Shuodi Biotech tshaj tawm theem 2b cov ntaub ntawv kho mob ntawm qhov hnyav poob ntawm me me molecule GLP-1
Thaum Lub Kaum Ob Hlis 8, 2025, Shuodi Biotechnology tshaj tawm tias kev tswj hwm qhov ncauj txhua hnub ntawm cov khoom me me.GLP-1 txhajreceptor agonist alenilipron tau ua tiav cov txiaj ntsig zoo saum toj kawg nkaus hauv ACCESS qhov chaw kho mob. Txoj haujlwm no yog tsom rau cov neeg rog rog uas rog rog thiab / lossis muaj tsawg kawg yog ib qho hnyav txog kev sib kis. Nws suav nrog 36 lub lis piam cov ntaub ntawv los ntawm cov tub ntxhais kawm Phase 2b ACCESS, kev tshawb nrhiav ACCESSI tsis tu ncua, nrog rau cov ntaub ntawv nruab nrab -cov ntaub ntawv los ntawm kev tshawb fawb lub cev thiab ACCESS qhib daim ntawv txuas ntxiv (OLE) cov kev tshawb fawb, muab lub hauv paus rau kev ntsuam xyuas kev ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj.
Cov ntaub ntawv tshiab kawg ntawm Phase 2b qhov chaw kho mob ACCESS tau tshaj tawm lub sijhawm no.
Tus tsim ntawm Phase 2b cov ntaub ntawv kho mob yog raws li hauv qab no: thawj feem tshawb nrhiav qhov poob phaus ntawm 45, 90, thiab 120mg koob tshuaj pab pawg tom qab 36 lub lis piam ntawm kev kho mob, qhov thib ob tshawb xyuas cov koob tshuaj ntau dua rau kev ua tau zoo dua, thiab qhov thib peb tshawb txog kev noj tshuaj ntawm kev pib titration ntawm cov koob tshuaj qis dua kom ua tiav qhov kev tiv thaiv zoo dua.
Wave Life Sciences siRNA cov tshuaj poob phaus zoo ib nrab - cov ntaub ntawv tso tawm
Thaum Lub Kaum Ob Hlis 8, 2025, Wave Life Sciences tau tshaj tawm cov ntaub ntawv ib ntus los ntawm Phase I INLGHT sim ntawm nws cov tshuaj rog rog WVE-007, uas tau muab rau 32 tus neeg uas tau txais ib qho kev txhaj tshuaj subcutaneous ntawm 240mg. Cov ntaub ntawv tau pom tias 9.4% txo qis hauv visceral rog, 4.5% txo qis hauv cov rog rog, thiab 3.2% nce hauv lub cev hnyav tom qab 12 lub lis piam. Raws li qhov tshwm sim ntawm cov xov xwm no, nws cov nqi Tshuag tau nce 147%.
WVE-007 yog RNA cuam tshuam cov tshuaj raws li GaINAC SiRNA thev naus laus zis, uas siv Wave proprietary SpiNA tsim kom raug INHBE gene mRNA nyob rau hauv daim siab, yog li txo cov kev qhia theem ntawm nws downstream protein cov khoom ActivinE. Kev xaiv ntawm lub hom phiaj no yog ua raws li cov pov thawj muaj zog ntawm tib neeg cov caj ces: cov neeg nqa cov kev tiv thaiv kev tiv thaiv kab mob sib txawv ntawm INHBE gene qhia tias lub cev muaj kev noj qab haus huv thiab txo qis kev pheej hmoo ntawm cov kab mob hauv lub plawv, suav nrog cov roj visceral tsawg, hom 2 mob ntshav qab zib thiab txo qis ntawm cov kab mob plawv.
Tsis zoo li cov tshuaj GLP-1 receptor agonists uas ua tiav qhov poob phaus los ntawm kev noj qab haus huv hauv nruab nrab, WVE-007 txhawb nqa lub cev nqaij daim tawv thiab txawm tias kev loj hlob los ntawm kev tswj hwm txoj hauv kev muaj feem xyuam rau cov roj metabolism thiab kev tiv thaiv cov leeg, thaum txo cov ntaub so ntswg adipose. Qhov no mechanism ntawm "qhov hnyav poob thiab kev tiv thaiv cov leeg" muab nws qhov tseem ceeb sib txawv qhov zoo hauv kev kho mob rog rog uas twb muaj lawm.