Feline sib kis tus mob peritonitis (FIP) yog ib qho kev hloov pauv ntawm cov tsos mob ntawm pawg neeg hauv tsev kawm qib siab, Davis, Tebchaws Asmeskas, Asmeskas, tau pom tias yog thawj zaug lub sij hawm uas nucleoside analogGs -441524tuaj yeem ua tiav kev kho mob rau fip los ntawm kev tiv thaiv tus kab mob ntawm cov fip {} tshuaj .
Precision thaiv ntawm tus kab mob kis tus kab mob
GS-441524 is the primary active metabolite of raltegravir (Remdesivir), whose molecular structure contains a cytidine nucleoside backbone and a 1'-cyano modifying moiety. In cats, the drug is phosphorylated by cellular kinases to the nucleoside triphosphate (NTP) form, and the product can compete with natural ATP for binding to the catalytic site of viral RNA-dependent RNA polymerase (RdRp), thereby terminating the extension of the viral RNA strand. Experimental data showed that the half inhibitory concentration (EC50) of GS-441524 against FIP virus (FIPV) was only 0.78 μM, which was much lower than the cytotoxicity concentration (CC50>100 μm), ua rau pom kev haj yam siv hluav taws xob siab heev .
Tsis zoo li GC376 (3C proteion inhibitor), gs-441524 Cov neeg ua haujlwm hauv lub ntsej muag zoo nkauj Gs -441524} mus rau qhov kev kho mob kom qhuav (Um, pom tias muaj kev sib tw ntawm lub tsev kawm ntawv qib siab ntawm lub tsev kawm ntawv qib siab. Kev ua raws li kev zam txim tiav, ntawm 62% yog Purebred thiab 52% tau tsawg dua 12 hlis.
Cov Ntawv Thov Kev Kho Mob
E► Cov Qauv Kho Mob Regimen
Nyob rau hauv 2019, kev kho mob cov lus qhia gs -441524}}}}}}}}}}}}}}}}}} developlyed los ntawm pedersen pawg, tsim lub moj khaum:
Dose Gradient: Pib koob tshuaj 4 mg / d kom qhuav fip, nrog kev xav tau kev nce rau8-10 mg / u nyob rau hauv rooj plaub ntawm cov neeg neurological
Kev Tsim Qauv Tsim: Nruam Tom Ntej Txhaj Tshuaj rau 12 12 lub lis piam ntawm kev soj ntsuam txhua 4 lub lis piam
Dais tsis zoo: Kev ploj ntawm cov tsos mob hauv tsev kho mob thiab ib txwm ntawm Cov Serum Globulin / Albumin Ratio (A: G) rau 2 lub lis piam
Kev tshawb nrhiav kev tshawb fawb tau qhia tias qhov kev kho mob uas muaj kev sib raug zoo ntawm " 79% .
► DOSAGE Daim Ntawv Tsim Tawm thiab Kev xa khoom tawm
Txhawm rau daws cov teeb meem ntawm kev txhaj tshuaj mob rau hauv kev txhaj tshuaj, lub ntiaj teb no yog tsim nyog tau tsim nyog rau kev txhaj tshuaj ntawm 101% hais tias qhov ncauj kev tswj hwm txo qhov tshwm sim ntawm cov chaw txhaj tshuaj ntawm 37%, ua rau nws haum ntau hauv tsev neeg thiab cov kws kho mob {8}
Rau cov mob hnyav, sib xyaw ua ke rau cov kev pom zoo {}}}}}}}}}}}} {teev nyob rau hauv 75% ntawm cov neeg mob.
Cov ntaub ntawv pov thawj ntawm kev ua tau zoo
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Cov Ntaub Ntawv Txiaj Ntsig Kho tus nqi: Hauv cov qauv khoom siv dag ntxias qauv qauv, tus kho tus nqi ntawm kev tswj hwm ntawm kev tswj hwm tshuaj tau txog 100%; Tus kho tus nqi ntawm 12- lub lim tiam ntawm kev kho mob ntawm kev kho mob hauv ib qho kis tau muaj 92% Rov qab tswj hwm: Tus lej rov qab tsuas yog 5.3% ntawm 6 lub hlis tom qab kev kho mob, thiab cov neeg mob rov qab tuaj yeem tau txais kev kho mob ntawm 89% tom qab kev kho mob thib ob Kev Nyab Xeeb: Ntawm qhov koob tshuaj ntawm tsawg dua lossis sib npaug ntawm 10mg / kg, lub ntsiab no cov kev tsis zoo ntawm qhov chaw (12%), tsis muaj myelosupression lossis muab cov tshuaj lom los yog cov khoom muaj kuab lom |
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Kev tshawb nrhiav cov ntawv thov hla Cov tshuaj tua hluav taws ntawm gs -441524 yog deb dhau ntawm cov kev sim ntawm fip ece}}}}} {}}}}}}}}}}}}}}}}}}}}}}}}}}}} {{{}} Fold ntau dua li ntawm r Xws li tus kab mob Ebola thiab cov kab mob rassa ua npaws, thiab cov kev tshawb fawb ua npaws tab tom tab tom ua haujlwm hauv cov kab mob 12 zoonotic. |
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Cov toj roob hauv pes ua lag luam thiab kev tswj hwm cov kev nyuaj
Refanfiguration ntawm cov hlua ntiaj teb
Tam sim no, gs -441524 apis yog tsim nyob rau hauv Suav teb tsim khoom thiab ua tiav los ntawm kev lag luam Indian tau tsim los ntawm kev ua synthesis los ua kev npaj ntau lawm, nrog ib qho batch muaj peev xwm ntawm 50kg, uas tuaj yeem ua tau txoj kev kho mob xav tau ntawm 10025 xav tau tag nrho cov ntawv pov thawj tshiab rau kev txhim kho cov neeg siv khoom tshiab kom nce qib thev naus laus zis rau ™ {11}
Ofulatory cov cai tswjfwm
Kev Lag Luam Kev Cai: Tebchaws Askiv, Tebchaws Askiv thiab lwm lub tebchaws tso cai rau cov kws kho tsiaj ", thiab cov khoom yuav tsum tau yuav cov kws kho tsiaj rau cov tsiaj ua tsiaj"
Cov cheeb tsam grey: U {. s {1} .}}} Teb Chaws Asmeskas FDA tseem muaj classifies Gs {-441524 Ua ib qho "kev tshawb fawb tshiab", tab sis 12 lub xeev tau sau cov me nyuam me los sau nws, ua tsaug rau Catm Kev Pabcuam Cat Kev Tiv Thaiv Kev Noj Qab Haus Huv.2024.
Cov kev tiv thaiv cuav: FIP Warriors kuaj thiab pom tias 23% ntawm cov tshuaj lag luam muaj txiaj ntsig, tab sis kev siv tshuaj lom ob zaug, tab sis kev siv tshuaj lom ob zaug
Yav tom ntej saib xyuas
Ntev-kav ntev tsim kev txhim kho: Aratus Bio (Tebchaws Asmeskas) yog kev pib ua kom cov ntshav tau muaj txiaj ntsig tau ntau dua 28 hnub tom qab tswj hwm .
Kev Kho Mob Kev Kho Mob Ua Si: Ua ke nrog Feline Interferon ω Yuav ua tau zoo tshaj plaws rau kev kho mob IK37
Kev txhais lus tib neeg cov tshuaj: gs -641524 derivive gs -6826 Cov kws tshawb fawb ua npaws tau nkag mus kev loj hlob "{.
Qhov kev tshawb pom ntawm gs -441524 Tsis tau tsuas yog siv tshuaj rau cov neeg siv hluav taws xob rau ntau lab tus neeg siv hluav taws xob, kev kho mob ntev thiab ua ke nrog kev kho mob, gs -441524}}}}} Cov Khoom Siv Hluav Taws Xob Txuas Ntxiv