Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm albendazole ncua kev kawm 10ml hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo albendazole ncua kev kawm ntawv 10ml rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Albendazole ncua kev kawm ntawv 10mlyog ib qho tshuaj tiv thaiv kab mob hauv qhov ncauj tshwj xeeb uas tsim los rau cov menyuam yaus thiab cov neeg mob dysphagic. Cov kua nplaum no, feem ntau flavored kua formulation muaj micronized albendazole hais (feem ntau 200mg / 5ml) tshem tawm nyob rau hauv ib tug palatable puag, hais txog kev nqos nyuaj los ntawm cov ntsiav tshuaj. Nws qhov txiaj ntsig tseem ceeb yog nyob rau hauv qhov tseeb koob tshuaj kho qhov hnyav -raws li kev noj tshuaj rau menyuam yaus, txawm hais tias kev tshawb fawb qhia pom qhov tsis zoo ntawm kev siv tshuaj vim qhov ntsuas tsis sib xws (piv txwv li, cov diav hauv tsev vs. Lub ncua kev kawm bioavailability nyob ntawm qhov tseem ceeb ntawm co homogeneity - sedimentation tsom xam qhia txog li 30% potency variation nyob rau hauv undisturbed fwj. Tsis zoo li cov ntsiav tshuaj, nws cov formulation zam crospovidone tab sis yuav tsum tau parabens los yog sorbitol ua stabilizers, tsa kev txhawj xeeb hauv cov neeg mob phenylketonuria. Cov ntaub ntawv pharmacovigilance tsis ntev los no qhia txog nws lub luag haujlwm tsis tau tshaj tawm hauv cov kev pabcuam deworming loj, qhov twg kev tswj hwm kev thauj mus los sai cuam tshuam qhov tseeb ntawm kev txhaj tshuaj. Ib txoj kev tshawb fawb Nigerian xyoo 2023 tau pom tias qhov kub thiab txias raug kub hnyiab tau nrawm API degradation los ntawm 1.8x piv rau cov ntawv ntsiav tshuaj.
Nyob rau tib lub sijhawm, peb lub tuam txhab tsis yog tsuas yog muab cov hmoov ntshiab, tab sis kuj muaj cov ntsiav tshuaj thiab kev ncua. Yog tias xav tau, thov koj xav tiv tauj peb txhua lub sijhawm.
Peb Cov Khoom
Albendazole hmoov
Albendazole ntsiav tshuaj
Albendazole Ncua tseg
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Albendazole hmoov COA
Physical thiab Chemical Properties
Cov tsos thiab cov khoom
Albendazole Suspension 10mlyog ib qho zoo -particle suspension tov. Tom qab sawv, cov khoom zoo nyob, thiab tom qab co, nws tsim ib qho xim dawb los yog tawm -dawb suspension nrog ib tug me ntsis tsw. Nws cov ntsiab lus tseem ceeb, albendazole, yog dawb mus rau daj daj crystalline hmoov. Nws melting point yog 207-211℃(decomposes). Nws yog me ntsis soluble hauv acetone lossis trichloromethane, yuav luag insoluble hauv ethanol, insoluble hauv dej, tab sis soluble hauv glacial acetic acid.
Kev ruaj ntseg thiab kev cia khoom
Qhov kev tshem tawm cov tshuaj no yuav tsum tau muab khaws cia rau hauv lub thawv kaw. Lub neej txee feem ntau yog 2 xyoos. Cov kev tshawb fawb tau pom tias albendazole nano- ncua kev kawm npaj los ntawm txoj kev rov qab hnyav thiab siab - txoj kev siab homogenization qhia tias tsis muaj kev hloov pauv tseem ceeb hauv cov tsos, xim, cov ntsiab lus, pH nqi, sediment volume ratio, thiab re-dispersibility thaum lub sij hawm 6-hli ceev kev ntsuam xyuas, qhia tau zoo stability.
Particle Loj thiab Bioavailability
Qhov nruab nrab particle loj ntawm nano- ncua kev kawm ntawv yog 358.1 nm, me me dua li cov kev npaj ib txwm muaj. Ib zaug - koob tshuaj qhov ncauj qhov kev sim hauv cov nas pom tau tias Cmax ntawm nano- ncua kev kawm ntawv (5.895 ug/mL) yog qhov siab dua qhov kev npaj siv (2.804-2.053 ug/mL), nrog rau cov txheeb ze bioavailability nce ntawm 214%-299.74%. Qhov no qhia tau hais tias nanotechnology tuaj yeem txhim kho qhov nqus tau zoo ntawm albendazole thiab txhim kho kev kho mob.
Pharmacological Mechanism
Antiparasitic Spectrum
Albendazole Suspension 10ml muaj zog tua cov kab mob nematodes, tapeworms, thiab flukes, tab sis tsis muaj txiaj ntsig tiv thaiv schistosomes. Nws cov txheej txheem ntawm kev ua yog los ntawm kev khi rau microtubulin protein ntawm cov kab mob parasites, tiv thaiv cov polymerization ntawm microtubules, yog li cuam tshuam nrog mitosis, protein sib dhos, thiab lub zog metabolism ntawm cov cab, thaum kawg ua rau lawv tuag.
Kev pab them nqi Insecticidal Stages
Cov tshuaj no tsis yog tsuas yog muaj zog rau cov neeg laus cov kab mob, tab sis kuj tseem muaj kev tua cov kab mob tseem ceeb ntawm cov kab mob tsis paub qab hau thiab cov larvae, thiab muaj cov nyhuv larvicidal. Piv txwv li, tus nqi tshem tawm ntawm npua roundworm thiab posterior roundworm neeg laus kab mob yog tshaj 98%, thiab tus nqi tshem tawm ntawm yaj cov ntshav- nqus nematode thiab Ostertagia lineolata cov neeg laus cab yog ntau dua lossis sib npaug li 95%.
Hwm Kev Nyab Xeeb
Qhov kev sib raug zoo ntawm albendazole rau microtubulin protein ntawm cov kab mob parasites yog siab dua li ntawm cov tsiaj nyeg, yog li cov tshuaj lom rau tus tswv tsev qis dua. Txawm li cas los xij, nws yuav tsum raug sau tseg tias kev siv thaum ntxov ntawm cev xeeb tub hauv cov tsiaj yuav ua rau teratogenicity thiab embryotoxicity, thiab nws yog txwv tsis pub thaum lactation. Kev siv rau hauv cov tsiaj cev xeeb tub thaum 45 hnub ua ntej cev xeeb tub yog ceev faj.
Pharmacokinetic yam ntxwv
Absorption thiab Distribution
Cov tshuaj albendazole ib txwm muaj cov solubility tsawg thiab muaj zog ua ntej- dhau los, ua rau muaj qhov nqus tsawg hauv cov hnyuv. Txawm li cas los xij, cov nano- ncua kev kawm tau zoo txhim kho cov dej solubility thiab nqus tau zoo ntawm cov tshuaj hauv plab hnyuv los ntawm kev txo qhov me me thiab ua rau thaj tsam loj.
Metabolism thiab excretion
Albendazole yog metabolized rau hauv sulfoxide los yog sulfone tebchaw nyob rau hauv lub cev, feem ntau yog los ntawm inhibiting parasites nqus cov piam thaj thiab fumaric acid reductase system, thaiv cov ATP ntau lawm, thiab tiv thaiv cov cab kom ciaj sia. Nws cov metabolites raug tso tawm hauv cov quav, thiab lub sijhawm tshem tawm txawv nyob ntawm seb hom tsiaj (14 hnub rau nyuj, 4 hnub rau yaj, 7 hnub rau npua, thiab 4 hnub rau nqaij qaib).
Cov tshuaj sib cuam tshuam
Kev sib xyaw nrog levamisole tuaj yeem ua rau kom muaj bioavailability ntawm albendazole thiab txhim kho cov nyhuv anthelmintic. Cov yam ntxwv no muab lub hauv paus theoretical rau kev kho mob ua ke.
Kev Npaj thiab Kev Tswj Xyuas Zoo
Txoj Kev Npaj
Kev npaj ntawm Albendazole Suspension yuav tsum tau tswj nruj ntawm cov txheej txheem tsis. Piv txwv li, kev npaj ntawm nano- ncua kev kawm ntawv siv cov txheej txheem rov qab hnyav thiab siab - siab homogenization txoj kev, ntxiv ib tug siab -molecular active neeg sawv cev ua ib tug stabilizer los xyuas kom meej uniform faib ntawm cov tshuaj particle loj.
Cov qauv zoo
Raws li "Suav Veterinary Drug Quality Standard (2017 Edition)", cov tshuaj raug ncua yuav tsum ua raws li cov cai hauv qab no:
Cov ntsiab lus:90.0% -110.0% ntawm cov ntawv sau npe
tus nqi pH: 5.0-7.0
Sediment volume ratio thiab re-dispersibility:Raws li cov kev cai rau kev tshem tawm qhov ncauj qhov ncauj Kev Qhia Txog: Kev txheeb xyuas tau ua los ntawm ultraviolet spectrophotometry (nrog rau qhov siab tshaj plaws nqus ntawm lub wavelength ntawm 295 nm) thiab tshuaj lom neeg cov tshuaj tiv thaiv (xws li tsim cov xim liab- xim av precipitate thaum poov tshuaj iodobismuthate tov ntxiv).
Clinical Application Advantages
Kev noj qab haus huv thiab kev tswj hwm yooj yim
Cov txheej txheem raug tshem tawm tuaj yeem nqus tau ncaj qha los ntawm txoj hnyuv, txo qis kev ntxhov siab thiab txhawb nqa ntau txoj hauv kev xws li kev pub noj ncaj qha, sib xyaw nrog zaub mov, lossis dej haus. Nws yog tshwj xeeb tshaj yog haum rau cov tsiaj thiab loj -scale liaj teb.
Broad -spectrum Deworming thiab Nqis -effectiveness
Qhov kev npaj no tuaj yeem tshem tawm cov kab mob sib kis xws li kab mob sib kis, kab mob sib kis, kab mob kab mob, kab mob npaws, thiab kab mob npaws, txo qhov poob ntawm qhov hnyav txhua hnub (8-15%), tsis zoo ntawm kev hloov pauv hloov pauv (5-10%), thiab kev pheej hmoo tuag (nce txog 15% ntawm cov nyuj tuag) tshwm sim los ntawm cov txiaj ntsig kev lag luam ntawm cov kab mob sib kis.
Kev nyab xeeb thiab kam rau ua
Cov tshuaj toxicity rau cov tsiaj muaj tsawg, thiab cov kev phiv tshuaj tsis tshua muaj. Txawm li cas los xij, kev ua raws cai nruj rau lub sijhawm tshem tawm yuav tsum tau zam kom tsis txhob muaj cov tshuaj residue tshaj qhov txwv.
Qhov teeb meem ntawm sedimentation tshwm sim los ntawm kev cia khoom tsis raug
Tsim Mechanism: Dual Kev Sib Tw ntawm Lub Cev thiab Tshuaj Muaj Zog
Raws li ib tug aqueous suspension formulation,Albendazole Suspension 10mlNws cov ntsiab lus tseem ceeb yog Albendazole, muaj cov dej solubility tsawg heev (tsuas yog 0.016 mg / mL, ntawm pH 6.0 thiab 24 degree). Nws yuav tsum tau ntxiv cov stabilizers (xws li xanthan gum, sodium carboxymethyl cellulose) kom muaj kev ruaj ntseg ntawm lub cev. Thaum cov xwm txheej khaws cia tsis raug (xws li kub hloov pauv, raug lub teeb, lossis tsis ua haujlwm ntawm kev sib khi), cov txheej txheem hauv qab no yuav ua rau muaj nag lossis daus:
Stabilizer tsis ua haujlwm
Xanthan cov pos hniav muab qhov kev ruaj ntseg zoo tshaj plaws ntawm qhov concentration ntawm 0.2% - 0.3%, tab sis yog tias qhov kub cia siab tshaj 30℃los yog raug rau lub teeb rau lub sijhawm ntev, nws cov saw hlau molecular yuav tawg, ua rau txo qis hauv viscosity thiab txo qis hauv qhov ntim ntim piv. Piv txwv li, cov formulation uas muaj 0.3% xanthan cov pos hniav tseem nyob ruaj khov tom qab cia nyob rau hauv chav tsev kub rau 4 lub hlis, thaum lub formulation muaj 1% sodium carboxymethyl cellulose qhia nyuaj los nag vim tsis txaus lub peev xwm ncua.
Particle aggregation
Tus nqi saum npoo ntawm albendazole hais yog cuam tshuam los ntawm pH. Nyob rau hauv pH ntau ntawm 5.0 - 7.0, cov khoom nqa cov nqi tsis zoo thiab tuav lub xeev dispersed los ntawm electrostatic repulsion; Yog tias qhov chaw cia khoom muaj cov av noo siab uas ua rau txo qis pH, cov nqi particle txo qis, thiab kev sib sau ua ke thiab nag lossis daus yuav tshwm sim.
Tshuaj degradation
Albendazole yog rhiab heev rau lub teeb. Tom qab raug rau lub teeb nyob rau hauv cov kev daws rau 10 teev, nws cov ntsiab lus yuav txo tau los ntawm ntau tshaj 30%. Cov khoom degradation tuaj yeem hloov cov khoom saum npoo ntawm cov khoom, txhawb flocculation thiab nag lossis daus.
Feem ntau scenarios ntawm kev cia khoom tsis raug thiab sedimentation yam ntxwv
Teeb meem tswj qhov kub thiab txias
Kev kub siab - ib puag ncig kub (xws li lub caij ntuj sov yam tsis muaj tub yees): Lub viscosity ntawm tus neeg sawv cev ncua kev txo qis, ua kom nrawm nrawm ntawm cov khoom, ua rau xoob sedimentation uas tuaj yeem rov ua dua tom qab co.
Tsawg- qhov kub thiab txias (piv txwv li, lub tub yees lub caij ntuj no): Yog tias cov txheej txheem muaj cov humectants xws li glycerin, qhov kub thiab txias yuav ua rau crystallization thiab nag lossis daus, tab sis cov khoom albendazole lawv tus kheej tsis cuam tshuam los ntawm qhov kub thiab txias.
Teeb pom kev zoo
Lub teeb raug ncaj qha ua rau albendazole degradation thiab cuam tshuam cov txheej txheem ncua kev kawm, tsim cov dej nag uas nyuaj rau tawg tom qab co. Cov precipitates no feem ntau nrog cov xim tsaus nti (los ntawm dawb mus rau daj daj) thiab kev loj hlob ntawm ib qho tawm - tsw.
foob tsis ua hauj lwm
Yog tias lub raj mis tsis kaw nruj nreem kaw, cov dej noo los ntawm huab cua tuaj yeem nkag mus rau hauv lub raj mis, uas tuaj yeem hloov kho cov qauv pH thiab txhawb kev sib sau ua ke. Tsis tas li ntawd, noo noo evaporation tuaj yeem ua rau cov concentration nce siab tshaj tus neeg sawv cev nqa lub peev xwm, ua rau nag lossis daus.
Kev cuam tshuam ntawm nag lossis daus ntawm kev ua tau zoo thiab kev nyab xeeb
Kev noj tshuaj tsis raug
Cov nag lossis daus ua rau tsis sib npaug ntawm cov khoom thaum lub sijhawm tswj hwm, ua rau cov koob tshuaj tiag tiag uas yuav qis dua lossis siab dua li cov ntawv sau npe, yog li cuam tshuam rau cov nyhuv deworming. Piv txwv li, tus nqi deworming rau npua roundworms yuav tsum muaj arbenazide concentration kom ncav cuag qhov zoo; Kev noj tshuaj tsis txaus tuaj yeem ua rau deworming tsis ua haujlwm.
Local irritation txaus ntshai
Nyias nag lossis daus nyob rau hauv lub plab hnyuv yuav tsim lumps, ncua cov tshuaj tso tawm thiab ua rau irritation rau gastric mucosa. Tshwj xeeb tshaj yog rau cov tsiaj hluas thiab tsiaj txhu, nws yuav ua rau muaj kev phiv xws li ntuav thiab raws plab.
Txo bioavailability
Cov arbenazide micro- cov khoom nyob rau hauv cov nag lossis daus, ua rau thaj chaw txo qis thiab qeeb qeeb qeeb, yog li txo qhov nqus. Cov kev tshawb fawb tau pom tias nano suspensions tuaj yeem txhim kho bioavailability los ntawm kev txo qhov me me, thaum nag lossis daus tsim rov qab qhov txiaj ntsig no.
Kev daws thiab kev tiv thaiv
Optimized cia tej yam kev mob
Kub: Khaws ntawm 2-8℃hauv lub tub yees; zam kom khov.
Lub teeb: Siv lub raj mis xim av los yog lub teeb -cov ntaub thaiv npog, thiab khaws cia rau hauv qhov chaw txias, qhuav.
Sealing: Tighten lub hau tam sim ntawd tom qab siv txhua zaus kom tsis txhob ya raws thiab cua nkag.
Ua ntej - siv Kev Tshawb Fawb
Saib xyuas cov tsos mob ntawm cov tshuaj: Yog tias muaj nag lossis daus loj, hloov pauv, lossis muaj ntxhiab tsw txawv txav, cov tshuaj suav tias yog degraded thiab yuav tsum tsis txhob siv.
Kev Tshawb Fawb: Tom qab maj mam co, nag lossis daus yuav tsum tawg sai sai. Yog hais tias nag lossis daus yog compact thiab nyuaj rau disperse, cov tshuaj yuav tsum muab pov tseg.
Formulation txhim kho cov lus qhia
Kev ua kom zoo ntawm cov neeg ua haujlwm ncua: Siv cov khoom sib xyaw ua ke (piv txwv li, xanthan gum + sodium carboxymethyl cellulose) los txhim kho kev ruaj ntseg.
Kev hloov pH: Ntxiv cov tshuaj buffering (piv txwv li, phosphates) kom tswj pH hauv thaj tsam ntawm 5.0–7.0.
Nanotechnology: Npaj albendazole nano- ncua kev ncua nrog qhov loj me me txo rau 200-500 nm los txhim kho lub cev ruaj khov.
Cov lus nug nquag
Yuav ua li cas muab albendazole qhov ncauj tshem tawm 10 mL?
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Nws yuav tsum tau noj nrog lossis tsis noj mov lossis raws li tus kws kho mob qhia. Lub sijhawm noj tshuaj ntawm albendazole ncua kev kawm 200 mg / 5 mL qhov ncauj raug tshem tawm yog hais raws li nram no: Cov neeg laus thiab cov menyuam yaus tshaj li ob xyoos: 10 ml ncua kev kawm ntawv (400 mg) ua ib koob. Cov menyuam yaus (1-2 xyoos): 5ml ncua kev kawm ntawv (200 mg) ua ib koob.
Dab tsi yog albendazole suspension siv rau?
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Albendazole yog siv los kho neurocysticercosis, ib qho kab mob ntawm lub paj hlwb tshwm sim los ntawm nqaij npuas tapeworms. Cov tshuaj no kuj tseem siv los kho cov kab mob cystic hydatid ntawm daim siab, ntsws, thiab peritoneum, ib qho kab mob los ntawm tus dev tapeworms. Albendazole yog siv los kho cov kab mob uas tshwm sim los ntawm kab mob.
Albendazole qhov ncauj ncua kev kawm 400 mg 10 mL yog dab tsi?
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Albendazole Suspension 400mg / 10mL yog ib qho dav -spectrum anthelmintic (dewormer) siv los kho ntau yam kab mob hauv plab hnyuv, nrog rau cov kab mob roundworms, hookworms, whipworms, thiab pinworms.
Cim npe nrov: albendazole ncua kev kawm ntawv 10ml, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom