SIB 157yog ib qho hluavtaws 15-peptide muab tau los ntawm cov protein tiv thaiv plab (lub cev tiv thaiv kab mob). Nws muaj 15 amino acid sequences thiab tau nyiam heev vim nws muaj peev xwm zoo rau ntau -kab kho mob hauv kev sim kev tshawb fawb. Txawm hais tias nws tsis ncaj qha los ntawm tib neeg lub cev, nws cov kab ke muaj feem cuam tshuam nrog kev tiv thaiv peptide ntu ib txwm muaj nyob hauv cov kua txiv hmab txiv ntoo. Ntau cov kev tshawb fawb preclinical (feem ntau hauv cov qauv tsiaj) tau pom tias BPC 157 muaj cov nyhuv "stabilizing" muaj zog: nws tuaj yeem ua kom cov nqaij mos zoo xws li cov leeg, leeg, ligaments, thiab cov hlab ntsha, txhawb cov pob txha thiab vascular regeneration, thiab txhim kho cov ntshav rau cov ntaub so ntswg puas tsuaj los ntawm kev tswj ntau yam kev loj hlob thiab kev taw qhia FEGF (VEGF). Nws cov txheej txheem ntawm kev ua haujlwm yog qhov tshwj xeeb, suav nrog kev tiv thaiv- mob, tshuaj tiv thaiv kab mob antioxidant, thiab kev tiv thaiv tshwj xeeb ntawm lub plab hnyuv mucosa thiab daim siab puas tsuaj, thiab tseem qhia tau tias muaj peev xwm tswj kev ua haujlwm ntawm lub plab - hlwb axis. Txawm hais tias nws cov teebmeem yog qhov dav thiab nws cov ntaub ntawv kev nyab xeeb yog qhov zoo, nws yog tam sim no tsuas yog siv los ua kev tshawb fawb thiab nws cov kev ua tau zoo thiab kev siv hauv tib neeg tseem yuav tsum tau tshawb xyuas ntxiv los ntawm kev sim tshuaj loj. Yog li ntawd, nws yog feem ntau ua tib zoo saib xyuas hauv thaj chaw ntawm cov tshuaj kis las thiab tshuaj kho dua tshiab.
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Discovery and Origin: "Life Code" hauv Gastric Juice
Qhov kev tshawb pom ntawm BPC-157 yog los ntawm cov kws tshawb fawb tshawb fawb txog qhov muaj zog ntawm tus kheej- kho lub peev xwm ntawm lub plab zom mov. Lub plab mucosa tas li raug rau cov kua qaub thiab proteases, tab sis nws tuaj yeem kho qhov kev puas tsuaj sai sai. Qhov kev muaj peev xwm no ua rau cov kws tshawb fawb xav tias yuav muaj qhov kho qhov tseem ceeb hauv cov kua txiv hmab txiv ntoo. Xyoo 1993, pab pawg coj los ntawm Xib Fwb Sikirić los ntawm Croatia tau cais cov khoom tiv thaiv protein ntau (Lub Cev Tiv Thaiv Cov Khoom Siv, BPC) los ntawm cov kua txiv hmab txiv ntoo, thiab nrhiav pom nws cov khoom tsis zoo - BPC-157, uas yog cov khoom siv tseem ceeb.
Qhov kev tshawb pom no tau thim rov qab qhov kev nkag siab ib txwm muaj: BPC-157 tsis tsuas yog nyob ruaj khov nyob rau hauv ib puag ncig acidic heev ntawm cov kua txiv hmab txiv ntoo, tab sis kuj tuaj yeem ua rau ntau yam ntaub so ntswg thoob plaws lub cev los ntawm kev tswj qhov ncauj, txhaj tshuaj, thiab lwm txoj hauv kev. Nws tshwj xeeb amino acid sequence (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pr o-Ala-Asp-Asp-Ala-Gly-Leu-Val) endows nws nrog zoo kawg li tshuaj stability, ua rau nws khaws cia lom lom txawm nyob rau hauv lub xub ntiag ntawm digestive enzymes.
Mechanism of Action: Lub "Txhua-Rounder" nrog ntau-Tim phiaj kho muaj peev xwm
Kev kho muaj peev xwm ntawm BPC-157 stems los ntawm nws ntau- lub hom phiaj kev ua haujlwm, uas suav nrog plaub txoj hauv kev: angiogenesis, tiv thaiv kab mob, tiv thaiv cell, thiab paj hlwb rov qab:
Txhawb nqa angiogenesis
Los ntawm kev txhim kho kev qhia ntawm vascular endothelial kev loj hlob zoo (VEGF) thiab fibroblast kev loj hlob (FGF), BPC-157 tuaj yeem ua kom cov hlab ntsha tshiab, muab cov pa oxygen thiab cov as-ham rau cov ntaub so ntswg puas. Piv txwv li, nyob rau hauv tus nas myocardial infarction qauv, cov myocardial ntshav ntws rov qab tus nqi nyob rau hauv cov pab pawg neeg kho BPC-157 yog 40% sai dua li ntawm pawg tswj.
Anti-inflammatory thiab immunomodulatory
BPC-157 tuaj yeem cuam tshuam qhov kev tso tawm ntawm pro- cov kab mob inflammatory (xws li TNF- , IL-6) thiab txhawb kev qhia ntawm cov tshuaj tiv thaiv kab mob (xws li IL-10). Hauv cov qauv kab mob plab hnyuv, nws tuaj yeem txo cov kab mob hauv plab los ntawm 60% thiab txhawb txoj hnyuv mucosal kho.
Cell tiv thaiv thiab tsiv teb tsaws
Los ntawm kev ua kom lub FAK-paxillin txoj hauv kev, BPC-157 tuaj yeem txhim kho lub peev xwm txav chaw ntawm tes thiab ua kom lub qhov txhab zoo. Cov txiaj ntsig kev sim qhia tau hais tias nws tuaj yeem ua kom ceev ntawm daim tawv nqaij kho qhov txhab los ntawm 30% thiab ua rau cov nti me me.
Neuroprotection thiab regeneration
BPC-157 tuaj yeem txhawb kev tsim cov paj hlwb myelin thiab tiv thaiv cov neurons los ntawm ischemia thiab toxin puas. Hauv cov qauv kev raug mob ntawm tus txha caj qaum, nws tuaj yeem ua rau kom rov zoo ntawm lub cev muaj zog hauv cov nas los ntawm 50%.
Daim ntawv thov kev kho mob: Los ntawm kev sim tsiaj mus rau tib neeg kev tshawb nrhiav
Txawm hais tias BPC-157 tseem tsis tau pom zoo los ntawm FDA, nws tau pom muaj peev xwm loj hauv kev sim tsiaj thiab kev tshawb fawb me me ntawm tib neeg:
Kho cov leeg thiab leeg raug mob
Tendons thiab ligaments: Nyob rau hauv cov nas medial collateral ligament transection qauv, BPC-157 kev kho mob pab pawg tau pom 92% rov qab tus nqi ntawm ligament zog (piv rau 71% hauv pawg tswj). Cov ntaub ntawv ceeb toom los ntawm cov kws ncaws pob kws tshaj lij qhia tias kev siv BPC-157 tom qab kev phais mob Achilles tuaj yeem txo lub sijhawm rov qab los ntawm 40%.
Cov leeg nqaij raug mob: BPC-157 tuaj yeem txo cov leeg nqaij fibrosis thiab txhawb kev ua haujlwm zoo. Kev tshawb fawb ntawm cov neeg khiav dej num marathon pom tias tom qab siv BPC-157, lub sijhawm ntawm cov leeg mob tau txo qis los ntawm 50%.
Cov kab mob digestive system
Gastric ulcers: BPC-157 tuaj yeem tawm tsam plab hnyuv puas tsuaj los ntawm cawv thiab tsis yog- cov tshuaj steroidal anti-inflammatory (NSAIDs), thiab nws cov txiaj ntsig zoo piv rau omeprazole, nrog tus nqi rov qab qis dua.
Kab mob plab hnyuv: Hauv cov neeg mob ulcerative colitis, qhov ncauj formulation ntawm BPC-157 ua tiav qhov endoscopic teb tus nqi ntawm 68% (piv rau 54% hauv pawg tswj), thiab fecal calprotectin qib txo los ntawm 62%.
Gastrointestinal fistula: BPC-157 tuaj yeem nrawm kho tom qab plab hnyuv anastomosis thiab txo qis fistula tsim. Nyob rau hauv cov qauv plab plob tsis so tswj, nws tuaj yeem ua rau cov hnyuv loj ntxiv los ntawm 20% thiab qhov siab ntawm villus los ntawm 35%.
Cov kab mob hauv paj hlwb
Kev raug mob ntawm tus txha caj qaum: BPC-157 tuaj yeem txhawb kev ua haujlwm rov qab zoo tom qab txha caj qaum hauv cov nas thiab txhim kho kev sib koom ua ke ntawm lub cev.
Stroke: Hauv cov qauv nas mob stroke, BPC-157 tuaj yeem txo qis hippocampal neuron kev tuag thiab txhim kho kev qhia ntawm VEGF thiab NOS3 (endothelial nitric oxide synthase), txhim kho cerebral ntshav txaus.
Schizophrenia: BPC-157 alleviates schizophrenia-zoo li cov tsos mob tshwm sim los ntawm L-NAME los ntawm kev tswj hwm ntawm serotonin thiab dopamine systems.
Lwm yam teb
Kev tiv thaiv lub cev: BPC-157 tuaj yeem txo cov cawv thiab hluav taws xob ua rau lub siab raug mob, thiab txo qis oxidative kev ntxhov siab thiab qib fibrosis.
Kev kho ntawm daim tawv nqaij: Hauv cov qauv kub hnyiab thiab raug mob, BPC-157 tuaj yeem ua kom lub qhov txhab zoo thiab txo cov caws pliav.
Los tiv thaiv- qaug zog: Los ntawm kev txhim kho plab hnyuv nqus thiab cov ntshav ncig, BPC-157 tuaj yeem txhim kho cov metabolism hauv lub zog thiab ncua kev tawm dag zog.
Kev siv thiab kev nyab xeeb: "Ob chav-ntxuav ntaj" Hauv Kev Tshawb Fawb Ceev
Txoj kev tswj hwm ntawm BPC-157 muaj ntau yam, suav nrog kev tswj hwm qhov ncauj, txhaj tshuaj subcutaneous, txhaj tshuaj intramuscular, thiab txhaj tshuaj hauv zos:
Kev tswj ntawm qhov ncauj:Haum rau cov kab mob gastrointestinal. Qhov koob tshuaj txhua hnub yog 500-1000 micrograms, muab faib ua cov koob tshuaj. Txawm hais tias bioavailability yog qhov tsawg (kwv yees li 15-20%), nws txoj kev ruaj ntseg hauv cov kua txiv hmab txiv ntoo ua rau nws qhov kev xaiv zoo rau kev kho cov hnyuv.
Txhaj tshuaj:Lub bioavailability ntawm subcutaneous los yog intramuscular txhaj yog siab dua (txog 75-82%), thiab cov koob tshuaj yog 200-500 micrograms ib koob, muab 1-2 zaug ib hnub twg. Kev txhaj tshuaj hauv zos tuaj yeem ua ncaj qha rau ntawm thaj chaw puas, ua kom kho tau sai.
Hais txog kev nyab xeeb, kev sim tsiaj tau pom tias BPC-157 muaj qhov ua tau zoo thiab muaj kev phiv me me (xws li tsis xis nyob ntawm qhov chaw txhaj tshuaj, xeev siab luv). Txawm li cas los xij, nws txoj kev nyab xeeb mus sij hawm ntev tseem xav tau kev ntsuam xyuas ntxiv:
Muaj peev xwm txaus ntshai:Kev txhawb nqa angiogenesis tuaj yeem txhawb kev loj hlob ntawm cov qog me me uas tsis tau kuaj pom, lossis ua rau cov kab mob loj zuj zus xws li ntshav qab zib retinopathy.
Kev xav txog kev cai lij choj thiab kev ncaj ncees:Tam sim no, BPC-157 tsuas yog tso cai rau kev tshawb fawb siv hauv ntau lub tebchaws. Cov neeg ncaws pob yuav tsum paub txog cov cai tiv thaiv doping (raws li nws tuaj yeem txhim kho kev ua kis las).
Kev pom yav tom ntej: " mais kawg" los ntawm chav kuaj mus rau chaw kho mob
Txawm hais tias BPC-157 qhia tau hais tias muaj peev xwm zoo, nws cov kev txhais lus kho mob tseem ntsib cov teeb meem:
Loj -kev sim tshuaj ntsuam xyuas
Cov ntaub ntawv tib neeg tam sim no feem ntau yog los ntawm me me - cov kev tshawb fawb me me, thiab ntau -center randomized controlled trials (RCTs) yuav tsum tau ua los xyuas lawv cov kev ua tau zoo thiab kev nyab xeeb.
Standardized raws tu qauv
Kev siv tshuaj zoo tshaj plaws, kev mus ncig, thiab kev kho mob ua ke yuav tsum tau tsim, xws li cov tswv yim kho tus kheej rau ntau hom kev raug mob.
Kev tshawb fawb pej xeem tshwj xeeb
Tshawb nrhiav kev nyab xeeb thiab kev ua tau zoo ntawm BPC-157 hauv cov menyuam yaus, cov poj niam cev xeeb tub, thiab cov neeg laus.
Mechanism deepening
Qhia meej nws lub hom phiaj ua haujlwm molecular thiab tshawb nrhiav nws cov txiaj ntsig zoo nrog rau lwm yam kev loj hlob (xws li EGF, FGF).
Raws li kev tshawb fawb tau ua tiav, BPC-157 xav tias yuav dhau los ua kev kho mob hauv kev kho cov ntaub so ntswg. Los ntawm "tus neeg saib xyuas" ntawm lub plab mucosa mus rau "kho" ntawm tag nrho lub cev cov ntaub so ntswg, cov peptide me me no tau los ntawm cov kua txiv hmab txiv ntoo yog sau ib tshooj tshiab hauv kev tshawb fawb txog lub neej. Txawm li cas los xij, thaum xav txog nws daim ntawv thov kev kho mob, peb tseem yuav tsum tau ceev faj - txoj hauv kev ntawm kev tshawb fawb tshawb fawb tsis tau nres.