Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm furosemide txhaj tshuaj hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo furosemide txhaj rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Kev txhaj tshuaj Furosemideyog ib tug muaj zog diuretic uas belongs rau Loop Diuretics qeb. Nws exerts ib tug diuretic nyhuv los ntawm inhibiting lub reabsorption ntawm sodium, chloride, thiab poov tshuaj los ntawm cov tuab ntu ntawm ascending ceg ntawm lub raum medullary voj, ua rau kom lub excretion ntawm cov electrolytes nyob rau hauv cov zis.
Cov tshuaj no nkag mus rau hauv cov hlab ntsha sai sai los ntawm kev txhaj tshuaj intravenous lossis intramuscular, txwv tsis pub thawj zaug dhau los ntawm kev tswj hwm qhov ncauj. Tom qab txhaj tshuaj, cov tshuaj sai sai sai rau ntau yam ntaub so ntswg thoob plaws lub cev, tshwj xeeb tshaj yog rau lub raum. Furosemide yog metabolized tsawg dua hauv daim siab thiab tsuas yog tawm los ntawm lub raum. Kwv yees li 80% ntawm cov tshuaj tau muab tso tawm hauv nws daim ntawv qub los ntawm cov zis, thaum seem seem yog tawm los ntawm cov kua tsib. Ib nrab-lub neej ntawm furosemide luv luv, txog 1-2 teev, tab sis nws cov nyhuv diuretic tuaj yeem kav ntev li 6-8 teev. Nyob rau tib lub sijhawm, furosemide yog metabolized tsawg dua hauv daim siab thiab feem ntau tawm los ntawm ob lub raum. Kwv yees li 80% ntawm cov tshuaj tau muab tso tawm hauv nws daim ntawv qub los ntawm cov zis, thaum seem seem yog tawm los ntawm cov kua tsib. Ib nrab-lub neej ntawm furosemide yog luv luv, txog 1-2 teev, tab sis nws cov nyhuv diuretic tuaj yeem kav li 6-8 teev.
Peb cov khoom
Furosemide COA
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| Certificate of Analysis | ||
| Compound npe | Furosemide | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 54-31-9 | |
| Ntau | Kev kho kom haum | |
| Ntim txheem | Kev kho kom haum | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090058 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.58% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.49% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.98% |
| Ib qho impurity | <0.8% | 0.67% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 150 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree | |
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| Chemical Formula: | C12H11ClN2O5S |
| Exact Mass: | 330.01 |
| Molecular Luj: | 330.74 |
| m/z: | 330.01 (100.0%), 332.00 (32.0%), 331.01 (13.0%), 332.00 (4.5%), 333.01 (4.1%), 334.00 (1.4%), 332.01 (1.0%) |
| Elemental Analysis: | C, 43,58; H, 3,35; 10,72; 10. N, 8,47; O, 24.19; Nws. ib 9,69 |
Kev hloov pauv loj hauv qhov ntim ntim (Vd) thiab kev sib khi tsis zoo ntawm Furosemide Txhaj protein
Cov txheej txheem faib cov tshuaj hauv lub cev yog ib qho tseem ceeb ntawm kev tshawb fawb pharmacokinetic, thiab nws cov yam ntxwv faib ncaj qha cuam tshuam rau kev siv tshuaj thiab tshuaj lom. Volume of Distribution (Vd), uas yog ib qho tseem ceeb rau kev txheeb xyuas cov tshuaj faib, qhia txog qhov dav ntawm cov tshuaj faib rau ntau yam ntaub so ntswg hauv lub cev. Thaum kev sib txuas ntawm cov tshuaj rau cov ntshav plasma protein cuam tshuam, Vd tuaj yeem hloov pauv, uas cuam tshuam rau tus cwj pwm pharmacokinetic ntawm cov tshuaj. Lub dynamic correlation ntawm cov protein khi cov yam ntxwv ntawmKev txhaj tshuaj Furosemidethiab Vd, muab kev nkag siab tob txog kev faib tshuaj.
Lub hauv paus ntawm lub cev thiab qhov tseem ceeb ntawm kev faib khoom ntim (Vd)
Txhais thiab lej qhia ntawm Vd
Distribution volume yog ib tug virtual parameter nyob rau hauv pharmacokinetics uas piav txog lub℃ntawm kev faib tshuaj nyob rau hauv lub cev, txhais raws li qhov ratio ntawm tag nrho cov tshuaj nyob rau hauv lub cev (D) rau cov ntshav plasma tshuaj concentration (Cp), piv txwv li Vd=D/Cp. Qhov kev ntsuas no xav tias cov tshuaj sib npaug sib npaug hauv lub cev, tab sis qhov tseeb qhia txog qhov sib npaug ntawm cov tshuaj hauv cov ntshav thiab cov ntaub so ntswg. Piv txwv li, yog tias Vd ntawm ib yam tshuaj yog 10 L, nws qhia tau hais tias nws qhov kev faib tawm yog ze rau tag nrho lub cev kua; Yog tias Vd tshaj 50 L, nws qhia tau tias cov tshuaj tuaj yeem sib sau ua ke ntau hauv cov ntaub so ntswg.
Physiological determinants ntawm Vd
Qhov loj ntawm Vd yog cuam tshuam los ntawm ntau yam:
Plasma protein binding tus nqi: Qhov ntim ntawm cov tshuaj molecules khi rau plasma proteins nce, ua rau nws nyuaj rau nkag mus rau phab ntsa capillary, ua rau txo qis hauv Vd. Piv txwv li, plasma protein khi tus nqi ntawm warfarin yog 99%, thiab nws Vd tsuas yog 0.15 L / kg.
Kev sib koom ua ke: Cov tshuaj liposoluble yooj yim nkag mus rau hauv cov ntaub so ntswg ntawm tes, khi rau cov ntaub so ntswg, thiab sib sau ua ke hauv cov ntaub so ntswg xws li rog thiab nqaij, ua rau muaj kev nce hauv Vd. Vd ntawm diazepam yog siab li 2.3 L / kg, uas muaj feem xyuam rau nws cov lipid solubility siab.
Lub cev pH thiab tshuaj ionization xeev: Cov tshuaj tsis muaj zog acidic muaj nyob rau hauv daim ntawv tsis muaj ionized nyob rau hauv acidic ib puag ncig (xws li kua txiv hmab txiv ntoo) thiab tuaj yeem yooj yim dhau ntawm cov cell membranes; Cov tshuaj tsis muaj zog alkaline tau yooj yim dua nyob rau hauv ib puag ncig alkaline xws li ntshav ntshav.
Kev kho mob tus nqi ntawm Vd
Vd yog lub hauv paus tseem ceeb rau kev tsim cov tshuaj noj:
Kev suav koob tshuaj: Vd tuaj yeem siv los kwv yees cov koob tshuaj thawj zaug uas yuav tsum tau ua kom tiav cov hom phiaj ntshav tshuaj (Loading Dose, LD=Vd × Cp).
Kev kwv yees siv tshuaj tau zoo: Cov tshuaj uas muaj Vd siab (xws li amiodarone) yuav tsum tau siv sijhawm ntev dua kom ncav cuag -lub xeev concentration, qhia qhov xav tau rau kev tswj hwm thaum ntxov.
Kev ntsuas tshuaj toxicity: Cov tshuaj uas muaj Vd qis (xws li cefazolin) yog nquag mus tsub zuj zuj hauv plasma thiab yuav tsum tau saib xyuas rau lub raum toxicity.
Kev tswj cov nyhuv ntawm plasma protein khi rau Vd
Molecular mechanism ntawm plasma protein khi
Kev sib txuas ntawm cov tshuaj thiab plasma proteins muaj cov yam ntxwv hauv qab no:
Reversibility: Binding thiab dissociation yog nyob rau hauv dynamic equilibrium, thiab lub binding tas li (K) txiav txim siab qhov sib piv.
Kev xaiv: Albumin feem ntau khi rau cov tshuaj acidic (xws li warfarin), thaum alpha 1-acid glycoprotein (AAG) khi rau cov tshuaj alkaline (xws li propranolol).
Saturation: Thaum cov tshuaj concentration ntau tshaj ntawm cov protein binding site, qhov kev faib ua feem ntawm cov tshuaj dawb yog nce.
Bidirectional cuam tshuam ntawm protein khi rau Vd
Kev sib txuas ntau ntxiv → txo Vd: Piv txwv li, thaum lub plasma protein khi tus nqi ntawm furosemide nce mus txog 91% -99%, nws Vd tsuas yog 0.11-0.22 L / kg, thiab cov tshuaj tsuas yog txwv rau cov ntshav.
Txo kev khi tus nqi → nce Vd: Nyob rau hauv cov ntaub ntawv ntawm hypoalbuminemia los yog kev sib tw binding, qhov kev faib ua feem ntawm cov tshuaj dawb nce, ua rau nws yooj yim dua rau cov tshuaj faib rau cov ntaub so ntswg, ua rau muaj kev nce hauv Vd. Piv txwv li, nyob rau hauv mob siab heev, albumin synthesis raug txo, thiab Vd ntawm warfarin yuav nce los ntawm 0.15 L / kg mus rau 0.3 L / kg.
Pathophysiological hauv paus ntawm cov protein binding mob
Plasma protein binding disorders muaj nyob rau hauv cov xwm txheej hauv qab no:
Txo cov protein synthesis: Cirrhosis thiab malnutrition ua rau txo qis hauv qib albumin (tus nqi li qub 35-50 g / L).
Cov qauv protein txawv txav: Hlawv thiab nephrotic syndrome ua rau lub cev tsis zoo ntawm albumin molecules thiab txo qhov muaj peev xwm binding.
Kev sib tw sib tw: Kev siv tshuaj aspirin ntau tuaj yeem tshem tawm cov kev khi warfarin, ua rau muaj kev nce ntxiv ntawm cov tshuaj dawb dawb.
Protein khi yam ntxwv thiab Vd dynamics ntawm furosemide txhaj
Kev txhaj tshuaj Furosemide(2- [(2-furanmethyl) amino] -5- (sulfamoyl) -4-chlorobenzoic acid) belongs rau lub voj diuretics, thiab pawg sulfonamide thiab furan nplhaib hauv nws cov qauv molecular tuaj yeem khi rau lub hnab ntim hydrophobic ntawm albumin. Kev tshawb fawb tau pom tias qhov chaw sib txuas ntawm furosemide thiab albumin nyob ntawm Sudlow site I (warfarin binding site), nrog qhov sib txuas tas li (K) ntawm 1.2 × 10 ⁵ L / mol.
Hauv cov neeg laus noj qab haus huv, Vd ntawm furosemide yog 0.11-0.22 L / kg, qhia tias nws qhov kev faib tawm tsuas yog txwv rau plasma thiab cov kua dej ntxiv. Cov yam ntxwv Vd qis no yog ncaj qha ntsig txog nws cov ntshav plasma protein ntau (91% -99%). Tom qab txhaj tshuaj, furosemide sai khi nrog albumin los ua "duab reservoir", tsuas yog ib qho me me ntawm cov tshuaj dawb nkag mus rau glomerular filtration membrane kom ua rau cov nyhuv diuretic.
Qhov cuam tshuam ntawm kev sib txuas ntawm cov protein ntau ntawm furosemide Vd
Hauv kev sim hauv vitro simulating hypoalbuminemia (albumin concentration txo mus rau 20 g / L), qhov feem pua ntawm cov tshuaj dawb ntawm furosemide tau nce los ntawm 1% -9% mus rau 15% -25%, uas ua rau nce hauv Vd rau 0.3-0.5 L / kg. Cov kws kho mob tau pom tias thaum siv furosemide hauv cov neeg mob cirrhosis, koob tshuaj yuav tsum tau nce ntawm 40 mg / d mus rau 80 mg / d kom ua tiav cov nyhuv diuretic tib yam, uas zoo ib yam nrog cov kev hloov pauv hauv cov tshuaj faib los ntawm kev nce hauv Vd.
Kev sib tw ua ke kev cuam tshuam
Thaum furosemide tau ua ke nrog siab - koob tshuaj aspirin (3 g ib hnub), cov tshuaj aspirin tuaj yeem hloov pauv cov tshuaj furosemide, ua kom cov concentration ntawm cov tshuaj dawb los ntawm peb zaug. Nyob rau lub sijhawm no, Vd ntawm furosemide tau nce los ntawm 0.15 L / kg rau 0.4 L / kg, ua rau muaj kev pheej hmoo ntawm ototoxicity (siab concentration ntawm cov tshuaj dawb). Kev soj ntsuam cov ntaub ntawv qhia tau hais tias qhov tshwm sim ntawm kev hnov lus tsis hnov lus hauv cov neeg mob hauv pawg ua ke tau nce los ntawm 2% mus rau 8%.
Cov teebmeem ntawm lub raum tsis ua haujlwm
Hauv cov neeg mob uas muaj kab mob raum ntev (GFR<30 mL/min), the protein binding rate of furosemide decreased to 85% and Vd increased to 0.25 L/kg. Due to the inability of bound drugs to pass through glomerular filtration, an increase in the proportion of free drugs leads to a decrease in tubular reabsorption, enhanced diuretic effect, but also increases the risk of electrolyte imbalance.
Qhov cuam tshuam ntawm Vd hloov pauv loj ntawm kev ua tau zoo thiab kev nyab xeeb ntawm furosemide
Pharmacodynamic hloov pauv
Txhim kho cov nyhuv diuretic: Qhov nce hauv Vd ua rau muaj kev nce hauv cov ntaub so ntswg, nce hauv cov tshuaj dawb concentration hauv lub raum tubules, thiab nce cov nyhuv inhibitory ntawm Na ⁺ - K ⁺ -2Cl ⁻ kev sib koom ua ke thauj. Piv txwv li, hauv cov neeg mob hypoalbuminemia, 2-teev tso zis ntawm furosemide nce los ntawm 800 mL mus rau 1200 mL.
Kev ncua sij hawm ntev ntawm kev txiav txim: Kev tso tawm qeeb ntawm cov tshuaj khi rau cov ntaub so ntswg ncua lub sijhawm ntawm cov nyhuv diuretic los ntawm 4 teev mus rau 6-8 teev.
Toxic reaction risk
Ototoxicity: Ntau dhau ntawm cov tshuaj dawb tuaj yeem ua rau cov plaub hau sab nraud ntawm cochlea, ua rau tsis hnov lus tsis zoo. Thaum ua ke nrog cov tshuaj tua kab mob aminoglycoside, qhov tshwm sim ntawm ototoxicity ntawm furosemide nce ntawm 3% mus rau 12%.
Electrolyte imbalance: nce Vd ua rau txo qis raum tubular reabsorption, thiab qhov tshwm sim ntawm hypokalemia (ntshav potassium<3.5 mmol/L) increases from 15% to 25%.
Sudden poob rau hauv cov ntshav siab: Thaum lub sij hawm txhaj tshuaj sai sai, ib qho kev nce siab ntawm cov tshuaj dawb tam sim ntawd tuaj yeem ua rau reflex tachycardia thiab hypotension, tshwj xeeb tshaj yog rau cov neeg laus uas muaj kev pheej hmoo siab dua.
Clinical coping lub tswv yim thiab kev soj ntsuam ntsuas
Kev npaj kho koob tshuaj
Cov neeg mob Hypoproteinemia: nce thawj koob tshuaj 50% thiab saib xyuas cov ntshav cov tshuaj concentration (lub hom phiaj: 50-100 μ g / L).
Thaum siv cov tshuaj sib tw ua ke: txo cov koob tshuaj furosemide mus rau 70% ntawm thawj koob tshuaj thiab txuas ntxiv lub sijhawm tshuaj.
Cov neeg mob lub raum tsis ua haujlwm: Kho cov koob tshuaj raws li eGFR (thaum eGFR yog 15-30 mL / min, txo qhov koob tshuaj rau 20 mg / d).
Pharmacokinetic xyuas
Kev txiav txim siab ntawm cov tshuaj dawb concentration: Ultrafiltration lossis equilibrium dialysis txoj kev siv los saib xyuas cov concentration ntawm dawbKev txhaj tshuaj furosemide, xyuas kom meej tias nws nyob hauv qhov chaw nyab xeeb (<10 μ g/L).
Kev ntsuam xyuas Vd dynamic: Xam Vd hloov pauv los ntawm ntau cov ntshav kos los qhia kev hloov koob tshuaj. Piv txwv li, yog tias Vd nce los ntawm 0.15 L / kg mus rau 0.3 L / kg, cov tshuaj noj yuav tsum tau muab faib ua ob npaug.
Kev Tiv Thaiv Kev Tsis Txaus Siab
Kev soj ntsuam Ototoxicity: Ua cov kev ntsuam xyuas hnov lus ua ntej noj tshuaj thiab txhua lub lim tiam kom tsis txhob ua ke nrog aminoglycosides.
Electrolyte tshuav nyiaj li cas: Ua ke siv cov tshuaj potassium sparing diuretics (xws li spironolactone) thiab kev saib xyuas cov ntshav potassium thiab sodium tsis tu ncua.
Kev tswj ntshav siab: Thaum lub sijhawm txhaj tshuaj, qhov ceev yuav tsum tau tswj ntawm 1-2 mg / min kom tsis txhob txhaj tshuaj sai.
Cov lus nug nquag
Furosemide feem ntau siv rau dab tsi?
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Furosemide (feem ntau paub los ntawm lub npe Lasix) yog ib lub voj diuretic, los yog "dej tshuaj," siv feem ntau los kho edema (kwv yees) thiab kub siab ( ntshav siab). Nws pab lub raum tshem tawm cov dej thiab ntsev ntau dhau ntawm lub cev los ntawm cov zis, txo qhov o ntawm lub plawv, lub raum, lossis kab mob siab.
Puas yuav furosemide tshem tawm cov kua dej ntawm ob txhais ceg?
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Yog lawm, furosemide (Lasix) yuav tshem tawm cov kua dej tawm ntawm koj ob txhais ceg. Nws yog lub voj diuretic (los yog "dej ntsiav tshuaj") uas ua haujlwm los ntawm kev yuam koj ob lub raum kom tshem tawm ntsev thiab dej ntau dhau los ntawm kev tso zis ntau ntxiv.
Thaum twg koj yuav tsum tsis txhob noj furosemide?
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Koj yuav tsum tsis txhob noj furosemide yog tias koj muaj anuria (ib yam mob uas koj lub raum tsis tsim cov zis) lossis yog tias koj muaj kev fab tshuaj rau furosemide lossis sulfonamides.
Cim npe nrov: furosemide txhaj tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom