Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom thiab cov khoom lag luam ntawm sulphadimiddine txhaj 100ml hauv Suav teb. Txais tos rau kev lag luam wholesale ntau qhov zoo sulphadimidine txhaj tshuaj 100ml rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Sulphadimidine txhaj tshuaj 100ml(Sodium Sulfonamide txhaj tshuaj 100ml) yog cov tshuaj tiv thaiv sulfonamide rau hauv kev coj ua kws kho tsiaj. Cov tshuaj yog cov kua tsis muaj kob lossis me ntsis kom tsis txhob poob ntsej muag thaum raug lub teeb, yog li nws yuav tsum tau muab cia kom deb ntawm lub teeb. Nws cov lus qhia tshwj xeeb muaj sib txawv, suav nrog 100ml, 250mL, 500ml, thiab 1000mL, kom tau raws li cov kev xav tau kev kho mob. Nyob rau hauv teb ntawm cov metarinary tshuaj, sulfamethoxo cua kev txhaj tshuaj yog dav siv rau kev kho tus mob hauv cov tsiaj txhu xws li nyuj, thiab npua, thiab nqaij qaib. Piv txwv li, hauv cov leeg yaj yaj, cov tshuaj tuaj yeem tawm ncaj qha rau ntws mus rau cov dej ntws ntawm cov dej ntws nrog, tab sis saib xyuas yuav tsum tau them rau cov kev muaj kuab paug uas nws yuav ua rau ib puag ncig. Ib qho ntxiv, hauv cov tsiaj txhu thiab nqaij qaib ua liaj ua teb, cov tshuaj no feem ntau yog siv tau los tiv thaiv thiab kho kab mob los ntawm cov kab mob uas rhiab.
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Sulphadimidine Coa
Sulphadimidine txhaj tshuaj 100ml(Sulfametazine sodium txhaj) yog qhov dav {- Cov tshuaj tua kab mob rau cov tsiaj txhu thiab nqaij qaib rau cov kab mob sib kis los ntawm cov kab mob tsis sib kis. Nws cov keeb kwm kev tsim khoom los ntawm cov thoob ntiaj teb kev lag luam, tshwj xeeb tshaj yog nyob rau hauv kev tsim kab mob thiab kev tswj hwm yog qhov txuas tseem ceeb hauv kev ua kom cov tsiaj txhu ua kom paub meej. Cov khoom no ua rau cov kab mob tshuaj tua kab mob los ntawm cov kab mob tsis sib haum xeeb, thiab cov kab mob tsis zoo, thiab xws li Coccidiosis). Nws yog haum rau kev kis mob hnyuv, mob plab, thiab cov zis thiab deev thiab ua me nyuam npua, yaj, thiab nees.
Khoom Tseem Ceeb Tshaj Tawm thiab Synthesis keeb kwm yav dhau
Sulfamethoxine (SM2) yog cov tseem ceeb ua kom muaj tshuaj tiv thaiv (API) Sulfonamide} Tus qauv tsim ntawm nws txoj kev synthesis yuav tsum tau raws li cov tseev kom ua hauv qab no:
Cov tshuaj tua kab mob tawm tsam kuj hloov tau: los ntawm cov kab mob ua ke thiab cov qauv molus yog qhov zoo sib xws
Pharmaconetic optimization: molecular polarity yuav tsum tau tswj kom tau txais kev faib tawm sai dua lossis sib npaug ntawm 85%
Kev ua tau los ntawm kev lag luam: nws yog qhov tsim nyog los xaiv txoj hauv kev muaj cov khoom siv muaj yooj yim, cov kauj ruam yooj yim, thiab lub hom phiaj nqi tsawg dua lossis sib npaug / kg).
Kev tsom xam ntawm cov ntsiab lus synthesis txoj kev
Thoob ntiaj teb, kev lag luam hluavtaws ntawmSulphadimidine txhaj tshuaj 100mlFeem ntau yog Adopts cov kev coj ua hauv qab no, thiab lawv cov kev sib piv ntawm kev lag luam thiab kev lag luam muaj txiaj ntsig tau qhia hauv cov lus hauv qab no:
| Txoj kev hom | Cov Khoom Siv Raw Ua Ke | Cov kauj ruam tseem ceeb | OVERAL | Cov Khoom Siv Raw | Kev loj hlob ntawm kev lag luam |
| Pyrimidine R nplhaib txoj kev hws hws | 4-acetylaminobenesulforonyl chloride +2- amino-4,6-dimethylpaphyrimidine | Sulfonylation → Cov Khaub Ncaws Kub → Hydrolysis | 68%-72% | 120-140 | Siab |
| Acetylacetone Cyclization Txuj Ci | Sulfonamide + Acetylacetone | Ntiv nplhaib synthesis → oxidation → kev kho mob | 75%-78% | 95-110 | Sab saud |
| Chloropyrimididididididididation | Sodium sulfonamide +2- chloro-4,6-dimethylpeprimidaude | Nucleophilic hloov → rov ua haujlwm | 62%-65% | 150-180 | Suav |
1.pyrimididide nplhaib txoj kev hws hws (classic classic)
Raw Khoom Npaj
4 {- Acetylaminobenesulforoningulforoningulforoningulforesulforesulforesulforesulforesulforoningulforoningulforoningulforoningulforoningulforony
2-amino-4,6-dimethylpernidine: synthesized los ntawm kev hws ntawm acetylacetone thiab refluxed ntawm 120% -8% -85%.
Cov lus ntseeg
Sulfonylation theem: ASC thiab 2 {- Amino-seeb-4,6-dideted nyob rau hauv pyridine kuab (itectionl
C₈h₈n₂o₃scl + c₆₆₁₀n₄ → c₁₄h₁₆n₆o₃s + hcl
Cov tshuaj hauv hydrolysis: lub Nruab Nrab yog hydrolyzed hauv Naoh daws (2m) (2/10) kom tshem tawm cov acetyl tiv thaiv pab pawg thiab tsim tawm ntawm 98% -99%.
Refining Txheej Txheem
Crystallization tswj: yaj cov khoom lag luam hauv dej kub (1% kev txiav txim siab, lub lim thiab recrystallization thiab recrystallization
Kev tswj kom zoo: residual pyridine (tsawg dua lossis sib npaug ntawm 0.1%, cov tshuaj hnyav (tsawg dua lossis sib npaug rau 0.5%) yuav tsum tau kuaj.
Cov txiaj ntsig kev ua haujlwm: Yooj yim kom tau txais cov ntaub ntawv raw, cov kauj ruam ntshiab, haum rau loj {{0} teev ntau lawm.
Kev sib tw technes: nws yog qhov tsim nyog kom tswj hwm cov nqi hydrolysis? (8.5-9.0), txwv tsis pub nws yuav ua rau lub nplhaib pyrimidine qhib.
2.Txhua txoj kev sib cav sib ceg (txoj kev tshiab)
Cov Khoom Siv Raw Ua Ntej
Sulfonamide: Nws yog synthesized los ntawm cov hws ntawm sulfonamide thiab nitroguanide, thiab cov particle loj faib (d} μ m) yuav tsum tau tswj hwm cov tshuaj tiv thaiv kev cuam tshuam.
Acetylacetone: Nws yuav tsum tau lub cev qhuav dej rau cov ntsiab lus noo noo ntawm tsawg dua lossis sib npaug rau nws yuav cuam tshuam rau kev xaiv ntawm kev xaiv ntsej muag.
Cov lus ntseeg
Ntiv taw theem: Sulfonamide, acetylacetone, thiab sodium bisulfite (1: 1.2 Cov lej Mail) yog ua kom muaj zog thiab ua kom muaj zog los ntawm kev sib tw los ntawm 78% mus rau 82%.
C₇h₉n₃o₂s + C₅h₈o₂ → C₁₂h₁₄n₄o₂s + H₂o + C ..
Oxidation theem: Cov Qib Nruab Nrab yog oxidized nrog h ₂ ₂ (30%) nyob rau pawg thiol rau ib pawg thiol rau ib pab pawg ntawm SulgonyL nrog 95% -97%.
Kev ua cov kev ua kom zoo dua
Neutralyam centstallization: neutralize cov kev daws teeb meem oxidizing nrog pH 5.5-6.0, Ntxiv cov noob crystallization, lim thiab qhuav kom tau txais API.
Cov txheej txheem kev hloov kho tshiab: tau txais cov tshuaj tiv thaiv ntws tsis tu ncua, ua rau lub sijhawm ua kom luv rau 4 teev thiab nce cov txiaj ntsig mus rau 85%.
Cov txiaj ntsig kev ua haujlwm: tsawg dua cov kauj ruam, cov khoom siv raw qis dua, tsim nyog rau ntau lawm.
Kev sib tw kev sib tw: thaum lub voj voog theem, los ntawm {- cov khoom xws li sulfamethoxole tau yooj yim tsim, thiab cov catalyst system yuav tsum tau ua kom zoo.
3.Chloropyrimidididine txoj kev hloov pauv (txheej txheem ntxiv)
Synthesis ntawm cov tseem ceeb intermediates
2-chloro-4,6-didethylpaphyrimidididble: npaj los ntawm chlorination ntawm 2,4,6-trimethylpimide yuav tsum tau tswj hwm (cov khoom lag luam ntau dua lossis sib npaug ntawm 90%).
Nucleophilic hloov cov kev tawm tsam
Sodium Sulfonamide reacts nrog 2-chloro-4,6-dimethylpimidium hauv DMF Hnyav (120 degree, 6H) los tsim los ntawm 65% -70%.
C₆h₈n₂o₂sna + C₆H₇Cln₂ → C₁₂h₁₄n₄o₂s + Nacl
Kev txwv kev ua haujlwm: tus nqi ntawm chloropyrimidine raw cov ntaub ntawv yog siab, thiab cov tshuaj tiv thaiv yuav tsum tau muaj kev lag luam nyuaj.
Txheej Txheem Tseem Ceeb Parameter Kev tswj
Kev ua kom zoo ntawm cov tshuaj tiv thaiv
Tswj Qhov Kub
Sulfonylation Reawer: 75-85℃(cov tshuaj ntsuab nce los ntawm 1.2 zaug rau txhua 5℃tau yooj yim coj mus rau kev rhuav tshem ntawm sulgoruall chloride).
Nplhaib Ring Reaction: 95-105℃(kev tswj kom meej yog yuav tsum tau kom tsis txhob muaj sab kev cawm).
PHOONATION
Hydrolysis theem: ph {=8.5-9.0 (saib xyuas nyob rau hauv tiag- siv lub lauj kaub, nrog kev sib txawv ntawm ± 0.2 xav tau ib qho ntxiv ntawm cov tshuaj alkaline).
Neutralization theem: ph {=5.5-6.0 (acid solution ((((acid solution solution needs needsောင်း yuav tsum tau maj mam ntxiv dropwise kom tiv thaiv hauv zos acidification).
Kev xaiv catalyst
Sulfonylation Reaction: Pyridine (ntau npaum li cas 1.5eq) tuaj yeem txhim kho cov neeg tawm tsam xaiv rau 92%.
Ntiv nplhaib kev tawm tsam: sodium bisulfite (0.1eq) tuaj yeem tiv thaiv cov oxidative sab.
Txawj xav txog kev tswj hwm lub tswv yim
Impurities nyob rau hauv pib cov ntaub ntawv
Asc xav tau tswj cov chaw seem p- nitrobenesulforesulforoningulforoningulforony (tsawg dua lossis sib npaug ntawm Nitro impurities tau tsim yooj yim.
Sulfonamide seem (tsawg dua los yog sib npaug rau 0.3%) yuav tsum tau kuaj xyuas sulfonamide, txwv tsis pub nws yuav ua rau muaj cov tshuaj muaj ntau ntawm cov khoom kawg.
Txheej txheem impurities
Sulfonylation bapproduct: txo qhov tsim ntawm disulfonyl impurities los ntawm kev tswj hwm lub sij hawm cov tshuaj tiv thaiv (tsawg dua los yog sib npaug rau 8h).
Canclic by - Cov Khoom: Cov ntsiab lus ntawm Sulefamethoxazazole raug rho tawm los ntawm kev siv cov txheej txheem pub mis (ntxiv acetylacetone hauv peb ntu).
Kev tsis txaus ntseeg impurities
Qhov yuam kev degradation tsom qhia tias SM2 yog nquag ua rau cov sulfonic acid immurities ntawm kev kub siab (105℃yuav tsum tau tswj kom tsawg dua lossis sib npaug rau 80 degree
Kev Siv Cov Txheej Txheem Tswjhwm Zoo
Tshuaj Tiv Thaiv Raw Khoom Siv Raw Khoom
| Tshuaj Ntsuam Xyuas | Txojkev | ciaj ciam |
| Kev coj dawb huv | HPLC (Cheeb Tsam Ib Leeg) | Ntau dua los yog sib npaug rau 99.5% |
| Dej | Karl Fischer txoj kev | Tsawg dua los yog sib npaug rau 0.5% |
| Residual Hnyav | GC (Headspace Txujcac) | Ethanol tsawg dua lossis sib npaug rau 0.5% |
| Hnyav Hlau | Atomic nqus spectroscopy | Tsawg dua los yog sib npaug rau 10ppm |
Qib Nruab Nrab
Sulfonylation intermediates
Melting taw tes: 198-202℃(kev ntsuas calorimetry, DSC).
Cov ntsiab lus: HPLC txiav txim siab ntau dua lossis sib npaug rau 98.0%.
Cyclic Intermediates
Tsis tas li cas (IR)
Cov ntsiab lus noo noo: txiav txim los ntawm Karl Fischer txoj kev tsawg dua los yog sib npaug ntawm 1.0%.
Tiav Cov Khoom Taw Qhia Tawm Cov Qauv
| Tshuaj Ntsuam Xyuas | Txojkev | ciaj ciam |
| Zoo siab | HPLC (Cov Qauv Sab Nraud) | 98.5%-101.0% |
| Lwm yam tshuaj | HPLC (Txoj kev sib piv tus kheej) | Ib qho impurity tsawg dua los yog sib npaug rau 0.5% |
| Residual Hnyav | GC (Headspace Txujcac) | Acetone tsawg dua lossis sib npaug rau 0.3% |
| Kev tshem tawm | Duav txoj kev (50rpm, 30min) | Ntau dua los yog sib npaug rau 85% |
| Microbial txwv | Membrane Kev Pom Kev | Tag nrho cov kab mob aerobic suav tsawg dua lossis sib npaug rau 100cfu / g |
Kev Lag Luam Kev Lag Luam thiab Yav Tom Ntej Cov Lus Qhia
Kev hloov dua tshiab thev naus laus zis
Nruam kev tsim khoom: Siv cov microchannel reactors kom ua tiav sulfonation hydrolysis, shortening ntau ntau lawm ua haujlwm rau 8 teev (cov khoom siv voj ib txwm yuav tsum muaj 16 teev).
Enzyme catalyeryerly: Tsim Sulfotransferase catalyzed synenesis ntawm SM2, txo kev siv tshuaj lom neeg tshuaj lom neeg los ntawm 30%.
Ntsuab Chemistry
Hnyav rov qab: Rov qab pyridine kuab (boiling point 115 degree) nrog kev ua dua tshiab ntawm ntau dua lossis sib npaug rau 90%.
Affic Economy: Txhim kho txoj kev Cycylization los txo cov e factor (ib puag ncig qhov) los ntawm 8.2 txog 5.6.
Cov Kev Pabcuam Customized
Polycrystalline Control: Kho cov Crystal Daim Ntawv (Daim Ntawv I / Daim Ntawv II) los ntawm Crystallization Hnyav (ethanol / Dej piv) kom tau raws li cov kev xav tau sib txawv.
Kev customization ntawm impurity spectra: Tswj tshwj xeeb impurities (xws li sulfamethoxole tsawg dua los yog sib npaug nrog 0.2%) raws li cov neeg siv khoom.
Cim npe nrov: Kev Muag Khoom Siv Sulphadimiddium 100ml, Cov Chaw Tsim Khoom, Chaw Tsim Tshuaj, Hoobkas, Lag Luam Wholesale, Yuav, Nqe, Hlua, Rau Muag