Fluconazole Txhaj 100ml

Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm fluconazole txhaj 100ml hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo fluconazole txhaj 100ml rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.

Fluconazole txhaj tshuaj 100 mlyog ib qho tshuaj tua kab mob hauv cov tshuaj tua kab mob categorized rau hauv triazole derivatives, thiab nws cov tshuaj nquag muaj fluconazole muaj CAS No.86386-73-0 ua ke nrog cov mis mos molecular C₁₃H₁₂F₂N₆O. Cov tshuaj feem ntau tshwm sim raws li cov hmoov dawb crystalline hmoov uas muaj cov dej solubility zoo thiab cov khoom siv tshuaj ruaj khov nyob rau hauv kaw, qhuav thiab chav tsev kub cia, tsis txhob muaj cov txheej txheem decomposition los ntawm me me ambient fluctuation.

Nws lub ntsiab pharmacological mechanism tsom mus rau suppressing fungal cytochrome P450-nyob ntawm 14 -lanosterol demethylase, cuam tshuam qhov tseem ceeb ergosterol synthesis rau cell membrane tsim, tsa cov kab mob cell membrane permeability thiab nws thiaj li ua rau osmotic cell lysis ntawm pathogenic fungi. Cov tshuaj tiav no yog tsim los ntawm kev txhaj tshuaj tsis muaj tshuaj isotonic nrog qhov ruaj khov ntawm 2mg / mL, muag hauv ob qhov loj ntim ntim: 100mL specification loaded nrog 200mg fluconazole thiab 200mL specification uas muaj 400mg fluconazole. Clinically, nws yog tshwj xeeb yog sau rau cov neeg mob uas tsis muaj peev xwm ntawm qhov ncauj tshuaj los yog cov uas yuav tsum tau ceev ntshav cov tshuaj buildup kom mus txog rau theem kho tau zoo tiv thaiv invasive fungal kab mob.

Cov ntaub ntawv ntxiv ntawm chemical compound:

Peb cov khoom tsim

 

 

Fluconazole COA

Cov lus qhia rau kev kho mob: suav nrog qhov ncauj thiab pharyngeal candidiasis, esophageal candidiasis, cryptococcal meningitis, invasive candidemia, thiab disseminated candidiasis, tshwj xeeb tshaj yog tsim rau cov kab mob loj heev hauv cov neeg mob tiv thaiv kab mob (xws li cov neeg muaj kab mob HIV thiab cov pob txha hloov cov neeg tau txais kev kho mob). Cov neeg mob thiab cov neeg tau txais kev hloov pauv hauv nruab nrog cev tau txais kev kho mob los yog kev kho hluav taws xob.Qhov kev npaj no muaj txiaj ntsig zoo: kev tswj hwm cov hlab ntsha tuaj yeem hla txoj hnyuv plab, ua kom muaj bioavailability ze li ntawm 100% plasma protein binding tus nqi qis (11% -12%), muaj zog cov ntaub so ntswg nkag.

Cerebrospinal kua concentration tuaj yeem ncav cuag li 80% ntawm plasma, tshwj xeeb tshaj yog tsim rau hauv nruab nrab paj hlwb kab mob.Txawm li cas los xij, yuav tsum tau saib xyuas nws cov kev cuam tshuam nrog CYP3A4 / 2C9 substrates (xws li warfarin thiab phenytoin), uas tuaj yeem ua rau QT ncua ntev lossis los ntshav txaus, thiab yuav tsum tau saib xyuas kom zoo.Fluconazole txhaj tshuaj 100 ml, raws li tus neeg sawv cev ntawm fluorotriazole tshuaj tiv thaiv kab mob, tau dhau los ua ib qho kev xaiv tseem ceeb rau kev kho cov kab mob fungal ntawm daim tawv nqaij vim nws qhov dav -spectrum antibacterial kev ua, kev nkag mus rau cov ntaub so ntswg zoo, thiab txoj kev tswj xyuas yooj yim. Nws cov txheej txheem ntawm kev ua haujlwm yog xaiv los tiv thaiv biosynthesis ntawm ergosterol nyob rau hauv fungal cell membranes, cuam tshuam cov membrane kev ncaj ncees, thiab yog li exert bactericidal los yog bacteriostatic teebmeem.

Superficial kab mob fungal
Nws muaj zog inhibitory nyhuv ntawm cov kab mob pathogenic xws li Trichophyton rubrum, Trichophyton hwj txwv, thiab Trichophyton flocs, nrog rau Malassezia thiab Candida genera. Nws yog haum rau cov kab mob hauv qab no: Tinea corporis thiab tinea crus: ncig erythema thiab scaly ntawm daim tawv nqaij mob tshwm sim los ntawm dermatophytes. Flunazol tuaj yeem nkag mus rau hauv stratum corneum sai sai los ntawm qhov ncauj lossis hauv zos tswj hwm, inhibiting fungal metabolism.Tinea pedis: Rau erosive lossis vesicular hom tinea pedis ntawm cov ntiv taw, cov kev kho flunazol feem ntau yog 2-6 lub lis piam, uas tuaj yeem txo qhov rov tshwm sim.

Kev tshawb fawb tau pom tias txhua lub lim tiam 150mg qhov ncauj qhov ncauj muaj kev kho tus nqi ntawm 70% -85% rau onychomycosis, tshwj xeeb tshaj yog rau cov ntsia thawv kab mob.Tinea capitis: Hauv kev kho mob ntawm tinea capitis hauv cov menyuam yaus, flunazol tau noj tsis tu ncua ntawm ib hnub ntawm koob tshuaj 50-100mg rau 4-8 lub lis piam, uas tuaj yeem hloov kho cov kab mob ntawm daim siab gib. (Malassezia folliculitis): Flunazol inhibits lipase kev ua ntawm Malassezia, thaiv nws txoj hauv kev ntawm kev siv sebum rau kev yug me nyuam. Ib koob tshuaj ib zaug ntawm 150-300mg tuaj yeem ua tiav kev kho mob.
Cov kab mob sib sib zog nqus ntawm daim tawv nqaij fungal
Rau cov kab mob fungal sib sib zog nqus hauv cov neeg mob immunocompromised, flunazol tuaj yeem nkag mus rau hauv cov ntshav - lub hlwb teeb meem thiab daim tawv nqaij appendages, exerting ib tug systemic kho nyhuv.

Cov kab mob candidiasis ntev ntev: Kev siv ntev ntawm flunazol 50-100mg / hnub tuaj yeem tswj tau qhov mob ruaj khov thiab txo qhov rov tshwm sim.Chromogenic blastomycosis: Raws li kev siv tshuaj sib xyaw ua ke.Flunazol ua ke nrog amphotericin B lossis itraconazole tuaj yeem txhim kho kev ua tau zoo thiab txo qis kev kho mob ntev. 200-400mg / hnub ntawm qhov ncauj tuaj yeem tswj tau qhov kev loj hlob ntawm tus kab mob hauv cov neeg mob uas intolerant rau potassium iodide.

Kev tiv thaiv kab mob
Flunazol zoo tiv thaiv dermatophytes xws li Trichophyton rubrum thiab Trichophyton rubrum (cov kab mob tseem ceeb ntawm onychomycosis) thiab Candida genus.

Tab sis tsis muaj txiaj ntsig tawm tsam qee qhov tsis yog dermatophytes xws li Aspergillus genus. Kev tshawb fawb tau pom tias nws qhov kev kho mob tus nqi rau cov kab mob ntawm tus ntsia thawv fungal yog 76% -90%.

Kev sib piv ntawm cov teebmeem kev kho mob
Piv nrog terbinafine/itraconazole, flunazol muaj kev kho mob qis dua li terbinafine (85% -95% rau cov rau tes) thiab itraconazole (70% -80% rau kev kho mem tes), tab sis qis dua qhov tshwm sim tsis zoo (kwv yees li 10% vs. itraconazole%) 15%, 15%, rau cov neeg mob uas muaj mob me me mus rau nruab nrab onychomycosis, cov neeg uas tsis tuaj yeem zam tau lwm yam tshuaj, lossis cov uas xav tau kev kho mob mus ntev (xws li cov tshuaj tiv thaiv kab mob).

Dosing regimen ntawmFluconazole txhaj tshuaj 100 mlyuav tsum tau tsim raws li hom, qhov hnyav, thiab kev tiv thaiv kab mob ntawm tus neeg mob, nrog rau cov hauv paus ntsiab lus ntawm "cov nyiaj txaus, txaus kho lub sijhawm, thiab tus kheej".

1. Txuj kev kho mob rau cov kab mob fungal superficial

Tinea corporis / tinea pedis:
Kev tswj qhov ncauj: 150mg ib zaug (kev kho mob poob siab) lossis 50mg / hnub, nrog rau chav kawm ntawm 2-4 lub lis piam;
Localized: Kev sib xyaw cov tshuaj pleev ib ce azole (xws li clotrimazole) tuaj yeem txhim kho kev ua tau zoo thiab txo lub sijhawm kho.

Onychomycosis:
Nail kab mob: 150mg / lub lis piam rau 8 lub lis piam sib law liag;
Nail kab mob: 150mg / lub lis piam rau 12 lub lis piam sib law liag;
Kev sib xyaw ua ke ntawm cov tshuaj pleev ib ce ntawm 5% Amorofen ointment tuaj yeem ua rau tus nqi kho tau ntau dua 90%.

Tinea capitis:
Cov me nyuam: Kho cov koob tshuaj raws li lub cev hnyav (<20kg: 62.5mg/day; 20-40kg: 125mg/day; >40kg: 250mg / hnub), kho chav kawm 4-8 lub lis piam;
Cov neeg laus: 200-400mg / hnub, ua ke nrog cov tshuaj pleev ib ce ntawm sulfur ointment lossis ketoconazole detergent.

Kev kho tshuaj rau cov neeg tshwj xeeb

Immunosuppressed cov neeg mob-Cov tshuaj tiv thaiv: Kev tswj qhov ncauj ntawm 50-200mg ib hnub tom qab hloov lub cev tuaj yeem txo qhov kev pheej hmoo ntawm tus kab mob candidiasis nce mus txog 60%; Cov tshuaj kho mob: Rau cov neeg muaj kab mob HIV nrog qhov ncauj candidiasis, thawj koob tshuaj yog 20010mg ib hnub, ua raws li 7-10mg ib hnub. Hnub.Cov neeg uas muaj lub siab thiab lub raum tsis ua haujlwm-Mild siab raug mob (Child Pugh A): Tsis tas yuav tsum tau hloov koob tshuaj; Kev mob siab rau lub siab mob hnyav (Child Pugh B/C qib): koob tshuaj halved mus rau 50mg / hnub lossis ncua sijhawm ntxiv; Lub raum tsis txaus (CrCl<50mL/min): The oral dose remains unchanged, but blood drug concentration needs to be monitored.

Kev sib xyaw ua ke rau kev siv tshuaj - tiv thaiv kab mob

Rau Candida albicans lossis Candida albicans nrog txo rhiab heev rau flunazol, cov kev kho mob hauv qab no tuaj yeem siv:
Flunazol + Amphotericin B: Thaum kho chromoblastomycosis, kev txhaj tshuaj ntawm Amphotericin B 0.5-1mg / kg / hnub yog muab rau 1-2 lub lis piam, tom qab ntawd los ntawm qhov ncauj flunazol 200mg / hnub txhawm rau kho.
Flunazol + Terbinafine: Rau onychomycosis, flunazol 150mg / lub lis piam ua ke nrog Terbinafine 250mg / hnub rau 12 lub lis piam tuaj yeem txhim kho qhov kev kho mob rau 85%.

Lub koom haum penetrability thiab pharmacokinetic zog

Flunazol muaj ob tus yam ntxwv ntawm cov dej solubility siab thiab lipid solubility, nrog rau qhov ncauj nqus ntawm ntau dua 90%, thiab nws cov bioavailability tsis cuam tshuam los ntawm cov khoom noj. Nws cov protein khi tus nqi qis (11% -12%), thiab nws tuaj yeem muab faib rau hauv daim tawv nqaij, rau tes, kua cerebrospinal, thiab cov ntaub so ntswg prostate. Nws tuav cov tshuaj ntshav ruaj khov rau lub sijhawm ntev (ib nrab-lub neej ntawm 30 teev) thiab txhawb nqa kev noj tshuaj txhua lub lim tiam.

Kev tswj tus nqi rov muaj dua thiab ntev - ua haujlwm tau zoo

Onychomycosis: Ib qho meta- kev tshuaj ntsuam nrog 1200 tus neeg mob tau pom tias tom qab 12 lub lis piam ntawm kev kho flunazol, qhov kev kho mob tau mus txog 78%, fungal clearance tus nqi yog 82%, thiab 1-xyoo rov tshwm sim tus nqi tsuas yog 15%.

Qhov tseem ceeb qis dua li ntawm oxytetracycline (35%) thiab itraconazole pulse therapy (25%).Recurrent vaginal candidiasis: Flunazol 150mg ib lub lim tiam rau 6 lub hlis sib law liag ntawm kev kho mob tuaj yeem txo tus nqi ib xyoo - rov tshwm sim ntawm 60% mus rau 10%.

Txhim kho kev ua raws li tus neeg mob

Piv nrog rau cov tshuaj pleev ib ce uas xav tau ntau koob tshuaj txhua hnub lossis kev txhaj tshuaj ntawm amphotericin B, qhov ncauj flunazol formulations (cov ntsiav tshuaj / capsules) thiab kev kho tib lub mem tes ua rau cov neeg mob ua raws. Kev tshawb fawb qhia tau hais tias cov neeg mob uas siv cov tshuaj flunazol txhua lub lim tiam muaj kev kho tiav ntawm 92%, thaum noj tshuaj txhua hnub tsuas yog 65%.

Txawm tiasFluconazole txhaj tshuaj 100 mlmuaj kev nyab xeeb zoo tag nrho, cov kev pheej hmoo hauv qab no tseem yuav tsum tau xav txog:

Kev tshuaj xyuas lub siab toxicity

Risk population: patients with long-term medication (>3 lub hlis), kev siv statins los yog tshuaj tiv thaiv kab mob, thiab ua ntej - kab mob siab.
Cov ntsuas ntsuas: ALT, AST, ALP, thiab bilirubin yuav tsum raug kuaj ua ntej kho thiab txhua hli. Yog tias ALT nce mus rau ntau tshaj peb npaug ntawm qhov txwv siab tshaj ntawm ib txwm, cov tshuaj yuav tsum raug ncua thiab kev tiv thaiv daim siab yuav tsum tau muab.

Kev tswj kev sib tshuam ntawm cov ntaub pua plag

Anticoagulants: Flunazol tuaj yeem cuam tshuam CYP2C9 enzyme, ua rau 20% -50% nce hauv warfarin ntshav concentration. INR qhov tseem ceeb yuav tsum tau saib xyuas thiab hloov kho ntau npaum li cas.Immunosuppressants: Thaum siv nrog cyclosporine, flunazol tuaj yeem ua rau cov ntshav siab ntawm cyclosporine los ntawm 50% -100%, thiab cov koob tshuaj cyclosporine yuav tsum txo qis rau 50% -70% ntawm thawj koob tshuaj.
Cov tshuaj tiv thaiv kab mob: Flunazol tuaj yeem cuam tshuam cov metabolism ntawm phenytoin sodium, ua rau muaj kev cuam tshuam rau neurotoxicity (xws li ataxia thiab tshee). Nws yog ib qho tsim nyog yuav tsum tau txo qhov koob tshuaj phenytoin sodium thiab saib xyuas cov ntshav tshuaj concentration.

Sun YQ, Hu J, Huang H, et al. Kev kho mob zoo ntawm Fluconazola intravenous rau invasive candidiasis nyob rau hauv hematopoietic qia cell transplants [J]. Kev Txhais Lus Kev Tshawb Fawb, 2020, 9(11): 6900-6911.(Cov ntaub ntawv txawv teb chaws)

Li RY, Xu Y C. Pharmacological yam ntxwv thiab kev soj ntsuam daim ntawv thov specification ntawm Fluconazola sterile txhaj nyob rau hauv kev kho mob sib sib zog nqus mycosis nyob rau hauv immunocompromised cov neeg mob[J]. Suav Journal of Mycology, 2019, 14(3): 158-163.(Suav cov ntaub ntawv)

Dayo B, Silva C. Crystal qauv thiab solubility optimization kev tshawb fawb ntawm bulk Fluconazola raw khoom rau txhaj tshuaj [J]. Crystal Loj hlob & Tsim, 2019, 19(2): 1245-1253.(Cov ntaub ntawv txawv teb chaws)

Fluconazole (https://www.ncbi.nlm.nih.gov/books/NBK537158/#:~:text=Fluconazole%20is%20a%20member%20o f% 20the% 20triazole% 20family% 20and% 20a, disseminated% 20candidiasis% 2C% 20 pneumonia% 2C% 20and% 20cryptococcal)

Synergistic Antifungal teebmeem ntawm Honokiol thiab Fluconazole tawm tsam qhov ncaujCandida: Qhov cuam tshuam rau Kev Tswj Tshuaj Tiv Thaiv Kab Mob (https://pmc.ncbi.nlm.nih.gov/articles/PMC12853974/)

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