Tianeptine sodium kuayog ib daim ntawv ua kua ntawm Tianeptine Sodium ntsev, feem ntau yog tsim los ntawm nws daim ntawv ntsev ntsev, uas muaj cov tshuaj pharmacological xws li tshuaj tiv thaiv kev nyuaj siab thiab kev ntxhov siab. Cov ntaub ntawv ua kua dej, piv rau cov ntsiav tshuaj lossis cov tshuaj ntsiav, yuav muaj qhov nqus tau sai dua thiab muaj bioavailability ntau dua, thiab yooj yim dua los kho cov tshuaj, tshwj xeeb tshaj yog rau cov menyuam yaus, cov neeg laus, lossis cov neeg mob nqos nyuaj.
Nws txhim kho cov tsos mob ntawm kev nyuaj siab los ntawm kev tswj cov neurotransmitters hauv lub hlwb, xws li glutamate thiab gamma aminobutyric acid (GABA). Nws txawv ntawm cov tshuaj antidepressants xws li xaiv serotonin reuptake inhibitors (SSRIs), tab sis ua haujlwm los ntawm kev cuam tshuam rau neural plasticity thiab glutamatergic system. Cov kev tshawb fawb soj ntsuam tau pom tias tianeptin sodium nthuav tawm cov txiaj ntsig zoo rau ntau hom kev nyuaj siab, suav nrog kev nyuaj siab endogenous, kev nyuaj siab reactive, thiab neurotic kev nyuaj siab.
Nyob rau tib lub sijhawm, peb lub tuam txhab tsis yog tsuas yog muab cov hmoov ntshiab, tab sis kuj muaj cov ntsiav tshuaj thiab tshuaj txhaj. Yog tias xav tau, thov koj xav tiv tauj peb txhua lub sijhawm.
Cov ntaub ntawv ntxiv ntawm chemical compound:
| Khoom npe | Tianeptine Sodium hmoov | Tianeptine Sodium ntsiav tshuaj | Tianeptine Sodium Capsules |
| Yam khoom | Hmoov | Tablet | Capsules |
| Khoom Purity | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% |
| Khoom Specifications | 100g / 1kg / thiab lwm yam. | 12.5 mg yog ' | 12.5 mg yog ' |
| Daim ntawv khoom | Organic synthesis | Noj Orally | Noj Orally |
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Tianeptine Sodium COA
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| Certificate of Analysis | ||
| Compound npe | Tianeptine sodium | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 30123-17-2 | |
| Ntau | Customize | |
| Ntim txheem | Customize | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090056 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.38% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.28% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.80% |
| Ib leeg impurity | <0.8% | 0.41% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 70 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 400ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree | |
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| Tshuaj Formula | C21H24ClN2NaO4S |
| Exact Mass | 458.10 |
| Molecular Luj | 458.93 |
| m/z | 458.10(100.0%),460.10(32.0%),459.11(22.7%),438.12(7.3%), 437.11(4.5%), 437.12(2.5%), 439.11(1.4%), 438.11(1.0%) |
| Elemental Analysis | C, 54.96; H, 5.27; Nc, 7.72; N, 6.10; Na, 5.01; O, 13.94:S, 7.35 |
Muaj zog Antidepressant nyhuv
Tianeptine sodium kuaexerts zoo kawg li kho cov teebmeem ntawm kev nyuaj siab loj thiab kev nyuaj siab lub sij hawm. Nws cov txheej txheem ntawm kev ua txawv ntawm cov kev tshawb xav monoamine ib txwm muaj-raws li tshuaj tiv thaiv kev nyuaj siab. Hloov chaw ntawm inhibiting reuptake ntawm monoamine neurotransmitters, nws ua raws li ib tug nruab nrab agonist ntawm μ-opioid receptors thiab tsis muaj zog agonist ntawm δ-opioid receptors. Lub caij no, nws hloov pauv txoj haujlwm ntawm glutamate receptors, txhim kho AMPA receptor kev ua haujlwm thiab antagonizes NMDA receptors, yog li ntsuas lub hauv paus paj hlwb neurotransmitters thiab txo cov tsos mob kev nyuaj siab.
Cov kev tshawb fawb soj ntsuam xyuas tias nws cov tshuaj tiv thaiv kev ntxhov siab yog piv rau cov tshuaj tiv thaiv kev ntxhov siab xws li amitriptyline, imipramine thiab fluoxetine, thaum nws ua rau tsawg dua sedative, anticholinergic thiab mob plawv nrog kev nyab xeeb zoo dua. Nws maj mam txo cov kev nyuaj siab tseem ceeb xws li kev xav tsis zoo, anhedonia, pw tsaug zog, tsis qab los noj mov thiab inattention los ntawm ntau yam - lub hom phiaj kev cai. Nws yog tshwj xeeb tshaj yog haum rau cov neeg mob nyuaj siab nyuaj nrog kev ntxhov siab, muaj peev xwm txo tau kev nyuaj siab thiab kev ntxhov siab ib txhij, nrog rau tag nrho cov txiaj ntsig zoo dua li qee cov tshuaj tiv thaiv kev ntxhov siab xws li maprotiline.
Txhim kho kev paub tsis meej
Cov neeg mob kev nyuaj siab feem ntau raug kev txom nyem los ntawm kev puas siab puas ntsws xws li kev nco tsis zoo, bradyphrenia thiab kev tsis txaus ntseeg, uas cuam tshuam nrog kev cuam tshuam hauv nruab nrab paj hlwb neuroplasticity. Tianeptine sodium nce qib ntawm lub hlwb- muab tau los ntawm neurotrophic factor (BDNF) thiab cov paj hlwb loj hlob (NGF) hauv cov cheeb tsam hauv lub hlwb xws li hippocampus thiab amygdala, ua rau muaj kev cuam tshuam rau neurogenesis hauv hippocampal dentate gyrus, tswj kev kho dendritic neurological remodeling ntawm myurgic thiab hippocamdal. synapses, txhawm rau txhim kho kev paub txog kev ua haujlwm thiab rov qab xav li qub thiab lub peev xwm nco.
Ib qho kev sim tshuaj Egyptian tau ua nyob rau xyoo 2005 kuj tau lees paub tias tianeptine sodium qhia tau hais tias muaj txiaj ntsig zoo hauv cov txiv neej cov neeg mob nyuaj siab nyuaj nrog kev ua haujlwm tsis zoo. Nws txo cov tsos mob ntawm kev nyuaj siab thiab txhim kho kev sib deev tsis ua hauj lwm synchronously, zoo txhim kho cov neeg mob lub neej zoo.
Anxiolytic Action
Nws muaj txiaj ntsig zoo hauv kev kho mob ntawm ntau yam kev ntxhov siab xws li kev ntxhov siab thiab kev ntxhov siab dav dav. Cov kev sim tshuaj pom tau hais tias hauv 35% carbogen inhalation - ua rau muaj kev phom sij txaus ntshai, tianeptine sodium ua tiav qhov kev ceeb toom sib npaug - thaiv kev cuam tshuam rau paroxetine hauv cov neeg mob tsis txaus siab, ua pov thawj nws qhov tseeb thiab muaj zog anxiolytic khoom.
Piv nrog rau cov tshuaj anxiolytics tshwj xeeb, cov khoom tuaj yeem ua rau muaj kev ntxhov siab ruaj khov yam tsis muaj kev tswj hwm lub sijhawm ntev, thiab ua rau tsis muaj kev cuam tshuam rau cov tshuaj muaj txiaj ntsig nrog cov tshuaj tiv thaiv mob me me, tsim nyog rau luv luv - lub sij hawm thiab nruab nrab - rau - ntev - tswj kev ntxhov siab. Nws cov txheej txheem anxiolytic zoo sib xws nrog μ- opioid receptor agonism thiab glutamate receptor modulation. Nws tswj cov kev ntxhov siab hauv nruab nrab thiab txo cov tsos mob ntawm kev ntxhov siab xws li palpitations, hauv siab nruj, hyperhidrosis thiab insomnia kom stabilize lub siab lub ntsws.
Cov teebmeem Neuroprotective
Nyob rau hauv kev ntxhov siab thiab inflammatory stimuli, tianeptine sodium muab cov teebmeem neuroprotective tseem ceeb. Nws inhibits PI3K/AKT-kho NF-κB txoj kev taw qhia, downregulates matrix metalloproteinase-9 (MMP-9) kev ua thiab txo cov neuronal puas. Tsis tas li ntawd, nws activates μ-opioid receptors los suppress polarization ntawm microglia thiab macrophages ntawm pro-inflammatory M1 phenotype, upregulates cov kev ua ntawm antioxidant enzymes xws li superoxide dismutase (SOD) thiab catalase, mitigates oxidative kev nyuaj siab raug mob thiab shields neurons los ntawm dawb radical puas.
Kev sim hauv vitro qhia tau tias tianeptine sodium (0.1-100 μM, 14-hnub kev cuam tshuam) txo qis hypoxia-induced lactate dehydrogenase (LDH) tso tawm hauv nas embryonic cortical neurons. Nyob rau hauv lub xub ntiag ntawm interleukin-1 (IL-1), nws ua rau me me tab sis tseem ceeb tiv thaiv los ntawm nas cortical neurons thiab inhibits neuronal apoptosis.
Expanded Clinical Application Value
Cov kev tshawb fawb soj ntsuam tau lees paub nws qhov kev ua tau zoo hauv cov neeg mob Parkinson's disease ua ke nrog kev nyuaj siab, uas tuaj yeem txo cov tsos mob ntawm kev nyuaj siab yam tsis ua rau cov tsos mob tshwm sim ntawm Parkinson tus kab mob. Rau cov neeg mob tom qab-kev nyuaj siab ntxhov plawv (PTSD), nws cov teebmeem kev kho mob zoo ib yam li fluoxetine thiab moclobemide nrog kev nyab xeeb txaus siab, txhim kho tau zoo tom qab- cuam tshuam kev puas siab puas ntsws thiab pw tsaug zog tsis zoo. Tsis tas li ntawd, cov kev tshawb fawb tseem ceeb qhia tau hais tias nws muaj peev xwm siv tau hauv kev mob hawb pob thiab mob plab plob tsis so tswj, txawm hais tias kev sim tshuaj ntxiv yuav tsum tau kuaj xyuas nws cov nqi kho mob hauv cov teb no.
Tianeptine sodium yog qhov tseem ceeb ntawm cov tshuaj muaj nyob hauvtianeptine sodium kua. Nws cov txheej txheem hluavtaws tau ua kom zoo rau ntau xyoo, tsim ntau txoj hauv kev zoo nkauj. Txoj kev lag luam tseem ceeb tau txais 3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-ol 5,5-dioxide ua cov khoom pib, pib ntawm plaub theem tseem ceeb: hydroxyl tiv thaiv, ammonolysis, hloov pauv thiab hydrolysis.
Cov txheej txheem no muaj cov nqi tsim khoom tsawg, muaj txiaj ntsig siab, tsawg dua peb - pov tseg thiab cov khoom lag luam siab purity, uas yog siv tau rau loj - nplai kev lag luam.
Keeb kwm tsim los ntawm Servier Laboratories ntawm Fabkis, txoj kev hluavtaws no tau ua kom zoo dua los ntawm cov kws tshawb fawb hauv tsev kom txhawb nqa cov khoom siv hluav taws xob thiab cov khoom lag luam zoo, tso lub hauv paus txheej txheem rau kev tsim khoom loj.
Thawj kauj ruam yog kev tiv thaiv hydroxyl, uas yog lub hom phiaj tiv thaiv hydroxyl pawg hauv cov ntaub ntawv raw kom tsis txhob muaj kev cuam tshuam sab hauv cov txheej txheem tom ntej thiab txhim kho cov tshuaj tiv thaiv xaiv thiab tag nrho cov txiaj ntsig. Tshwj xeeb, ntxiv Solvent I (dichloromethane lossis 1,2-dichloroethane) rau hauv cov tshuaj tiv thaiv lub raj mis, tom qab ntawd ntxiv triethylamine thiab cov khoom pib ntawm molar piv ntawm 1.53: 1, ua raws li dropwise ntxiv ntawm hydroxyl tiv thaiv reagent ntawm molar ratio ntawm 1.2: 1 txheeb ze rau cov khoom siv raw.
Cov tshuaj tiv thaiv muaj xws li p-toluenesulfonyl chloride, trimethylsilyl chloride, trifluoromethanesulfonyl chloride thiab trifluoromethanesulfonic anhydride. Tom qab tso tseg, ua kom sov cov tshuaj tiv thaiv rau 30℃~ 80℃rau cov tshuaj tiv thaiv, saib xyuas cov tshuaj tiv thaiv kev nce qib ntawm - txheej txheem tswj. Thaum cov tshuaj tiv thaiv tag nrho, lim tawm cov impurities insoluble, mloog zoo rau cov filtrate, txias rau crystallization, lim thiab qhuav kom tau Intermediate I nrog cov txiaj ntsig kwv yees li ntawm 86%.
Cov kauj ruam thib ob yog ammonolysis, uas hloov cov tshuaj chlorine atoms hauv Intermediate I nrog cov amino pawg los npaj rau cov kev hloov pauv tom ntej. Hloov cov kuab tshuaj II (methanol, ethanol, isopropanol lossis tetrahydrofuran) thiab Intermediate I mus rau hauv autoclave, hloov cov huab cua sab hauv nrog nitrogen kom tshem tawm cov pa cuam tshuam, tom qab ntawd qhia cov pa roj ammonia thiab cua sov rau 30℃~ 60℃rau ammonolysis nrog tiag - lub sij hawm tshuaj xyuas.
Tom qab ua tiav cov tshuaj tiv thaiv, mloog zoo rau cov tshuaj tiv thaiv rau dryness, ntxuav cov khoom crude nrog distilled dej, lim thiab qhuav kom tau Intermediate II nrog ib tug yield tshaj 96%, uas zoo txo cov nqi hluavtaws.
Qhov thib peb kauj ruam yog hloov cov tshuaj tiv thaiv, cov txheej txheem tseem ceeb rau kev tsim cov pob txha yooj yim ntawm tianeptine sodium. Dissolve Intermediate I hauv dichloromethane thiab ntxiv triethylamine ntawm qhov sib piv loj ntawm 2.06: 1, tom qab ntawd dropwise ntxiv 7-bromoheptanenitrile nrog cov molar ratio tswj hauv 1: 0.95 ~ 1: 1.05.
Khaws cov tshuaj tiv thaiv ruaj khov thiab saib xyuas cov tshuaj tiv thaiv kev nce qib. Tom qab kev txiav tawm cov tshuaj tiv thaiv, ntxiv cov dej distilled rau cov kua - kua extraction, cais thiab sau cov organic theem, mloog zoo, txias rau crystallization, lim thiab qhuav kom tau Intermediate III. Cov kauj ruam no ua tiav kev tsim cov saw hlau sab ntawm tianeptine sodium.
Cov theem plaub yog hydrolysis, cov txheej txheem hluavtaws kawg. Nws hloov cyano pawg hauv Intermediate III rau hauv pawg carboxyl, uas ntxiv cov tshuaj sodium hydroxide los ua sodium ntsev, yielding tiav tianeptine sodium. Dissolve Intermediate III hauv Solvent III (methanol, ethanol lossis isopropanol), ntxiv sodium hydroxide thiab ua kom sov qhov sib tov rau 80℃rau hydrolysis.
Tom qab ua tiav cov tshuaj tiv thaiv, mloog zoo rau cov tshuaj, txias rau crystallization thiab sau cov ncuav mog qab zib lim. Ntxuav lub ncuav mog qab zib lim nrog cov kuab tshuaj tsim nyog rau kev tshem tawm impurity thiab qhuav kom tau txais siab -purity tianeptine sodium. Txoj kev hluavtaws no ua tiav tag nrho cov txiaj ntsig siab nrog cov khoom purity tshaj 99%. Nws nta cov tshuaj tiv thaiv me me, ua haujlwm yooj yim thiab qis peb - pov tseg, ua raws li cov qauv kev tiv thaiv ib puag ncig rau kev tsim khoom.
FAQ
Tianeptine sodium siv rau dab tsi?
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Tianeptine yog ib yam tshuaj muaj nyob rau hauv qee lub tebchaws European, Neeg Esxias thiab South America los kho kev ntxhov siab, kev nyuaj siab thiab mob plab plob tsis so tswj. Hauv lwm lub tebchaws, suav nrog Asmeskas, tianeptine tsis raug pom zoo rau kev siv kho mob.
Puas yog tianeptine sodium yog ib qho tshuaj tiv thaiv zoo?
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Tianeptine qhia tau hais tias muaj txiaj ntsig tiv thaiv kev nyuaj siab loj heev (kev nyuaj siab loj), piv rau amitriptyline, imipramine thiab fluoxetine, tab sis muaj cov kev mob tshwm sim tsawg dua. Nws tau pom tias muaj txiaj ntsig zoo dua li maprotiline hauv ib pawg neeg uas muaj kev sib koom ua ke- muaj kev nyuaj siab thiab kev ntxhov siab.
Cim npe nrov: tianeptine sodium kua, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom