AOD 9604 Txhaj

Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm aod 9604 txhaj tshuaj hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo aod 9604 txhaj rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.

Kev rog rog dhau los ua teeb meem kev noj qab haus huv thoob ntiaj teb. Kev sib sau ntau dhau ntawm cov ntaub so ntswg subcutaneous adipose zoo sib xws nrog cov kab mob metabolic, kab mob plawv, thiab lwm yam. Cov tshuaj poob phaus feem ntau txwv lawv daim ntawv thov vim muaj kev mob tshwm sim. Yog li ntawd, kev tshawb fawb thiab kev loj hlob ntawm cov tshuaj tsom rau cov ntaub so ntswg adipose hauv zos tau dhau los ua lub ntsiab lus kub.TIAB SA 9604txhaj tshuaj, raws li hom tshiab ntawm kev tiv thaiv - rog polypeptide, ua ncaj qha rau ntawm cov ntaub so ntswg adipose los ntawm kev txhaj tshuaj subcutaneous. Nws cov yam ntxwv pharmacological hauv zos muab lub tswv yim tshiab rau kev kho mob rog rog.AOD 9604, raws li kev tiv thaiv - rog polypeptide tsom rau cov ntaub so ntswg subcutaneous adipose, ua tiav cov txiaj ntsig ntawm cov rog hauv zos los ntawm kev ua kom lipolysis thiab inhibiting rog ntau lawm. Nws cov qauv molecular tshwj xeeb thiab cov khoom siv tshuaj muab rau nws muaj txiaj ntsig zoo hauv kev kho mob rog. Txawm li cas los xij, tseem xav tau kev tshawb fawb ntxiv los txhim kho nws daim ntawv thov kho mob, suav nrog kev txhim kho ntau npaum li cas, cov tswv yim kho mob ua ke thiab kev ntsuas kev nyab xeeb ntev ntev. Nyob rau hauv lub neej yav tom ntej, AOD 9604 xav tias yuav dhau los ua ib qho tshuaj tseem ceeb hauv kev txo cov rog hauv zos, muab kev kho mob zoo dua thiab muaj txiaj ntsig zoo rau cov neeg mob rog rog.

AOD 9604 hmoov COA

Certificate of Analysis
Compound npe	ib 9604
Qib	Pharmaceutical qib
CAS Nr.	221231-10-3
Ntau	35g
Ntim txheem	PE hnab + Al foil hnab
Chaw tsim tshuaj paus	Shaanxi BLOOM TECH Co., Ltd
Ntau No.	202501090056
MFG	Peb 9, 2025
EXP	Peb 8, 2028
Qauv
Yam khoom	Enterprise txheem	Kev txheeb xyuas qhov tshwm sim
Qhov tshwm sim	Dawb los yog yuav luag dawb hmoov	Ua raws
Cov ntsiab lus dej	Tsawg dua lossis sib npaug li 5.0%	0.54%
Poob rau ziab	Tsawg dua lossis sib npaug li 1.0%	0.42%
Hnyav Hlau	Pb Tsawg dua lossis sib npaug li 0.5ppm	N.D.
	Tsawg dua lossis sib npaug li 0.5ppm	N.D.
	Hg Tsawg dua lossis sib npaug li 0.5ppm	N.D.
	Cd Tsawg dua lossis sib npaug li 0.5ppm	N.D.
Purity (HPLC)	Ntau dua lossis sib npaug li 99.0%	99.98%
Ib leeg impurity	<0.8%	0.52%
Tag nrho microbial suav	Tsawg dua lossis sib npaug li 750cfu / g	95
E. Coli	Tsawg dua lossis sib npaug li 2MPN / g	N.D.
Salmonella	N.D.	N.D.
Ethanol (los ntawm GC)	Tsawg dua lossis sib npaug li 5000ppm	500 ppm
Cia	Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree

Molecular Structure

 

AOD Lub npe tshuaj ntawm 9604 yog L-phenylalanine-L-tyrosyl-L-L-leucyl-L-L-arginyl-L-Isoleucyl-L- valinyl-L-Glutamide-L-Cysteinyl-L-arginyl-L-seramide-L-valinyl-L - -glutamide-glycyryl-L-Seramide-L-cysteineylglycyryl-L (cyclic disulfide bonds txuas ntawm txoj hauj lwm 7-14 Nws muaj cov mis molecular3 C723H12 thiab molecular formula C723H12 1815.1 Da Nws cov yam ntxwv muaj xws li:

N-terminal tyrosine hloov kho:Txhim kho affinity nrog receptors.

Cyclic disulfide daim ntawv cog lus:Txhim kho molecular stability thiab ncua ib nrab -lub neej.

Amino acid ib ntus tshwj xeeb:Nws yog homologous heev rau 177-191 amino acids ntawm qee yam tshuaj, tab sis lipolysis kev ua tau zoo los ntawm kev hloov kho tshuaj.

 

 

Ua kom cov rog rog (lipolysis)

AOD 9604 txhawb kev rog rog los ntawm txoj hauv qab no:

Ua kom lub 3-AR signaling txoj kev:AOD 9604 khi rau 3-AR ntawm lub adipocyte daim nyias nyias, activates adenylic acid cyclase (AC), nce intracellular cyclic adenosine monophosphate (cAMP) qib, thiab yog li activates protein kinase A (PKA). PKA phosphorylates hormone-sensitive lipase (HSL), txhawb nqa cov hydrolysis ntawm triglycerides rau hauv cov rog dawb (FFA) thiab glycerol.

Kev tswj tsis ncaj ntawm adipose triglyceride lipase (ATGL):AOD 9604 tuaj yeem txhim kho lipolysis ntxiv los ntawm kev nce - tswj kev qhia lossis kev ua ntawm ATGL.

 

 

Inhibition ntawm rog ntau lawm

AOD 9604 inhibits adipogenesis los ntawm cov txheej txheem hauv qab no:

 

Inhibition ntawm adipocytes sib txawv:AOD 9604 tuaj yeem txo qis - tswj kev qhia ntawm peroxisome proliferator-activated receptor (PPAR) thiab CCAAT / enhancer binding protein (C/EBP ), thiab thaiv qhov sib txawv ntawm preadipocytes rau hauv cov laus adipocytes.

Inhibition ntawm lipid synthase kev ua haujlwm:AOD 9604 txo cov kev ua ntawm fatty acid synthase (FAS) thiab acetyl-CoA carboxylase (ACC), thiab txo de novo synthesis ntawm fatty acids.

Kev soj ntsuam kev nyab xeeb

Mob toxicity

Ib qho kev txhaj tshuaj subcutaneous ntawm AOD 9604 (50 mg / kg) tsis ua rau tuag los yog pom tseeb cov tshuaj lom hauv cov nas.

Ntev - toxicity

Kev txhaj tshuaj txuas ntxiv ntawm AOD 9604 (10 mg / kg) rau 8 lub lis piam tsis ua rau lub siab thiab lub raum ua haujlwm tsis zoo lossis hloov pauv hauv cov ntshav qabzib.

Kev kho mob muaj peev xwm ntawm AOD 9604

 

Cov lus qhia rau kev txo cov rog hauv zos

AOD 9604 muaj feem xyuam rau:

Cov rog hauv zos hauv cheeb tsam xws li lub plab thiab tus ncej puab: Los ntawm kev txhaj tshuaj ncaj qha rau hauv lub hom phiaj, cov roj tuab tuaj yeem txo.

Adjuvant therapy tom qab phais bariatric: Txhim kho postoperative daim tawv nqaij laxity thiab rog residue.

Kev sib xyaw ua ke nrog lwm cov kev kho mob

Ua ke nrog kev tawm dag zog: AOD 9604 tuaj yeem txhim kho kev tawm dag zog -induced lipolysis thiab txhim kho cov rog rog.

Ua ke nrog cryolipolysis: Los ntawm inhibiting rog regeneration, nws prolongs cov nyhuv ntawm cryolipolysis.

Kev Npaj Kho Mob Tus Kheej

Kev Kho Kom Zoo: Kho qhov kev txhaj tshuaj raws li tus neeg mob qhov hnyav thiab kev faib roj.

Kev sib hloov ntawm qhov chaw txhaj tshuaj: Zam tsis txhob muaj qhov tshwm sim ntawm daim tawv nqaij.

AOD 9604 Txhaj, raws li ib tug active raw khoom nrog yuag poob los, qhia ntau yam muaj peev xwm nyob rau hauv nws txoj kev loj hlob zeem muag. Cov hauv qab no yog kev tshuaj xyuas los ntawm cov khoom xws li kev xav tau ntawm kev ua lag luam, kev tshawb nrhiav kev vam meej, thiab kev nthuav dav ntawm daim ntawv thov:

Kev ua lag luam xav tau muaj peev xwm

Qhov teeb meem ntawm kev rog rog yog qhov hnyav zuj zus: Cov teeb meem rog rog thoob ntiaj teb tau dhau los ua kev nyuaj rau pej xeem kev noj qab haus huv. Ntau dhau ntawm cov ntaub so ntswg subcutaneous adipose yog txuam nrog ntau yam kab mob. Cov tshuaj poob phaus ib txwm muaj feem ntau txwv vim muaj kev mob tshwm sim. AOD 9604, raws li cov tshuaj txo cov rog hauv zos, tuaj yeem ua raws li cov ntaub so ntswg adipose thiab txo cov rog rog, thiab xav kom ua tau raws li kev lag luam xav tau rau kev nyab xeeb thiab siv tau zoo.

Cov neeg siv khoom xav tau kev loj hlob: Raws li tib neeg tau mloog ntau dua rau kev noj qab haus huv thiab kev tswj hwm lub cev, qhov kev thov rau cov khoom poob phaus yog nce ntxiv. AOD 9604 ua ncaj qha rau ntawm cov ntaub so ntswg adipose los ntawm kev txhaj tshuaj subcutaneous kom ua tiav cov rog hauv zos. Qhov kev txiav txim siab meej no tuaj yeem nyiam cov neeg siv khoom ntau dua.

 

Kev Pabcuam Kev Tshawb Fawb

Cov tsiaj sim tau ua tiav cov txiaj ntsig zoo: Hauv cov qauv nas rog rog, tom qab txhua hnub subcutaneous txhaj ntawm AOD 9604 (250 ug / kg) rau 8 lub lis piam, lub cev hnyav ntawm cov nas poob 12%, cov rog subcutaneous txo los ntawm 25%, thiab qhov hnyav ntawm epididymal adipose cov ntaub so ntswg txo qis, thiab nws cov txiaj ntsig zoo.

Kev nyab xeeb tau raug txheeb xyuas ua ntej: Kev kuaj mob toxicity pom tau tias ib qho kev txhaj tshuaj subcutaneous ntawm AOD 9604 (50 mg / kg) tsis ua rau tuag lossis pom tseeb cov tshuaj lom hauv cov nas; Hauv qhov ntev -kev sim tshuaj toxicity, kev txhaj tshuaj txuas ntxiv ntawm AOD 9604 (10 mg / kg) rau 8 lub lis piam tsis ua rau lub siab thiab lub raum ua haujlwm tsis zoo lossis hloov pauv hauv cov ntshav qabzib, muab lub hauv paus kev nyab xeeb rau nws cov kev tshawb fawb ntxiv thiab kev siv.

 

Application expansion possibilities

Cov lus qhia rau kev txo cov rog hauv zos: Nws yog qhov tsim nyog rau cov cheeb tsam nrog cov rog hauv zos xws li lub plab thiab ncej puab. Los ntawm kev txhaj tshuaj ncaj qha rau hauv lub hom phiaj, nws txo cov rog tuab. Nws kuj tseem tuaj yeem siv los ua kev kho mob tom qab phais bariatric los txhim kho cov tawv nqaij tom qab laxity thiab cov roj residue.

Kev sib xyaw ua ke nrog lwm cov kev kho mob: Thaum ua ke nrog kev tawm dag zog, nws tuaj yeem txhim kho lipolysis vim kev tawm dag zog thiab txhim kho kev ua haujlwm ntawm cov rog. Thaum siv ua ke nrog cryolipolysis, nws tuaj yeem ua kom ntev li cov nyhuv ntawm cryolipolysis los ntawm inhibiting rog rov tsim dua tshiab.

 

Kev lag luam kev loj hlob tiam sis pab

Kev lag luam kev loj hlob ntawm ua ntej- cov koob txhaj tshuaj tsis siv neeg puv: Lub ntiaj teb kev lag luam loj ntawm ua ntej- cov koob txhaj tshuaj tsis siv neeg yuav tsum tau loj hlob ntxiv, uas muab kev xaiv yooj yim dua thiab muaj kev nyab xeeb rau txoj kev tswj hwm ntawmAOD 9604 Txhajthiab pab txhim kho cov neeg mob kev ua raws li kev noj tshuaj.

Kev tshawb fawb tshuaj thiab kev tsim kho tshiab: Nrog rau kev nce qib ntawm kev tshawb fawb tshuaj thiab kev tsim kho thev naus laus zis, kev tshawb fawb ntawm AOD 9604 tuaj yeem dhau los ua - qhov tob, suav nrog cov yam xws li kev siv tshuaj kho kom zoo thiab cov tswv yim tshuaj ua ke, txhawm rau tshawb nrhiav nws lub peev xwm ntxiv.

1. AOD 9604 yog dab tsi?
AOD 9604 yog ib qho khoom siv hluavtaws peptide fragment. Nws yog muab los ntawm 176-191 amino acid ib ntu ntawm tib neeg kev loj hlob hormone (hGH), khaws cov roj metabolism hauv kev ua haujlwm thaum tshem tawm cov haujlwm ntawm kev txhawb nqa kev loj hlob. Yog li, nws feem ntau hu ua "fat-burning peptide".
2. Cov txiaj ntsig tseem ceeb thiab kev siv yog dab tsi?
Nws tsuas yog txhawb lub zos los yog tag nrho cov rog poob los ntawm stimulating rog rog thiab inhibiting rog synthesis. Nws yog feem ntau siv los txhim kho lub cev rog faib thiab pab tswj qhov hnyav. Hauv kev tshawb fawb soj ntsuam, nws cov txiaj ntsig zoo rau kev kho pob txha mos thiab metabolic syndrome kuj tau tshawb pom.
3. Puas muaj kev nyab xeeb? Puas muaj tej yam tshwm sim?
Cov kev tshawb fawb tau pom tias nws muaj kev nyab xeeb nrog cov kev mob me me, uas tuaj yeem suav nrog ib ntus liab, khaus lossis mob taub hau ntawm qhov chaw txhaj tshuaj. Vim nws cov qauv zoo ib yam li hGH nyob rau hauv qee qhov chaw, nws yuav tsum tsis txhob siv ntev -lub sij hawm los yog siv ntau dhau yam tsis tau saib xyuas. Ntxiv mus, nws yog txwv tsis pub rau cov poj niam cev xeeb tub, cov neeg nyob rau hauv lub sij hawm lactation, thiab cov neeg mob uas muaj mob hnyav.
4. Yuav siv li cas kom raug?
Nws yuav tsum yog cov tshuaj kws kho mob lossis kev sim tshuaj, thiab yuav tsum tau siv raws li kev qhia ntawm tus kws kho mob. Feem ntau, kev txhaj tshuaj subcutaneous tau txais yuav, thiab cov koob tshuaj thiab kev kho mob yuav tsum tau ua tus kheej. Thov muab cov khoom pov thawj los ntawm cov kev cai lij choj thiab tsis txhob sib xyaw nrog cov tshuaj tsis tau lees paub.

Cim npe nrov: aod 9604 txhaj tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom