Loratadine ntsiav tshuaj(Loranox) yog ib qho siv dav tshaj -- cov tshuaj tiv thaiv kab mob, koom nrog rau tiam thib ob ntawm cov tshuaj tiv thaiv kab mob. Cov khoom xyaw tseem ceeb yog loratadine, thiab nws kuj muaj qee cov khoom ntxiv xws li cov hmoov txhuv nplej siab, lactose, magnesium stearate, thiab lwm yam. Cov khoom siv no pab nrog kev ua kom zoo, ruaj khov, thiab kev tswj hwm ntawm cov tshuaj. Tom qab tib neeg lub cev los rau hauv kev sib cuag nrog allergens, lub cev tiv thaiv kab mob tso tawm tshuaj xws li histamine.
Histamine khi rau histamine receptors ntawm lub xovtooj ntawm tes, ua rau muaj cov tsos mob ua xua xws li txham, los ntswg, qhov ntswg congestion, khaus ntawm daim tawv nqaij, ua pob liab liab, thiab lwm yam.
Nyob rau tib lub sijhawm, peb lub tuam txhab tsis yog tsuas yog muab cov hmoov ntshiab, tab sis kuj muaj cov ntsiav tshuaj thiab tshuaj txhaj. Yog tias xav tau, thov koj xav tiv tauj peb txhua lub sijhawm.
Cov ntaub ntawv ntxiv ntawm chemical compound:
Khoom Description
Loratadine COA
Loratadine ntsiav tshuajFeem ntau yog siv los txo cov tsos mob tshwm sim los ntawm ntau yam kab mob ua xua thiab muaj ntau yam kev siv tshuaj kho mob. Nrog nws cov txiaj ntsig zoo thiab muaj zog tiv thaiv - ua xua, nws tau dhau los ua ib qho ntawm cov tshuaj nyiam rau kev kho mob ntawm ntau yam kab mob ua xua. Cov kev qhia tshwj xeeb yog raws li nram no:
(I) Allergic Rhinitis
Nws yog ib qho ntawm feem ntau thiab cov ntsiab lus qhia ntawm cov khoom. Cov tshuaj muab cov txiaj ntsig zoo rau kev ua xua rau ob lub caij nyoog tsis haum rhinitis thiab perennial allergic rhinitis, muaj feem xyuam rau cov menyuam yaus, cov hluas, cov neeg laus thiab cov neeg laus (cov ntawv tsim nyog thiab cov koob tshuaj yuav tsum raug xaiv raws li pawg hnub nyoog).
Cov kab mob rhinitis raws caij nyoog, tseem hu ua hay fever, feem ntau tshwm sim los ntawm kev ua xua raws caij nyoog xws li paj ntoos thiab catkins nyob rau lub caij nplooj ntoos hlav, nrog rau artemisia thiab ragweed nyob rau lub caij nplooj zeeg.
Cov tsos mob tshwm sim muaj xws li txham tsis tu ncua, muaj dej ntws tawm ntawm qhov ntswg, qhov ntswg congestion thiab khaus qhov ntswg. Qee cov neeg mob kuj tsim cov tsos mob ntawm qhov muag pom xws li khaus qhov muag, lacrimation, conjunctival congestion thiab daim tawv muag edema. Hauv qhov xwm txheej hnyav, nws cuam tshuam rau kev ua haujlwm, kev kawm thiab kev pw tsaug zog, thiab txawm tias ua rau lub cev tsis zoo thiab lub cim xeeb poob qis.Perennial allergic rhinitis yog tshwm sim los ntawm lub xyoo - cov tshuaj tsis haum xws li plua plav mites, tsiaj dander, pwm, kab laum tawm thiab plua plav sab hauv tsev. Nws cov tsos mob tshwm sim rau ntau tshaj 4 lub lis piam nyob rau nruab nrab, nthuav tawm raws li qhov ntswg congestion, qhov ntswg khaus, txham thiab rhinorrhea.
Ntev - ntu ntu yuav ua rau muaj teeb meem xws li sinusitis, otitis media thiab qhov ntswg polyps, ua rau mob qhov ntswg thiab lub neej zoo.
Loranox precisely blocks histamine H1 receptors, zoo relieving qhov ntswg mucosal congestion, edema thiab inflammatory tshua, thiab sai alleviating cov saum toj no tsis haum cov tsos mob los txhim kho qhov ntswg qhov ntswg thiab kev nplij siab. Nws yog qhov tshwj xeeb tshaj yog tsim rau cov neeg mob uas muaj kev tsis haum tshuaj rhinitis uas xav tau ntev - lub sijhawm tswj cov tsos mob. Kev tswj xyuas lub sij hawm ntev - tsis tshua muaj kev cuam tshuam cov tshuaj tiv thaiv, ua kom tus mob nyob ruaj khov, txo qhov zaus ntawm kev tawm tsam, thiab pab cov neeg mob rov ua lub neej zoo. Clinically, nws feem ntau ua ke nrog intranasal glucocorticoids thiab qhov ntswg decongestants los txhim kho kev ua tau zoo, tshwj xeeb tshaj yog rau cov neeg mob uas muaj cov tsos mob hnyav.
(II) Urticaria
Urticaria yog ib hom kab mob ua xua rau ntawm daim tawv nqaij, muab faib ua hom mob thiab mob ntev raws li kab mob. Nws pathogenesis zoo sib xws nrog cov kab mob tsis haum tshuaj. Feem ntau predisposing yam muaj xws li kev ua xua rau zaub mov (khoom noj nqaij nruab deg, mis nyuj, qe, txiv ntseej, thiab lwm yam), tshuaj tsis haum tshuaj (penicillins, cephalosporins, antipyretic analgesics, thiab lwm yam), kev ua xua ntawm ib puag ncig (pollen, plua plav mites, huab cua txias, ultraviolet rays, thiab lwm yam), kab mob (kab mob thiab kab mob ntawm cov kab mob thiab cov kab mob endocrine.
Qhov tshwm sim tseem ceeb ntawm kev kho mob yog qhov tshwm sim ntawm qhov sib txawv ntawm qhov ntau thiab tsawg thiab cov duab tsis sib xws ntawm daim tawv nqaij, nthuav tawm xim liab, daj ntseg liab los yog xim dawb nrog cov xim ntshiab lossis qhov muag plooj, nrog rau khaus khaus. Wheals downs spontaneously nyob rau hauv cov sij hawm tsis muaj residual cim tab sis yog nquag mus rov tshwm sim, ua rau muaj kev txom nyem loj rau cov neeg mob.
Mob urticaria muaj qhov pib tshwm sim sai sai, txhim kho nyob rau hauv feeb mus rau teev tom qab kis tus kab mob allergen.
Qee cov neeg mob muaj cov tsos mob hnyav nrog rau kev tsis xis nyob hauv plab xws li mob plab, raws plab, xeev siab thiab ntuav, thiab txawm tias lub neej - hem ua rau muaj kev fab tshuaj hnyav xws li ua tsis taus pa, hauv siab nruj thiab laryngeal edema yog tias tsis kho raws sijhawm.
Cov kab mob urticaria ntev yog txhais tau tias yog kab mob kab mob ntau dua 6 lub lis piam nrog tsawg kawg 2 ntu ntu. Nws cov tsos mob rov tshwm sim yog qhov nyuaj rau kho, cuam tshuam rau cov neeg mob lub neej zoo thiab kev noj qab haus huv ntawm lub hlwb; Qee cov neeg mob muaj kev ntxhov siab thiab kev nyuaj siab vim khaus tas li.
Loratadine ntsiav tshuajmuaj txiaj ntsig zoo hauv kev kho mob hnyav thiab mob urticaria. Nws sai sai inhibits histamine tso tawm, txo cov tawv nqaij pruritus thiab wheals, thiab txo cov zaus rov tshwm sim. Rau mob urticaria, nws ceev ceev tswj cov tsos mob kom tsis txhob deterioration thiab yuav lub sij hawm rau kev kho mob tom ntej. Rau cov mob ntev, kev noj tshuaj ntev ntev - lub sij hawm ua kom tus mob stabilizes tus mob thiab txo tus nqi rov qab.
Tsis muaj cov nyhuv sedative pom tseeb, nws tsis cuam tshuam nrog kev ua haujlwm niaj hnub, kev kawm lossis kev pw tsaug zog, ua rau nws tsim nyog rau kev siv sijhawm ntev - piv nrog thawj - tiam antihistamines. Clinically, rau mob hnyav urticaria, nws tuaj yeem ua ke nrog lwm yam thib ob - tiam antihistamines lossis leukotriene receptor antagonists rau kev kho mob sib koom ua ke los txhim kho kev ua tau zoo.
(III) Lwm yam kab mob ntawm daim tawv nqaij ua xua
Ntxiv nrog rau urticaria, cov khoom siv dav siv los txo cov pob khaus los ntawm ntau yam kab mob ntawm daim tawv nqaij ua xua, nrog rau kev siv tshuaj kho mob xws li eczema, hu rau dermatitis, atopic dermatitis, pruritus, tshuaj -induced dermatitis thiab neurodermatitis.
Cov kab mob no muaj cov txheej txheem nyuaj, feem ntau cuam tshuam nrog kev tsis haum tshuaj (cov tshuaj pleev ib ce, tshuaj ntxuav tes, paj ntoos, plua plav mites, hlau ornaments, tshuaj raw khoom, thiab lwm yam), autoimmune yam, genetic yam thiab ib puag ncig yam. Txawm hais tias kev kho mob tshwm sim txawv,daim tawv nqaij pruritusyog cov tsos mob tseem ceeb, feem ntau nrog erythema, papules, hlwv, desquamation, yaig thiab exudation.
Cov mob hnyav raug kev txom nyem los ntawm kev cuam tshuam kev pw tsaug zog, ua haujlwm tsis zoo txhua hnub thiab txawm tias muaj kab mob ntawm daim tawv nqaij.
Eczema yog ib hom kab mob inflammatory ntawm daim tawv nqaij nrog lub sijhawm ntev thiab rov tshwm sim, tshwm sim raws li erythema, papules thiab hlwv nrog pruritus, thiab yaig thiab exudation nyob rau hauv mob hnyav. Kev sib cuag dermatitis yog hais txog kev mob tshwm sim los ntawm kev sib cuag ntawm daim tawv nqaij nrog cov khoom siv sab nraud, nthuav tawm erythema, papules thiab khaus ntawm qhov chaw sib cuag, nrog hlwv thiab yaig thaum mob hnyav.
Atopic dermatitis feem ntau muaj feem xyuam nrog kev sib deev thiab kev tsis haum tshuaj, feem ntau pom hauv cov menyuam yaus, muaj cov tawv nqaij qhuav, pruritus thiab erythema, nrog rau exudation thiab crusting nyob rau theem siab. Tshuaj-induced dermatitis yog ib qho kev tsis haum tshuaj uas tshwm sim los ntawm qhov ncauj lossis kev sib cuag, nthuav tawm erythema, papules thiab pruritus nrog cov tsos mob ntawm cov mob hnyav.
Los ntawm inhibiting histamine tso tawm, loranox alleviates ntawm daim tawv nqaij inflammatory teb thiab pruritus los txo cov kev kho mob tsis xis nyob. Nws feem ntau ua ke nrog cov tshuaj pleev ib ce xws li glucocorticoid tshuaj pleev, calamine lotion thiab moisturizers rau synergistic kho cov teebmeem, txhim kho kev ua tau zoo, txo cov kab mob, txo qhov khaus pom tseeb, txhim kho daim tawv nqaij thiab kho cov tawv nqaij noj qab haus huv.
(IV) Lwm yam kab mob ua xua
Tsis tas li ntawd, nws tuaj yeem txo qhov tsis xis nyob los ntawm lwm yam kab mob ua xua, nrog rau cov ntawv thov dav dav uas suav nrog kev tsis haum tshuaj ntawm ntau lub cev.
Hais txog kev ua xua ntawm qhov muag, nws txo qhov khaus qhov muag, lacrimation, conjunctival congestion, txawv teb chaws lub cev thiab daim tawv muag edema tshwm sim los ntawm allergic conjunctivitis, txo qhov muag tsis xis nyob thiab tiv thaiv ob lub qhov muag kab mob los ntawm lub qhov muag nquag - txhuam. Nws yog qhov tshwj xeeb tshaj yog rau kev ua xua rau lub caij nyoog uas tshwm sim los ntawm paj ntoos, plua plav mites thiab lwm yam tshuaj tsis haum.
Rau kev ua xua ua pa, nws yog ib qho kev kho mob ntxiv rau kev ua xua rau mob hawb pob - tus kab mob ua pa ntev uas tshwm sim los ntawm txoj hlab ntsws hyperresponsiveness ze ze rau kev ua xua. Asthma tawm tsam tam sim no hnoos, hawb pob, hauv siab nruj thiab ua tsis taus pa. Loranox txo cov kev tsis haum ntawm cov hlab ntsws thaum muaj kev tawm tsam, txo cov hnoos thiab hawb pob, thiab ua haujlwm nrog cov tshuaj tiv thaiv - mob hawb pob xws li nqus tau cov glucocorticoids thiab bronchodilators txhawm rau txhim kho kev ua pa thiab txo qhov mob hawb pob.
Rau cov mob me me txhua hnub, nws ua kom cov tawv nqaij khaus khaus thiab o los ntawm yoov tshaj cum tom. Nrog me me thiab ntev - ua haujlwm tau ntev, nws sai sai txo qhov tsis xis nyob hauv zos thiab tiv thaiv cov tawv nqaij puas thiab kis kab mob los ntawm khawb, ua rau nws yog ib qho tseem ceeb ntawm cov tshuaj nyob hauv tsev.
Tsis tas li ntawd, nws tuaj yeem siv los kho lwm yam kab mob ua xua xws li Henoch-Schönlein purpura - kab mob vascular inflammatory ze ze nrog kev tsis haum tshuaj, tshwm sim raws li daim tawv nqaij purpura, arthralgia thiab mob plab. Loranox txo cov kev tsis xis nyob uas tshwm sim los ntawm kev tsis haum tshuaj, pab tswj tus mob thiab txhawb cov neeg mob rov zoo.
Loratadine ntsiav tshuajyog ib hom tshuaj siv thib ob - tiam tshuaj antihistamine, feem ntau yog siv los txo cov tsos mob ntawm kev tsis haum tshuaj xws li allergic rhinitis thiab mob urticaria. Nws tuav txoj haujlwm tseem ceeb hauv khw muag tshuaj vim nws cov txiaj ntsig kho mob tseem ceeb thiab cov kev mob tshwm sim me me. Kev nkag siab txog cov txheej txheem tsim khoom ntawm nws yog qhov tseem ceeb heev rau kev ua kom cov tshuaj zoo, ua tau raws li kev xav tau ntawm cov tshuaj kho mob, thiab txhawb kev txhim kho kev lag luam kws tshuaj.
Kev npaj ua ntej ntau lawm
Kev xaiv thiab tshuaj xyuas cov khoom siv raw thiab cov khoom siv pabcuam
Main tshuaj Loranox
Cov txheej txheem zoo: Nws yuav tsum ua raws li cov kev cai ntawm Suav Pharmacopoeia lossis cov chaw muag tshuaj thoob ntiaj teb, thiab qhov purity feem ntau yuav tsum siab dua 98.0%. Cov tsos mob yuav tsum yog dawb los yog tawm dawb crystalline hmoov, tsw tsw thiab tasteless.
Cov khoom soj ntsuam: suav nrog cov yam ntxwv, kev txheeb xyuas, cov khoom muaj feem xyuam, kev txiav txim siab cov ntsiab lus, thiab lwm yam.
Kev txheeb xyuas tuaj yeem ua tiav los ntawm txoj hauv kev xws li infrared spectroscopy thiab siab -kua kua chromatography.
Kev tswj nruj ntawm cov ntsiab lus impurity yuav tsum muaj rau kev tshuaj xyuas cov khoom kom ntseeg tau tias nws tsis pub dhau qhov kev txwv; Kev txiav txim siab tseeb ntawm cov ntsiab lus ntawm loranox yuav tsum tau ua kom ntseeg tau tias nws ua tau raws li qhov xav tau ntawm cov ntawv sau npe.
Cov khoom siv pabcuam
Cov hmoov txhuv nplej siab: feem ntau yog siv los ua cov muab tub lim kom nce ntim thiab qhov hnyav ntawm cov ntsiab lus capsule. Cov hmoov txhuv nplej siab dawb, tsis muaj ntxhiab, thiab impurity tsis muaj hmoov txhuv nplej siab yuav tsum tau xaiv, nrog cov dej noo feem ntau tsis tshaj 12%. Cov khoom soj ntsuam muaj xws li cov yam ntxwv, noo noo, cov ntsiab lus tshauv, thiab lwm yam.
Lactose: Nws kuj yog ib qho khoom siv uas feem ntau siv nrog fluidity zoo thiab compressibility. Nws yuav tsum ua raws li cov qauv zoo uas tau teev tseg hauv cov tshuaj pharmacopoeia, thiab cov khoom kuaj xyuas muaj xws li cov khoom, acidity, sulfate, hnyav hlau, thiab lwm yam.
Magnesium stearate: Raws li lub roj nplua nyeem, nws tuaj yeem tiv thaiv cov khoom los ntawm adhering rau saum npoo ntawm qhov tuag thaum lub ntsiav tshuaj nias txheej txheem, kom ntseeg tau tias du demolding ntawm cov ntsiav tshuaj. Dawb, tsis muaj ntxhiab thiab tsis qab ntsev magnesium stearate yuav tsum tau xaiv, thiab nws cov ntsiab lus yuav tsum ua raws li cov cai. Cov khoom kuaj xyuas muaj xws li cov khoom, cov hlau hnyav, arsenic ntsev, thiab lwm yam.
Cov txheej txheem ntau lawm
Kev kho ua ntej ntawm cov khoom siv raw thiab cov khoom pabcuam
Crushing thiab tshuaj ntsuam xyuas ntawm loranox: Cov khoom siv raw ntawm loranox yog crushed nyob rau hauv ib tug universal crusher, thiab cov khoom crushed yog soj ntsuam los ntawm ib tug vibrating screen los xaiv cov khoom uas yuav tsum tau particle loj (feem ntau yuav tsum tau dhau los ntawm ib tug 80-100 mesh screen) rau tom qab siv.
Kev ua cov khoom siv ntxiv: Cov hmoov txhuv nplej siab, lactose thiab lwm cov khoom ntxiv kuj yuav tsum tau crushed thiab tshuaj xyuas kom lawv cov particle loj zoo ib yam li loranox granules. Magnesium stearate feem ntau tsis tas yuav crushed, tab sis nws yuav tsum tau sieved kom tshem tawm clumps.
Sib tov
Kev sib xyaw qhuav: Sib tov cov sieved loranox granules nrog cov nqi ntawm cov hmoov txhuv nplej siab, lactose, thiab lwm yam ntxiv rau hauv ib qho kev faib ua feem rau hauv V- hom tov khoom. Tig lub tov khoom thiab sib tov ntawm qhov tsim nyog ceev rau 15-20 feeb kom ua tiav thawj zaug thiab sib xyaw ntawm cov ntaub ntawv.
Kev sib xyaw ntub dej: Npaj cov nplaum tsim nyog, xws li 10% hmoov txhuv nplej siab slurry.
Maj mam ntxiv cov nplaum rau cov khoom sib xyaw qhuav, thaum pib lub tshuab ntub dej granulation rau nplawm thiab granulation. Thaum lub sij hawm pub mis, kev saib xyuas yuav tsum tau them nyiaj rau kev tswj qhov ceev ceev thiab cov khoom siv nplaum, kom cov khoom tuaj yeem sib npaug ntawm cov ntub dej thiab tsim cov khoom ntub dej me me. Lub sij hawm ntub dej granulation yog 3-5 feeb.
Granulation
Tom qab ntub granulation tiav lawm, hloov cov khoom ntub mus rau ib qho cua kub circulating qhov cub kom qhuav. Kev ziab ziab yog feem ntau tswj ntawm 60-70 degree, thiab lub sij hawm ziab yog nyob ntawm cov dej noo ntawm cov khoom ntub thiab kev ua haujlwm ntawm cov khoom ziab, feem ntau 2-3 teev. Tsis tu ncua tig cov khoom thaum lub sij hawm ziab kom paub meej tias txawm tias ziab. Cov dej noo ntawm cov khoom qhuav yuav tsum tau tswj ntawm 3% thiab 5%.
Tag nrho cov nplej
Qhuav cov khoom thiab siv lub viav vias granulator los puag ncig lawv. Xaiv ib lub sieve haum (feem ntau yog 14-20 mesh) kom tshem tawm cov khoom uas loj dhau los yog me me, ua rau cov khoom me me zoo sib xws. Tag nrho cov khoom yuav tsum xoob thiab tsis muaj lumps.
Tag nrho kev sib xyaw
Ntxiv tag nrho cov granules thiab magnesium stearate mus rau V-hom mixer rau tag nrho cov sib tov, nrog rau lub sij hawm sib tov ntawm 10-15 feeb. Lub hom phiaj ntawm kev sib xyaw yog kom sib npaug faib magnesium stearate rau ntawm qhov chaw ntawm cov khoom, muab lubrication thiab ntxiv kom ntseeg tau tias cov khoom sib xws.
Capsule filling
Kev xaiv lub plhaub capsule: Xaiv lub plhaub uas tsim nyog raws li cov lus qhia tshwj xeeb thiab kev thauj khoom ntawmLoratadine ntsiav tshuaj. Qhov zoo ntawm lub plhaub capsule yuav tsum ua raws li cov qauv tsim nyog thiab tsis muaj qhov tsis xws luag xws li kev puas tsuaj thiab deformation.
Kev ua haujlwm puv: ntxiv tag nrho cov khoom sib xyaw rau hauv lub hopper ntawm lub tshuab tsis siv neeg capsule filling, kho tus nqi filling thiab filling ceev, thiab pib cov khoom siv tshuaj ntsiav filling. Thaum lub sij hawm sau cov txheej txheem, nws yog ib qho tsim nyog yuav tsum tsis tu ncua xyuas qhov sib txawv ntawm cov tshuaj capsule filling ntim thiab cov tsos zoo kom ua raws li cov kev cai tswj hwm.
pob
Aluminium yas blister ntim: Muab cov ntim ntim rau hauv cov pwm ntawm lub tshuab ntim yas yas ntim, thiab kaw cov tshuaj ntsiav ntawm aluminium foil thiab yas blister los ntawm cua sov, siab, thiab lwm yam txheej txheem. Thaum lub sij hawm ntim cov txheej txheem, yuav tsum tau them nyiaj mloog mus rau kev tswj lub tshav kub sealing kub thiab siab los xyuas kom meej lub sealing ntawm lub ntim.
Kev ntim khoom sab nraud: Muab cov tshuaj ntsiav ntim rau hauv aluminium- cov hnab yas ntim rau hauv cov thawv ntawv lossis lub raj mis yas, sau cov npe tshuaj, cov lus qhia tshwj xeeb, batch naj npawb, hnub tas sijhawm, thiab lwm yam ntaub ntawv. Lub ntim sab nrauv yuav tsum ruaj khov, zoo nkauj, thiab muaj peev xwm tiv thaiv cov tshuaj los ntawm kev puas tsuaj.
FAQ
Loratadine zoo rau dab tsi?
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loranox yog ib qho siv dav heev, dhau - lub- txee (OTC) thib ob- tiam antihistamine tsim los kho cov tsos mob ua xua, xws li txham, los ntswg, khaus ntawm qhov ntswg lossis caj pas, thiab khaus / dej qhov muag, feem ntau muab 24- teev, tsis tsaug zog. Nws yog feem ntau siv rau kev ua xua raws caij nyoog (thaum ua npaws) thiab khaus khaus, feem ntau noj ib hnub los ntawm qhov ncauj.
Puas yog loratadine tib yam li Zyrtec?
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Loranox (feem ntau muaj npe xws li Claritin) thiab Zyrtec (cetirizine) yogtsis zoo ib yam, txawm tias ob qho tib si zoo, thib ob - tiam, dhau - - tshuaj tiv thaiv kab mob rau kev ua xua. Zyrtec ua sai dua (hauv 1 teev) thiab feem ntau muaj zog dua tab sis feem ntau yuav ua rau qaug zog dua li feem ntau tsis yog - tsaug zog loratadine.
Cim npe nrov: Loratadine capsules, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom