Sermorelin Peptide Txhajyog ib tug luv luv saw peptide uas muaj 29 amino acids, nws ib theem zuj zus yog zoo tib yam rau cov amino terminal fragment ntawm endogenous loj hlob hormone tso tawm hormone (GHRH) nyob rau hauv tib neeg lub cev. Raws li qhov tsawg tshaj plaws active analogue ntawm GHRH, Sermorelin activates adenylate cyclase signaling txoj kev los ntawm tshwj xeeb khi rau GHRH receptors nyob rau saum npoo ntawm anterior pituitary hlwb, txhawb lub synthesis thiab pulsatile tso tawm ntawm kev loj hlob hormone (GH). Nws qhov hnyav molecular tsuas yog 3357.88 Da, ntau me dua li 22 kDa ntawm recombinant human growth hormone (rhGH), thiab qhov sib txawv ntawm cov qauv no muab nws cov yam ntxwv pharmacokinetic. Ib nrab-lub neej ntawm ntuj GHRH tsuas yog 3-7 feeb, thaum Sermorelin tau txhim kho nws cov bioavailability los ntawm kev ncua ib nrab-lub neej mus rau 30-40 feeb los ntawm kev txhim kho cov qauv. Tsis zoo li kev tso tawm ntawm rhGH mus tas li, Sermorelin induced GH secretion nthuav tawm cov qauv ntawm lub cev nqaij daim tawv uas muaj ntau dua nyob rau hauv txoj kab nrog tib neeg circadian atherosclerosis, txo qhov kev pheej hmoo ntawm receptor desensitization los ntawm kev siv mus ntev. Raws li kev coj ua ntawm cov tshuaj hormones endogenous, Sermorelin tsis induce antibody ntau lawm thiab tuaj yeem tswj hwm los ntawm cov tswv yim tsis zoo thaum siv ntau dhau, tsis txhob muaj kev phiv xws li acromegaly uas yuav tshwm sim los ntawm rhGH.
| Khoom npe | Sermorelin hmoov | Sermorelin ntsiav tshuaj | Sermorelin Capsules | Kev txhaj tshuaj Sermorelin | Sermorelin Drops |
| Yam khoom | Hmoov | Tablet | Capsules | ua kua | ua kua |
| Khoom Purity | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% |
| Khoom Specifications | 100g / 1kg / thiab lwm yam. | 1 mg / 5 mg / 10 mg / 50 mg | 1 mg/5 mg/10 mg | 1 mg/5 mg/10 mg | 2 mg/1 g |
| Daim ntawv khoom | Organic synthesis | Noj Orally | Noj Orally | Organic synthesis | Kev thov sab nraud |
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Sermorelin COA
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| Certificate of Analysis | ||
| Compound npe | Sermorelin | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 86168-78-7 | |
| Ntau | 3 37,3kg | |
| Ntim txheem | 25kg / nruas | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202501090051 | |
| MFG | Peb 9, 2025 | |
| EXP | Peb 8, 2028 | |
| Qauv |  |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.52% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.35% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib qho impurity | <0.8% | 0.47% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 95 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
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Sermorelin Peptide Txhaj, raws li GHRH receptor agonist, activates adenylate cyclase signaling txoj kev los ntawm tshwj xeeb khi rau GHRH receptors nyob rau saum npoo ntawm anterior pituitary hlwb, ua rau pulsatile tso tawm ntawm kev loj hlob hormone (GH). Qhov kev tswj hwm ntawm lub cev no yog qhov sib txawv ntawm qhov sib txawv ntawm qhov kev tso tawm ntawm exogenous recombinant human growth hormone (rhGH), thiab nws qhov txiaj ntsig yog nyob rau hauv nws lub peev xwm los tswj lub ncov ntawm nocturnal GH secretion, uas ua raws li lub ntuj tso tawm qauv ntawm tib neeg lub cev. Thaum cov piam thaj GH siab dhau lawm, nws tuaj yeem cuam tshuam qhov tso tawm ntawm GHRH los ntawm hypothalamus, txo qhov kev pheej hmoo ntawm kev tso tawm ntau dhau. Tsis txhob pituitary receptor desensitization tshwm sim los ntawm ntev - siv rhGH.
Kev kho mob tseem ceeb ntawm Sermorelin
Sermorelin provocation xeem tau pom zoo los ntawm FDA raws li ib txoj kev kuaj mob rau GHD. Tom qab txhaj tshuaj ntawm 1 μ g / kg, yog tias GH ncov tsawg dua 10ng / mL, qhov kev kuaj mob tuaj yeem lees paub, thiab tus nqi tsis zoo (3.2%) yog qhov qis dua li 12.5% ntawm insulin resistance test (ITT). Qhov kev sim no tshwj xeeb yog tsim rau cov neeg mob menyuam yaus vim nws zam kev pheej hmoo ntawm kev mob ntshav qab zib tsis zoo uas yuav tshwm sim los ntawm ITT.
Kev txhim kho kev loj hlob: Kev txhaj tshuaj subcutaneous ntawm 30 μ g / kg ua ntej yuav mus pw rau 12 lub hlis tuaj yeem nce qhov siab ntawm cov menyuam yaus los ntawm 4.2cm / xyoo mus rau 8.9cm / xyoo, thiab txo cov pob txha hnub nyoog ncua los ntawm 40% piv rau rhGH kho pawg.
Kev ua tau zoo nyob rau lub sijhawm ntev: Qhov kawg siab kawg ntawm 36 lub hlis kho pab pawg tau nce los ntawm 2.3 tus qauv sib txawv (SDS) los ntawm lub hauv paus, nce mus txog qhov siab ntawm cov noob caj noob ces, thiab tsis muaj rhGH cuam tshuam txog kev mob tshwm sim xws li scoliosis lossis cov piam thaj metabolism tsis zoo.
Kev tswj cov neeg laus Metabolic Syndrome
Txhim kho lub cev muaj pes tsawg leeg: Hauv cov neeg laus rog,Sermorelin Peptide Txhajua ke nrog kev noj zaub mov tsis muaj calorie tuaj yeem txo lub cev rog feem pua ntawm 6.2% thiab nce ntshiv lub cev hnyav los ntawm 3.1%, uas yog qhov zoo dua li kev noj zaub mov ib leeg (feem pua ntawm cov rog hauv lub cev tau txo los ntawm 2.8% thiab lean lub cev hnyav nce 0.9%). Cov txheej txheem yuav cuam tshuam nrog GH induced rog rog thiab ua kom cov leeg ntshav nce ntxiv.
Ua kom cov tshuaj insulin rhiab heev: tom qab 6 lub hlis ntawm kev kho mob, yoo mov qib insulin txo qis los ntawm 35% thiab HOMA-IR Performance index tau nce 42%, qhia tias nws tuaj yeem txo qhov kev pheej hmoo ntawm atherosclerosis los ntawm kev txhim kho endothelial. Kev sim rau cov neeg mob ntshav qab zib hom 2 tau pom tias Sermorelin ua ke nrog metformin tuaj yeem txo cov glycosylated hemoglobin (HbA1c) los ntawm 1.2%, zoo dua li ib pawg tshuaj kho mob.
Kev tiv thaiv kab mob plawv: Lub intima-media thickness (CIMT) ntawm cov hlab ntsha carotid txo qis los ntawm 0.08mm, thiab cov dej ntws nruab nrab vasodilation muaj nuj nqi (FMD) nce 12%, uas cuam tshuam rau kev tswj hwm ntawm endothelial nitric oxide synthase (eNOS) qhia los ntawm GH.
Kev tu cov leeg nqaij: Hauv cov neeg laus noj qab haus huv, kev kho mob Sermorelin tuaj yeem ua rau tus ntoo khaub lig- ntu ntu ntawm cov leeg quadriceps los ntawm 5.7% thiab txhim kho tuav lub zog los ntawm 8.3%. Nws cov nyhuv yog piv rau kev kawm tiv thaiv tab sis nrog kev ua raws siab dua. Txoj kev tshawb nrhiav 2- xyoo tom qab tau pom tias pab pawg kho mob txo qhov kev pheej hmoo ntawm kev poob los ntawm 41% thiab qhov tshwm sim ntawm pob txha pob txha los ntawm 28%.
Kev tswj lub cev tiv thaiv kab mob: Los ntawm kev txhim kho phagocytic kev ua haujlwm ntawm macrophages thiab kev loj hlob muaj peev xwm ntawm T lymphocytes, lymphocyte subpopulation feem ntawm cyclophosphamide induced immunosuppressed nas yog rov qab los li qub. Cov kev tshawb fawb soj ntsuam tau pom tias tom qab tau txais kev kho mob Sermorelin, cov neeg muaj tus kab mob HIV muaj 15% nce hauv CD4+T cell suav thiab 33% txo qis hauv qhov tshwm sim ntawm kev kis kab mob kis tau zoo.
Kev nrawm ntawm kev kho qhov txhab: Hauv cov neeg mob ntshav qab zib ko taw rwj, kev txhaj tshuaj hauv zos ntawm Sermorelin ua ke nrog kev saib xyuas neeg mob tuaj yeem txo lub sijhawm kho mob los ntawm 14 hnub thiab nce tus nqi kho tau los ntawm 32%. Lub tshuab muaj feem xyuam rau GH kev txhawb nqa ntawm collagen synthesis thiab angiogenesis.
Daim ntawv thov tshwj xeeb ntawm Sermorelin
Kev ua kis las kev ua tau zoo: Txawm hais tias WADA tau teev Sermorelin ua cov tshuaj txwv tsis pub, nws cov teebmeem ntawm kev ua kom lub cev hnyav (nruab nrab{0}}kg) thiab lub zog tawg (nce dhia qhov siab +5.2cm) tseem nyiam qee cov neeg ncaws pob siv nws tsis raug cai. Nws yuav tsum tau hais qhia tias kev siv li no tsis muaj kev txhawb nqa ntev - cov ntaub ntawv kev nyab xeeb.
Kev ua kis las raug mob rov qab: Hauv cov neeg mob tom qab ACL rov tsim kho kev phais, Sermorelin pab pawg kho mob tau pom 30% nrawm dua ntawm lub hauv caug sib koom ua ke thiab txuas ntxiv zog piv rau pawg tswj hwm, thiab 21 hnub txo qis rov qab mus rau lub sijhawm qoj ib ce, uas yuav cuam tshuam nrog GH txhawb nqa pob txha kho.
Kev pab kho mob rau cov kab mob neurodegenerative
Alzheimer's kab mob: Tsiaj thwmsim tau pom tias Sermorelin tuaj yeem txhim kho kev txawj ntse los ntawm kev ua kom hippocampal GH secretion, ua rau Morris dej tshawb nrhiav kev khiav tawm latency los ntawm 40%. Cov kev tshawb fawb soj ntsuam tau tshawb fawb txog qhov muaj peev xwm ua kom muaj txiaj ntsig zoo ntawm nws txoj kev sib xyaw nrog acetylcholinesterase inhibitors.
Amyotrophic lateral sclerosis (ALS): Cov ntaub ntawv ua ntej qhia tau hais tias kev kho mob Sermorelin tuaj yeem ua rau cov leeg nqaij muaj zog poob qis los ntawm 22% thiab ua kom lub sijhawm ua pa ntev ntev los ntawm 18% hauv cov neeg mob ALS, uas tej zaum yuav cuam tshuam rau cov nyhuv neuroprotective ntawm GH.
kev phiv tshuaj
Sermorelin Peptide Txhaj, raws li cov tshuaj peptide uas txhawb kev tso tawm ntawm endogenous loj hlob hormone (GH) los ntawm lub caj pas pituitary, muaj kev cuam tshuam tsis zoo uas cuam tshuam nrog ntau lub tshuab, thiab qhov hnyav muaj feem cuam tshuam nrog kev siv tshuaj, tus neeg rhiab heev, thiab kev siv cov xwm txheej (xws li kev kho mob lossis tsis yog - siv tus qauv)
Digestive system teb
Nausea Thiab ntuav
Sermorelin activates GLP-1 receptors (zoo ib yam li cov txheej txheem ntawm kev ua ntawm semaglutide), inhibits gastrointestinal emptying, tsub kom satiety, thiab ncaj qha nkoos du nqaij contraction nyob rau hauv lub plab hnyuv ib ntsuj av, ua rau xeev siab thiab ntuav. Tsis tas li ntawd, qhov stimulation ntawm lub hauv paus paj hlwb los ntawm cov tshuaj kuj yuav ua rau ntuav reflex. Kev xeev siab yog feem ntau me me mus rau nruab nrab, tsis tu ncua los yog paroxysmal, thiab tej zaum yuav nrog los ntawm kev poob qab los noj mov; Kev ntuav tuaj yeem qhuav lossis dav hlau zoo li, thiab thaum mob hnyav tuaj yeem ua rau lub cev qhuav dej thiab electrolyte tsis txaus (xws li hypokalemia).
Mob plab thiab mob plab
Cov tshuaj cuam tshuam rau qhov sib npaug ntawm plab microbiota, ua kom plab hnyuv peristalsis, thiab ua rau raws plab; Gastrointestinal spasms yuav ua rau mob plab. Kev mob plab feem ntau yog cov quav dej, tshwm sim 3-5 zaug hauv ib hnub, thiab tuaj yeem ncav cuag ntau dua 10 zaug hauv qhov hnyav; Mob plab feem ntau yog paroxysmal colic, nyob ib ncig ntawm lub plab los yog hauv plab.
Pancreatitis
Sermorelin tuaj yeem cuam tshuam qhov tso tawm ntawm cholecystokinin (CCK), ua rau cov kua dej hauv pancreatic tsub zuj zuj, nce pancreatic duct siab, thiab ua rau mob pancreatitis; Tsis tas li ntawd, tshuaj -induced dyslipidemia (xws li nce triglycerides) kuj yuav ua rau muaj kev pheej hmoo ntawm tus mob pancreatitis. Mob plab heev, xeev siab, ntuav, nce ntshav amylase thiab lipase, thiab thaum mob hnyav, kev poob siab thiab ntau yam hauv nruab nrog cev yuav tshwm sim.
Neurological teb
Mob taub hau thiab kiv taub hau
Cov tshuaj yuav ua rau mob taub hau los ntawm kev cuam tshuam intracranial siab (xws li vasodilation ua rau muaj zog cerebrospinal kua siab) los yog ncaj qha stimulating lub hauv paus paj hlwb; kiv taub hau tej zaum yuav muaj feem xyuam rau qhov hloov pauv ntawm cov ntshav siab los yog kev ua haujlwm vestibular txawv txav. Mob taub hau feem ntau pulsatile los yog compressive, nyob rau hauv ob qho tib si ntawm lub cev los yog occipital cheeb tsam; kiv taub hau yog tshwm sim raws li kev xav ntawm kiv taub hau lossis sawv tsis ruaj.
Insomnia thiab qaug zog
Cov tshuaj yuav cuam tshuam rau lub voj voog pw tsaug zog (xws li inhibiting melatonin secretion) lossis ua rau muaj kev nce hauv metabolic, ua rau insomnia; Kev siv lub sijhawm ntev tuaj yeem ua rau muaj zog siv zog thiab qaug zog. Insomnia yog tus cwj pwm los ntawm kev nyuaj pw tsaug zog, thaum sawv ntxov, lossis pw tsaug zog tsis zoo; Fatigue manifests raws li kev qaug zog thiab kev puas siab puas ntsws lethargy.
cuam tshuam ntawm kev nco qab
Kev tsis haum tshuaj hnyav lossis kev siv tshuaj ntau dhau tuaj yeem ua rau cerebral edema, nce intracranial siab, thiab tsis nco qab (xws li coma). Tus neeg mob tam sim ntawd ntsib kev tsis meej pem, poob ntawm kev taw qhia, thiab txawm tias tsis nco qab.
Cim npe nrov: Sermorelin peptide txhaj tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom