Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm magnesium threonate capsules hauv Suav teb. Txais tos rau kev lag luam wholesale bulk zoo magnesium threonate capsules rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Magnesium threonate capsulesyog cov khoom noj khoom haus nrog magnesium L-threonate (MgT) ua cov khoom tseem ceeb. Nws cov mis molecular yog C8H14MgO10, tsim los ntawm chelation cov tshuaj tiv thaiv ntawm L-threnic acid (a tetracarbolic acid) thiab magnesim ions. Cov qauv no muab nws ob qho tshwj xeeb zoo:
High bioavailability: Sucrose acid raws li ib tug ligand tuaj yeem tiv thaiv magnesium ions los ntawm kev khi ntawm phytic acid, oxalic acid thiab lwm yam tshuaj nyob rau hauv txoj hnyuv, thiab tus nqi nqus yog 3-5 npaug ntau dua li cov tshuaj inorganic magnesim ntsev (xws li magnesim oxide thiab magnesim sulfate).
Ntshav-brain barrier penetrability: MgT tsuas yog ib qho tshuaj magnesim ntxiv rau kev kho mob kom muaj txiaj ntsig zoo rau cov kua dej hauv lub hlwb magnesim concentration, nrog rau 1.5-2 npaug ntau dua cov txiaj ntsig ntawm kev nce magnesim concentration hauv lub hlwb piv rau lwm cov ntsev magnesim.
Mainstream dosage forms
Hard capsules:
Siv hydroxypropyl methylcellulose (HPMC) lossis gelatin ua cov khoom siv tshuaj ntsiav, ntim nrog micronized MgT (particle loj D90<50 μ m), with a bioavailability of 85-90%.
Cov ntsiav tshuaj:
Los ntawm cov txheej txheem ntub dej granulation, hla - txuas carboxymethyl cellulose sodium (CCNa) yog ntxiv los ua ib qho kev sib cais kom ua tiav kev tawg hauv 15 feeb.
Hmoov:
Npaj siv khov- tshuab ziab khaub ncaws, nrog cov dej noo ntawm<3%, and maintains stability for 24 hours after reconstitution.
Kev Tswj Xyuas Zoo
Heavy hlau ntes:
coj<0.5ppm, arsenic<1ppm, cadmium<0.3ppm
Microbial txwv:
Tag nrho cov colony suav<1000 CFU/g, mold and yeast<100 CFU/g
Cov ntsiab lus uniformity:
RSD% Tsawg dua lossis sib npaug li 5% (USP<905>txheem)
Cov txheej txheem tsim khoom tseem ceeb
Micronization tshuab:
Sib tsoo MgT raw cov ntaub ntawv rau D90<50 μ m, significantly improving solubility and absorption rate.
ntub dej granulation:
Ntxiv cov ntoo khaub lig- txuas carboxymethyl cellulose sodium (CCNa) ua ib qho kev sib cais kom ntseeg tau tias cov ntsiav tshuaj puas sai sai.
Freeze drying:
Cov thev naus laus zis no yog siv los ua cov hmoov nplej kom txo cov dej noo kom tsawg dua 3% thiab txuas lub neej txee rau 36 lub hlis.
Cov ntaub ntawv ntxiv ntawm chemical compound:
Peb Cov Khoom
Magnesium Threonate +. COA
Magnesium threonate capsulesyog cov khoom noj khoom haus nrog magnesim L-threonate (MgT) ua cov ntsiab lus tseem ceeb. Nws cov qauv molecular tshwj xeeb ua rau nws tsuas yog cov tshuaj magnesim ntxiv uas tau kuaj pom los ua kom muaj zog cerebrospinal kua magnesim concentration. Raws li kev tshawb fawb tau los ntawm cov tsev kawm ntawv xws li Massachusetts Institute of Technology (MIT) thiab kev soj ntsuam thoob ntiaj teb, nws cov kev qhia tau nthuav dav los ntawm kev noj zaub mov zoo rau ntau yam xws li paj hlwb, kab mob plawv, metabolic syndrome, thiab kev tawm dag zog rov qab.
1. Lub hnub nyoog ntsig txog kev txawj ntse poob
Cov txheej txheem tseem ceeb: Tom qab dhau los ntawm cov ntshav- lub hlwb thaiv, Magnesim L-threonine tuaj yeem ua kom cov magnesim concentration hauv cov kua cerebrospinal ntawm hippocampus los ntawm 15-20%, txhawb kev nce hauv synaptic ntom ntom. Kev tshawb fawb MIT qhia tau hais tias cov neeg laus noj qab haus huv hnub nyoog 55-70 uas ntxiv nrog 200mg ntawm cov ntsiab lus magnesim (hauv daim ntawv ntawm MgT) txhua hnub rau 12 lub lis piam sib law liag muaj 18% nce hauv cov qhab nia xeem thiab 30% txo qis hauv kev paub tsis meej. Lub mechanism muaj xws li:
NMDA receptor regulation: txhim khu lub sij hawm ntev -lub sij hawm potentiation (LTP), txhim kho kev kawm thiab nco encoding;
Neuroinflammation inhibition: txo cov kev qhia ntawm pro-inflammatory yam xws li IL-1 thiab TNF - ;
Microbial plab hnyuv hlwb txoj cai: cuam tshuam neurotransmitter synthesis los ntawm metabolites ntawm plab microbiota.
Cov ntaub ntawv pov thawj kho mob: Hauv ob - qhov muag tsis pom kev sim tsom rau cov neeg laus Suav, noj txhua hnub ntawm 2g Magnesim L-threonine (muaj 130mg elemental magnesim) rau 30 hnub ua rau muaj kev txhim kho tseem ceeb hauv cov qhab nia xeem thiab tsis muaj kab mob plab feem ntau pom nrog cov tshuaj magnesim ib txwm muaj.
2. Kev pab cuam rau cov kab mob neurodegenerative
Alzheimer's disease (AD): Magnesim L-threonine tuaj yeem txo - amyloid deposition los ntawm 35%, inhibit Tau protein hyperphosphorylation, thiab txhim kho mitochondrial kev ua haujlwm los ntawm kev ua kom txoj hauv kev AMPK. Tsiaj qauv qhia tau hais tias tom qab ntxiv MgT hauv AD nas, synaptic poob hauv hippocampus yog txo los ntawm 40%, thiab spatial nco muaj peev xwm rov qab los rau 75% ntawm cov nas noj qab haus huv.
Parkinson's disease (PD): Magnesim L-threonine txo oxidative kev nyuaj siab puas tsuaj los ntawm kev tswj cov kev ua ntawm calcium channels hauv dopaminergic neurons hauv substantia nigra. Hauv kev sim qhib daim ntawv lo rau cov neeg mob PD thaum ntxov, kev noj tshuaj txhua hnub ntawm 300mg ntawm elemental magnesim rau 6 lub hlis sib law liag tau ua rau 22% txo qis hauv UPDRS tus qhab nia (Parkinson's Disease Rating Scale) thiab tsis muaj kev cuam tshuam ntawm lub cev muaj zog.
3. Kev xav thiab kev pw tsaug zog tsis zoo
Kev ntxhov siab vim: Magnesim L-threonine, raws li qhov zoo allosteric modulator ntawm GABAergic receptors, tuaj yeem txhim kho GABA induced inhibitory tam sim no. Cov ntaub ntawv kho mob qhia tau hais tias tom qab 4 lub lis piam ntawm kev ntxiv cov magnesim L-threonine hauv cov neeg mob uas muaj kev ntxhov siab ntau dhau, Hamilton Anxiety Scale (HAMA) tau qis dua 31%, uas yog sib npaug rau cov nyhuv ntawm benzodiazepines tab sis tsis muaj yees.
Insomnia: Magnesim L-threonine txo cov qib cortisol los ntawm kev tswj cov haujlwm ntawm hypothalamic pituitary adrenal axis (HPA axis). Hauv kev sim multicenter tsom rau cov neeg mob uas muaj insomnia ntev, noj 150mg ntawm cov tshuaj magnesim ib teev ua ntej yuav mus pw txhua hnub txo lub sij hawm pw tsaug zog los ntawm 22 feeb, nce pw tsaug zog ntev li 25%, thiab tsis muaj hangover rau hnub tom qab.
1. Kev kub siab thawj zaug
Mechanism of action: Magnesim L-threonine activates magnesim dependent enzymes hauv vascular du leeg hlwb, txhawb kev tso tawm ntawm nitric oxide (NO), thiab txo cov hlab ntsha peripheral los ntawm 12-15%. Ib qho meta- kev soj ntsuam nrog rau 1200 tus neeg mob ntshav siab tau pom tias MgT supplementation tuaj yeem txo cov ntshav siab los ntawm qhov nruab nrab ntawm 7-9 mmHg thiab diastolic ntshav siab los ntawm 4-6 mmHg, nrog rau cov nyhuv piv rau cov tshuaj diuretics qis.
Kev sib xyaw ua ke: Kev sib xyaw ntawm magnesim L-threonine thiab calcium channel blockers (xws li amlodipine) tuaj yeem txhim kho cov nyhuv antihypertensive thiab txo cov kev mob tshwm sim ntawm qis qis qis. Hauv kev sim tshuaj randomized, cov ntshav siab ua raws tus nqi (<130/80mmHg) of the combination therapy group reached 82%, significantly higher than the 61% of the monotherapy group.
2. Arrhythmia
Atrial fibrillation tiv thaiv: Magnesim L-threonine txo qhov kev pheej hmoo ntawm cov calcium ntau dhau los ntawm kev tswj hwm cov haujlwm ntawm L- hom calcium channels hauv myocardial cells. Tom qab 6 lub hlis ntawm kev ntxiv cov magnesim L-threonine hauv cov neeg mob plawv tsis ua haujlwm, qhov zaus ntawm atrial fibrillation ntu tau txo qis los ntawm 42% yam tsis muaj kev pheej hmoo ntawm bradycardia.
ventricular premature beats: Magnesim L-threonine tuaj yeem txhim kho myocardial cell membrane muaj peev xwm thiab txo qis reentry arrhythmia. Hauv kev soj ntsuam kev tshawb fawb ntawm cov neeg mob uas muaj kab mob plawv, kev noj tshuaj txhua hnub ntawm 250mg ntawm elemental magnesim txo tus naj npawb ntawm ventricular contractions ntxov ntxov ntawm 1200 txog 450 ib hnub, nrog rau cov nyhuv kav ntev li 12 lub hlis tom qab supplementation.
1. Hom 2 mob ntshav qab zib
Txhim kho cov tshuaj insulin rhiab heev:Magnesium threonate capsulesactivates AMPK txoj hauv kev, txhawb cov leeg nqaij pob txha glucose transporter 4 (GLUT4) translocation. Cov kev tshawb fawb soj ntsuam tau pom tias tom qab 12 lub lis piam ntawm MgT supplementation, ceev cov ntshav qabzib thiab insulin tsis kam Performance index (HOMA-IR) ntawm cov neeg mob ntshav qab zib tau txo qis los ntawm 15% thiab 22%, feem, thiab cov txiaj ntsig zoo dua li ntawm tib koob tshuaj magnesim oxide.
Tiv thaiv cov teeb meem: Magnesim L-threonine txo qhov kev pheej hmoo ntawm ntshav qab zib nephropathy los ntawm kev txo qis oxidative kev nyuaj siab thiab cov tshuaj tiv thaiv inflammatory. Hauv txoj kev tshawb fawb yav tom ntej, ntev -MgT supplementation txo qhov tshwm sim ntawm microalbuminuria hauv cov neeg mob ntshav qab zib los ntawm 37% thiab tus nqi poob ntawm glomerular pom tus nqi los ntawm 40%.
2. Cov ntshav lipids txawv txav
Kev tswj hwm lipid metabolism: Magnesim L-threonine upregulates qhov kev qhia ntawm low-density lipoprotein receptor (LDL-R) hauv siab, txhawb LDL-C clearance. Cov ntaub ntawv kho mob qhia tau hais tias tom qab 8 lub lis piam ntxiv MgT hauv cov neeg mob hypercholesterolemia, cov roj cholesterol tag nrho cov ntshav tau txo qis los ntawm 8%, LDL-C poob los ntawm 12%, thiab HDL-C nce 10%. Cov nyhuv yog piv rau nruab nrab siv statins tab sis tsis muaj mob leeg.
1. Kev tawm dag zog-ua rau cov leeg nqaij qaug zog
Mechanism: Magnesim L-threonine txo cov calcium ion to thiab lactate tsub zuj zuj thaum lub sij hawm qoj ib ce los ntawm kev tswj cov dej num ntawm sarcoplasmic reticulum calcium twj (SERCA). Hauv kev tshawb fawb ntawm triathletes, ntxiv nrog MgT rau 4 lub lis piam ua rau txo qis 3.2% hauv 10 km khiav lub sijhawm thiab 45% txo cov leeg mob cov qhab nia hnub tom qab.
Kev ua kom zoo dua koob tshuaj: Cov neeg ncaws pob raug pom zoo kom siv cov kev hloov pauv ntawm "kev cuam tshuam" (300mg ntawm lub zog magnesim ib hnub twg thaum lub sijhawm kev cob qhia) thiab "txoj kev kho" (150mg ib hnub twg thaum tsis muaj kev cob qhia) kom ua kom muaj txiaj ntsig zoo ntawm kev ua kis las.
2. Cov leeg nqaij spasms thiab fibromyalgia
Thawj cov leeg nqaij spasms: Magnesim L-threonine txo qis qis qis los ntawm kev tswj hwm acetylcholine tso tawm ntawm cov hlab ntsha neuromuscular. Hauv ob qho - qhov muag tsis pom kev sim tsom rau cov neeg mob uas muaj mob thaum hmo ntuj, ntxiv nrog 200mg ntawm cov tshuaj magnesim txhua hnub txo qhov zaus ntawm cramps los ntawm 4.2 zaug hauv ib lub lis piam mus rau 1.1 zaug hauv ib lub lis piam, thiab tsis muaj mob raws plab los ntawm cov tshuaj magnesim ib txwm muaj.
Fibromyalgia syndrome: Magnesim L-threonine alleviates generalized leeg mob los ntawm inhibiting central sensitization mechanisms. Hauv kev sim qhib daim ntawv lo, cov neeg mob ntxiv nrog MgT rau 12 lub lis piam tau pom qhov txo qis hauv qhov mob qhov muag pom kev sib piv (VAS) los ntawm 7.2 txog 4.1 cov ntsiab lus, thiab kev txhim kho tseem ceeb hauv kev pw tsaug zog zoo.
1. Cov kab mob neurodevelopmental
Kev tshawb fawb ua ntej qhia tias magnesim L-threonine tuaj yeem txhim kho kev sib raug zoo ntawm kev sib raug zoo hauv cov tib neeg uas muaj kev puas siab puas ntsws autism spectrum (ASD) los ntawm kev tswj cov synaptic plasticity. Hauv kev sim qhib daim ntawv lo rau cov menyuam yaus uas muaj ASD, tom qab ntxiv nrog MgT rau 6 lub hlis, ABC nplai (Kev Cwj Pwm Tsis Zoo) tau txo qis los ntawm 28% thiab tsis muaj cov teebmeem metabolic feem ntau pom nrog cov tshuaj psychotropic.
2. Kev tswj qhov mob ntev
Magnesim L-threonine txo qhov mob neuropathic los ntawm inhibiting TRPV1 channel kev ua si. Hauv ob qhov - qhov muag tsis pom kev sim rau cov neeg mob ntshav qab zib peripheral neuropathy, qhov mob tus lej (NRS) tau txo qis los ntawm 7.5 cov ntsiab lus mus rau 4.2 cov ntsiab lus tom qab noj txhua hnub ntxiv ntawm 300mg ntawm cov ntsiab lus magnesim, nrog rau cov nyhuv tib yam li gabapentin tab sis tsis muaj kiv taub hau thiab cov kev mob tshwm sim.
3. Kev tiv thaiv kev laus
Cov kev sim tsiaj tau pom tias magnesim L-threonine tuaj yeem txuas ntxiv lub neej ntawm nematodes los ntawm 15% thiab txhim kho kev laus muaj feem xyuam nrog cov phenotypes xws li txo qis zog thiab nce oxidative kev nyuaj siab. Cov txheej txheem tuaj yeem koom nrog kev ua kom FOXO hloov pauv yam tseem ceeb thiab inhibiting txoj hauv kev mTOR, muab cov phiaj xwm cuam tshuam rau kev ncua sijhawm tib neeg kev laus.
Magnesium threonate capsulestau sawv tawm ntawm cov tshuaj magnesim ib txwm muaj vim lawv cov ntshav tshwj xeeb - lub hlwb thaiv kev nkag mus thiab ntau qhov kev tswj xyuas cov teebmeem. Nws cov lus qhia npog ntau qhov chaw los ntawm kev paub txog kev txhim kho mus rau kev tswj kab mob ntev, thiab nws txoj kev nyab xeeb zoo dua li cov tshuaj magnesim ib txwm muaj.
Daim ntawv qhia txog kev yuav khoom
Daim ntawv pov thawj Mark:
Hauv tsev: Blue kaus mom logo lossis ISO system ntawv pov thawj
Ntshuam: FDA tso npe lossis TGA ntawv pov thawj
Cov ntsiab lus kuaj:
Magnesium cov ntsiab lus Ntau dua los yog sib npaug rau 150mg / granule
Cov hlau hnyav (lead<0.5ppm, arsenic<1ppm)
Cov khoom xyaw ua ke:
Kev paub txog kev txhawb nqa: PS + MgT + vitamin B12
Kev txhim kho pw tsaug zog: GABA + MgT + Theanine
Magnesium threonate, raws li lub cim tshiab ntawm cov tshuaj magnesim, tab tom nkag mus rau hauv kev lag luam kev noj qab haus huv loj los ntawm cov khoom noj khoom haus kev tshaj lij vim lawv lub hlwb lub hom phiaj thiab ntau qhov kev tswj hwm cov teebmeem. Nrog rau cov ntaub ntawv pov thawj-raws li cov ntaub ntawv pov thawj tshuaj thiab kev siv thev naus laus zis ntau lawm, cov khoom no xav tias yuav dhau los ua kev cuam tshuam tseem ceeb hauv kev paub txog kev noj qab haus huv, kev noj zaub mov noj, thiab kev tswj kab mob ntev.
FAQ
1. Cov yam ntxwv tseem ceeb thiab cov txiaj ntsig zoo ntawm Sucamet Magnesium Sulfate yog dab tsi?
Nws qhov tseem ceeb tshaj plaws yog nws lub hlwb bioavailability zoo heev, uas ua rau nws nkag mus rau hauv cov ntshav zoo - lub hlwb thaiv thiab nce qib ntawm magnesium ions hauv lub hlwb. Cov kev tshawb fawb tau pom tias nws muaj txiaj ntsig zoo hauv kev txhawb nqa kev pw tsaug zog zoo (tshwj xeeb tshaj yog hauv kev txhim kho kev pw tsaug zog thiab lub qhov muag nrawm nrawm), txhim kho lub siab, lub zog, thiab kev puas siab puas ntsws thaum nruab hnub. Tsis tas li ntawd, nws tseem qhia tau tias muaj txiaj ntsig zoo hauv kev paub txog kev ua haujlwm thiab kev tiv thaiv neuroprotection.
2. Yuav ua li cas txog nws txoj kev nyab xeeb thiab bioavailability?
Raws li kev pom zoo ntawm European Food Safety Authority (EFSA) hauv 2024, magnesium succinate raug suav hais tias muaj kev nyab xeeb raws li hom zaub mov tshiab. Raws li kev pom zoo siv cov xwm txheej (nrog rau cov neeg laus noj txhua hnub txog li 3000 milligrams), tsis muaj kev txhawj xeeb txog kev tshuaj ntsuam genetic toxicity, thiab cov ntsiab lus magnesium muaj bioavailability zoo. Ib qho kev soj ntsuam randomized kuj tau tshaj tawm tias cov neeg tuaj koom tau pom qhov ua siab ntev zoo thaum lub sijhawm kho.
3. Puas yog nws lees paub thiab siv thoob ntiaj teb?
Yog, nws tau txais kev lees paub hauv ntau thaj tsam thoob ntiaj teb. Piv txwv li, nws tau raug suav nrog hauv cov npe lus ntawm National Cancer Institute ntawm Tebchaws Meskas thiab muaj tus cim tshwj xeeb uas tsim los ntawm FDA. European Food Safety Authority kuj tau pom zoo tias nws yog ib qho khoom noj tshiab ntawm magnesium hauv cov khoom noj khoom haus. Tsis tas li ntawd, University of California, Los Angeles (UCLA) tab tom ua txoj kev tshawb fawb los tshawb txog nws cov teebmeem ntawm kev pw tsaug zog thiab rov qab los ntawm cov neeg ncaws pob hauv tsev kawm qib siab.
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