiv thaiv cov kev cov nyom hauv kev ua lag luam thoob ntiaj teb.
Peb cov khoom
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
GS-441524: Kev Cia Siab Tshiab rau Kev Tiv Thaiv Kev Tiv Thaiv Kab Mob rau Feline Infectious Peritonitis
GS-441524 yog ib qho me me molecule nucleoside analogue. Nws lub npe tshuaj yog (2R,3R,4S,5R)-2-(4-amino pyrrolo[2,1-F][1,2,4]triazine-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carboxamide, nrog rau CAS tus naj npawb ntawm 1191237-69- Raws li lub ntsiab active metabolite ntawm Remdesivir (GS-5734), GS-441524 qhia tshwj xeeb zoo nyob rau hauv lub tshav pob ntawm kev kho mob antiviral, tshwj xeeb tshaj yog ua ib tug landmark tshuaj nyob rau hauv kev kho mob ntawm feline infectious peritonitis (FIP).
Mechanism of Action: Thaiv ib kauj ruam tseem ceeb hauv kev kis tus kab mob
GS-441524 mimics natural nucleotides thiab cuam tshuam nrog kev ua haujlwm ntawm tus kab mob RNA-dependent RNA polymerase (RdRp). Hauv lub cell, nws yog phosphorylated los ntawm kinases los ua ib qho active triphosphate metabolite (NTP), sib tw nrog ntuj triphosphate nucleotides (xws li ATP, GTP) rau khi rau RdRp. Thaum cov kab mob RNA tau tsim ua ke, GS-441524-NTP tau muab tso rau hauv cov khoom luam tawm, ua rau kev txiav tawm ntxov ntawm cov saw txuas ntxiv thiab yog li inhibiting tus kab mob replication. Cov txheej txheem no ua rau nws muaj txiaj ntsig zoo rau ntau yam kab mob RNA, suav nrog cov kab mob coronaviruses, Ebola kab mob, cov kab mob ua pa syncytial, thiab lwm yam.
Daim Ntawv Thov Kev Kho Mob: Kev Kho Mob Rau Feline Infectious Peritonitis
FIP yog ib tus kab mob tuag taus los ntawm kev hloov pauv ntawm tus kab mob feline (FCoV), thiab cov kev kho mob ib txwm muaj txwv nrog kev pom tsis zoo. Qhov tshwm sim ntawm GS-441524 tau coj kev hloov pauv hloov mus rau kev kho FIP:
Kev tiv thaiv kab mob zoo
Hauv kev sim ntawm tes, qhov ib nrab ntawm -kev ua tau zoo concentration (EC50) ntawm GS-441524 tiv thaiv FIPV tsuas yog 0.78 μM, thiab nws muaj cytotoxicity tsawg heev rau feline hlwb (CC50 > 100 μM), nrog lub qhov rais kho dav dav.
Qhov tseem ceeb ntawm kev kho mob ua tau zoo
Ntau qhov kev sim tau pom tau tias kev txhaj tshuaj subcutaneous ntawm GS-441524 ( koob tshuaj 4 mg / kg / hnub, rau 12 lub lis piam) tuaj yeem ua tiav kev tshem tawm hauv kwv yees li 80% ntawm FIP miv, nrog tus nqi rov qab tsawg dua 20%. Rau cov neeg mob ntawm FIP qhuav lossis cov tsos mob ntawm cov hlab ntsha, cov txiaj ntsig zoo tseem tuaj yeem ua tiav los ntawm kev kho cov koob tshuaj (xws li, nce mus rau 8-10 mg / kg / hnub).
Nkag mus rau hauv cov ntshav - hlwb barrier
GS-441524 tuaj yeem dhau los ntawm cov ntshav- qhov muag teeb meem thiab cov hlab ntsha hauv lub hlwb, thiab muaj txiaj ntsig zoo rau FIP miv nrog qhov muag cuam tshuam thiab lub hauv nruab nrab lub paj hlwb, uas yog qhov zoo dua uas cov tshuaj tsis tuaj yeem sib xws.
Ua kom tiav daim ntawv cog lus koom tes
Kev them nyiaj, kev xa khoom, thiab kev npaj cov ntaub ntawv tom ntej.
Qhov project tshwm sim
Qhov project tau ua tiav tiav nrog:
Ntawm - lub sijhawm xa khoom
Tag nrho cov khoom xa tuaj nyob rau hauv lub sijhawm pom zoo
Zero zoo tsis txaus siab
Tag nrho cov batch ua tau raws li los yog tshaj specification yuav tsum tau
Ua kom tiav cov ntaub ntawv
Txhua daim ntawv pov thawj thiab cov ntaub ntawv thov tau muab tsis tau ncua
Cov neeg siv khoom txaus siab
Tus neeg tau txais kev tso cai rov ua dua thiab nthuav dav kev lag luam kev sib raug zoo
Vim li cas thiaj xaiv Shaanxi Achieve Chem-tech?
Cov ntaub ntawv no qhia txog peb cov peev txheej tseem ceeb:
Kev txawj ntse: Kev nkag siab tob txog kev sib xyaw tshuaj lom neeg thiab kev ua kom huv
Kev cog lus zoo: Cov kev tswj xyuas nruj nruj raws li cov qauv thoob ntiaj teb
Cov ntaub ntawv muaj peev xwm: Muaj peev xwm npaj cov ntaub ntawv kev tswj hwm
Cov neeg siv khoom tsom: Yooj yim kom tau raws li cov neeg siv khoom xav tau
Kev paub logistics thoob ntiaj teb: Cov ntaub ntawv pov thawj hauv kev xa khoom thoob ntiaj teb
Peb txuas ntxiv ua haujlwm rau cov tuam txhab muag tshuaj thoob ntiaj teb nrog siab -cov khoom nruab nrab zoo thiab APIs, txhawb nqa los ntawm peb txoj kev cog lus rau qhov zoo, kev ntseeg siab, thiab kev txaus siab rau cov neeg siv khoom.