Dsip Txhajyog ib txwm tshwm sim tsis peptide neuromodulatory tshuaj. Txij li thaum nws nrhiav tau nyob rau xyoo 1970, nws tau dhau los ua qhov kev tshawb fawb hotspot hauv thaj chaw ntawm neuroscience thiab tshuaj vim nws txoj cai pw tsaug zog tshwj xeeb, tiv thaiv kev ntxhov siab, thiab muaj peev xwm siv tshuaj kho mob. DSIP Kev Txhaj Tshuaj, raws li nws daim ntawv thov, ncaj qha ua rau lub hauv paus paj hlwb los ntawm kev txhaj tshuaj subcutaneous lossis intravenous, aiming los txhim kho kev pw tsaug zog zoo, txo cov kev ntxhov siab, thiab tshawb nrhiav qhov muaj peev xwm kho ntau yam kab mob. DSIP tuaj yeem ua rau kom lub amplitude thiab ncua sij hawm ntawm delta nthwv dej (0.5-4Hz) hauv electroencephalography (EEG), ua rau lub sijhawm pw tsaug zog qeeb qeeb, thiab yog li txhim kho kev pw tsaug zog tob. Cov kev sim tsiaj tau pom tias tom qab txhaj tshuaj DSIP, lub sijhawm pw tsaug zog qeeb ntawm nas nce los ntawm 30% -50%. DSIP txo lub sijhawm los ntawm kev pw tsaug zog los ntawm kev txo qis cortisol, inhibiting sympathetic paj hlwb kev ua ub no, thiab txo cov kev ntxhov siab thiab kev ntxhov siab. DSIP tuaj yeem pab rov pib dua lub moos lom neeg, txhim kho dav hlau lag lossis pw tsaug zog theem qeeb los ntawm kev cuam tshuam lub moos gene qhia hauv hypothalamic suprachiasmatic nucleus (SCN).
| Khoom npe | Dsip | Dsip Txhaj |
| Yam khoom | Hmoov | ua kua |
| Khoom Purity | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% |
| Khoom Specifications | 100g / 1kg / thiab lwm yam. | 1 mg/2 mg |
| Daim ntawv khoom | Organic synthesis | Organic synthesis |
Dsip COA
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| Certificate of Analysis | ||
| Compound npe | Dsip | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 62568-57-4 | |
| Ntau | 3 37,3kg | |
| Ntim txheem | 25kg / nruas | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202501090050 | |
| MFG | Peb 9, 2025 | |
| EXP | Peb 8, 2028 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.51% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.34% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib qho impurity | <0.8% | 0.48% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 91 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree | |
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DSIP Txhaj Kev Nyuaj Siab Axis Decoupling: Los ntawm "Resistance Exhaustion" mus rau "Adaptation Reset"
Hauv thaj chaw ntawm kev ntxhov siab physiology, cov qauv ib txwm saib cov lus teb kev ntxhov siab raws li ib qho -txoj kev "ua pa tawm" txheej txheem: lub cev teb rau kev ntxhov siab los ntawm kev ua kom lub cev hypothalamic pituitary adrenal axis (HPA axis) thiab sympathetic nervous system (SNS), tab sis ntev - lub sij hawm overactivation tuaj yeem ua rau cov kab mob hauv lub cev, thiab kev puas tsuaj. Txawm li cas los xij, cov kev tshawb fawb tsis ntev los no tau pom tias cov endogenous neuropeptide Delta pw tsaug zog inducing peptide (DSIP) tuaj yeem ua tiav qhov kev txiav txim siab ntawm qhov kev ntxhov siab los ntawm nws daim ntawv txhaj tshuaj (DSIP Txhaj), hloov kho cov qauv ib txwm siv rau kev tswj hwm kev tswj hwm kev tswj hwm ntawm "kev hloov kho dua tshiab". Qhov kev tawg no tsis tsuas yog nthuav tawm lub luag haujlwm tseem ceeb ntawm DSIP hauv neuroendocrine, kev tiv thaiv kab mob, thiab kev tswj hwm cov metabolism, tab sis kuj tseem muab cov tswv yim tshiab rau kev kho kev ntxhov siab- cov kab mob xws li kev ntxhov siab, tom qab- kev nyuaj siab ntxhov plawv (PTSD), thiab mob nkees nkees.
Cov kev txwv ntawm cov tsoos "ua pa nyuaj" qauv
Cov qauv ib txwm tuav cov lus teb kev ntxhov siab ua raws li cov txheej txheem linear ntawm "lub sijhawm ceeb toom → lub sijhawm tiv thaiv → lub sijhawm qaug zog":
Lub sij hawm ceeb toom: SNS ua kom, tso tawm adrenaline thiab noradrenaline, nce plawv dhia thiab ntshav siab;
Lub sij hawm tsis kam: HPA axis activation, nce cortisol secretion, inhibition ntawm o, thiab kev saib xyuas lub zog;
Lub sij hawm qaug zog: Lub sij hawm ntev cortisol siab ua rau hippocampal atrophy, tiv thaiv kab mob, thiab metabolic ntshawv siab.
Qhov kev txwv ntawm cov qauv no yog tias nws tsis quav ntsej txog qhov muaj peev xwm sib npaug ntawm qhov kev ntxhov siab. Piv txwv li, kev sim tsiaj tau pom tias tom qab kev ntxhov siab ntau zaus, qee tus neeg tuaj yeem txhim kho qhov kev tawm tswv yim tsis zoo los ntawm kev txhawb nqa glucocorticoid receptor (GR) qhia, yog li tsis txhob qaug zog; Thiab lwm pab pawg ntawm cov tib neeg tau poob rau hauv lub xeev kev ua haujlwm ruaj khov vim kev txo qis ntawm GR qhia. Qhov kev sib txawv ntawm tus kheej no qhia txog lub peev xwm ntawm "kev hloov kho dua tshiab" hauv cov lus teb kev ntxhov siab, tab sis cov qauv qub tsis tau piav qhia nws lub hauv paus molecular.
Molecular markers ntawm cell exhaustion
Cov cim qhia ntawm kev qaug zog ntawm tes muaj xws li:
T cell depletion: Nyob rau hauv cov kab mob ntev los yog cov qog microenvironments, CD8+T cells muaj kev qhia siab ntawm PD-1, txo cov cytokine secretion, thiab tsis muaj peev xwm loj hlob vim muaj kev txhawb nqa antigen;
Neuron depletion: Kev ntxhov siab ntev ua rau dendritic atrophy, txo cov synaptic plasticity, thiab inhibition ntawm neurogenesis hauv hippocampal neurons;
Endocrine cell depletion: Pituitary ACTH hlwb muaj kev txo qis cov kua qaub thiab cov cell apoptosis vim ntev - lub sij hawm CRH stimulation.
Cov xwm txheej no qhia tias kev qaug zog yog "kev hloov pauv tsis zoo" ntawm cov hlwb rau kev txhawb nqa, thaum kev hloov pauv tiag tiag yuav tsum suav nrog kev muaj peev xwm rov ua dua tshiab. Qhov kev tshawb pom ntawm DSIP Txhaj Tshuaj muab cov pov thawj sim rau qhov kev xav no.
Molecular mechanism ntawm DSIP txhaj tshuaj: decoupling tseem ceeb nodes ntawm kev nyuaj siab axis
Kev sib cuam tshuam ntawm DSIP thiab NMDA receptors
Kev tswj hwm kev ntxhov siab ntawm DSIP yog ze ze rau nws txoj cai ntawm NMDA receptors. NMDA receptors yog cov tub ntxhais ion channel ntawm glutamatergic neurons, koom nrog hauv kev kawm thiab kev nco, kev nkag siab, thiab kev ntxhov siab. Cov kev sim tsiaj tau pom tias:
Inhibition ntawm NMDA receptor overactivation:Kev txhaj tshuaj DSIP(60 nmol / kg, intraperitoneal) txo qis c-Fos qhia nyob rau hauv paraventricular nucleus (PVN) ntawm hypothalamus induced los ntawm kev nruj kev tsiv. Cov nyhuv no tau thaiv los ntawm NMDA receptor antagonist MK-801 (90 nmol, intraventricular txhaj), qhia tias DSIP txo HPA axis activation los ntawm inhibiting NMDA receptor signaling;
Kev tswj cov calcium influx: DSIP tuaj yeem cuam tshuam qhov qhib T- hom calcium channels, txo cov neuronal overexcitation, thiab tiv thaiv hippocampal neurons los ntawm glutamate toxicity puas.
Phosphorylation hloov kho txhim kho DSIP kev ua haujlwm
Lub 7-serine residue ntawm DSIP tuaj yeem ua phosphorylated los tsim P-DSIP, uas muaj cov haujlwm lom neeg 5-300 npaug siab dua DSIP. Phosphorylation hloov kho txhim kho DSIP muaj nuj nqi los ntawm cov hauv qab no:
Txuas ntxiv ib nrab-lub neej: Ib nrab- lub neej ntawm DSIP yog li 15 feeb, thaum P-DSIP txuas ntxiv mus rau 2-3 teev, ua rau nws cov nyhuv ntev dua;
Txhim kho receptor binding muaj peev xwm: Phosphorylation nce qhov tsis zoo nqi ntawm DSIP molecules, txhawb lawv cov electrostatic cuam tshuam nrog cell membranes thiab receptors;
Kev ua kom muaj kev hloov pauv hloov pauv: P-DSIP tuaj yeem ua rau muaj kev cuam tshuam ntawm kev hloov pauv cov ntsiab lus xws li c-Fos thiab CREB, xa cov kab xev receptor rau lub nucleus, thiab tswj cov kev qhia gene.
Kev siv tshuaj lom neeg ntawm DSIP txhaj tshuaj
Kev ua haujlwm lom neeg ntawmDSIP Txhaj(phosphorylated Delta pw tsaug zog inducing peptide txhaj) yog qhov dav thiab tseem ceeb, npog ntau yam xws li kev tswj kev pw tsaug zog, antioxidant, tiv thaiv kev ntxhov siab, tiv thaiv- qog, tiv thaiv kev kub siab, neuroprotection, thiab kev tswj hwm metabolic. Cov hauv qab no yog cov ncauj lus kom ntxaws ntxiv rau nws cov haujlwm lom neeg:
Pw tsaug zog tswj kev ua si
DSIP tau pom thawj zaug rau nws txoj kev pw tsaug zog tseem ceeb. Hauv kev sim tsiaj, DSIP kev txhaj tshuaj tuaj yeem ua rau muaj kev pw tsaug zog zoo li qub, pom tau tias muaj kev nce ntxiv hauv delta yoj thiab spindle yoj ua haujlwm hauv electroencephalography, thaum txo qis hauv kev ua haujlwm ntawm lub cev muaj zog. Hauv kev tshawb fawb tib neeg, kev txhaj tshuaj DSIP kuj tau pom tias yuav txhim kho kev pw tsaug zog zoo, txo lub sijhawm pw tsaug zog, ncua sij hawm pw tsaug zog, thiab txo qis kev tsaug zog thaum hmo ntuj. Qhov kev tswj kev pw tsaug zog no tuaj yeem ua tiav los ntawm kev tswj hwm cov kab mob neurotransmitter xws li GABA thiab NMDA, uas tuaj yeem pab txo qis kev pw tsaug zog xws li insomnia thiab kev ntxhov siab.
Antioxidant kev ua haujlwm
DSIP muaj zog antioxidant zog thiab tuaj yeem qhib lub cev lub cev lub cev los tiv thaiv oxidative kev nyuaj siab. Hauv kev sim tsiaj, DSIP txhaj tshuaj tuaj yeem ua rau muaj kev ua haujlwm ntawm catalase thiab superoxide dismutase (SOD) hauv daim siab homogenate ntawm cov nas muaj kev ntxhov siab. Cov enzymes no yog cov enzymes tseem ceeb rau lub cev kom tshem tawm cov dawb radicals thiab tiv thaiv cov hlwb los ntawm kev puas tsuaj oxidative. Nyob rau tib lub sijhawm, DSIP tuaj yeem txo qhov concentration ntawm malondialdehyde (MDA), uas yog ib qho ntawm biomarkers ntawm oxidative kev nyuaj siab. Qhov txo qis hauv nws cov concentration qhia tau tias DSIP tuaj yeem txo qhov kev puas tsuaj ntawm oxidative kev nyuaj siab rau lub cev.
Kev tiv thaiv kev ntxhov siab thiab tiv thaiv kev ntxhov siab
DSIP kuj nthuav tawm cov haujlwm tseem ceeb hauv kev tiv thaiv kev ntxhov siab thiab tiv thaiv kev ntxhov siab. Hauv kev sim tsiaj, kev txhaj tshuaj DSIP tuaj yeem txo cov kev ntxhov siab- ua rau muaj kev ntxhov siab, xws li txo tus cwj pwm tshawb nrhiav thiab ua rau muaj kev ntxhov siab txog tus cwj pwm hauv kev sim qhib. Hauv kev tshawb fawb tib neeg, DSIP txhaj tshuaj kuj tau pom tias yuav txhim kho tib neeg cov kev ntxhov siab thiab kev daws teeb meem, nrog rau kev txhim kho lawv lub siab lub ntsws. Qhov kev tiv thaiv kev ntxhov siab thiab kev ntxhov siab no tuaj yeem ua tiav los ntawm kev tswj hwm cov haujlwm ntawm hypothalamic pituitary adrenal axis (HPA axis) thiab lub paj hlwb, uas tuaj yeem pab txo qis kev puas siab puas ntsws xws li kev ntxhov siab thiab kev nyuaj siab.
Kev tiv thaiv- qog nqaij hlav
DSIP kuj muaj cov tshuaj tiv thaiv -cov teebmeem qog nqaij hlav. Hauv kev sim tsiaj, kev txhaj tshuaj ntev ntev ntawm DSIP tuaj yeem txo qhov tshwm sim ntawm cov qog nqaij hlav thiab ua kom lub neej ntev ntawm cov tsiaj sim. Qhov kev tiv thaiv no -cov nyhuv qog tuaj yeem ua tiav los ntawm cov txheej txheem xws li tswj lub cev tiv thaiv kab mob, inhibiting qog cell proliferation, thiab inducing qog cell apoptosis. Txawm hais tias cov txheej txheem tshwj xeeb ntawm DSIP's anti-cov nyhuv qog nqaij hlav tsis tau nkag siab tam sim no, nws cov peev txheej ntawm kev tiv thaiv qog nqaij hlav thiab kev kho mob tsim nyog rau kev tshawb fawb ntxiv.
Antihypertensive kev ua haujlwm
DSIP kuj nthuav tawm qee yam haujlwm hauv kev kho mob ntshav siab. Hauv cov qauv nas hypertensive, kev txhaj tshuaj ntawm DSIP tuaj yeem txo cov ntshav siab thiab txhim kho cov hlab plawv. Qhov kev tiv thaiv kab mob siab no tuaj yeem ua tiav los ntawm cov txheej txheem xws li tswj hwm cov kab mob angiotensin, inhibiting sympathetic paj hlwb, lossis txhim kho endothelial muaj nuj nqi. Txawm hais tias cov txheej txheem tshwj xeeb ntawm DSIP's anti-hypertensive nyhuv tseem tsis tau nkag siab tag nrho, nws cov peev txheej hauv kev kho mob ntshav siab yuav tsum tau saib xyuas.
Kev ua haujlwm ntawm Neuroprotective
DSIP muaj kev tiv thaiv ntawm lub paj hlwb. Hauv kev sim tsiaj, DSIP txhaj tshuaj tuaj yeem tiv thaiv cov neurons los ntawm kev puas tsuaj xws li ischemia, hypoxia, thiab excitotoxicity, txhawb kev ciaj sia thiab kho. Cov nyhuv neuroprotective no tuaj yeem ua tiav los ntawm cov txheej txheem xws li tswj cov kab mob neurotransmitter, inhibiting neuroinflammation, lossis txhawb kev qhia txog cov teeb meem neurotrophic.
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