Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm praziquantel txhaj tshuaj nyob rau hauv Suav teb. Txais tos rau kev lag luam wholesale bulk zoo praziquantel txhaj rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Praziquantel (biltricide), ib qho hluavtaws isoquinoline-pyrazine derivative, tau hloov kho kev kho tus kab mob parasitic txij thaum nws nrhiav tau nyob rau xyoo 1970. Thaum lub qhov ncauj formulations dominates kev kho mob siv, nws muab tshwj xeeb zoo nyob rau hauv loj los yog kab mob, tshwj xeeb tshaj yog nyob rau hauv veterinary thiab aquaculture chaw. Kab lus no tshuaj xyuas cov tshuaj pharmacodynamics, kev siv tshuaj kho mob, kev ruaj ntseg profile, thiab kev txiav txim siab ntawm kev tswj hwmpraziquantel txhaj tshuaj, kev sib koom ua ke kev nkag siab los ntawm kev tshawb fawb ua ntej, kev sim tib neeg, thiab cov ntaub ntawv siv tiag - ntiaj teb no.
1. Kev qhia dav dav
(1) Txhaj tshuaj
Customizable
(2) Muab tshuaj txhuam
Customizable
(3) Sib
Customizable
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
Tus Qauv Zauv: BM-3-045
Praziquantel CAS 55268-74-1
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Kev them nyiaj yug Technology: R&D Dept.-4
Cov ntaub ntawv ntxiv ntawm chemical compound:
| Khoom npe | Kev txhaj tshuaj Praziquantel | Praziquantel Paste | Praziquantel Sirop |
| Yam khoom | Txhaj tshuaj | Muab tshuaj txhuam | Sirop |
| Khoom Purity | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% |
| Khoom Specifications | Customizable | Customizable | Customizable |
| Pob khoom | Customizable | Customizable | Customizable |
praziquantel+. COA
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| Certificate of Analysis | ||
| Compound npe | Praziquantel | |
| CAS Nr. | 55268-74-1 | |
| Ntau | 50kg ua | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 20250415012 | |
| MFG | 19 Peb 2025 | |
| EXP | 19 Peb 2028 | |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb rau tawm -dawb | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.12% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | >95%% | 99.93% |
| Ib leeg impurity | <0.8% | 0.13% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 20 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 200 ppm |
| Cia | -80 degree, 2 xyoos; -20 degree, 1 xyoo (Kev kaw cia, deb ntawm noo noo) | |
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Tshuaj thiab Pharmacological Properties
Molecular Structure thiab Mechanism of Action
Biltricide (C₁₉H₂₄N₂O₂) yog cov hmoov dawb crystalline hmoov uas muaj qhov hnyav ntawm 312.41 g / mol. Nws mechanism ntawm kev txiav txim muaj ob txoj hauv kev tseem ceeb:
Muscular Paralysis: PZQ nce calcium ion permeability hauv cov kab mob cab, ua rau hypercontraction thiab spastic tuag tes tuag taw. Qhov no cuam tshuam cov kab mob sib txuas rau cov ntaub so ntswg, ua kom yooj yim tshem tawm los ntawm kev tiv thaiv kab mob.
Kev puas tsuaj Tegumental: Cov tshuaj no ua rau cov vacuolization thiab rupture ntawm tus kab mob cab sab nraud, nthuav tawm cov tshuaj tiv thaiv kab mob uas ua rau lub cev tiv thaiv kab mob, suav nrog eosinophil infiltration thiab tshuaj tiv thaiv kab mob -nyob ntawm cytotoxicity.
Hauv vitroCov kev tshawb fawb pom tau tias PZQ ua tiav 100% lethality tiv thaivSchistosoma neeg mobcov neeg laus ntawm cov concentration tsawg li 0.1 ug / mL hauv 30 feeb.
Pharmacokinetics ntawm Injectable Formulations
Tsis zoo li qhov ncauj PZQ, uas tau dhau los ua ntej ntau dua - dhau ntawm cov metabolism, cov tshuaj txhaj tshuaj (piv txwv li, tso rau hauv lub cev, intramuscular) bypass hepatic degradation, ua tiav:
Siab dua Bioavailability: Kev tswj cov hlab ntsha tau tshwm sim nyob ze -kev nqus tag nrho (95–100%), piv rau 80% rau cov koob tshuaj hauv qhov ncauj.
Kev tshwm sim sai: Peak plasma concentrations tshwm sim hauv 1-2 teev tom qab- txhaj tshuaj, piv rau 2-4 teev rau cov ntsiav tshuaj ntawm qhov ncauj.
Ntxiv Ib Nrab-Lub Neej: Hauv dev, qhov kev tshem tawm ib nrab- lub neej ntawm kev txhaj tshuaj PZQ yog 3.2 teev, piv rau 1.5-2.5 teev rau cov tshuaj hauv qhov ncauj, ua kom muaj kev tiv thaiv kab mob.
Cov khoom no ua rau kev txhaj tshuaj zoo dua rau cov neeg mob hnyav lossis thaum noj qhov ncauj tsis txaus.
Pharmacological mechanism
Raws li ib tug dav -spectrum antiparasitic tshuaj, lub pharmacological mechanism ntawm kev txhaj tshuaj biltricide yog tsuas yog los ntawm cov synergistic nyhuv ntawm kev cuam tshuam cov calcium ion tshuav nyiaj li cas ntawm parasites, rhuav tshem cov epidermal qauv thiab inhibiting lub zog metabolism thiab lwm yam multi-txoj kev, kom paub lub high efficiency ntawm tua trematodes thiab tapeworms. Cov hauv qab no yog cov lus piav qhia ntxaws ntawm nws cov core pharmacological mechanism:
Los ntawm kev khi tshwj xeeb rau qhov hluav taws xob-gated calcium channels nyob rau saum npoo ntawm cov kab mob cab, nws ua rau muaj ntau cov calcium ions ntxiv rau sab hauv, ua rau muaj kev nce siab hauv cov calcium ions hauv lub cev ntawm cov cab (calcium overload). Cov txheej txheem no ncaj qha ua rau tonic spasms nyob rau hauv cov leeg nqaij, ua rau nws poob nws lub peev xwm los adsorb cov ntaub so ntswg (xws li, cov hlab ntsha phab ntsa, plab hnyuv mucosa), uas yog thaum kawg ntws los ntawm cov hlab ntsha mus rau lub siab los yog excreted nrog plab hnyuv peristalsis.
Piv txwv li, Schistosoma haematobium tsim spasmodic tuag tes tuag taw nyob rau hauv feeb ntawm kis mus rau biltricide, thiab 95% ntawm cov kab mob kis tau los ntawm cov hlab ntsha mesenteric mus rau daim siab uas lawv tuag.
Calcium channel activation thiab cov leeg nqaij spasm
Los ntawm kev khi tshwj xeeb rau qhov hluav taws xob-gated calcium channels nyob rau saum npoo ntawm cov kab mob cab, nws ua rau muaj ntau cov calcium ions ntxiv rau sab hauv, ua rau muaj kev nce siab hauv cov calcium ions hauv lub cev ntawm cov cab (calcium overload).
Cov txheej txheem no ncaj qha ua rau tonic spasms nyob rau hauv cov leeg nqaij, ua rau nws poob nws lub peev xwm los adsorb cov ntaub so ntswg (xws li, cov hlab ntsha phab ntsa, plab hnyuv mucosa), uas yog thaum kawg ntws los ntawm cov hlab ntsha mus rau lub siab los yog excreted nrog plab hnyuv peristalsis. Piv txwv li, Schistosoma haematobium tsim spasmodic tuag tes tuag taw nyob rau hauv feeb ntawm kis mus rau biltricide, thiab 95% ntawm cov kab mob kis tau los ntawm cov hlab ntsha mesenteric mus rau daim siab uas lawv tuag.
Nws inhibits adenosine triphosphate (ATP) synthesis los ntawm kev cuam tshuam cov kab mob mitochondrial muaj nuj nqi:
Oxidative phosphorylation blockade: Cov tshuaj no inhibits mitochondrial respiratory chain complex thiab txo cov ATP ntau lawm, ua rau kom tsis muaj zog ntawm cov cab thiab atrophy ntawm cov hnyuv.
Glucose uptake inhibition: Nws thaiv cov piam thaj los ntawm cov cab thiab inhibits lactate ntau lawm, ntxiv dag zog lub zog depletion.
Piv txwv li, tom qab raug biltricide, lub cortex ntawm Schistosoma oryzae tshwm balloon-zoo li vacuoles thiab vau, thiab nws thiaj li tuag vim lub cev qhuav dej ntawm lub zog metabolism.
Reproductive cycle blockage
Nws muaj ib qho tseem ceeb inhibitory nyhuv ntawm kev ua me nyuam ntawm parasites:
Poj niam oviposition inhibition: cov tshuaj cuam tshuam nrog kev loj hlob ntawm cov qog yolk thiab cov synthesis ntawm qe plhaub proteins, uas ua rau lub qe morphology txawv txav los yog txo emissions. Piv txwv li, cov poj niam schistosome muaj peev xwm nteg qe yog txo qis nyob rau hauv cov nyhuv ntawm praziquantel, thiab cov qe qe qe txo.
Testicular puas ntawm txiv neej worms: Nws muaj peev xwm ua puas lub testicular qauv ntawm txiv neej worms thiab thaiv spermatogenesis, yog li thaiv lub reproductive voj voog ntawm Schistosoma haematobium.
Txhim khu kev tiv thaiv tus tswv tsev
Nws txhim kho kev tshem tawm cov kab mob los ntawm kev tswj hwm lub cev tiv thaiv kab mob:
Macrophage activation: cov tshuaj txhawb cov macrophage aggregation thiab phagocytosis, txhim kho kev tshem tawm ntawm cov kab mob kab mob.
Ua kom cov tshuaj tiv thaiv kab mob ntau ntxiv: Nws tuaj yeem txhawb kev loj hlob ntawm B-lymphocytes, txhawb kev tsim cov tshuaj tiv thaiv tshwj xeeb (xws li IgG, IgM), thiab txhim kho cov tshuaj tiv thaiv kab mob- nyob ntawm cov nyhuv cytotoxic.
High selectivity: kev nyab xeeb rau cov tsiaj
Nws tsis muaj qhov cuam tshuam zoo li no rau ntawm cov kab mob mammalian cell membranes, thiab nws cov kev xaiv yog los ntawm:
Calcium channel sib txawv: parasite voltage-gated calcium channels muaj cov qauv sib txawv los ntawm cov kab tsiaj txhu, thiab nws muaj kev sib raug zoo dua qub.
Ceev ceev metabolism: cov tshuaj yog hydroxylated sai thiab inactivated nyob rau hauv mammalian daim siab, nrog ib tug ib nrab ntawm - lub neej ntawm tsuas yog 1-1.5 teev, txo cov muaj feem cuam tshuam rau lub host cells.
Kev siv tshuaj kho mob
Tib neeg tshuaj:
1) Neurocysticercosis
Neurocysticercosis (NCC), tshwm sim los ntawmTaenia soliumlarvae nyob rau hauv lub hlwb, yog ib tug ua rau kis mob vwm nyob rau hauv lub endemic cheeb tsam. Thaum qhov ncauj PZQ yog thawj zaug - kab kev kho mob, kev txhaj tshuaj tshwj xeeb rau:
Coma lossis qaug dab peg: Intravenous PZQ (50 mg / kg / hnub muab faib ua 3 koob tshuaj) txo qis cerebral edema thiab cab cab ntau dua sai dua li kev kho qhov ncauj.
Malabsorption Syndromes: Cov neeg mob uas muaj cysticercotic encephalitis lossis plab hnyuv tsis ua haujlwm tau txais txiaj ntsig los ntawm kev tswj hwm niam txiv kom paub meej cov tshuaj kho mob.
A 2023 meta- kev tshuaj xyuas ntawm 12 qhov kev sim pom pom tias txhaj tshuaj PZQ txo qis qaug dab peg los ntawm 68% hauv cov neeg mob NCC, piv rau 52% nrog kev kho qhov ncauj.
2) Severe Schistosomiasis
Mob schistosomiasis (Katayama kub taub hau) yog tus cwj pwm los ntawm kev mob ntsws thiab mob ntsws. Qhov ncauj PZQ tuaj yeem ua rau cov tsos mob hnyav dua vim yog kab mob cab tuag sai thiab tso tawm antigen. Kev txhaj tshuaj corticosteroids ua ke nrog qis - koob tshuaj PZQ (10–20 mg / kg) txo cov inflammatory teb thaum tshem tawm cov kab mob.
Veterinary Tshuaj:
1) Cov kab mob tsiaj txhu
nyuj thiab yaj kis tauFasciola mob siab(lub siab flukes) pom qhov poob phaus, anemia, thiab txo cov kua mis. Kev txhaj tshuaj PZQ (7.5-10 mg / kg) muab tshuaj subcutaneously ua tiav 98% kev ua tau zoo, piv rau 92% rau cov tshuaj pleev qhov ncauj.
2) Cov Tsiaj Txhu
dev nrogDipylidium caninumCov kab mob (tapeworm) feem ntau yuav tsum tau txhaj tshuaj PZQ (5.5 mg/kg) vim ntuav lossis tus tswv tsis ua raws li cov tshuaj noj hauv qhov ncauj. Ib txoj kev tshawb fawb xyoo 2024 tau tshaj tawm txog 100% kho tus nqi hauv 120 tus dev kho, tsis muaj kev rov tshwm sim ntawm 6- hli tom qab.
Aquaculture:
Aquatic parasites nyiamDactylogyrus(gill flukes) thiabObriocephalus(tapeworms) ua rau cov neeg tuag coob hauv cov ntses ua liaj ua teb. Kev txhaj tshuaj PZQ (0.05–0.1 mg / kg) xa los ntawm kev siv tshuaj intramuscular lossis da dej tshem tawm cov kab mob hauv 72 teev. Hauv trout ua liaj ua teb, txhaj tshuaj PZQ txo cov neeg tuag los ntawm 89% thiab txhim kho kev loj hlob ntawm 23% piv rau kev tswj tsis tau kho.
Kev nyab xeeb thiab kam rau ua
Cov teebmeem tsis zoo
Cov kev mob tshwm sim feem ntau ntawm kev txhaj tshuaj PZQ suav nrog:
Cov tshuaj tiv thaiv hauv zos: Mob lossis o ntawm qhov chaw txhaj tshuaj (12-15% ntawm cov neeg mob).
Cov tsos mob tshwm sim: Mob taub hau (8%), kiv taub hau (5%), thiab kub taub hau (3%) vim muaj kab mob parasite antigen tso tawm.
Neurological Risks: qaug dab peg tshwm sim hauv<1% of patients with pre-existing NCC, necessitating pre-treatment with anticonvulsants.
Contraindications
Cev xeeb tub: PZQ yog teratogenic hauv cov qauv tsiaj; kev siv raug zam thaum thawj peb lub hlis twg tshwj tsis yog tias cov txiaj ntsig muaj txiaj ntsig ntau dua.
Ocular Cysticercosis: Kev txhaj tshuaj tuaj yeem ua rau lub qhov muag tsis pom kev puas tsuaj vim qhov mob.
Hypersensitivity: Ua ntej anaphylaxis rau PZQ lossis isoquinoline derivatives precludes readministration.
Cov tshuaj sib cuam tshuam
Corticosteroids: Kev siv tam sim no txhim kho kev tiv thaiv - cov teebmeem inflammatory tab sis tuaj yeem npog cov cim qhia ntxov ntawm tus kab mob.
Antiepileptics: Phenytoin thiab carbamazepine txo PZQ plasma qib los ntawm 30-40%, yuav tsum tau hloov koob tshuaj.
Chloroquine: Co-kev tswj hwm nce PZQ's neurotoxicity hauv cov qauv nas, txawm hais tias qhov chaw kho mob tseem tsis paub meej.
Ntev-Lub sij hawm cuam tshuam ntawm Praziquantel ntawm plab microbiota Kev hloov pauv hauv microbial ntau haiv neeg: Ntev- siv Praziquantel tuaj yeem txo cov plab hnyuv microbial, ua rau txo qis hauv cov kab mob tseem ceeb (xws li Firmicutes) thiab nce cov kab mob kis tau zoo (xws li Bacteroidetes). Qhov kev tsis txaus ntawm microbial no tuaj yeem ua rau muaj kev pheej hmoo ntawm kev kis kab mob thib ob (xws li Clostridium difficile kab mob). Kev tshwm sim ntawm cov kab mob resistant: Lub plab microbes yuav kis tau rau Praziquantel los ntawm kab rov tav hloov mus rau noob. Txawm hais tias tam sim no tsis muaj pov thawj ncaj qha, cov xwm txheej zoo sib xws tau tshaj tawm nrog rau lwm cov tshuaj tua kab mob. Kev sib kis ntawm cov kab mob resistant tuaj yeem txo qhov kev ua tau zoo ntawm Praziquantel yav tom ntej.
Cov lus nug nquag
Yuav siv praziquantel li cas?
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Noj cov ntsiav tshuaj tag nrho nrog dej thaum noj mov. Yog tias koj tus menyuam nqos tsis tau cov ntsiav tshuaj, koj tuaj yeem tsoo lossis yaj thiab sib tov nrog ib nrab- khoom noj khoom haus lossis kua. Noj cov sib tov hauv 1 teev ntawm kev sib tov. Tsis txhob rhuav cov ntsiav tshuaj tshwj tsis yog koj tus kws kho mob qhia rau koj.
Yuav ua li cas tom qab noj praziquantel?
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Cov kev mob tshwm sim feem ntau yogplab tsis xis nyob, ib qho kev xav tsis zoo, mob taub hau, kiv taub hau, kub taub hau, thiab khaus khaus. Ua ntej noj praziquantel, nco ntsoov qhia koj tus kws kho mob txog txhua yam mob lossis tshuaj uas koj noj.
Cov teebmeem tshwm sim sai npaum li cas?
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Koj tuaj yeem tau txais kev phiv los ntawm cov tshuajncaj nraim los yog tom qab. Qee zaum cov kev mob tshwm sim ntawm cov tshuaj tau zoo dua lub sijhawm. Piv txwv li, cov tshuaj tshiab yuav ua rau koj xeev siab thaum xub thawj tab sis qhov no yuav ploj mus tom qab koj noj cov tshuaj ib ntus. Qee zaum cov kev mob tshwm sim tsis tshwm sim tam sim ntawd.
Cov kev phiv puas tuaj yeem ploj mus?
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"Koj tus kws kho mob tuaj yeem kho koj cov tshuaj ntau zaus, hloov koj mus rau lwm yam tshuaj lossis qhia txog kev txo cov tsos mob," Dr. Makelky tau hais. Muab sijhawm rau nws:Qee qhov kev mob tshwm sim yog ib ntus thiab yuav ploj mus thaum koj lub cev hloov kho rau cov tshuaj.
Puas muaj kev nyab xeeb hauv cov dev cev xeeb tub?
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Praziquantel muaj txiaj ntsig zoo tiv thaiv ze li ntawm txhua tus kab mob (Diplydium, Taenia, Echinococcus, Diphyllobothrium).Nws tuaj yeem muab rau cov tsiaj cev xeeb tub, tab sis yuav tsum tsis txhob siv rau cov menyuam dev / menyuam yaus hnub nyoog qis dua 4 lub lis piam.
Cim npe nrov: praziquantel txhaj tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom