Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm calcitonin salmon txhaj nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo calcitonin salmon txhaj rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Kev txhaj tshuaj Calcitonin salmonyog ib qho tshuaj siv los kho cov pob txha metabolic xws li osteoporosis, hypercalcemia, thiab osteoarthritis. Lub luag haujlwm tseem ceeb yog inhibit qhov kev ua ntawm osteoclasts, yog li txo qis calcium thiab phosphorus hauv cov pob txha thiab txo cov concentration ntawm calcium ions hauv cov ntshav. Nws simulates physiological teebmeem ntawm endogenous calcitonin nyob rau hauv tib neeg lub cev thiab ncaj qha ua rau cov pob txha, slowing down tus txheej txheem ntawm pob txha resorption.
Calcitonin Salmon COA
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| Certificate of Analysis | ||
| Compound npe | Calcitonin salmon | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 47931-85-1 | |
| Ntau | 80g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090056 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.31% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.62% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.80% |
| Ib qho impurity | <0.8% | 0.44% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 209 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 5 12 ppm |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree | |
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| Chemical Formula: | C145H240N44O48S2 |
| Exact Mass: | 3430 |
| Molecular Luj: | 3432 |
| m/z: | 3431 (100.0%), 3432 (77.9%), 3430 (63.8%), 3433 (40.1%), 3432 (16.3%), 3433 (12.3%), 3431 (10.4%), 3433 (9.9%), 3433 (9.0%), 3434 (8.8%), 3434 (7.7%), 3434 (7.0%), 3434 (6.6%), 3432 (6.3%), 3432 (5.8%), 3434 (5.0%), 3435 (3.2%), 3435 (3.0%), 3435 (3.0%), 3432 (2.8%), 3433 (2.1%), 3432 (1.8%), 3431 (1.8%), 3435 (1.7%), 3434 (1.6%), 3432 (1.6%), 3434 (1.5%), 3434 (1.5%), 3433 (1.4%), 3435 (1.3%), 3433 (1.3%), 3433 (1.2%), 3435 (1.2%), 3431 (1.2%), 3435 (1.2%), 3435 (1.1%), 3433 (1.0%), 3431 (1.0%) |
| Elemental Analysis: | C, 50.75; H, 7.05; N, 17.96; O, 22.38; S, 1.87 |
Kev txhaj tshuaj Calcitonin salmonyog calcium regulating hormone muab rho tawm los ntawm salmon thyroid caj pas, nrog ib tug tshuaj qauv zoo ib yam li tib neeg calcitonin tab sis muaj zog biological ua. Txij li thaum nws thawj daim ntawv thov kev kho mob hauv xyoo 1960, salmon calcitonin tau dhau los ua ib qho tshuaj tseem ceeb rau kev kho mob pob txha thiab Paget's skeleton kab mob vim nws muaj ntau yam cuam tshuam xws li inhibiting skeleton resorption, tswj calcium thiab phosphorus metabolism, thiab txo qhov mob.
Kho osteoporosis
1. Mechanism ntawm kev txiav txim: Ntau lub hom phiaj ntawm cov pob txha metabolism
Cov txheej txheem tseem ceeb ntawm cov kab mob osteoporosis yog qhov tsis txaus ntawm cov pob txha resorption thiab cov pob txha tsim, ua rau txo qis hauv pob txha pob txha thiab kev puas tsuaj ntawm pob txha microstructure. Siv tshuaj tiv thaiv osteoporosis los ntawm cov hauv qab no:
Inhibition ntawm osteoclast kev ua ub no: Nws khi rau G protein ua ke receptors nyob rau saum npoo ntawm osteoclasts, activates adenylate cyclase, nce intracellular cyclic adenosine monophosphate (cAMP) qib, thiab inhibits osteoclast skeleton resorption muaj nuj nqi.
Kev tshawb fawb tau pom tias nws tuaj yeem ua rau osteoclasts cog lus pseudopodia thiab tshem tawm cov npoo npoo, ncaj qha thaiv cov txheej txheem ntawm pob txha resorption.
Kev tswj cov calcium thiab phosphorus metabolism: Los ntawm kev txo cov ntshav calcium concentration, txo lub raum tubular reabsorption ntawm calcium, thiab inhibiting plab hnyuv nqus ntawm calcium, "tsawg calcium ib puag ncig" yog tsim los inhibit skeleton resorption. Tsis tas li ntawd, nws tuaj yeem txhawb nqa phosphorus excretion thiab tswj cov ntshav phosphorus sib npaug.
Txhawb kev tsim cov pob txha: Tsiaj thwmsim tau pom tias nws tuaj yeem ua rau osteoblast proliferation thiab sib txawv, thiab ua kom cov pob txha matrix synthesis. Txawm hais tias qhov nce ntawm cov pob txha tsim cov cim (xws li pob txha pob txha alkaline phosphatase) hauv cov kev tshawb fawb soj ntsuam me me, nws tsis ncaj qha tsim cov xwm txheej rau pob txha tsim los ntawm inhibiting skeleton resorption.
Cov nyhuv analgesic: Los ntawm inhibiting prostaglandin E2 synthesis, txo cov ntshav calcium concentration (txo calcium nkag mus rau hauv cov hlab ntsha), thiab muab cov nyhuv analgesic hauv nruab nrab, nws tuaj yeem txo qhov mob pob txha pob txha sai, tshwj xeeb tshaj yog tsim rau cov neeg mob uas mob vertebral pob txha.
2. Cov xwm txheej thov kev kho mob thiab kev txhawb nqa pov thawj
Postmenopausal osteoporosis:
Estrogen deficiency yog lub ntsiab ua rau kom ceev pob txha resorption nyob rau hauv cov poj niam postmenopausal. Txo cov pob txha poob los ntawm inhibiting osteoclast kev ua haujlwm. Ib qho randomized tswj kev sim (RCT) uas muaj 1200 tus poj niam tom qab yug menyuam tau pom tias kev siv tas li ntawmcalcitonin salmon txhajrau 12 lub hlis nce lumbar qaum pob txha pob txha ceev los ntawm 3.2% thiab txo qhov kev pheej hmoo ntawm pob txha pob txha los ntawm 40%. Lwm qhov ntev -lub sij hawm ua raws- nce kev kawm (5 xyoos) tau pom tias qhov tshwm sim ntawm pob txha pob txha hauv pawg kho mob yog 25% qis dua li hauv pawg tswj hwm.
Senile osteoporosis:
Cov neeg laus muaj feem cuam tshuam rau kev hloov pauv osteoporosis qis vim qhov poob ntawm osteoblast muaj nuj nqi thiab cov vitamin D metabolism tsis zoo. Los ntawm ncaj qha stimulating osteoblast txawv (hauv vitro thwmsim pom ib tug 20% nce nyob rau hauv osteoblast proliferation rate), thaum inhibiting osteoclast kev ua si, ib tug "dual pronged" nyhuv yog tsim. Ib qho kev soj ntsuam randomized tswj (RCT) tsom rau cov neeg laus hnub nyoog 70 xyoo thiab siab dua tau pom tias tom qab 3 xyoos ntawm kev kho mob nrog salmon calcitonin, cov pob txha pob txha ceev tau nce 2.1% thiab qhov pheej hmoo ntawm cov pob txha tsis muaj pob txha txo qis los ntawm 28%.
Corticosteroid induced osteoporosis (GIOP):
Kev siv ntev ntawm glucocorticoids tuaj yeem cuam tshuam kev ua haujlwm ntawm osteoblast thiab qhib osteoclasts, ua rau lub cev poob sai. Los ntawm antagonizing lub cev pob txha resorption txhawb nqa cov nyhuv ntawm glucocorticoids, nws tau dhau los ua qhov kev xaiv tseem ceeb rau cov neeg mob zoo li no. Ib txoj kev tshawb fawb uas muaj 200 tus neeg mob mob rheumatoid mob caj dab tau pom tias kev sib xyaw ua ke ntawm salmon calcitonin, calcium ntxiv, thiab vitamin D tuaj yeem ua rau qeeb ntawm pob txha pob txha pob txha los ntawm 60% thiab txo qhov kev pheej hmoo ntawm pob txha los ntawm 35%.
Kev tswj mob tom qab mob osteoporotic pob txha:
Kev kuaj mob vertebral fractures tshiab feem ntau nrog mob pob txha hnyav, uas txwv tus neeg mob txoj kev txav mus los thiab ua rau muaj kev pheej hmoo ntawm kev ntog. Los ntawm inhibiting prostaglandin synthesis thiab tso tawm neuropeptide, nws ncaj qha ua rau lub hauv nruab nrab lub paj hlwb, sai sai tshem tawm qhov mob. Ob qhov - qhov muag tsis pom kev sim tsom rau cov neeg mob uas mob pob txha pob txha tau pom 50% txo qis hauv qhov mob (VAS) hauv 72 teev tom qab kev kho mob nrog salmon calcitonin, zoo dua li pawg tswj hwm (ibuprofen), thiab cov nyhuv analgesic tau mus txog thaum kawg ntawm kev kho mob (4 lub lis piam).
Vivamus tortor risus, pharetra ut venenatis ac, rutrum eget anten fusce convallis nibh felis, eget hendrerit diam rhoncus rana nco dictum lacus eleifend nisl efficitur venenatis.
Aliquam eros justo,posuere loborti viverra laoreet matti ullamcper posuere viverra .Aliquam s justo,posuere so lobortis non,viverra laoreet posuere loborti Aliquam eros justo,posuere loborti viverra laoreet perquaue . justo, posuere so lobortis non, viverra laoreet posuere loborti
4. Kev ntsuas kev ua tau zoo thiab kev saib xyuas kev nyab xeeb
Kev saib xyuas pob txha density:
Dual zog X-ray absorptiometry (DXA) yog siv los kuaj lub lumbar lossis hip skeletondensity ua ntej kev kho mob thiab ib xyoos ib zaug, nrog rau lub hom phiaj ntawm nws nce 1% -3% txhua xyoo. Yog tias pob txha pob txha txuas ntxiv txo qis, kev ua raws cai yuav tsum tau soj ntsuam lossis kho cov phiaj xwm kho.
Pob txha turnover markers:
Tom qab 3 lub hlis ntawm kev kho mob, ntshav qab zib - CTX (carboxy terminal peptide ntawm hom I collagen) lossis cov zis NTX (N-terminal peptide ntawm hom I collagen) yuav tsum tau kuaj.
Yog tias qhov txo qis tsis ntau dua 30%, qhov ntau npaum li cas yuav tsum tau hloov kho lossis siv cov tshuaj sib xyaw ua ke.
Kev saib xyuas kev ruaj ntseg:
Kev siv mus ntev yuav tsum tau kuaj ntshav tsis tu ncuacalcitonin salmon txhaj, ntshav phosphorus, thiab lub raum ua haujlwm (tshwj xeeb tshaj yog rau cov neeg mob lub raum tsis txaus). Tej zaum yuav ua rau hypocalcemia (cov tsos mob muaj xws li convulsions thiab loog ntawm tes thiab ko taw), nws yog ib qho tsim nyog los xyuas kom meej cov calcium txaus. Tsis tshua muaj tshwm sim muaj xws li kev tsis haum tshuaj (xws li urticaria, ua pa nyuaj) thiab qhov ntswg mucosal irritation (nasal spray), thiab yuav tsum tau kuaj tawv nqaij ua ntej noj tshuaj.
Kev kho mob ntawm Paget's Osteoarthritis
1. Pathological mechanism thiab kho lub hom phiaj
Deformable osteoarthritis yog tus cwj pwm los ntawm lub cev pob txha hloov kho hauv zos, tshwm sim los ntawm kev ua kom lub cev pob txha resorption thiab cov pob txha txawv txav, ua rau pob txha deformities, mob, thiab muaj kev pheej hmoo ntawm pob txha. Ua lub luag haujlwm los ntawm cov channel hauv qab no:
Inhibition ntawm pathological skeleton resorption: Cov neeg mob nrog Paget's skeleton kab mob tau nce osteoclast kev ua si (cov ntshav alkaline phosphatase, ALP tuaj yeem ncav cuag ntau dua 10 npaug ntawm qhov qub).
Los ntawm inhibiting osteoclast muaj nuj nqi, txo cov pob txha resorption, thiab txo cov pob txha tig rov qab mus rau qhov qub.
Kho cov pob txha deformities: Lub sij hawm ntev kev hloov pauv hauv lub xeev ua rau pob txha loj thiab curvature (xws li thickening ntawm pob txha taub hau thiab khoov ntawm cov pob txha ntev). Los ntawm kev txo cov pob txha hloov pauv thiab txo qis kev tsim cov pob txha tshiab, qhov chaw ruaj khov yog muab rau kev kho pob txha.
Txo qhov mob: Mob tshwm sim los ntawm kev puas tsuaj ntawm pob txha pob txha microstructure, paj hlwb compression, los yog inflammatory teb. Nws cov nyhuv analgesic tuaj yeem txhim kho lub neej zoo ntawm cov neeg mob sai sai.
Tiv thaiv cov teeb meem: suav nrog pob txha, tsis hnov lus (vim pob txha taub hau thickening compressing lub paj hlwb), thiab nce lub nra hnyav (vim lub plawv tsis ua haujlwm siab).
2. Cov xwm txheej thov kev kho mob thiab kev txhawb nqa pov thawj
Kev tswj mob:
Paget's skeleton disease cov neeg mob feem ntau ntsib kev mob pob txha loj heev vim kev puas tsuaj ntawm pob txha pob txha microstructure. Los ntawm inhibiting prostaglandin E2 synthesis thiab tso tawm neuropeptide, nws ncaj qha ua rau lub hauv paus paj hlwb, sai sai tshem tawm qhov mob. Ib qho kev sim ntau qhov kev sib tw uas muaj 150 tus neeg mob tau pom tias tom qab 2 lub lis piam ntawm kev kho mob, tus qhab nia mob (VAS) tau txo qis los ntawm 60%, zoo dua li cov pab pawg tswj hwm bisphosphonate (pamidronate disodium) (45%), thiab muaj qhov pib ua haujlwm sai dua (2 hnub vs . 7 hnub).
Kho cov pob txha deformities:
Lub sij hawm ntev kev hloov pauv siab ua rau lub cev pob txha loj thiab khoov. Los ntawm kev txo cov pob txha hloov pauv, qhov txawv txav ntawm pob txha tshiab tuaj yeem txo qis. Kev yees duab ua raws- nce pom pom qhov txo qis ntawm pob txha taub hau 15% thiab kev txhim kho 20% hauv lub cev pob txha ntev curvature tom qab 6 lub hlis ntawm kev kho mob. Rau qhov deformities hnyav xws li lub duav inversion, nws tuaj yeem siv los ua cov tshuaj npaj ua ntej kom txo qhov nyuaj ntawm kev phais.
Tiv thaiv cov teeb meem:
Fracture: Cov neeg mob Paget's disease muaj 2-10 npaug ntawm kev pheej hmoo ntawm pob txha ntau dua piv rau cov tib neeg ib txwm muaj. Los ntawm stabilizing skeleton metabolism, qhov kev pheej hmoo ntawm pob txha yuav raug txo. Kev tshawb fawb qhia tau hais tias qhov tshwm sim ntawm pob txha pob txha txo qis los ntawm 45% tom qab 3 xyoos ntawm kev kho mob.
Tsis hnov lus: Thickening ntawm pob txha taub hau tuaj yeem ua rau cov paj hlwb. Los ntawm kev txo cov pob txha taub hau, txhim kho cov ntshav cochlear, thiab txo qhov tsis hnov lus. Ib txoj kev tshawb fawb uas muaj 50 tus neeg mob tau pom qhov kev txhim kho ntawm 10 dB hauv kev hnov lus tom qab 1 xyoo ntawm kev kho mob.
Lub nra hnyav: Kev hloov pauv siab hauv lub xeev ua rau cov pob txha pob txha calcium ntau rau hauv cov hlab ntsha, uas tuaj yeem ua rau hypercalcemia thiab ua rau lub nra hnyav ntxiv.Kev txhaj tshuaj Calcitonin salmoncalcitonin txo qis ntshav qab zib los ntawm kev txo cov ntshav calcium concentration.
4. Kev ntsuas kev ua tau zoo thiab kev saib xyuas kev nyab xeeb
Pob txha turnover markers:
Tom qab 3 lub hlis ntawm kev kho mob, ntshav ALP thiab urinary hydroxyproline tau ntsuas nrog lub hom phiaj ntawm kev txo qis rau hauv 1.5 npaug ntawm qhov txwv ntawm qhov ib txwm muaj. Yog tias ALP tseem nce ntxiv, kev ntsuas kev ua raws cai lossis kev cais tawm ntawm lwm yam kab mob (xws li pob txha metastases) yog qhov tsim nyog.
Kev ntsuam xyuas duab:
Tshawb xyuas X-rays lossis pob txha pob txha soj ntsuam txhua xyoo los soj ntsuam qhov kev loj hlob ntawm cov pob txha deformities thiab cov kab mob tshiab.
Rau pob txha taub hau, lub taub hau CT saib xyuas ntawm cov tuab tuab tuaj yeem ua tau.
Kev saib xyuas kev ruaj ntseg:
Kev siv lub sijhawm ntev yuav tsum ceev faj txog hypocalcemia (tshwj xeeb tshaj yog thaum ua ke nrog cov vitamin D tsis txaus), thiab nws raug pom zoo kom tswj cov ntshav calcium ntau dua lossis sib npaug ntawm 2.1 mmol / L thaum kho. Tsis tshua muaj kev phiv tshwm sim muaj xws li kev tsis haum tshuaj (nrog qhov tshwm sim ntawm kwv yees li 1% -3%) thiab qhov ntswg mucosal irritation (nasal spray), uas yuav tsum tau kuaj tawv nqaij ua ntej noj tshuaj.
Qhov chaw ntawm cov ntaub ntawv:
Dr. Bohe's official website "Cov nyhuv ntawm Salmon Calcitonin"
Min Fukang's "Kev Ua Tau Zoo thiab Kev Ua Haujlwm ntawm Salmon Calcitonin Txhaj" thiab "Kev Ua Haujlwm ntawm Salmon Calcitonin"
Tus Kws Kho Mob Caij Nplooj Ntoos Hlav "Salmon calcitonin yog dab tsi? Vim li cas nws thiaj tuaj yeem kho pob txha
Yuav siv salmon calcitonin txhaj li cas ntawm WeChat pej xeem platform
39 Kev Noj Qab Haus Huv Network "Safe Dosage and Use of Salmon Calcitonin Injection"
Suav Cov Lus Qhia rau Kev Ntsuas thiab Kev Kho Mob Osteoporotic Fractures (2022 Edition)
Cov kws tshaj lij pom zoo rau kev kuaj mob thiab kev kho mob ntawm Paget's Bone Disease (2021 Edition)
FAQ
Calcitonin salmon siv rau dab tsi?
Nws yog siv los kho osteoporosis ntawm cov poj niam uas muaj tsawg kawg yog 5 xyoo dhau los lawm thiab tsis tuaj yeem lossis tsis xav noj cov tshuaj estrogen. Osteoporosis yog ib yam kab mob uas ua rau cov pob txha tsis muaj zog thiab tawg yooj yim dua. Nws yog tib neeg cov tshuaj hormones uas tseem muaj nyob rau hauv salmon.
Puas yog calcitonin salmon tshuaj tsuag qhov ntswg raug txiav?
US Food and Drug Administration (FDA) tshaj tawm kev txiav tawm ntawm calcitonin -salmon [rDNA keeb kwm] (Fortical) tshuaj tsuag qhov ntswg. Upsher-Smith Laboratories txiav txim siab txiav kev tsim cov khoom, raws li tsab ntawv ceeb toom FDA.
Leej twg yuav tsum tsis txhob noj calcitonin salmon?
Nws tuaj yeem ua rau muaj kev tsis haum tshuaj, uas tuaj yeem ua rau mob hnyav. Tsis txhob siv cov khoom lag luam thiab tau txais kev pab tam sim yog tias koj muaj cov tsos mob hauv qab no ntawm kev tsis haum tshuaj loj.
Koj puas tuaj yeem tau txais calcitonin los ntawm kev noj salmon?
Ntau qhov chaw exogenous ntawm calcitonin muaj nyob, ntawm cov ntses salmon yog cov muaj zog tshaj plaws. Nws tau pom zoo rau kev kho mob osteoporosis thiab lwm yam kab mob uas cuam tshuam nrog cov pob txha nrawm nrawm.
Cim npe nrov: calcitonin salmon txhaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom