Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm pinealon txhaj tshuaj hauv Suav teb. Txais tos rau kev lag luam wholesale bulk zoo pinealon txhaj rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Pinealon txhaj tshuajyog ib qho tshwj xeeb EDR tripeptide lom regulator. Tsis zoo li feem ntau cov tshuaj peptide uas tsuas yog khi rau ntawm tes -nto receptors, nws muaj peev xwm nkag mus rau ob lub cell membranes thiab nuclear membranes ncaj qha rau lub hom phiaj thiab tswj cov noob qhia. Nws yog kev tshawb fawb - qib kev npaj tshwj xeeb uas tsim los kho cov paj hlwb thiab cellular anti-aging.Nws cov yam ntxwv tseem ceeb nyob rau hauv exerting los ntawm lub hauv paus genetic thiab cellular theem. Nws upregulates cov kev qhia ntawm neuroprotective proteins thiab antioxidant enzymes, inhibits neuronal apoptosis, tshem tawm reactive oxygen hom nyob rau hauv lub hlwb, thiab alleviates oxidative kev nyuaj siab nrog rau hypoxic puas. Qhov txawv ntawm luv luv - ua yeeb yam stimulant formulations, cov khoom muab gradual thiab cumulatively txhim khu kev ua tau zoo.
Peb Cov Khoom Muag Khoom
Pinealon COA
 |
||
| Certificate of Analysis | ||
| Compound npe | Pinealon | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 175175-23-2 | |
| Ntau | 41g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090056 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
|
|
| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.31% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.62% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.80% |
| Ib qho impurity | <0.8% | 0.44% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 209 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 5 12 ppm |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree | |
|
|
||
Mechanism ntawm Action
Pinealon txhaj tshuajyog ib qho hluavtaws tripeptide (glutamic acid-aspartic acid-arginine). Nws daim ntawv txhaj tshuaj sai hla cov ntshav-hlwb teeb meem, nrog rau cov txheej txheem tseem ceeb ntawm peb qhov loj: kev tswj cov noob, tshuaj tiv thaiv kab mob, tiv thaiv -apoptosis, thiab tiv thaiv mitochondrial. Ua ntej, nws cov qauv me me nkag mus rau hauv daim nyias nyias thiab ncaj qha khi rau DNA los tswj cov kev qhia ntawm neuroprotective 3, AT thiab AT rel. inhibits qhov txawv txav ERK1/2 ua kom, thiab thaiv oxidative kev nyuaj siab signaling txoj kev.
Thib ob, nws tau txais txiaj ntsig zoo ROS, inhibits lipid peroxidation, txo H₂O₂- thiab hyperhomocysteineemia-induced oxidative puas rau neurons, thiab tswj cov cell membrane kev ncaj ncees.Third, nws downregulates pro-apoptotic proteins (Bax){2}proteining (Bax) thiab upregulates Lub mitochondrial apoptotic txoj kev thiab txo qhov tshwm sim ntawm tus kab mob neuronal tuag.Fourth, nws optimizes mitochondrial zog metabolism, txhim kho ATP synthesis efficiency, txhim khu lub zog mov rau neurons, thiab tswj calcium homeostasis los tiv thaiv calcium overload raug mob. Tsis tas li ntawd, nws modulates pineal gland muaj nuj nqi, txhawb kev sib txuas ntawm cov yas melatonin.
Cov ntaub ntawv qhov chaw: MedChemExpress Pinealon Datasheet (2023), Extension Health Peptide Research Report (2025).
Daim ntawv thov hauv Cov Kab Mob Neurodegenerative
Alzheimer's Disease (AD): Ntau -Lub Hom Phiaj Thaiv ntawm Pathological Progression thiab qeeb kev paub txog kev poob qis
Alzheimer's tus kab mob yog tus yam ntxwv pathologically los ntawm A plaque deposition, hyperphosphorylation ntawm Tau protein, neuronal apoptosis, thiab ntau oxidative kev nyuaj siab, nrog rau kev loj hlob ntawm kev txawj ntse poob. Pinealon Kev cuam tshuam cuam tshuam rau AD kev nce qib los ntawm plaub txoj hauv kev: tshuaj tiv thaiv oxidation, tiv thaiv -apoptosis, kab mob kab mob, thiab txhim kho neural atherosclerosis, muab kev taw qhia tshiab rau kab mob- hloov kho.
Inhibition ntawm Synergistic puas los ntawm Oxidative Stress thiab A Toxicity
ROS loj heev nyob rau hauv lub hlwb ntawm cov neeg mob AD ncaj qha puas neuronal DNA, proteins, thiab lipids, thiab txhawb A misfolding thiab aggregation, tsim ib tug vicious voj voog ntawm "oxidative stress-A deposition". Pinealon koob tshuaj-nyob ntawm qhov scavenges ROS, nce cov dej num ntawm superoxide dismutase (SOD) thiab glutathione peroxidase (GSH-Px), thiab blocks A -induced oxidative bursts.
Cov kev tshawb fawb hauv vitro tau lees paub tias kev kho mob ua ntej nrog cov khoom (10-100 nM) ua rau kom muaj sia nyob ntawm cerebellar granule hlwb raug cuam tshuam los ntawm A ₁₋₄₂ los ntawm ntau dua 40%, txo cov intracellular ROS tsub zuj zuj ntawm 50%, thiab inhibits A - oxidation peripheral. Nws kuj tseem tswj hwm -secretase noob qhia, txo A precursor ntau lawm, thiab txo qis cov quav hniav tsim kev pheej hmoo ntawm qhov chaw.
Blockade ntawm Neuronal Apoptosis thiab Kev Cuam Tshuam ntawm Kev Paub-Neurons
Loj apoptosis ntawm cholinergic thiab hippocampal neurons nyob rau hauv AD yog ib qho tseem ceeb ua rau kev txawj ntse poob. Cov khoom lag luam blocks intrinsic thiab extrinsic apoptotic signals los ntawm kev tswj cov proteins tseem ceeb hauv txoj kev apoptotic.
Cov kev tshawb fawb pom tau tias nws txo qis cov kev qhia ntawm pro-apoptotic protein Bax thiab cleaved caspase-3, upregulates anti-apoptotic protein Bcl-2, inhibits mitochondrial membrane tej zaum depolarization, thiab tiv thaiv cytochrome c tso tawm. Hauv AD tsiaj qauv, txhua hnubkev txhaj tshuaj pinealon(10 ug / kg) rau 21 hnub sib law liag txo qhov apoptosis tus nqi ntawm hippocampal CA1 neurons los ntawm 62%, khaws cia hippocampal neuron suav, thiab tswj kev ncaj ncees ntawm kev kawm- thiab nco- cuam tshuam nrog neural circuits.
Txhim kho Neural Rhythm thiab Cognitive Function
Cov neeg mob AD feem ntau tshwm sim nrog pineal calcification thiab tsis txaus melatonin secretion, ua rau pw tsaug zog thiab circadian atherosclerosis abnormalities, uas ua rau kev txawj ntse ntxiv.Cov khoom ua rau pinealocytes los tswj cov kev qhia ntawm cov noob tseem ceeb rau melatonin synthesis (xws li AAAT, {{1}, HMONICAL atherosclerosis) zais cia.
Cov kev tshawb fawb preclinical qhia tau hais tias nws kev cuam tshuam txhim kho kev pw tsaug zog hauv AD qauv nas, ua kom ntev ntev ntawm kev pw tsaug zog, thiab txo cov kev pw tsaug zog thaum hmo ntuj.Nws kuj sib npaug glutamate thiab GABA neurotransmission, txhim kho synaptic plasticity, thiab txhim kho spatial nco thiab khoom paub hauv cov qauv nas. Hauv kev sim Morris dej tshawb nrhiav, kev khiav tawm latency tau luv los ntawm 35% thiab lub hom phiaj quadrant nyob hauv lub sijhawm txuas ntxiv los ntawm 40%.
Clinical Translation thiab Combination Therapy Potential
Kev tshawb fawb soj ntsuam ua ntej tso npe rau 72 tus neeg mob uas mob me - mus rau - nruab nrab AD tau txais cov khoom (10 mg rau ib qho kev txhaj tshuaj subcutaneous, ib zaug ib hnub, rau 30 hnub sib law liag) ua ke nrog cov tshuaj ua tiav.
Cov txiaj ntsig tau pom qhov nruab nrab ntawm 3.2- taw tes nce hauv MMSE cov qhab nia thiab 4.5- cov ntsiab lus txo qis hauv ADAS-Cog cov qhab nia, nrog kev txhim kho tseem ceeb hauv kev nco, kev mloog, thiab kev ua haujlwm, thiab tsis muaj qhov cuam tshuam loj heev.Piv nrog ib leeg cholinesterase inhibitors, nws cuam tshuam los ntawm ntau lub hom phiaj suav nrog oxidative kev nyuaj siab, kev cuam tshuam nrog kev sib txuam, thiab muaj kev cuam tshuam rau kev sib txuam. lub tswv yim tshiab rau kev tswj hwm AD mus ntev.
Cov ntaub ntawv qhov chaw: Innerbody Research Pinealon Clinical Review (2026), Exploring Peptides Neurodegenerative Disease Report (2025).
Parkinson's Disease (PD): Kev Tiv Thaiv ntawm Dopaminergic Neurons thiab Lub Cev Muaj Zog Ua Haujlwm Degeneration
Parkinson tus kab mob yog pathologically tshwm sim los ntawm kev loj hlob poob ntawm dopaminergic neurons nyob rau hauv lub substantia nigra pars compacta thiab aggregation ntawm -synuclein rau hauv Lewy lub cev, kev kho mob manifesting li so tremor, muscular rigidity, bradykinesia, thiab lwm yam. Cov khoom lag luam lub hom phiaj ntawm kev tiv thaiv plaub hau tsis zoo ntawm cov txheej txheem neuropamine, thiab lwm yam. -synuclein aggregation, txhim kho mitochondrial muaj nuj nqi, thiab kev hloov kho ntawm neuroinflammation, kom qeeb PD kev loj hlob.
Dopaminergic neuronal tuag nyob rau hauv PD feem ntau yog kho los ntawm oxidative kev nyuaj siab, mitochondrial tsis ua hauj lwm, thiab neuroinflammation. Neurotoxins xws li 6-hydroxydopamine (6-OHDA) thiab rotenone mimic PD pathology thiab induce dopaminergic apoptosis.In vitro thwmsim qhia tau hais tias Pinealon (50 nM) pretreatment ho inhibits 6-OHDA-induced apoptosis nyob rau hauv dopamine 5% cellability thiab nce SY-5 ROS ntau lawm los ntawm 60%.
Hauv PD tsiaj qauv nrog unilateral 6-OHDA substantia nigra lesions, 14 hnub sib law liag ntawmkev txhaj tshuaj pinealon(20 ug / kg) txhim kho substantia nigra dopaminergic neuron ciaj sia taus los ntawm 48%, rov qab qib striatal dopamine rau 65% ntawm qhov qub, thiab txo qis kev coj tus cwj pwm txawv txav hauv nas.
Kev ua yuam kev, kev sib sau ua ke, thiab kev nthuav tawm lub hlwb ntawm -synuclein yog cov txheej txheem tseem ceeb hauv PD kev loj hlob. Cov khoom lag luam tswj cov kev qhia ntawm chaperone proteins (xws li HSP70) los txhawb kev tsim nyog -synuclein folding thiab inhibit nws oligomerization thiab fibrillation.Studies paub meej tias nws cuam tshuam txo insoluble -synuclein aggregates los ntawm 58% nyob rau hauv PD qauv nas hlwb thiab blocks. Nws kuj inhibits microglial ua kom tsis zoo, txo cov pro-inflammatory cytokines (TNF- , IL-1 , IL-6), thiab rhuav tshem lub voj voog ntawm "-synuclein aggregation-neuroinflammation-neuronal death", slowing pathological kis.
Mitochondrial Function Kho thiab txhim kho Neuronal Energy Metabolism
Mitochondrial dysfunction yog ib qho tseem ceeb ntawm kev puas tsuaj dopaminergic hauv PD, cim los ntawm kev txo qis ATP synthesis, txo qis mitochondrial membrane muaj peev xwm, thiab ua tsis taus pa ua haujlwm. peev xwm.
Hauv rotenone-induced PD cell qauv, nws nce mitochondrial ATP theem los ntawm 42% thiab txo ROS ntau lawm los ntawm 50%, txhim kho mitochondrial morphology thiab txo fragmentation.Nws kuj tswj mitophagy kom tshem tawm cov puas mitochondria, tswj kev raug mob mitochondrial popochdrial, thiab tiv thaiv kev raug mob.
Kev txo qis ntawm cov teeb meem ntawm lub cev muaj zog thiab txhim kho ntev - Kev Kho Mob Lub Sij Hawm
Ntev -lub sij hawm levodopa txoj kev kho rau PD feem ntau ua rau muaj teeb meem xws li dyskinesia thiab "on-off" tshwm sim, txuas rau oxidative kev nyuaj siab thiab kev loj hlob dopaminergic poob.Nws ua ke nrog levodopa exerts synergistic teebmeem: nws txo ROS los ntawm levodopa metabolism thiab oxidative puas, khaws cia qhov seem dopaminergic poob neurons, txo qis dopaminergic neurons. Cov kev tshawb fawb Preclinical qhia tau hais tias PD qauv nas tau txais nws ntxiv rau levodopa muaj 45% qis dua qhov tshwm sim ntawm dyskinesia, 50% luv "tawm" lub sijhawm, thiab kev txhim kho lub cev muaj zog rau ntau tshaj 8 lub lis piam, zoo dua rau levodopa monotherapy.
Cov ntaub ntawv qhov chaw: MCE Pinealon Neuroprotection Data (2023), Skool Peptide-Raws li Parkinson's Therapy Report (2025).
Raws li muaj cov ntaub ntawv preclinical, Pinealon nthuav qhia ntau yam kev tshawb fawb qhia tsim nyog rau kev tshawb nrhiav tas li. Thawj qhov lus dag hauv thaj tsam ntawm neuroprotection. Cov kev sim ntawm tes thiab tsiaj txhu tau tshawb pom tias nws txhawb nqa cov tshuaj tiv thaiv kab mob antioxidant xws li SOD2 thiab GPX1 thiab inhibits Caspase-3- kho mob neuronal apoptosis. Nws nthuav tawm cov peev xwm neurorestorative hauv cov qauv ntawm cerebral hypoxia, kev raug mob ntawm lub hlwb thiab lub hnub nyoog txog kev paub txog kev poob qis, thiab tuav cov lus cog tseg rau kev tshawb fawb txog kev cuam tshuam txog kev cuam tshuam txog kev mob hlwb thiab kev mob hlwb tom qab ischemic.
Qhov kev tshawb fawb thib ob tsom mus rau kev tswj hwm circadian atherosclerosis. Cov kev sim qhia tau hais tias Pinealon tuaj yeem txhim kho pinealocyte muaj nuj nqi, txhawb nqa endogenous melatonin synthesis thiab txhim kho kev pw tsaug zog zoo.
Nws muaj kev tshawb fawb tus nqi rau circadian atherosclerosis cuam tshuam los ntawm kev pw tsaug zog, ua haujlwm ua haujlwm thiab kev ntxhov siab ntev.
Tsis tas li ntawd, qhov tripeptide no nta qhov hnyav molecular, ib txoj hauv kev ua kom muaj tshuaj lom neeg thiab cov qauv molecular yooj yim, ua rau cov nqi tswj tau rau kev tsim khoom lag luam. Ntawm qhov kev tshawb fawb tseem ceeb, yog tias qhov kev xav tias "luv peptides ncaj qha tswj cov noob hloov pauv", nws yuav ua rau muaj txiaj ntsig zoo rau kev xav txog kev tswj hwm epigenetic thiab peptide-nucleic acid cuam tshuam, thiab pab txhawb kev txhim kho ntawm tiam tshiab ntawm cov neeg sib tw neuromodulatory molecules.
Qhia thiab Contraindicated Population
Contraindications: nruj me ntsis txwv nyob rau hauv cov tib neeg hypersensitive rau lub active ingredient los yog excipients ntawm cov khoom no. Allergy keeb kwm yuav tsum tau tshuaj xyuas ua ntej kev tswj hwm.
Cev xeeb tub & lactation: Tsis pom zoo siv.
Cov menyuam yaus: Txwv tsis pub.
Mob siab lossis raum tsis zoo: Siv ceev faj; Cov kab mob siab thiab lub raum ua haujlwm yuav tsum tau saib xyuas.
Information Source: DR. DOPING Pinealon Package Insert (2025 Edition), Peptide Sciences Safe Use Guidelines for Peptide Preparations.
FAQ
Leej twg yuav tsum tsis txhob noj cov khoom no?
+
-
Nws yuav tsum tau zam nyob rau hauv:Active psychotic ntshawv siab los yog kev puas siab puas ntsws loj heev. Cev xeeb tub thiab pub niam mis (cov ntaub ntawv muaj kev nyab xeeb tsis txaus) Kev pw tsaug zog hnyav uas xav tau kev tswj xyuas mob hnyav.
Cov txiaj ntsig ntawm cov khoom no yog dab tsi?
+
-
Nws tuaj yeem hais tias qhov kev tiv thaiv ntawm pinealon yog vim qhov tseeb tias nws inhibits ROS tsub zuj zuj hauv cov hlwb neuronal, ua rau lawv tiv taus oxidative kev nyuaj siab, thiab tiv thaiv HC thiab nws cov derivatives los ntawm kev cuam tshuam nrog glutamate receptors.
Lwm lub npe rau cov khoom no yog dab tsi?
+
-
EDR peptide
Pinealon, tseem hu uaEDR peptide, yog ib qho hluavtaws tripeptide ntawm ib ntus (Glu-Asp-Arg) thiab purported geroprotector sau tseg nyob rau hauv Lavxias teb sab ntaub ntawv scientific. Pinealon yog ib qho ntawm ntau tripeptide "bioregulators" tsim nyob rau hauv Russia.
Cim npe nrov: pinealon txhaj tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom