Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm cefpodoxime proxetil capsules hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo zoo cefpodoxime proxetil capsules rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Cefpodoxime proxetil capsulesyog thib peb - tiam qhov ncauj dav - spectrum cephalosporin tshuaj tua kab mob. Raws li ib tug prodrug, lawv tsis muaj cov tshuaj tua kab mob thiab yuav tsum tau hydrolyzed los ntawm esterases nyob rau hauv lub plab hnyuv ib ntsuj av tau los tsim cov active metabolite Cefpodoxime. Lub tom kawg inhibits tus ntoo khaub lig-txuas ntawm peptidoglycan chains los ntawm tshwj xeeb khi rau penicillin binding proteins (PBPs) nyob rau hauv cov kab mob cell phab ntsa, ua rau cell phab ntsa tsis xws luag thiab kab mob rupture thiab tuag vim osmotic siab imbalance. Cov txheej txheem no ua rau nws muaj cov kab mob muaj zog ntawm cov kab mob Gram zoo (xws li Streptococcus pneumoniae, Streptococcus genus) thiab cov kab mob Gram tsis zoo (xws li Haemophilus influenzae, Moraxella catarrhalis, Escherichia coli), thaum tswj kev ua haujlwm tawm tsam qee hom kab mob uas tsim tawm -.
Pharmacokinetic zoo:
Qhov ncauj bioavailability yog kwv yees li 50%, thiab zaub mov tuaj yeem txhim kho kev nqus tau zoo (Cmax nce 15% -24%, AUC nce 21% -33%). Cov tshuaj yog dav faib nyob rau hauv cov hlab ntsws, urinary ib ntsuj av, thiab cov ntaub so ntswg ntawm daim tawv nqaij, nrog ib tug tsawg protein losis tswvyim dabtsi npaum li cas (21% -29%) thiab ib tug siab feem ntawm cov tshuaj dawb los xyuas kom meej lub hom phiaj cov ntaub so ntswg concentration. Metabolism tsuas yog tso siab rau ntawm plab hnyuv esterases, tsis muaj kev koom tes ntawm daim siab cytochrome P450 enzymes, txo qhov kev pheej hmoo ntawm daim siab toxicity. Kwv yees li 60% yog tawm hauv nws daim ntawv qub los ntawm ob lub raum, nrog rau ib nrab-lub neej ntawm 2-3 teev, txhawb kev noj ob zaug ib hnub.
Cov ntaub ntawv ntxiv ntawm chemical compound:
| Khoom npe | Cefpodoxime Proxetil Powder | Cefpodoxime Proxetil ntsiav tshuaj | Cefpodoxime Proxetil kua | Cefpodoxime Proxetil Capsules |
| Yam khoom | Hmoov | Cov ntsiav tshuaj | Ua kua | Capsules |
| Khoom Purity | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% |
| Khoom Specifications | Customizable | Customizable | Customizable | Customizable |
| Pob khoom | Customizable | Customizable | Customizable | Customizable |
Peb cov khoom tsim
Cefpodoxime Proxetil +. COA
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Certificate of Analysis |
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Compound npe |
Cefpodoxime Proxetil | |
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CAS Nr. |
87239-81-4 | |
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Qib |
Pharmaceutical qib | |
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Ntau |
Customized | |
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Ntim txheem |
Customized | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
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Ntau No. |
20250109001 |
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MFG |
Jan 12th 2025 |
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EXP |
Jan 8th 2029 |
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Qauv |
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| TEST STANDARD | GB/T24768-2009 Kev lag luam. Stnndard | |
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Yam khoom |
Enterprise txheem |
Kev txheeb xyuas qhov tshwm sim |
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Qhov tshwm sim |
Dawb los yog yuav luag dawb hmoov |
Ua raws |
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Cov ntsiab lus dej |
Tsawg dua lossis sib npaug li 4.5% |
0.30% |
| Poob rau ziab |
Tsawg dua lossis sib npaug li 1.0% |
0.15% |
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Hnyav Hlau |
Pb Tsawg dua lossis sib npaug li 0.5ppm |
N.D. |
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Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Hg Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Cd Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Purity (HPLC) |
Ntau dua lossis sib npaug li 99.0% |
99.5% |
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Ib qho impurity |
<0.8% |
0.48% |
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Residue ntawm ignition |
<0.20% |
0.064% |
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Tag nrho microbial suav |
Tsawg dua lossis sib npaug li 750cfu / g |
80 |
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E. Coli |
Tsawg dua lossis sib npaug li 2MPN / g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (los ntawm GC) |
Tsawg dua lossis sib npaug li 5000ppm |
400ppm ua |
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Cia |
Khaws rau hauv qhov chaw kaw, tsaus thiab qhuav ntawm -20 degrees |
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Mastitis feem ntau tshwm sim hauv cov poj niam lactating thiab feem ntau tshwm sim los ntawm cov kab mob xws li Staphylococcus aureus. Cov neeg mob yuav hnov qhov liab, o, thiab mob hauv lawv ob lub mis, nrog rau qhov kub siab hauv zos thiab qee zaum nrog cov tsos mob xws li ua npaws.Cefpodoxime proxetil capsulestuaj yeem cuam tshuam cov kab mob ntawm cov phab ntsa ntawm tes, tua cov kab mob uas ua rau mastitis, txo qhov mob ntawm lub mis, txo cov tsos mob, thiab txhawb kev tso kua mis. Thaum kho tus mob mastitis, cov neeg mob yuav tsum tau txhawb kom pub niam mis ntau dua lossis siv lub tshuab nqus mis kom tshem tawm cov kua mis kom tswj tau lub mis patency.
Cov kab mob vestibular gland o thiab vestibular gland abscess
Lub caj pas vestibular yog nyob rau hauv lub posterior ntawm tus poj niam labia majora. Thaum cov kab mob ua rau lub caj pas vestibular o, lub pob liab liab, o, thiab mob tshwm sim nyob rau hauv qis dua -feem peb ntawm labia majora, thiab nyob rau hauv mob hnyav, ib qho abscess tuaj yeem tsim. Cefotaxime ester qhuav suspension muaj cov tshuaj tua kab mob ntawm cov kab mob uas ua rau lub caj pas vestibular o, tuaj yeem tswj tau tus kab mob, txhawb kev kho mob los yog abscess absorption. Rau cov neeg mob uas twb tau tsim abscesses, kev phais thiab kev phais yuav tsum tau siv, thiab cov tshuaj yuav tsum tau siv los tiv thaiv kab mob tom qab phais.
Periodontitis yog ib qho mob ntev ntawm cov ntaub so ntswg, thaum periapical periodontitis yog ib qho mob ntawm cov nqaij mos uas nyob ib puag ncig ntawm cov hniav hniav uas tshwm sim thaum cov hniav tsis zoo tag nrho los yog muaj kev cuam tshuam. Cefotaxime ester qhuav suspension tuaj yeem pab kho cov kab mob periapical thiab periapical periodontitis los ntawm cov kab mob rhiab heev, txo cov tsos mob xws li cov pos hniav liab, mob, thiab los ntshav, thiab txhawb kev kho mob. Thaum kho cov kab mob ntawm cov kab mob thiab cov kab mob hauv lub cev, cov kev taw qhia ntawm qhov ncauj yuav tsum tau muab ib txhij, xws li txhuam hniav kom raug thiab siv cov tshuaj txhuam hniav.
Cefpodoxime proxetil yog ib qho thib peb - tiam ntawm qhov ncauj cephalosporin tshuaj tua kab mob, thiab nws cov txheej txheem ntawm kev ua muaj ntau yam lom thiab tshuaj.
Cov tshuaj npe ntawm cefpodoxime axetil yog (±) -1-hydroxyethyl (+) - (6R, 7R) -7- [2- (2-amino-4-thiazolyl) glyoxylate] -3- (methoxymethyl) -8-oxo-5-abyloaz-1- [4.2.0] oct-2-en-2-carboxylate, 72- (Z) - (O-methyloxime) isopropyl carbonate, nrog rau cov mis mos ntawm C21H27N5O9S2 thiab molecular hnyav ntawm 557.6. Nws cov yam ntxwv muaj xws li:
Cefotaxime skeleton: Muaj ib pawg methoxythiazole ntawm txoj hauj lwm 7, ib pawg methoxymethyl ntawm txoj hauj lwm 3, thiab pawg proxetil (isopropoxycarbonyloxyethyl) ntawm carboxylic acid ntawm txoj hauj lwm 4.
Precursor tshuaj tsim: Lub xub ntiag ntawm cov pab pawg proxetil ua rau nws tsis muaj zog prodrug uas yuav tsum tau hydrolyzed nyob rau hauv vivo kom tso cov active ingredient Cefpodoxime.
Cov qauv no tsis tsuas yog ua kom lub qhov ncauj nqus tau zoo ntawm cov tshuaj, tab sis kuj ua kom ntev ib nrab ntawm - lub neej ntawm cov tshuaj hauv lub cev los ntawm kev tsim cov tshuaj prodrug, txhim kho cov nyhuv antibacterial.
Precursor tshuaj yam ntxwv thiab hauv vivo hloov dua siab tshiab
Cefpodoxime axetil capsules lawv tus kheej tsis muaj cov tshuaj tua kab mob, thiab lawv qhov kev ua yog nyob ntawm cov txheej txheem hloov dua siab tshiab hauv lub cev tom qab tswj qhov ncauj:
Kev nqus thiab hydrolysis: Tom qab kev tswj hwm qhov ncauj, cefpodoxime axetil yog hydrolyzed los ntawm tsis yog - tshwj xeeb esterases hauv plab hnyuv, tso tawm cov metabolite cefpodoxime. Cov txheej txheem no feem ntau tshwm sim nyob rau hauv lub plab hnyuv phab ntsa thiab daim siab, xyuas kom meej tias cov tshuaj hloov dua siab tshiab ua ntej nkag mus rau hauv cov hlab ntsha.
Bioaccumulation: Qhov tseeb bioavailability ntawm cefoperazone yog kwv yees li 50% (thaum muab tshuaj rau ntawm lub plab khoob). Cov zaub mov tuaj yeem txhawb nqa cov ntsiav tshuaj tawg, ua kom cov ntshav siab tshaj plaws (Cmax) thiab thaj tsam hauv qab lub sijhawm siv tshuaj (AUC) los ntawm 15% -24% thiab 21% -33%, feem, yam tsis muaj kev cuam tshuam rau kev nqus. Qhov no feature optimizes qhov ncauj tswj kev tswj ntawm cov tshuaj.
Cefotaxime exerts antibacterial teebmeem los ntawm inhibiting kab mob cell phab ntsa synthesis, nrog rau nws lub hom phiaj tseem ceeb yog penicillin binding proteins (PBPs):
Kev ua haujlwm ntawm PBPs: PBPs yog cov enzymes tseem ceeb hauv kev sib txuas ntawm peptidoglycans hauv cov kab mob ntawm cov phab ntsa ntawm tes, suav nrog transpeptidases, carboxypeptidases, thiab endopeptidases, lub luag haujlwm rau catalyzing tus ntoo khaub lig- txuas ntawm peptidoglycan chains, tswj kev ncaj ncees thiab lub zog ntawm lub zog.
Lub mechanism ntawm kev txiav txim ntawm cefuroxime:
Kev khi tshwj xeeb: Cefotaxime khi nrog siab affinity rau PBPs (tshwj xeeb tshaj yog PBP1A, PBP1B, PBP2, thiab PBP3), inhibiting lawv enzymatic kev ua si.
Blocked cell phab ntsa synthesis: Lub inactivation ntawm PBPs ua rau tsis muaj peev xwm ntawm peptidoglycan chains rau crosslink, ua rau lub cell phab ntsa tsis xws luag. Cov kab mob swells thiab deform vim osmotic siab tsis txaus, thaum kawg ua rau rupture thiab tuag.
Lub sij hawm dependence ntawm bactericidal concentration: Cefotaxime muaj ib tug bactericidal concentration ntawm 1-4 zaug qhov tsawg kawg nkaus inhibitory concentration (MIC) tiv thaiv cov kab mob Enterobacteriaceae (xws li - lactase tsim hom); Cov kab mob bactericidal tawm tsam Haemophilus influenzae thiab Moraxella catarrhalis (xws li - lactase tsim cov kab mob) tuaj yeem ncav cuag 99.9% hauv 6 teev (qhov concentration tsawg dua lossis sib npaug li 4 zaug MIC).
Cefpodoxime proxetil capsulesmuaj cov tshuaj tua kab mob muaj zog tiv thaiv ntau yam kab mob Gram zoo thiab Gram tsis zoo:
Gram positive bacteria:
Streptococcus genus: suav nrog Pawg A - hemolytic streptococcus (GAS), Streptococcus pneumoniae (tseem siv tau rau penicillin insensitive hom), Streptococcus agalactiae, thiab lwm yam.
Staphylococcus genus: Siv tau rau methicillin - tiv taus Staphylococcus aureus thiab coagulase tsis zoo Staphylococcus aureus, tab sis tsis muaj txiaj ntsig tiv thaiv methicillin - tiv taus Staphylococcus aureus (MRSA).
Gram negative bacteria:
Haemophilus influenzae: suav nrog cov kab mob uas tsim - lactase.
Catamora: ib qho kab mob uas feem ntau ua rau mob ua pa.
Enterobacteriaceae: xws li Escherichia coli, Klebsiella, Proteobacter, thiab lwm yam.
Neisseria gonorrhoeae: Ib koob tshuaj 200mg tuaj yeem kho tus kab mob gonorrhea yooj yim.
Lwm cov kab mob pathogenic: kuj muaj qee yam kev ua haujlwm tiv thaiv Neisseria gonorrhoeae, Citrobacter, Salmonella, Shigella, thiab lwm yam.
Txawm hais tias cefuroxime axetil capsules tswj siab rhiab heev rau feem ntau cov kab mob, qhov teeb meem ntawm cov tshuaj tiv thaiv tseem xav tau kev saib xyuas:
- lactase ntau lawm: Qee cov kab mob Gram tsis zoo (xws li Escherichia coli thiab Klebsiella) tuaj yeem ua tsis tau cefuroxime los ntawm kev tsim tawm - lactase los hydrolyze nws - lactam nplhaib. Txawm li cas los xij, cefoperazone tseem muaj txiaj ntsig zoo rau qee hom kab mob uas tsim - lactase, ua tsaug rau kev ruaj ntseg ntawm nws pawg methoxythiazole ntawm cov enzyme.
PBPs variation: Cov kab mob tuaj yeem txo qhov kev sib raug zoo ntawm cefuroxime los ntawm kev hloov cov qauv ntawm PBPs, ua rau cov tshuaj tiv thaiv. Piv txwv li, kev tiv thaiv ntawm Streptococcus pneumoniae rau macrolide lincosamide streptomycin (MLS) cov tshuaj tua kab mob tuaj yeem cuam tshuam nrog kev hloov pauv hauv PBPs.
Overexpression ntawm efflux twj: Qee cov kab mob siv cov twj tso kua mis efflux kom tshem tawm cefoperazone los ntawm qhov chaw extracellular, txo cov tshuaj intracellular concentration thiab ua rau cov tshuaj tiv thaiv.
Clinical resistance rate: Cov kev tshawb fawb hauv tsev tau pom tias cefuroxime axetil muaj txiaj ntsig zoo tiv thaiv Streptococcus pneumoniae GAS, Tus nqi tiv thaiv ntawm Haemophilus influenzae (xws li - lactase tsim hom) yog tsawg, tab sis nws tsis muaj txiaj ntsig tiv thaiv methicillin - tiv thaiv kab mob BL-Staphyusticus, uas tsis muaj zog. coli, thiab lwm yam kab mob.
Cefpodoxime Proxetil Capsules, raws li qhov thib peb -cov tshuaj tua kab mob hauv qhov ncauj cephalosporin, muaj cov tshuaj pharmacokinetic uas cuam tshuam ncaj qha rau kev kho mob thiab kev nyab xeeb.
Cefpodoxime yog ib qho tshuaj uas tsis muaj zog uas yuav tsum tau hydrolyzed los ntawm tsis yog -cov kab mob plab tshwj xeeb esterases los tsim cov tshuaj metabolite Cefpodoxime tom qab kev tswj hwm qhov ncauj txhawm rau txhawm rau tiv thaiv kab mob.
Bioaccumulation: Nyob rau hauv kev yoo mov, qhov bioavailability yog kwv yees li 50%, thiab zaub mov tuaj yeem txhim kho nws txoj kev nqus tau zoo. Cov kev tshawb fawb tau pom tias kev tswj hwm nrog cov zaub mov tuaj yeem ua rau cov ntshav siab siab tshaj plaws (Cmax) los ntawm 15% -24% thiab thaj chaw hauv qab lub sijhawm siv tshuaj (AUC) los ntawm 21% -33%. Cov yam ntxwv no tshwm sim los ntawm kev txhawb nqa cov nyhuv ntawm cov khoom noj ntawm cov tshuaj tua kab mob, txo cov sij hawm khaws cia ntawm cov tshuaj hauv plab hnyuv thiab yog li txo cov txiaj ntsig thawj zaug.
Dose dependence: Pharmacokinetic parameters qhia ib koob tshuaj -dependent kev sib raug zoo. Tom qab kev tswj hwm qhov ncauj ntawm 0.1g, 0.2g, thiab 0.4g, Cmax nce mus txog 1.4mg / L, 2.3mg / L, thiab 3.9mg / L, feem, nrog lub sijhawm siab tshaj (Tmax) ntawm 2-3 teev. Thaum noj ib koob tshuaj 400mg, cov ntshav cov tshuaj concentration tseem nyob ntawm 0.38mg / L rau 6 teev, uas yog 1-4 npaug ntawm MIC ntawm cov kab mob feem ntau, kom ntseeg tau cov kab mob bactericidal.
Cefotaxime tau dav dav hauv lub cev thiab tuaj yeem nkag mus rau thaj chaw muaj kab mob xws li cov kab mob ua pa, tso zis, tawv nqaij, thiab cov nqaij mos.
Lub koom haum concentration: Cov concentration hauv cov ntsws, tonsils, thiab cov kua dej ntawm daim tawv nqaij yog 2.7 npaug, 0.17 npaug, thiab 0.4-0.7 npaug ntawm cov ntshav, feem. Piv txwv li, tom qab kev tswj qhov ncauj ntawm 0.2g, lub ntsws cov ntaub so ntswg concentration mus txog 0.63mg / L thiab cov tonsil cov ntaub so ntswg concentration yog 0.24mg / L, ho siab dua MIC qhov tseem ceeb ntawm feem ntau cov kab mob.
Protein binding tus nqi: Qhov sib txuas ntawm cov ntshav plasma protein tsawg (21% -29%), thiab qhov feem pua ntawm cov tshuaj dawb yog siab, uas muaj txiaj ntsig zoo rau kev nkag mus rau cov cell membranes thiab cov ntaub so ntswg teeb meem, thiab ua rau cov kab mob tua kab mob.
Cov metabolism ntawm cefuroxime axetil feem ntau yog nyob ntawm plab hnyuv esterase hydrolysis, tsis muaj kev koom tes ntawm daim siab cytochrome P450 enzymes. Yog li ntawd:
Ib txoj hauv kev metabolic: Kwv yees li 90% ntawm cov koob tshuaj tau hloov mus rau cefpodoxime hauv plab hnyuv, tsuas yog me me (<10%) entering the liver in its original form or metabolite form, significantly reducing the risk of liver toxicity.
Tsis muaj kev sib cuam tshuam tshuaj: Thaum siv nrog cov tshuaj antacids lossis H2 receptor antagonists, tom kawg tuaj yeem txo qis pH tus nqi hauv plab, inhibit esterase kev ua, thiab ua rau txo qis kev nqus ntawm cefuroxime axetil, ua rau 30% -50% txo hauv Cmax. Yog li ntawd, nws raug pom zoo kom tsis txhob noj hom tshuaj no ua ke.
Cefotaxime feem ntau yog tawm los ntawm lub raum, nrog ib nrab -lub neej (t1/2) ntawm 1.9-3.7 teev:
Txoj kev tshem tawm: Kwv yees li 60% ntawm cov koob tshuaj tau tawm hauv nws daim ntawv qub los ntawm glomerular pom thiab tubular secretion, 29% -33% yog tawm hauv daim ntawv ntawm cefuroxime, thiab ib qho me me yog tawm los ntawm cov kua tsib.
Ib nrab lub neej kom zoo: Txawm hais tias ib nrab - lub neej luv luv, nws cov kab mob bactericidal tuaj yeem khaws cia rau 6-8 teev, txhawb kev noj tshuaj ob zaug ib hnub. Piv txwv li, tom qab kev tswj qhov ncauj ntawm 0.2g, cov ntshav tshuaj concentration tseem nyob ntawm 0.18mg / L rau 12 teev, tswj kev cuam tshuam rau feem ntau cov kab mob.
Cim npe nrov: Cefpodoxime Proxetil Capsules, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom