Los ntawm 2025, lub ntiaj teb lub nra ntawm kev rog rog thiab cov kab mob metabolic tseem nce ntxiv, nrog rau US cov rog rog nce mus txog 42.4%. Cov kev kho niaj hnub ntsib kev txwv vim muaj kev txwv tsis pub muaj txiaj ntsig thiab cov kev mob tshwm sim tseem ceeb. Tawm tsam qhov teeb meem no, ib tus neeg muag khoom hauv Asmeskas tau xaj ib lub thawv ntawmRetatrutide60mg (kev qhia tshwj xeeb: 60mg / vial × 10 vials / box) los ntawm Bloom Tech platform rau kev kho tus kheej rog thiab tom qab kev lag luam validation.
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Daim ntawv thov
Retatrutide yog ib qho kev tshawb nrhiav triple hormone receptor agonist tam sim no tau tsim los rau kev kho mob rog rog, hom 2 mob ntshav qab zib, thiab kev ua haujlwm tsis zoo hauv cov metabolism -koom nrog steatohepatitis (MASLD). Cov ntsiab lus yog raws li nram no:
Kev rog rog
Mechanism of Action: Retatrutide synergistically tswj cov metabolism thiab qab los noj mov los ntawm ib txhij ua kom GLP-1, GIP, thiab glucagon receptors. GLP-1 thiab GIP txo cov ntshav qabzib thiab txo cov zaub mov noj los ntawm kev txhawb nqa insulin secretion thiab suppressing qab los noj mov; glucagon txhawb kev poob phaus los ntawm kev siv zog ntxiv thiab lipolysis thaum txo cov rog hauv siab.
Clinical Efficacy: Cov kev sim tshuaj ntsuam xyuas pom tau tias muaj txiaj ntsig zoo ntawm Retatrutide hauv cov neeg mob rog. Piv txwv li, tom qab 48 lub lis piam ntawm kev kho mob ntawm qhov koob tshuaj ntau tshaj (12 mg), qhov hnyav nruab nrab poob mus txog 24.2% (kwv yees li 58 lbs / 26.2 kg), ua tau zoo dua cov placebo pawg (2.1%). Hauv lwm qhov kev sim, lub duav ncig hloov pauv ntawm -2.1 cm txog -10.2 cm ntawm cov tib neeg tau kho rau 26 lub lis piam.
Hom 2 Ntshav Qab Zib
Mechanism of Action: Retatrutide txo qis cov piam thaj hauv cov ntshav los ntawm kev ua kom GLP-1 thiab GIP receptors, yog li txhawb nqa insulin secretion thiab inhibiting glucagon secretion.
Cov txiaj ntsig kho mob: Hauv cov neeg mob ntshav qab zib hom 2, Retatrutide txo qis HbA1c qib, nrog qee tus neeg mob mus txog qib qabzib ib txwm. Piv txwv li, tom qab 6 lub hlis ntawm kev kho Retatrutide ntawm ntau koob tshuaj, HbA1c txo qis los ntawm 1.3% mus rau 2.0% hauv cov neeg mob ntshav qab zib hom 2. Tsis tas li ntawd, cov neeg mob tau txais 12 mg ntawm Retatrutide tau ua tiav qhov hnyav nruab nrab ntawm 16.9% hauv 8 lub hlis, sib npaug li qhov hnyav tag nrho ntawm 34.4 jin (kwv yees li 17.2 kg), dhau ntawm pawg placebo los ntawm 6.6 jin (kwv yees li 3.0 kg).
Metabolic dysfunction-sociated steatohepatitis (MASLD)
Mechanism ntawm kev txiav txim: Retatrutide txhim kho daim siab ua haujlwm los ntawm kev txo cov rog hauv siab.
Kev ua tau zoo ntawm kev kho mob: Hauv cov neeg mob MASLD, Retatrutide tau pom tias muaj peev xwm txo qis cov rog hauv siab. Piv txwv li, hauv cov neeg mob MASLD, pawg koob tshuaj 8 mg thiab 12 mg tau pom tias txo qis hauv cov rog hauv siab ntawm 81.4% thiab 82.4%, feem, dhau 24 lub lis piam. Tom qab 48 lub lis piam ntawm kev kho mob nrog ob koob tshuaj ntau tshaj ntawm Retatrutide hauv cov neeg mob uas tsis yog -alcoholic steatohepatitis (NASH), 9 ntawm 10 tus neeg mob tau ua tiav cov ntsiab lus ntawm cov rog hauv siab.
kev mob tshwm sim
Cov kev mob tshwm sim ntawm Retatrutide feem ntau suav nrog cov tsos mob plab hnyuv, nce lub plawv dhia, kev puas siab puas ntsws, thiab tawv nqaij rhiab, raws li cov lus qhia hauv qab no:
Cov tsos mob ntawm plab hnyuv
Cov no sawv cev rau cov kev mob tshwm sim feem ntau ntawm Retatrutide, nrog rau xeev siab, ntuav, raws plab, thiab cem quav. Cov tsos mob no feem ntau yog koob tshuaj - cuam tshuam, thiab pib kho nrog qis pib koob tshuaj (piv txwv li, 2mg) tuaj yeem txo cov xwm txheej tsis zoo no. Hauv kev sim tshuaj, xeev siab, ntuav, thiab raws plab tshwm sim ntawm tus nqi siab, tab sis feem ntau cov tsos mob me me mus rau nruab nrab thiab maj mam txo qis los yog daws nrog kev kho mob ntev.
Nce lub plawv dhia
Qee tus neeg mob yuav hnov mob siab tom qab siv Retatrutide. Cov kev mob tshwm sim no feem ntau daws tau hauv 24 lub lis piam, tab sis cov neeg mob yuav tsum tau ceev faj txog kev hloov pauv hauv lub plawv thiab nrhiav kev kho mob sai yog tias muaj kev txawv txav tshwm sim.
Kev puas siab puas ntsws
Hauv Phase III kev sim tshuaj ntsuam xyuas, qee cov neeg mob tau ntsib dysesthesia-qhov tsis txaus siab lossis txawv txav ntawm kev nkag siab. Cov kev mob tshwm sim no tshwm sim ntau dua hauv cov koob tshuaj ntau tshaj (12 mg), tshwm sim hauv kwv yees li 20.9% ntawm cov neeg mob. Feem ntau qhov mob me me thiab tsis tshua muaj kev cuam tshuam rau kev kho mob.
Daim tawv nqaij rhiab heev
Cov tawv nqaij rhiab heev: Qee cov neeg mob yuav hnov cov tawv nqaij rhiab heev rau kov, mob, siab, lossis kub tom qab siv Retatrutide. Txawm hais tias qhov tshwm sim ntawm cov tsos mob no kuj tsawg hauv kev sim tshuaj, lawv tau txais kev saib xyuas.
Retatrutide puas ua rau cov leeg nqaij atrophy
Retatrutide feem ntau tsis ncaj qha ua rau cov leeg nqaij atrophy, tab sis cov leeg nqaij tsawg tsawg tuaj yeem tshwm sim thaum poob phaus, xav tau kev ua kom zoo ntawm lub cev muaj pes tsawg leeg. Cov hauv qab no muab cov ncauj lus kom ntxaws tsom xam:
Raws li GLP-1 receptor agonist, liraglutide feem ntau ua tiav qhov poob phaus los ntawm kev txo qis qab los noj mov, ncua kev ua pa ntawm plab, thiab tswj cov metabolism. Ntau cov kev tshawb fawb qhia tias nws qhov kev poob phaus feem ntau yog los ntawm cov ntaub so ntswg adipose, tshwj xeeb tshaj yog cov rog rog. Piv txwv li, cov kev tshawb fawb LEAD tau pom tias tom qab 12 lub lis piam ntawm kev kho liraglutide, cov neeg mob tau txais kev txo qis ntawm 3.8 kg ntawm tag nrho cov rog thiab 1.5 kg ntawm tag nrho cov leeg nqaij, nrog rau cov rog poob ntau tshaj cov nqaij ntshiv. Lwm txoj kev tshawb fawb qhia tau hais tias kwv yees li 63% ntawm cov neeg rog rog lossis rog rog tau ua tiav tsawg kawg yog 5% qhov hnyav txo tom qab ib xyoos ntawm kev siv liraglutide, nrog rau cov nqaij ntshiv suav nrog cov feem me me.
Txawm hais tias cov leeg nqaij poob qis, cov leeg nqaij tseem xav tau kev saib xyuas thaum lub sij hawm ntev - poob phaus. Cov leeg nqaij nkim feem ntau cuam tshuam nrog kev ua kom cov protein ntau ntxiv, cov kab mob metabolic, lossis kev noj zaub mov tsis txaus, thiab liraglutide nws tus kheej tsis ncaj qha ua rau cov txheej txheem no. Txawm li cas los xij, tsis ua raws li cov leeg nqaij - tiv thaiv kev ntsuas thaum poob phaus (xws li kev noj zaub mov muaj protein ntau lossis kev ua haujlwm tsis zoo) tuaj yeem ua rau muaj kev pheej hmoo ntawm cov leeg nqaij. Piv txwv li, thaum cov neeg mob rog rog tau poob phaus, cov rog hauv lub cev feem ntau ntau dua li cov leeg nqaij, ua kom zoo dua ntawm lub cev muaj pes tsawg leeg tseem ceeb.
Txhawm rau txo qis cov leeg nqaij, cov tswv yim hauv qab no raug pom zoo thaum siv liraglutide:
High- noj zaub mov muaj protein ntau: Kev noj cov protein ntau ntxiv txhawb kev tsim cov protein ntau, tiv thaiv kev cuam tshuam ntawm kev ua kom muaj zog ntxiv.
Kev cob qhia tsis kam: Kev cob qhia lub zog tsis tu ncua pab tswj cov leeg nqaij thiab txhim kho cov metabolism hauv kev noj qab haus huv.
Kev saib xyuas lub cev muaj pes tsawg leeg: ntsuas cov rog txhua lub sijhawm- rau- cov leeg nqaij uas siv cov roj ntsha hauv lub cev lossis kev kuaj mob (xws li CT scans) los kho cov phiaj xwm kho mob sai.
Tsis tas li ntawd, liraglutide cov kev mob tshwm sim (piv txwv li, kev mob plab hnyuv, kev pheej hmoo ntawm hypoglycemia) tuaj yeem cuam tshuam rau cov leeg nqaij. Piv txwv li, xeev siab lossis ntuav tuaj yeem ua rau cov khoom noj tsis txaus, yog li cuam tshuam rau cov leeg nqaij. Yog li ntawd, ua tib zoo saib xyuas lub cev cov lus teb thaum kho thiab sab laj cov kws kho mob kom kho cov tshuaj noj lossis tshawb xyuas cov kev kho mob sib xyaw ua ke.
Yuav tsum noj cov protein ntau npaum li cas thaum noj Retatrutide
Thaum noj Retatrutide, qhov pom zoo kom noj cov protein txhua hnub yog xam raws li lub hom phiaj lub cev hnyav: kwv yees li 1 gram ntawm cov protein ib phaus (li 0.45 kg) ntawm lub cev qhov hnyav. Piv txwv li, yog tias koj qhov hnyav tam sim no yog 200 phaus tab sis koj lub hom phiaj kev noj qab haus huv yog 140 phaus, koj lub hom phiaj protein txhua hnub yuav yog 140 grams.
Lub Hom Phiaj Qhov Ntsuas Qhov Ntsuas
Thaum siv Retatrutide rau kev poob phaus, kev noj cov protein yuav tsum yog raws li lub hom phiaj qhov hnyav, tsis yog qhov hnyav tam sim no. Txoj hauv kev no tiv thaiv kev noj cov protein tsis txaus vim qhov poob phaus, yog li tswj cov leeg nqaij thiab txhawb lub cev ua haujlwm.
Kev kho rau lub raum tsis zoo
Cov neeg muaj lub raum tsis zoo yuav tsum sab laj nrog tus kws kho mob nephrologist lossis tus kws kho mob thawj zaug los kho cov protein kom noj txhua hnub raws li lub raum ua haujlwm. Piv txwv li, cov neeg mob raum mob yuav tsum txwv tsis pub muaj protein ntau rau 0.5-0.7 grams ib kilogram ntawm lub cev hnyav ib hnub twg, saib xyuas cov protein zoo (xws li qe dawb, mis nyuj, ntses, nqaij ntshiv).
Cov ntsiab lus tseem ceeb rau kev noj cov protein
Ua ntej tshaj -cov protein zoo: Xyuas kom 50%-70% ntawm cov protein los ntawm cov tsiaj txhu (xws li qe dawb, mis nyuj, ntses, nqaij ntshiv), uas yog nplua nuj nyob hauv cov amino acids tseem ceeb thiab muaj kev nqus tau zoo thiab siv tau.
Tsis txhob overestimating kom tsawg: Cov neeg feem coob nyiam overestimate protein noj; siv cov ntawv teev zaub mov lossis cov cuab yeej nrhiav zaub mov kom raug xam.
Kev hloov pauv kev ua neej: Thaum noj Retatrutide, ib txhij tswj cov calories kom tsawg, tswj lub cev ua si, thiab ua kom tsaug zog txaus los ua kom pom qhov poob phaus.
Yuav tsum tau siv ntev -Tsev Kawm Ntawv
Retatrutide yuav tsum muaj tsawg kawg yog 6 lub hlis ntawm kev siv txuas ntxiv kom txo qis lub cev qhov hnyav "teeb taw tes." Kev siv sijhawm ntev - pab txhawb kev tswj qhov hnyav. Nyob rau lub sijhawm no, kev saib xyuas tsis tu ncua ntawm cov protein kom tsawg thiab kev hloov kho kev noj haus yog qhov tseem ceeb.