Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm c-peptide kua hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo c-peptide tov rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
C-peptide yog ib feem ntawm polypeptide tawg tawm thaum proinsulin secreted los ntawm pancreatic -cells. Nws raug tso tawm rau hauv cov hlab ntsha hauv cov nyiaj sib npaug nrog beta-cov tshuaj hormone cell, tsis metabolized los ntawm lub siab, thiab feem ntau yog tawm los ntawm ob lub raum. Raws li kev siv tshuaj ntsuam xyuas reagent feem ntau siv,c- tshuaj peptideplays lub luag haujlwm tseem ceeb hauv kev kuaj mob, kev taw qhia kev kho mob thiab kev soj ntsuam kev soj ntsuam ntawm ntau yam kab mob xws li polycystic zes qe menyuam syndrome (PCOS), daim siab cirrhosis, kab mob raum ntev thiab gestational diabetes mellitus.
Peb Cov Khoom Muag Khoom
C-peptide COA
Daim ntawv thov hauv Polycystic Ovary Syndrome (PCOS)
Polycystic ovary Syndrome (PCOS) yog cov kab mob endocrine thiab metabolic ntau tshaj plaws hauv cov poj niam uas muaj hnub nyoog me nyuam. Los ntawm kev txheeb xyuas cov ntshav qabzib peptide kom raug,c- tshuaj peptidetuaj yeem soj ntsuam cov qib ntawm beta{0}}cov tshuaj hormone tiv thaiv cell hauv cov neeg mob, muab lub hauv paus txhim khu kev qha rau kev tsim, kev hloov kho thiab kev saib xyuas cov kev kho mob zoo.
Nyob rau hauv cov nqe lus ntawm beta-kev ntsuam xyuas ntawm cov tshuaj hormones tsis kam, cov ntshav cov qib peptide kuaj pom los ntawm cov khoom tuaj yeem cuam tshuam ncaj qha rau tag nrho cov tso tawm ntawm endogenous beta-cov tshuaj hormones ntawm tes thiab zam kev cuam tshuam ntawm exogenous beta-cov tshuaj hormones ntawm tes txhaj tshuaj ntawm cov tshuaj ntsuam xyuas, uas yog tshwj xeeb tshaj yog haum rau PCOS cov neeg mob uas tau txais beta{3}}cov tshuaj hormones.
Cov kev tshawb fawb soj ntsuam tau pom tias kev yoo mov thiab postprandial cov qib peptide hauv cov neeg mob PCOS muaj ntau dua li cov poj niam noj qab haus huv; qib peptide siab dua, qhov hnyav dua qhov beta-cov tshuaj hormone tsis kam ntawm tes, uas qhia txog kev sib raug zoo nrog Homeostatic Model Assessment rau beta-cell hormone Resistance (HOMA-IR). Rau cov neeg mob uas tsis yog- rog PCOS, cov cim BMI ib txwm ua tsis tau zoo los ntsuas beta-cov tshuaj tiv thaiv kab mob ntawm tes, thaum nws tshawb pom tuaj yeem ua qhov ntsuas ntsuas ntsuas ntau dua los pab txheeb xyuas qhov muaj peev xwm metabolic txawv txav thaum ntxov. Tsis tas li ntawd, ua ke nrog glucagon stimulation test thiab prodcut detection, lub peev xwm cia ntawm pancreal -cells kuj raug soj ntsuam, muab cov ntaub ntawv siv rau cov kab mob hnyav.
Cov Ntaub Ntawv Keeb Kwm: BioArt Review: C-peptide nyob rau hauv Polycystic Ovary Syndrome, Minfukang Dab Tsi Yog Qhov Tseem Ceeb Ntawm C-peptide thiab Insulin.
Daim ntawv thov nyob rau hauv daim siab Cirrhosis thiab Chronic raum Kab Mob
Ob lub siab cirrhosis thiab mob raum kab mob yog cov kab mob hauv lub cev tsis ua haujlwm uas cuam tshuam rau hauv vivo metabolism thiab excretion, yog li cuam tshuam nrog cov txheej txheem metabolic ntawm nws thiab ua rau cov ntshav tsis zoo ntawm cov qib peptide. Daim ntawv thov tseem ceeb ntawm kev tshawb nrhiav cov khoom hauv daim teb no yog txhawm rau txheeb xyuas qhov ua rau pseudo- nce qib ntawm cov tshuaj peptide, qhia kev txhais cov tshuaj ntsuam xyuas kom raug, tiv thaiv kev sib txawv hauv cov phiaj xwm kho mob vim kev txiav txim siab tsis raug, thiab muab cov ntaub ntawv pabcuam rau kev soj ntsuam qhov hnyav ntawm daim siab thiab lub raum ua haujlwm puas.
Cov yam ntxwv metabolic ntawm peptide txiav txim siab qhov tshwj xeeb ntawm nws qhov kev kuaj pom hauv cov neeg mob uas muaj lub siab tsis zoo thiab lub raum ua haujlwm: peptide tsis ua ntej - dhau cov metabolism hauv lub siab, yog li daim siab ua haujlwm tsis zoo hauv cov neeg mob cirrhotic tsis cuam tshuam ncaj qha rau cov metabolic clearance ntawm peptide.Txawm li cas los xij, daim siab cirrhosis feem ntau nrog rau cov ntshav qab zib kom tsis txhob muaj ntshav qab zib. pancreal -cells thiab indirectly ua rau kom nce qib peptide. Hauv cov neeg mob uas muaj kab mob raum ntev, lub raum tsis ua haujlwm txo qis ua rau txo qis lub raum tshem tawm ntawm peptide, ua rau cov ntshav qabzib peptide thiab pseudo- nce.
Qhov hnyav dua lub raum ua haujlwm puas tsuaj, qhov pom tseeb ntau dua ntawm pseudo-nce ntawm peptide. Hauv kev xyaum kho mob, txhais cov txiaj ntsig ntawm peptide yam tsis muaj kev sib txuas ntawm lub siab thiab lub raum kev ua haujlwm tuaj yeem txiav txim siab pseudo-nce raws li beta-cov tshuaj tiv thaiv cell lossis hyperfunction ntawm pancreal -cells, ua rau tsis tsim nyog hypoglycemic kev kho mob.Nyob rau hauv cov neeg mob uas muaj daim siab cirrhosis, kev txhais lus ntawm nws daim siab ua haujlwm (8) cov txiaj ntsig ntawm daim siab ua haujlwm yuav tsum yog grading), ntshav qabzib qib thiab beta-cov txiaj ntsig ntawm cov tshuaj hormones ntawm tes.Rau cov neeg mob cirrhotic nyuaj nrog hyperglycemia, nce qib peptide nrog rau kev nce beta{11}}cov tshuaj hormones ntawm tes qhia tias beta-cov tshuaj tiv thaiv ntawm tes thiab kev kho mob hypoglycemic yog xav tau.
Ib txwm lossis qis qis peptide nrog cov ntshav qabzib siab tswj cov qib siab tuaj yeem tshwm sim los ntawm kev txo qis hauv cov ntshav qab zib hauv cov ntshav qab zib kom tsis muaj peev xwm ua kom muaj peev xwm ua haujlwm, yog li qhov tseem ceeb yuav tsum tau muab rau kev kho mob siab mob siab rau nws tus kheej es tsis yog dig muag hypoglycemia. Tsis tas li ntawd, cov qib peptide tuaj yeem pab ntsuas kev ntsuas ntawm cov neeg mob cirrhotic; tsis tu ncua nce C- qib peptide nrog kev tswj cov ntshav qabzib tsis zoo qhia tau tias muaj kev cuam tshuam loj hauv metabolic thiab ua rau muaj kev pheej hmoo siab ntev - teeb meem.
Hauv cov neeg mob uas muaj kab mob raum ntev,c- tshuaj peptideCov txiaj ntsig kev ntsuas yuav tsum tau kho ua ke nrog rau lub raum ntsuas ntsuas xws li kwv yees glomerular filtration rate (eGFR), creatinine thiab ntshav urea nitrogen. Thaum eGFR ＜ 60 ml / min / 1.73m², lub raum muaj peev xwm tso tawm peptide txo qis, ua rau pseudo- nce siab ntawm cov ntshav peptide. Lub sijhawm no, qhov kev siv ib txwm siv ntawm peptide yuav tsum raug kho raws li qhov hnyav ntawm lub raum ua haujlwm puas tsuaj kom tsis txhob muaj kev txiav txim siab ntawm pancreal - cell function.
Cov ntaub ntawv Source: National Center for Biotechnology Information A Practical Review of C-Peptide Testing in Diabetes.
Daim ntawv thov hauv Gestational Diabetes Mellitus (GDM)
Gestational glycuresis mellitus (GDM) yog hais txog cov piam thaj hauv cov ntshav tsis zoo ua ntej tshwm sim lossis kuaj pom thaum cev xeeb tub, nrog rau kev nthuav dav thoob ntiaj teb ntawm 7.1%-27.6%. Yog tias tsis muaj kev cuam tshuam rau lub sijhawm thiab muaj txiaj ntsig, nws yuav ua rau muaj kev pheej hmoo ntawm kev xeeb tub tsis zoo xws li ntu ntu ntu, macrosomia thiab preeclampsia, nrog rau kev pheej hmoo mus sij hawm ntev ntawm hom 2 mob ntshav qab zib hauv cov niam thiab cov metabolism hauv cov fetuses.
Kev tshawb nrhiav kev daws teeb meem tuaj yeem paub qhov txawv ntawm hom kab mob ntawm GDM (pancreal secretion deficiency lossis yooj yim cov ntshav qab zib regulator resistance), muab cov lus qhia meej rau kev tsim cov txheej txheem kev kho tus kheej ua ntej yug menyuam thiab tom qab yug me nyuam, thiab ua rau qhov tsis txaus ntawm cov tshuaj ntshav qabzib uas tsuas yog qhia txog qib ntshav qabzib tab sis tsis tuaj yeem ntsuas kev ua haujlwm.
Nyob rau hauv cov nqe lus ntawm pathogenesis hom sib txawv, los ntawm kev ntsuas C- peptide theem ntawm txhua lub sij hawm taw tes (0h, 1h, 2h) thaum lub sij hawm yoo mov thiab qhov ncauj glucose tolerance test (OGTT) thiab combining nrog cov ntshav qabzib hloov, cov tshuaj ntsuam xyuas yuav qhia tau meej lub pancreal islet function status ntawm cov neeg mob.
Los ntawm kev tsim lub dynamic trajectory qauv ntawm peptide hauv OGTT, cov kev tshawb fawb soj ntsuam tau txheeb xyuas ob hom metabolic subtypes ntawm GDM:
Ncua Peak Hom: Cov qib peptide nce qeeb thiab nce siab ntawm 120 feeb nrog tus nqi siab siab, qhia txog kev ua haujlwm tsis zoo ntawm pancreal -cov cell uas tsis tuaj yeem tiv thaiv gestational ntshav qab zib regulator kuj, cais raws li pancreal secretion deficiency hom.
Thaum ntxov Hyper- teb hom: C-peptide qhia pom pom tseeb qhov siab tshaj plaws ntawm 60 feeb nrog tus nqi nce siab siab ua raws li qhov poob sai, qhia txog kev ua haujlwm tsis zoo ntawm pancreatic -cells tab sis hnyav ntshav qab zib tswj tsis kam, cais raws li beta yooj yim -cell hormone kuj hom.
Nyob rau hauv cov nqe lus ntawm kev qhia kev kho mob ua ntej yug menyuam, cov kev kho mob tus kheej tuaj yeem tsim tau raws li cov kab mob pathogenesis txawv los ntawm kev kuaj pom peptide. Rau cov neeg mob uas yooj yim beta-cov tshuaj hormone tiv thaiv hom GDM, kev tswj kev noj zaub mov ua ke nrog kev tawm dag zog yog qhov tseem ceeb hauv kev kho mob. Kev tswj kom tsim nyog ntawm tag nrho cov calories kom tsawg thiab kev tawm dag zog ib nrab tuaj yeem txhim kho cov ntshav qab zib rhiab heev thiab txo qis C-peptide thiab ntshav qabzib qib. Kev tshawb nrhiav peptide tsis tu ncua tuaj yeem saib xyuas cov teebmeem kev kho mob; Kev maj mam poob rau hauv cov qib peptide qhia tau hais tias kev txhim kho cov ntshav qab zib regulator kuj tsis xav tau kev pib noj tshuaj.
Yog tias C- qib peptide tseem pheej ua siab ntev thiab cov ntshav qabzib tswj tsis tau zoo tom qab kev noj zaub mov thiab kev tawm dag zog, cov tshuaj tswj ntshav qab zib lossis GLP-1 receptor agonist therapy tuaj yeem siv. Kev kuaj pom peptide yuav tsum tau siv los kho cov tshuaj noj thaum lub sijhawm kho kom tiv thaiv hypoglycemia. Rau cov neeg mob uas muaj pancreal secretion deficiency hom GDM, pancreal -cells tsis tuaj yeem ua tau raws li qhov xav tau ntawm cev xeeb tub, thiab kev noj zaub mov yooj yim thiab kev tawm dag zog feem ntau ua rau tsis zoo. Kev pib ntxov ntawm ntshav qab zib regulator hloov kho yog yuav tsum tau. Kev kuaj pom C-peptide yog siv los ntsuas qhov kev rov qab los ntawm pancreatic islet secretory muaj nuj nqi thiab kho cov ntshav qab zib kom ntau npaum li cas kom ntseeg tau cov ntshav qabzib nyob rau hauv qhov qub thiab txo qhov tshwm sim tsis zoo ntawm cev xeeb tub.
Cov Ntaub Ntawv Keeb Kwm: PMC Cov kev cia siab yav tom ntej ntawm C- kev kuaj peptide hauv kev kuaj mob ntxov ntxov ntawm gestational diabetes, BMC Medicine Dynamic OGTT- muab tau C-peptide trajectories rau metabolic heterogeneity thiab tsis zoo cev xeeb tub tshwm sim hauv gestational diabetes mellitus.
Cov Lus Qhia Txog Kev Tshawb Fawb Txog Kev Tshawb Fawb thiab Kev Ntsuas Kev Tswj Xyuas Zoo
Hauv kev sim tshuaj, C-peptide AUC (Area Under the Curve) yog qhov qhia txog kev ua tau zoo. Cov qauv qauv rau lub sijhawm sau cov ntshav, kev ua cov qauv kuaj thiab kuaj cov tshuaj reagents yuav tsum tau ua nruj me ntsis txhawm rau txo qhov kev ua yuam kev.
Cov khoom siv kuaj mob yuav tsum tau ua raws nrog cov tib neeg C-peptide calibrators; cov coefficient ntawm kev hloov pauv (CV) ntawm kev tswj xyuas kev ua tau zoo yuav tsum tsawg dua 10%, thiab kev ntsuam xyuas sab nraud yuav tsum ua raws li cov qauv ntawm National Center for Clinical Laboratories ntawm National Health Commission ntawm Tuam Tshoj.
Cov Ntaub Ntawv Keeb Kwm: BioArt 2025 Evolution of the Role of C-peptide in Diabetes Care; 2024 Kev Tshuaj Ntsuam Xyuas Kev Tswj Xyuas Kev Tswj Xyuas Zoo Tshaj Tawm los ntawm National Center for Clinical Laboratories of the National Health Commission of the People's Republic of China.
FAQ
Yuav txo qis C-peptide siab li cas?
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Kev yoo mov thiab kev txwv calorieTej zaum yuav yog cov tswv yim zoo rau txo nws qib yog tias koj muaj insulin tsis kam thiab / lossis rog dhau. Hauv 12 tus poj niam uas muaj mob rheumatoid mob caj dab, txwv tsis pub calorie thiab yoo mov txo cov zis nws qib ntau dua 50% thaum lub sijhawm yoo mov.
Puas yog C-peptide tseem ceeb?
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Nws yog lub cim qhia tias koj lub cev tsim cov tshuaj insulin. Qib qis (lossis tsis muaj) qhia tias koj lub txiav ua rau cov tshuaj insulin tsawg lossis tsis muaj. Qib qis tej zaum yuav zoo li qub yog tias koj tsis tau noj tsis ntev los no. Koj cov ntshav qab zib thiab cov tshuaj insulin ib txwm yuav qis dua.
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