Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm etelcalcetide txhaj nyob rau hauv Suav teb. Txais tos rau kev lag luam wholesale bulk zoo etelcalcetide txhaj rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Kev txhaj tshuaj Etelcalcetideyog ib tug tshiab calcium mimetic agent. AMG416 khi thiab ua kom cov calcium rhiab heev receptors ntawm lub caj pas parathyroid, ua rau txo qis hauv parathyroid hormone (PTH) qib. Nws muaj kev cia siab dav hauv kev txhim kho cov tshuaj tshiab rau kev kho mob ntawm theem nrab hyperparathyroidism.
FDA tau pom zoo ib yam tshiab ntawm calcium mimetic tshuaj rau kev kho mob ntawm theem nrab hyperparathyroidism nyob rau hauv cov neeg laus hemodialysis, cim thawj zaug nyob rau hauv ze li ntawm 12 xyoo uas ib tug tshuaj tau pom zoo rau kev kho mob ntawm theem nrab hyperparathyroidism nyob rau hauv cov neeg mob dialysis.
Peb Cov Khoom Muag Khoom
Etelcalcetide COA
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| Certificate of Analysis | ||
| Compound npe | Etelcalcetide | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 1262780-97-1 | |
| Ntau | 40g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090057 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.47% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.35% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib leeg impurity | <0.8% | 0.56% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 170 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 400ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
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| Chemical Formula: | C38H73N21O10S2 |
| Exact Mass: | 1048 |
| Molecular Luj: | 1048 |
| m/z: | 1048 (100.0%), 1049 (41.1%), 1050 (9.0%), 1050 (8.2%), 1049 (7.8%), 1051 (3.7%), 1050 (3.2%), 1050 (2.1%), 1049 (1.6%), 1051 (1.1%) |
| Elemental Analysis: | C, 43.54; H, 7.02; N, 28.06; O, 15.26; S, 6.12 |
Kev txhaj tshuaj Etelcalcetide, tseem hu ua AMG416, yog calcium rhiab heev receptor (CaSR) agonist nrog kev siv tshwj xeeb hauv kev kho mob. Cov hauv qab no yuav muab cov ncauj lus qhia ntxaws txog nws cov kev siv thiab cov ntaub ntawv ntsig txog.
Lub hom phiaj tseem ceeb
(1) Kev kho mob theem nrab hyperparathyroidism (SHPT)
Feem ntau yog siv los kho tus mob hyperparathyroidism hauv cov neeg mob ntshav qab zib uas muaj kab mob raum ntev (CKD). Secondary hyperparathyroidism yog ib qho teeb meem ntawm lub raum tsis ua haujlwm ntev. Vim lub raum tsis ua haujlwm, lub raum lub peev xwm los tswj cov metabolism ntawm calcium, phosphorus, thiab vitamin D txo qis, ua rau ntau dhau ntawm cov tshuaj hormones parathyroid (PTH) los ntawm lub caj pas parathyroid. Kev tso tawm ntau dhau ntawm PTH tuaj yeem yaj phosphorus thiab calcium hauv cov pob txha thiab sib sau ua ke hauv cov hlab plawv, ua rau hyperkalemia, hyperphosphatemia, thiab arteriosclerosis, ua rau cov kab mob plawv.
Los ntawm kev tswj hwm txoj hlab ntshav, calcium rhiab heev receptors ntawm cov hlwb parathyroid tau khi thiab ua haujlwm, txhim kho lawv qhov kev nkag siab zoo rau cov calcium ions extracellular. Qhov no tso cai rau cov hlwb parathyroid kom pom cov cim qhia txog calcium ntawm qis calcium ion concentrations, yog li inhibiting synthesis thiab secretion ntawm PTH thiab txo PTH qib hauv cov ntshav. Ntau qhov kev sim tshuaj tau lees paub qhov ua tau zoo thiab kev nyab xeeb ntawm verapamil hauv kev kho SHPT hauv CKD cov neeg mob lim ntshav. Piv txwv li, hauv cov neeg mob hemodialysis uas muaj qhov nruab nrab mus rau qhov hnyav hyperparathyroidism, kev kho mob nrog verapamil txo qis PTH qib, thiab cov txiaj ntsig zoo dua li cov placebo thiab tsis qis dua cinacalcet.
Cov ntaub ntawv tshawb fawb ntsig txog tuaj yeem tau txais ntawm cov platforms xws li ChemicalBook thiab Sohu lub platform pej xeem.
(2) Txhim kho calcium thiab phosphorus metabolism tsis zoo
Ntxiv nrog rau kev txo qis PTH, nws tuaj yeem tswj cov calcium thiab phosphorus metabolism. Nws tuaj yeem txhawb kev tso tawm ntawm phosphorus los ntawm ob lub raum, txo cov ntshav phosphorus concentration, thiab txo cov pob txha calcium tso tawm kom tswj cov ntshav calcium stability. Qhov no yog qhov tseem ceeb heev rau kev txhim kho cov pob txha metabolic abnormalities tshwm sim los ntawm hyperparathyroidism thiab txo cov kev pheej hmoo ntawm pob txha kab mob. Piv txwv li, qee cov neeg mob maj mam rov qab mus rau cov ntshav phosphorus li qub thiab txo cov tsos mob xws li mob pob txha tom qab tau txais kev kho mob nrog.Kev txhaj tshuaj etelcalcetide.
Yog xav paub ntxiv, thov xa mus rau Chemicalbook (Booker Chemical Network), Zhihu kem, thiab lwm yam.
(3) Txo cov tsos mob
Txo cov pob txha mob thiab khaus tawv nqaij: Nws tuaj yeem pab tswj cov qib parathyroid ntau dhau, yog li txo cov tsos mob xws li mob pob txha thiab khaus tawv nqaij los ntawm SHPT hauv cov neeg mob. Mob pob txha yog ib qho ntawm cov tsos mob tshwm sim hauv cov neeg mob SHPT, uas cuam tshuam rau lawv lub neej zoo. Los ntawm kev txo cov qib PTH thiab txo cov pob txha calcium tso tawm, verapamil tuaj yeem txo cov tsos mob ntawm pob txha. Cov tawv nqaij khaus kuj yog ib qho teeb meem tshwm sim rau cov neeg mob SHPT, thiab kev kho mob nrog verapamil tuaj yeem txhim kho tus neeg mob cov tawv nqaij thiab txo cov tsos mob khaus khaus.
Txhim kho lub neej zoo: Los ntawm kev txhim kho calcium thiab phosphorus metabolism tsis zoo thiab txo cov tsos mob, verapamil tuaj yeem pab txhim kho cov neeg mob lub neej zoo thiab ua kom muaj sia nyob ntev. Tom qab siv, cov neeg mob cov tsos mob ntawm lub cev tsis xis nyob yuav raug txo, thiab lawv tuaj yeem ua haujlwm zoo dua hauv kev ua ub no txhua hnub, thiab lawv lub siab lub ntsws kuj tseem yuav txhim kho.
Cov ntaub ntawv ntsig txog tuaj yeem pom ntawm lub platform xws li Chemicalbook thiab WeChat pej xeem platform.
(4) Txo qhov kev pheej hmoo ntawm cov teeb meem
Nws tuaj yeem txo qhov kev pheej hmoo ntawm cov teeb meem xws li vascular calcification. Vascular calcification yog ib qho teeb meem tshwm sim hauv cov neeg mob CKD, ze ze rau qhov tshwm sim thiab tuag ntawm cov kab mob plawv. Los ntawm kev tswj cov calcium thiab phosphorus metabolism, lub deposition ntawm calcium nyob rau hauv lub vascular phab ntsa yog txo, yog li txo qhov kev pheej hmoo ntawm vascular calcification. Piv txwv li, cov kev tshawb fawb cuam tshuam tau pom tias qhov kev nce qib ntawm vascular calcification hauv cov neeg mob tau txais kev kho mob qeeb qeeb.
Cov ntaub ntawv ntsig txog tuaj yeem pom hauv Chemicalbook (Booker Chemical Network) thiab lwm qhov chaw.
Qhov zoo ntawm cov tshuaj
Nws tau raug tsim los ua kev txhaj tshuaj rau hauv cov hlab ntsha, uas tuaj yeem ntseeg tau los ntawm venous sab ntawm lub tshuab lim ntshav raws li kev tswj hwm ntawm tus kws kho mob thaum rov qab mus rau cov hlab ntshav thaum kawg ntawm kev lim ntshav. Txoj kev tswj hwm no tsis yog tsuas yog yooj yim xwb, tab sis kuj ua kom muaj kev noj qab haus huv thiab kev siv tshuaj raws sijhawm. Piv nrog rau cov tshuaj noj hauv qhov ncauj, kev txhaj tshuaj txhaj tshuaj tiv thaiv kev cuam tshuam ntawm plab hnyuv ntawm kev nqus tshuaj thiab txhim kho bioavailability ntawm cov tshuaj.
Cov ntaub ntawv ntsig txog tuaj yeem tau txais ntawm lub platform xws li Chemicalbook thiab lub vev xaib raug cai ntawm Hangzhou Gutuo Biotechnology Co., Ltd.
(2) Tsis tshua muaj kev pheej hmoo ntawm kev siv tshuaj yeeb
D-amino acid peptide qaum qaum, uas yuav luag tsis cuam tshuam los ntawm metabolic enzymes thiab pab txhawb rau nws txoj haujlwm, tsis metabolized hauv lub cev thiab tuaj yeem ua haujlwm ntev mus txog thaum nws raug tshem tawm thaum lub sijhawm lim ntshav tom ntej. Qhov no txo qis kev pheej hmoo ntawm kev sib cuam tshuam ntawm cov tshuaj thaum siv nrog rau lwm cov tshuaj, txo cov kev tsis zoo tshwm sim los ntawm kev siv tshuaj sib cuam tshuam thiab kho cov phiaj xwm kho mob. Piv txwv li, hauv kev kho mob, verapamil tuaj yeem siv ua ke nrog cov vitamin D thiab nws cov analogues, phosphate binders, thiab lwm yam tshuaj kom zoo dua tswj cov calcium thiab phosphorus metabolism thiab txo cov qib PTH.
Cov ntaub ntawv ntsig txog tuaj yeem pom hauv Chemicalbook (Booker Chemical Network) thiab lwm qhov chaw.
Vim yog txoj kev tswj hwm yooj yim thiab lub sijhawm ntev ntawm kev siv tshuaj, nws tuaj yeem txo cov sijhawm cov neeg mob noj tshuaj, yog li txhim kho cov neeg mob ua raws cai thiab txo lawv cov nqi tshuaj. Rau cov neeg mob CKD dialysis uas xav tau kev kho mob ntev -, kev ua tau zoo yog qhov tseem ceeb rau kev tswj xyuas kev kho mob thiab tswj tus mob. Cov zoo ntawm noKev txhaj tshuaj etelcalcetidetuaj yeem pab txhim kho cov neeg mob kev ua raws li kev kho mob thiab txhim kho kev kho mob.
Cov ntaub ntawv ntsig txog tuaj yeem pom ntawm lub platform xws li Chemicalbook thiab WeChat pej xeem platform.
Cov lus nug nquag
Etelcalcetide siv rau dab tsi?
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Kev txhaj tshuaj Etelcalcetide yog siv los kho tus mob hyperparathyroidism theem nrab hauv cov neeg mob uas muaj kab mob hauv lub raum uas tau lim ntshav. Hyperparathyroidism yog ib yam mob uas tshwm sim thaum lub caj pas parathyroid nyob rau hauv lub caj dab ua ntau dhau lawm parathyroid hormone (PTH).
Dab tsi yog qhov txawv ntawm cinacalcet thiab etelcalcetide?
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Parsabiv feem ntau ua tau zoo dua li cinacalcet (Sensipar) ntawm kev txo qis cov tshuaj parathyroid hormone (PTH) hauv cov neeg mob hemodialysis vim nws muaj peev xwm ntau dua thiab kev tswj hwm hauv cov hlab ntsha, uas ua kom 100% ua raws. Thaum etelcalcetide tau muab peb zaug-ib lub lim tiam ntawm kev lim ntshav, cinacalcet tau noj txhua hnub ntawm qhov ncauj. Ob leeg muaj kev pheej hmoo ntawm hypocalcemia thiab kev mob plab hnyuv.
Qhov txawv tseem ceeb:
Kev tswj hwm: Etelcalcetide yog txhaj tshuaj (IV) thiab muab thaum kawg ntawm kev sib kho hemodialysis, txhim kho kev ua raws cai. Cinacalcet yog ib qho tshuaj noj txhua hnub.
Efficacy: Etelcalcetide is more effective at lowering PTH levels. In studies, 68.2% of patients on etelcalcetide achieved >30% PTH txo, piv rau 57.7% ntawm cinacalcet.
Mechanism: Ob leeg yog calcimimetics, tab sis etelcalcetide khi rau Calcium -Sensing Receptor (CaSR) nyob rau hauv ib txoj kev uas tsis xav tau calcium los ua, muaj peev xwm piav qhia nws lub zog zoo tshaj.
Kev ua raws li: Kev tswj hwm hauv cov hlab ntsha daws qhov siab tsis yog - kev ua raws li kev noj qab haus huv cuam tshuam nrog kev noj tshuaj txhua hnub.
Cov teebmeem tshwm sim: Ob leeg tuaj yeem ua rau hypocalcemia, tab sis nws nquag nrog etelcalcetide. Ob leeg muaj cov txiaj ntsig zoo sib xws ntawm kev mob plab hnyuv (xws li xeev siab / ntuav).
Qhov twg xaiv?
Etelcalcetide feem ntau nyiam nyob rau hauv cov chaw kho mob hemodialysis nrhiav kev ua tau zoo dua hauv kev tswj cov refractory theem nrab hyperparathyroidism thiab qhov twg cov neeg mob ua raws li cov tshuaj hauv qhov ncauj txhua hnub yog kev txhawj xeeb. Txawm li cas los xij, cinacalcet yog ib qho zoo - tsim, kev xaiv qhov ncauj zoo.
Cim npe nrov: Etelcalcetide txhaj tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom