Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov kws tshaj lij thiab cov neeg muag khoom ntawm kev txhaj tshuaj vermox hauv Suav teb. Txais tos rau kev lag luam wholesale bulk zoo zoo vermox txhaj rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Mebendazole (Kev txhaj tshuaj Vermox) yog ib qho dav -spectrum anthelmintic uas muaj cov teebmeem tseem ceeb hauv kev tua cov larvae thiab inhibiting kev loj hlob ntawm cov qe kab. Ob qho tib si hauv vivo thiab hauv vitro kev sim tau pom tias nws tuaj yeem cuam tshuam ncaj qha kev nce ntawm cov piam thaj los ntawm nematodes, ua rau glycogen depletion thiab txo qis kev tsim ntawm adenosine triphosphate hauv cov cab, ua rau nws tsis muaj sia nyob, tab sis nws tsis cuam tshuam rau cov ntshav qabzib hauv tib neeg lub cev. Kev soj ntsuam ntawm ultrastructure qhia tau hais tias microtubules nyob rau hauv cytoplasm ntawm kab kab cell membrane thiab plab hnyuv cell undergo degeneration, ua rau lub aggregation ntawm secretory granules nyob rau hauv lub Golgi apparatus, ua rau thauj blockage, cytoplasmic dissolution thiab nqus, ua kom tiav cell degeneration, thiab kab tuag.
Cov ntaub ntawv yooj yim
1. Cov tshuaj muaj pes tsawg leeg thiab cov qauv tshuaj
Lub npe tshuaj ntawm benzimidazole yog (5-benzoyl-1H-benzimidazol-2-yl) methyl formate, nrog rau cov mis mos ntawm C16H13N3O3 thiab molecular hnyav ntawm 295.30. Raws li ib tug benzimidazole compound, benzimidazole inhibits tus kab mob no uptake ntawm qabzib, ua rau glycogen depletion nyob rau hauv parasite thiab tom qab ntawd inhibiting nws txoj kev loj hlob thiab kev loj hlob, thaum kawg ua tiav lub hom phiaj ntawm tua cov cab.
2. Pharmacokinetic yam ntxwv
Methylimidazole tau nqus sai sai tom qab kev tswj hwm qhov ncauj, tab sis nws cov bioavailability tsawg vim tias cov tshuaj feem ntau yog metabolized rau hauv cov metabolism hauv cov hnyuv. Txawm li cas los xij, nws cov metabolites nquag tswj cov ntshav siab hauv cov hnyuv, tua cov kab mob zoo. Rau cov tshuaj txhaj tshuaj, nws tuaj yeem cia siab tias lawv yuav dhau los ntawm cov teeb meem ntawm qhov ncauj nqus thiab nkag mus rau cov hlab ntsha ncaj qha, uas tuaj yeem txhim kho bioavailability thiab kev ua tau zoo ntawm cov tshuaj, tshwj xeeb tshaj yog nyob rau hauv kev kho mob ntawm cov kab mob parasitic.
Peb cov khoom
Cov ntaub ntawv ntxiv ntawm chemical compound:
| Khoom npe | Vermox Txhaj | Vermox Chewable Tablets | Vermox Syrup | Vermox Cream |
| Yam khoom | Txhaj tshuaj | Tablet | Syrup | Cream |
| Khoom Purity | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% |
| Khoom Specifications | Customizable | Customizable | Customizable | Customizable |
| Pob khoom | Customizable | Customizable | Customizable | Customizable |
Peb Cov Khoom
Toltrazuril +. COA
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Certificate of Analysis |
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Compound npe |
Mebendazole (Vermox) | |
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CAS Nr. |
31431-39-7 | |
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Qib |
Pharmaceutical qib | |
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Ntau |
Customized | |
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Ntim txheem |
Customized | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
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Ntau No. |
20250109001 |
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MFG |
Jan 12th 2025 |
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EXP |
Jan 8th 2029 |
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Qauv |
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| TEST STANDARD | GB/T24768-2009 Kev lag luam. Stnndard | |
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Yam khoom |
Enterprise txheem |
Kev txheeb xyuas qhov tshwm sim |
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Qhov tshwm sim |
Dawb los yog yuav luag dawb hmoov |
Ua raws |
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Cov ntsiab lus dej |
Tsawg dua lossis sib npaug li 4.5% |
0.17% |
| Poob rau ziab |
Tsawg dua lossis sib npaug li 1.0% |
0.23% |
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Hnyav Hlau |
Pb Tsawg dua lossis sib npaug li 0.5ppm |
N.D. |
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Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Hg Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Cd Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Purity (HPLC) |
Ntau dua lossis sib npaug li 99.0% |
99.7% |
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Ib leeg impurity |
<0.8% |
0.52% |
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Residue ntawm ignition |
<0.20% |
0.07% |
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Tag nrho microbial suav |
Tsawg dua lossis sib npaug li 750cfu / g |
90 |
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E. Coli |
Tsawg dua lossis sib npaug li 2MPN / g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (los ntawm GC) |
Tsawg dua lossis sib npaug li 5000ppm |
500 ppm |
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Cia |
Khaws rau hauv qhov chaw kaw, tsaus thiab qhuav ntawm 2-8 degree |
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Kev txhaj tshuaj Vermox(feem ntau hu ua metronidazole) yog ib qho dav - spectrum antiparasitic tshuaj, thiab nws cov tshuaj noj hauv qhov ncauj tau siv dav hauv kev kho mob, feem ntau yog siv rau kev kho mob ntawm cov kab mob hauv plab hnyuv xws li kab mob sib kis, kab mob sib kis, thiab kab mob pinworms.
Raws li daim ntawv thov sib txawv, cov khoom siv bendazole tuaj yeem muab faib ua ob pawg: tib neeg siv thiab siv tsiaj. Hauv kev siv tshuaj, nws yog ib qho zoo -paub tshuaj antiparasitic feem ntau yog siv los kho cov kab mob uas tshwm sim los ntawm cov kab mob hauv plab hnyuv xws li kab mob khaub thuas, kab mob sib kis, thiab kab mob pinworms.
Pharmacological hauv paus ntawm metronidazole
Xylimidazole belongs rau benzimidazole chav kawm ntawm cov tebchaw, thiab nws cov tshuaj tiv thaiv kab mob feem ntau cuam tshuam nrog kev cuam tshuam cov kab mob parasite's uptake ntawm qabzib, ua rau glycogen depletion nyob rau hauv cov cab thiab cuam tshuam nrog nws txoj kev muaj sia nyob thiab kev muaj peev xwm ntawm kev loj hlob. Tshwj xeeb, metronidazole tuaj yeem cuam tshuam kev sib sau ntawm microtubule proteins hauv cov kab mob cab, thaiv kev nqus thiab thauj cov piam thaj los ntawm cov kab mob cab, ua rau cov kab mob endogenous glycogen hauv cov cab, thiab inhibit mitochondrial malate reductase system, txo qis ATP ntau lawm thiab thaum kawg ua rau cov kab mob tuag taus. Cov txheej txheem no ua rau benzimidazole muaj qhov dav -spectrum tua cov nyhuv ntawm ntau yam kab mob hauv plab.
Muaj peev xwm qhia tau
Vermox daim ntawv txhaj tshuaj yuav muaj peev xwm thov tau tus nqi hauv cov xwm txheej hauv qab no:
Mob plab hnyuv parasitic:
Rau cov neeg mob uas muaj teeb meem hauv kev tswj hwm qhov ncauj lossis kev nqus plab tsis zoo (xws li coma, ntuav tsis txaus, lossis cov neeg mob tom qab phais plab uas tsis tuaj yeem noj cov tshuaj hauv qhov ncauj), kev txhaj tshuaj Vermox tuaj yeem nkag ncaj qha rau hauv cov hlab ntsha. Qhov no hla txoj kev nqus ntawm plab hnyuv, zam kev cuam tshuam ntawm plab hnyuv ua haujlwm ntawm kev nqus tshuaj thiab ua kom muaj txiaj ntsig zoo ntawm cov tshuaj mus rau qhov chaw mob plab hnyuv.
Nyob rau hauv cov xwm txheej ntawm tus kab mob parasitic hnyav nrog cov tsos mob tshwm sim, qhov ncauj noj tsis txaus, lossis kev kho mob tsis zoo, daim ntawv txhaj tshuaj tuaj yeem muab ntau dua thiab ruaj khov ntawm cov tshuaj hauv lub cev, yog li txhim kho cov tshuaj tua kab thiab ua kom lub voj voog kho.
Kab mob parasitic nyob rau hauv lub koom haum:
Qee cov kab mob, xws li trichinella thiab cysticercus, tsis yog tsuas yog ua rau cov hnyuv, tab sis kuj tuaj yeem cuam tshuam cov ntaub so ntswg sib sib zog nqus xws li cov leeg thiab hlwb, ua rau muaj teeb meem loj thiab ua rau tus neeg mob noj qab haus huv. Kev txhaj tshuaj Vermox tuaj yeem faib rau ntau cov ntaub so ntswg thiab cov kabmob thoob plaws hauv lub cev los ntawm cov ntshav ncig, ua rau muaj kev tua ncaj qha rau cov kab mob hauv cov ntaub so ntswg.
Rau cov kab mob hnyav xws li cerebral cysticercosis, uas nyuaj rau kho, daim ntawv txhaj tshuaj tuaj yeem nkag mus rau hauv cov ntshav - lub hlwb thaiv, mus txog qhov kev kho mob zoo hauv cov ntaub so ntswg hauv hlwb, thiab tsom mus tshem tawm cov kab mob kom txo tau cov tsos mob ntawm lub paj hlwb.
Mixed parasitic kab mob:
Hauv kev kho mob, cov neeg mob qee zaum kis tau ntau yam kab mob xws li kab mob sib kis, kab mob sib kis, kab mob npaws, thiab lwm yam. Qhov dav -spectrum antiparasitic nyhuv ntawm Vermox txhaj tshuaj tuaj yeem npog ntau hom kab mob, ua kom yooj yim rau txoj kev kho mob. Qhov no zam qhov nyuaj ntawm kev noj ntau yam tshuaj ntawm qhov ncauj thiab txo cov tshuaj muaj peev xwm -kev cuam tshuam tshuaj los ntawm kev siv tshuaj sib xyaw ua ke, txhim kho kev ua raws li kev kho mob thiab kev nyab xeeb.
Cov neeg mob tshwj xeeb:
Rau cov neeg tshwj xeeb xws li cov poj niam cev xeeb tub, cov me nyuam mos thiab cov menyuam yaus, thiab cov neeg laus uas muaj lub cev tsis muaj zog, kev tswj xyuas qhov ncauj yuav ua rau muaj teeb meem hauv kev hloov koob tshuaj lossis kev pheej hmoo kev nyab xeeb vim qhov sib txawv ntawm kev nqus thiab metabolism. Kev txhaj tshuaj Vermox tuaj yeem hloov kho qhov ntau npaum li cas raws li tus neeg mob lub hnub nyoog, qhov hnyav, thiab lub cev mob, ua kom muaj kev nyab xeeb rau kev kho mob thaum ua kom muaj txiaj ntsig zoo.
Tsis tas li ntawd, thaum muaj tus kab mob parasitic tshwm sim los yog tshwm sim kev noj qab haus huv rau pej xeem, daim ntawv txhaj tshuaj tuaj yeem siv tau sai thiab loj heev rau cov neeg muaj tus kab mob, ua rau muaj kev xa tshuaj sai thiab tswj kev kis tus kab mob.
Metronidazole, raws li ib tug dav -spectrum antiparasitic tshuaj, plays lub luag hauj lwm tseem ceeb nyob rau hauv kev kho mob ntawm parasitic kab mob vim nws tshwj xeeb pharmacological mechanism thiab kev nyab xeeb zoo.
Case 1: Kev kho mob sib xyaw ntawm tus kab mob pinworm thaum yau
Ib tug txiv neej 5-xyoo-laus tus neeg mob tau nrhiav kev kho mob vim khaus perianal nocturnal thiab pw tsis tsaug zog. Tus menyuam nyob hauv cov chaw nyob deb nroog uas muaj kev tu cev tsis zoo thiab keeb kwm ntawm kev sib cuag tsiaj. Kev sim kuaj pom pom cov qe pinworm zoo hauv cov quav, thaum kuaj serological pom tias muaj peev xwm kis tus kab mob hookworm.
TswjVermox Txhaj200mg (10ml) intravenously ib hnub ib zaug rau 3 hnub sib law liag. Tus nqi ntawm infusion yuav tsum tau tswj ntawm 1-2ml ib feeb kom tsis txhob muaj kev cuam tshuam sai ua rau hypotension. Thaum kho, cov tshuaj tiv thaiv qhov ncauj (100mg / hnub ferrous sulfate) tau siv los kho cov kab mob ntshav qab zib los ntawm tus kab mob hookworm.
Qe tig tsis zoo: Hnub 7 ntawm kev kho mob, fecal rov kuaj pom tias pinworm qe ploj thiab hookworm qe txo los ntawm 80%; Hnub tim 14, cov qe hookworm tau rov kuaj dua thiab ua tsis zoo tag nrho.
Cov tsos mob zoo li no: Perianal khaus txo qis thiab pw tsaug zog zoo dua li ntawm 24 teev tom qab noj tshuaj.
Kev nyab xeeb: Thaum lub sij hawm kho mob, tsuas yog xeev siab me ntsis tshwm sim (ob zaug hauv ib hnub), uas tsis cuam tshuam rau kev noj mov thiab tsis muaj lwm yam tsis zoo.
4. Case tsom xam
Nyob rau hauv cov ntaub ntawv no, cov tshuaj ntshav zoo concentration tau ua tiav sai heev los ntawm txoj kev intravenous, thaum npog dual kab mob ntawm pinworms thiab hookworms. Nws cov nanoscale particle dispersion technology txhim kho bioavailability ntawm cov tshuaj nyob rau hauv cov me nyuam lub cev, tsis txhob noj ntau npaum li cas los ntawm nqos nyuaj nyob rau hauv lub qhov ncauj ntsiav tshuaj. Kev sib xyaw ua ke ntawm kev kho cov hlau ntxiv tau zoo kho cov kab mob ntshav qab zib ntsig txog kab mob hookworm, qhia txog qhov tseem ceeb ntawm kev kho mob dav dav.
Case 2: Kev kho cov neeg laus kab mob hookworm ua ke nrog daim siab ua haujlwm tsis zoo
Ib tug txiv neej uas muaj hnub nyoog 42 xyoos tau nrhiav kev kho mob rau qhov mob plab thiab nkees. Tus neeg mob muaj keeb kwm ntev ntawm kev ua hauj lwm hauv av thiab kuaj ntshav fecal occult zoo. Cov kev sim kuaj pom pom cov qe qe qe qe (20-30/HPF), lub siab ua haujlwm tsis zoo (ALT 120U/L, AST 95U/L), thiab qhov siab me me ntawm tag nrho bilirubin (28 μ mol / L).
Kev txhaj tshuaj 150mg (7.5ml) intravenously ib zaug ib hnub rau 5 hnub sib law liag. Nthuav lub sij hawm infusion mus rau 90 feeb kom txo tau cov metabolic lub nra ntawm cov tshuaj nyob rau hauv daim siab. Ib txhij muab tshuaj tiv thaiv daim siab (diammonium glycyrrhizinate 150mg / hnub) los kho lub siab ua haujlwm tsis zoo.
Qe tig tsis zoo: Nyob rau hnub 10 ntawm kev kho mob, qhov ploj ntawm cov qe hookworm thiab txo cov tsos mob ntawm qhov mob plab tau pom nyob rau hauv kev kuaj xyuas fecal.
Kev txhim kho lub siab ua haujlwm: Hnub 14 ntawm kev kho mob, ALT txo qis rau 50U / L, AST poob rau 40U / L, thiab tag nrho cov bilirubin rov qab mus rau qhov qub (18 μ mol / L).
Kev nyab xeeb: Thaum lub sijhawm kho, tsis muaj kev cuam tshuam ntawm plab hnyuv xws li xeev siab thiab ntuav, thiab lub siab ua haujlwm ntawm lub siab txuas ntxiv mus.
Hauv qhov no, tus neeg mob muaj lub siab ua haujlwm tsis tu ncua, thiab cov tshuaj tiv thaiv kab mob hauv qhov ncauj tuaj yeem ua rau tus neeg mob hnyav dua vim tias muaj zog metabolic hauv daim siab. Los ntawm kev hla thawj qhov kev cuam tshuam los ntawm txoj hauv kev hauv cov hlab ntsha, lub siab metabolic siab txo qis, thiab lub sij hawm infusion yog ntev dua kom txo tau qhov kev pheej hmoo ntawm kev phiv. Kev sib xyaw ua ke ntawm daim siab tiv thaiv kev kho mob zoo tiv thaiv daim siab ua haujlwm, qhia txog qhov tseem ceeb ntawm cov tshuaj ib leeg.
Case 3: Multidrug resistant kev kho mob ntawm refractory roundworm kab mob
An 8-year-old female child was diagnosed with recurrent abdominal pain and malnutrition. The child resides in an area with poor hygiene conditions and has a history of multiple deworming treatments (such as albendazole and praziquantel), but the symptoms are recurrent. Fecal examination showed positive roundworm eggs (50-60/HPF), and the sensitivity of the worm body to albendazole decreased (in vitro drug sensitivity test showed MIC>10 μg / ml).
Kev txhaj tshuaj 200mg (10ml) intravenously ib hnub ib zaug rau 7 hnub sib law liag. Tus nqi infusion yog tswj ntawm 1ml ib feeb, thiab probiotics (Bifidobacterium triple active hmoov) tau ua ke los tswj lub plab microbiota thiab txo cov kev cuam tshuam ntawm cov tshuaj hauv plab microbiota.
Qe tig tsis zoo: Nyob rau hnub 14 ntawm kev kho mob, qhov ploj ntawm cov qe qe qe thiab ua tiav cov tsos mob ntawm qhov mob plab tau pom nyob rau hauv kev kuaj quav.
Kev txhim kho kev noj haus: Nyob rau hnub 30 ntawm kev kho mob, qhov hnyav nce 1.5kg thiab qib hemoglobin nce los ntawm 105g / L txog 120g / L.
Kev nyab xeeb: Thaum lub sijhawm kho, tsis muaj kev ua haujlwm ntawm plab hnyuv xws li zawv plab lossis cem quav, thiab kev sib xyaw ntawm cov tshuaj probiotics zoo tswj qhov sib npaug ntawm plab hnyuv microbiota.
4. Case tsom xam
Nyob rau hauv cov ntaub ntawv no, tus me nyuam tsim tsis kam mus rau ib txwm deworming tshuaj thiab kov yeej qhov teeb meem ntawm multidrug tsis kam los ntawm nws tshwj xeeb microtubule inhibition mechanism. Nws cov nanoscale particle dispersion technology txhim kho cov permeability ntawm cov tshuaj nyob rau hauv txoj hnyuv, kom ntseeg tau tias muaj txiaj ntsig tua cov tshuaj - cov kab mob resistant. Kev sib xyaw ua ke ntawm kev kho mob probiotics txo qis kev cuam tshuam ntawm cov tshuaj hauv plab hnyuv microbiota, qhia txog qhov zoo ntawm kev kho mob dav dav hauv cov kab mob parasitic refractory.
Case 4: Prophylactic kev kho mob ntawm toxoplasmosis nyob rau hauv cov neeg mob immunosuppressed
Ib tug txiv neej hnub nyoog 35 xyoo hloov lub raum tau txais kev kho mob rau kev kho mob tom qab kev tiv thaiv kab mob (tacrolimus + mycophenolate mofetil). Tus neeg mob muaj keeb kwm ntawm kev sib cuag nrog cov tsiaj miv, thiab kev soj ntsuam serological qhia tau tias zoo IgG thiab tsis zoo IgM rau Toxoplasma gondii, qhia tau hais tias muaj kab mob yav dhau los. Txhawm rau tiv thaiv qhov rov tshwm sim ntawm toxoplasmosis, kev tiv thaiv kev kho mob yog tsim nyog.
Vermox Txhaj100mg (5ml) tau txhaj tshuaj intravenously ob zaug ib lub lim tiam rau 12 lub lis piam sib law liag. Lub sij hawm infusion yuav tsum tau tswj ntawm 60 feeb, thaum saib xyuas cov ntshav concentration ntawm tacrolimus kom tsis txhob muaj kev cuam tshuam tshuaj.
Kev tiv thaiv zoo: Thaum lub sij hawm kho, tsis muaj cov tsos mob cuam tshuam txog toxoplasmosis (xws li ua npaws, mob taub hau, lymph node loj), thiab qhov kev ntsuam xyuas serological tseem tsis zoo rau IgM.
Kev saib xyuas lub cev tsis muaj zog: CD4+T cell suav nyob ruaj khov ntawm 400-500/μ l thaum kho thiab tsis txo qis ntxiv vim yog siv tshuaj.
Kev nyab xeeb: Thaum lub sijhawm kho, tsis muaj qhov cuam tshuam tsis zoo xws li lub siab ua haujlwm tsis zoo lossis cov pob txha pob txha, thiab cov ntshav siab ntawm tacrolimus tseem nyob ruaj khov hauv lub hom phiaj (5-10ng / ml).
Nyob rau hauv cov ntaub ntawv no, cov neeg mob immunosuppressed muaj kev pheej hmoo ntawm rov tshwm sim ntawm toxoplasmosis, thiab cov tshuaj nyob rau hauv lub qhov ncauj tej zaum yuav cuam tshuam rau kev ua tau zoo vim tsis ruaj tsis khov nqus. Kev nqus tau ruaj khov ntawm cov tshuaj tau lees paub los ntawm txoj hauv kev hauv cov hlab ntsha, thiab nws cov yam ntxwv ntawm tsis muaj pob txha pob txha thiab tsis muaj nephrotoxicity yog tsim rau kev siv sijhawm ntev -. Kev saib xyuas cov ntshav concentration ntawm tacrolimus zam kev sib cuam tshuam ntawm cov tshuaj thiab qhia txog qhov tseem ceeb ntawm kev tiv thaiv kev kho mob hauv cov neeg tshwj xeeb.
FAQ
Kev siv tshuaj mebendazole yog dab tsi?
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Mebendazole ua raws li tus neeg sawv cev anthelmintic, tiv thaiv kev loj hlob ntawm worms. Yog li ntawd, nws yog siv rau deworming, periodic worming, thiab kho cov kab mob tshwm sim los ntawm ntau yam worms. Txhawm rau ua kom nws cov txiaj ntsig zoo, cov neeg siv yuav tsum ua raws li cov lus qhia los ntawm lawv cov kws kho mob lossis kws muag tshuaj.
Vermox mebendazole siv rau dab tsi?
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Mebendazole yog ib hom tshuaj raukho worms. Nws yog siv feem ntau rau cov kab mob ntawm lub plab xws li threadworms (qee zaum hu ua pinworms) thiab lwm yam kab mob tsis tshua muaj kab mob (whipworm, roundworm thiab hookworm).
Nws siv sijhawm ntev npaum li cas rau Vermox ua haujlwm?
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Cov tshuaj yuav tsum pib ua hauj lwm tam sim ntawd tab sis nws yuav siv sij hawm ob peb hnub los tua tag nrho cov cab. Nws yog ib qho tseem ceeb uas yuav tau noj cov tshuaj raws li kws muag tshuaj lossis kws kho mob qhia rau koj. Tsis txhob nres ntxov yog tias koj tau hais kom coj nws ob peb hnub.
Thaum twg yog lub sijhawm zoo tshaj los noj mebendazole?
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Rau cov kab mob kab mob sib kis, kab mob hookworms, thiab whipworms: Cov neeg laus thiab menyuam yaus hnub nyoog 2 xyoos thiab laus dua-100 milligrams (mg) ob zaug ib hnub, sawv ntxov thiab yav tsaus ntuj, rau 3 hnub sib law liag. Kev kho yuav tsum tau rov ua dua hauv 3 lub lis piam.
Cim npe nrov: Vermox txhaj tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom