Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom lag luam thiab cov chaw muag khoom ntawm cov hmoov ntshiab procaine hmoov) hmoov 59-46-1 nyob rau hauv Suav teb. Txais tos rau kev lag luam wholesale loj zoo ntshiab ntshiab hmoov li 59-46-1 rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
NTSHIM PLIGHE HMOOV, yog 99% + cov khoom ntshiab. Nws yog luv {{3} ua yeeb yam ester hauv zos tshuaj loog, qis lipophilic, tsis muaj zog nkag ntawm mucous membrane. Proppaine yog tshuaj tshuaj loog, tseem hu ua procaine. Cov qauv molecular yog c13h20n2o2, nrog tus txheeb ze lub cev hnyav ntawm 236.3g / mol. Nws yog cov hmoov dawb nrog qee qhov tshwj xeeb lub cev tshwj xeeb uas tseem ceeb rau nws siv thiab ruaj khov. Qhov ceev yog 1.11 g / ml. Qhov no txhais tau tias nws hnyav dua nyob rau hauv lub xeev ruaj dua nyob rau hauv lub xeev ua kua. Cov Lidocaine Lidocaine feem ntau siv hauv kev sib xyaw ua ke.
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Tshuaj Cov Qauv |
C13H20N2O2 |
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Muaj pes tsawg leej |
236.15 |
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Molecular hnyav |
236.32 |
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m/z |
236.15 (100.0%), 237.16 (14.1%) |
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Kev Ntsuam Xyuas |
C, 66.07; H, 8.53; N, 11.85; O, 13.54 |
Proppaine yog qhov txhawb nqa rau cov hlwb ntawm cov limbic system. Hauv cov miv tas, 15 mg / kg procaine kev ua si ntawm amygroal kev ua si los ntawm amygdala, tus neclect zaus thiab amplitude ntawm atheroscicmic excenterating kev ua si ntawm cov chaw ua ntej tshaj tawm, lossis hauv lub chaw nruab nrab ntawm cov neeg noj khoom haus ua ntej lub ntsej muag ua ntej lub ntsej muag ua ntej lub ntsej muag ua ntej Kev ua si (RSA), tsis muaj kev cuam tshuam ntawm zaus.Procaine txhaj rau hauv lub xaib ntawm kev ua kom tiav ob qho zaus thiab amplitude eliculately RSA. Zaus thiab amplitude ntawm RSA.
Lub sim synthesis txoj kev ntawmNTSHIM PLIGHE HMOOVtuaj yeem faib ua cov kauj ruam hauv qab no:
1. Nitricification thiab txo ntawm Paba
Firstly, nitricification thiab txo cov kev cuam tshuam yog nqa tawm ntawm aminobenzoic acid (kaba). Qhov tshuaj tiv thaiv no feem ntau ua rau p- nitroaminobenl (ponba), uas tuaj yeem txo kom tau p} aminoaminobenzoic acid (pama).
Cov tshuaj tiv thaiv cov tshuaj tiv thaiv muaj raws li nram no:
Paba + hno3 → ponba + h2o
Ponba + H2 → Pama + H2O
2. Esterification cov tshuaj tiv thaiv ntawm Pama nrog Ethyl Clorooacetate
Ntxiv Paa thiab Ethyl chloroacetate ua ke rau cov tshuaj tiv thaiv flask rau cov tshuaj tiv thaiv esterification raws li cov sulfuric acid. Qhov no yuav ua rau tsim kev tsim ntawm organic sib xyaw o {{{
Cov tshuaj tiv thaiv cov tshuaj tiv thaiv muaj raws li nram no:
Paama + clch2chococoCoch2ch3 → clch2choco 2} benzoic acid anter
3. Tiam ntawm P - oinobenzoic acid hydrochloride
Tus O - Acetic Acid Chloroacetyl p} Amixed} Amixed} Amiobenzoic acid hydrochloride.
Cov tshuaj tiv thaiv cov tshuaj tiv thaiv muaj raws li nram no:
Clch2ch2oco - kabla- {{→ procaine hydrochloride + ethanol
Tag nrho cov txheej txheem ntawm synthesis cov tshuaj tiv thaiv yog qhia tau raws li hauv qab no:
Paba + hno3 → ponba + h2o
Ponba + H2 → Pama + H2O
Paama + clch2chocoCoCoCoch3ch3 → clch2choco {}} kaba {{8} }coch2ch3
Clch2ch2oco - kabla- {{→ procaine hydrochloride + ethanol
NTSHIM PLIGHE HMOOVyog ib qho ntawm cov tshuaj loog hauv cheeb tsam uas muaj tsawg dua kev lom zem. Cov nyhuv tuaj yeem txhawb nqa rau 30 - 45 feeb tom qab kev txhaj tshuaj 1-3 feeb tom qab lub sij hawm tu tau los ntawm 20% nrog ntxiv ntawm epinephrine. Nws tuaj yeem yog hydrolyzed los ntawm esterase nyob rau hauv ntshav thiab hloov mus rau p-aminobenzoic acid (kaba) thiab diethylaminoethanol. Tus qub tuaj yeem tiv thaiv cov tshuaj tua kab mob ntawm Sulfonamides, yog li nws yuav tsum zam kev siv ua ke nrog sulfonamides. Cuav tsis tuaj yeem siv rau kev kaw hauv zos ntawm lub xaib ntawm kev raug mob. Kev siv ntau dhau heev tuaj yeem ua rau nruab nrab ntawm cov hlab ntsha thiab cov hlab ntsha cov kev mob plawv. Qee zaum tuaj yeem ua kom haum rau cov tawv nqaij ua ntej kuaj ua ntej daim tawv nqaij ua ntej, tab sis kev sim tawv nqaij tsis zoo. Cov uas ua xua rau cov tshuaj no tuaj yeem siv cloprocaine thiab liidocaine hloov.
Cov tshuaj loog hauv zos
Cov Txheej Txheem Kho Mob: Proppaine yog feem ntau ua haujlwm los muab tshuaj loog hauv zos, zoo kawg ntawm lub vev xaib phais thiab txo tus neeg mob tsis xis nyob. Nws tuaj yeem muab tshuaj rau kev nkag siab rau tshuaj loog, cov tshuaj loog ntawm tus loog (epidaciaid), thiab lwm yam kev ua yeeb yam hauv cheeb tsam.
Kev Kho Hniav: Hauv tsev kho hniav, procaine siv rau kev tshuaj loog hauv zos thaum lub sij hawm txhuam hniav, thiab lwm yam kev phais hniav, tso cai rau kev kho mob {} Kev kho mob dawb.
Qhov muag phais: Nws tseem pom cov ntawv thov hauv Ophthalmology, qhov twg nws tuaj yeem ua kom lub ntsej muag lub qhov muag pom thaum lub sijhawm phais.
Kev tswj hwm qhov mob
Cov thaiv cov pob zeb: Proppaine tuaj yeem siv rau hauv cov hlab ntsha kom tswj cov mob ntev, xws li cov uas cuam tshuam nrog mob qog noj ntshav, thiab lwm yam mob neuropathic mob.
Postoperative mob nyem: Nws kuj tseem tuaj yeem tswj cov postoperatively los muab tshuaj mob ntawm qhov chaw phais mob.
Kho cov siv dhau kev ua yeeb yam
Kev kho mob ntawm qee yam mob: Proppaine tau siv nyob rau hauv kev kho mob ntawm ntau yam kev kho mob, suav nrog tab sis tsis txwv rau tus neeg mob qog ntshav (hem kom ntshav), thiab lub raum (raum pob zeb mob). Txawm li cas los xij, cov ntawv thov no tsis tshua muaj thiab tej zaum yuav xav tau kev qhia txog kev qhia thiab kev kho mob.
Neuropychiatric tsis zoo: Hauv qee kis, tsis tshua muaj tshuaj ntawm procaine tau tshawb nrhiav rau lawv cov peev xwm kho tau rau neuropychiatric tsis zoo thiab yuav tsum tau txais kev tshawb fawb no.
Sib sau ua qauv
Procaine penicillin: Proppaine tau sib xyaw ua ke nrog penicillin los ua cov penifice penicillin, uas yog muab tshuaj rau kev kho mob los ntawm penicillin - rhe artgisms. Daim qauv no tso cai rau kev tso tawm lub sijhawm ntev ntawm cov kab mob penicillin, txo qhov zaus ntawm kev txhaj tshuaj.
Compound formulations: Page Xaa kuj tseem yuav ua ke nrog lwm cov tshuaj, xws li cov tshuaj bromide thiab cov khoom siv hluav taws xob (piv txwv li siv rau kev kho mob ntawm xeev siab thiab ntuav los ntawm ntau yam kev mob.
Crystal Qauv
Cov tub rog monoclinic crystal system crystal, qhov chaw xov tooj yog p21, lub cell parameter yog ib tug {}} ∨ ∨ ∨, {} {}}}}}}}}}}}}}}}}}}}}}}}} degree. Molaine molecules tshwm sim raws li lub semisted semi ellipipical puab thiab tsim cov qauv roj av uas tsis xwm txheej. Cov qauv siv lead ua yog tsim ntawm cov qauv dej thiab cov qauv siv lead ua ib puag ncig ntawm cov qauv siv nyiaj tsis kawg ntawm cov molecules.
Crystallography Cov yam ntxwv
Cov tsos ntawm crystallineNTSHIM PLIGHE HMOOVzoo nkaus li dawb lossis yuav luag dawb los yog yuav luag cov hmoov dawb nrog lub ntom ntom ntawm 1.07 g / cm, melting point yog 61 degree, nrog kev muaj pes tsawg lub thermal ruaj khov. Nyob rau hauv ib puag ncig huab cua, cov txheeb ze cov av noo ntawm procaine yuav nce, ua kom muaj kev txhim kho hydrophobic tshuaj thiab yog li ntawd muaj qhov ruaj khov.
Crystal Topology
Tus qauv siv lead ua ke yog ib qho piv txwv ntawm cov qauv tshuaj lom zem nanoparticle (DCN) Crystal qauv. Lub ntsiab hydrogen kev sib txuas lus hauv tus qauv procaine tsim ob kab cov kab txuas sib txuas, nrog txhua saw txuas nrog plaub txoj sia. Lwm cov kev sib tham hydrogening sib cuam tshuam ntawm cov saw hlau thiab tom kawg ntawm cov saw, nrog qee cov molecules txuas rau lwm txoj saw hlau los ntawm kev ua cov hlua khau ntawm ob txoj saw hlau. Qhov muaj txiaj ntsig ntawm cov qauv siv lead ua ke yog cov kev sib xyaw ntawm cov qauv ntawm cov qauv tshuaj nanoparticles, uas yog cov grids tsim los ntawm molecules thiab pawg me.
Lattice tas li
Lub lattice tas li yog {=9.64 Å, b {{{{{{{{{{{{}} degree. Lub xub ntiag ntawm cov kab ke hydrogen hauv lub lattice ntawm cov molaine molecules tau tshwm sim hauv cov khoom muaj txiaj ntsig ntawm lub ntxaij. Qhov ceev ntawm cov huab hauv hluav taws xob cuam tshuam rau cov hydrogen bond cuam tshuam rau cov atomic txoj hauj lwm cuam tshuam thiab lattice tas li, ua rau kev hloov ntawm procaine lattice tas li.
Hauv daim duab ntev ntawm cov keeb kwm kev kho mob, qhov kev kov yeej ntawm tib neeg los ntawm tib neeg yog kev sib ntaus sib tua nyob mus ib txhis. Ntawm txoj kev taug kev los ntawm barbarism rau kev phais mob hauv kev phais, qhov tsim muaj ntawm cov tshuaj loog yog undoubtedly ib qho ntawm cov cim glorious tshaj plaws. Nyob rau hauv lub hnub qub hnub qub ntawm kev ua yeeb yam zoo nkauj hauv zos, procaine- Tias ntshiab dawb hmoov- yog zoo li lub hnub qub ci ntsa iab. Nws qhov kev tshawb nrhiav tsis yog qhib lub sijhawm tshiab ntawm kev ua kom zoo, tab sis kuj tau kho kho hniav kiag, kev kho hniav, thiab suav tias cov haujlwm kho mob thiab suav tau.
Xyoo 1884, Austrian Ophthalmologist Carl Koller qhov kev tshawb pom tau zoo li lub ntsia liaj qhov rooj ntawm qhov tsaus ntuj. Nws paub tseeb thawj zaug rau kev tshuaj loog hauv zos ntawm yeeb (alkaloids muab rho tawm los ntawm coca nplooj). Qhov kev tshawb pom no tau nrawm nrawm nrawm thoob ntiaj teb kev kho mob hauv zej zog, ua rau tsis muaj peev xwm ua tsis tau zoo. Cov kws kho hniav thiab cov kws kho hniav thaum kawg muaj tej yam yees siv uas tuaj yeem thaiv qhov mob hauv zos tsis ua rau cov neeg mob kom tsaug zog. Kohler li no los ua nto moo nyob rau hauv keeb kwm, thiab yeeb dawb sai sai los ua tus qauv kub rau kev tshuaj loog hauv cheeb tsam.
Germanist Alfred Einhorn tau ua tus yeej kawg. Nws tsis yog sib ntaus sib ceg ib leeg, tom qab nws lies lub chav haujlwm muaj hwj chim uas muaj hwj chim, nrog rau nws txoj kev sib koom tes nrog cov kws muag tshuaj heinrich Braun. Braunch nws tus kheej yog tus kws phais mob siab rau txhim kho cov tshuaj loog hauv zos, thiab nws muaj kev nkag siab tob txog ntawm cov yeeb yaj kiab.
Qhov tig tau tshwm sim hauv xyoo 1905. Tom qab yuav luag ib xyoo caum ntawm kev tshawb nrhiav tsis zoo, Eindhoven pawg synthesized ib qho tshiab. Raws li nws cov hluavtaws ua ntu zus, nws yuav pib tsuas yog sau npe ua ib tus lej. Cov qauv ntawm cov compound no yog qhov yooj yim heev thiab zoo nkauj: nws yog tsim los ntawm esterification ntawm p- aminobenzoic acid thiab diethylaminoThanol.
Nws lub npe tshuaj tag nrho yog 4 {{{-}}}}}}} (diethylamino) - ensyl ester. Tom qab ntawd, nws tau muab lub ntiaj teb -} lub npe nrov - procaine. Eindhoven thaum pib sau npe rau lub cim lag luam "Novocain", lub ntsiab lus "(yeeb tshuaj"
Cim npe nrov: Ntshuam Cov Hmoov Zoo Li 59-46-1, Tuam Tshoj Chaw Tsim Tshuaj, Hoobkas, lag luam Wholesale, Yuav, Nqe, loj, rau muag