Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm terbinafine hydrochloride lotion hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo terbinafine hydrochloride lotion rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Terbinafine hydrochloride tshuaj pleevyog ib qho kev siv tshuaj tua kab mob tshuaj tua kab mob dav dav, cais nyob rau hauv chav kawm allylamine ntawm cov kws tshuaj. Nws cov khoom xyaw tseem ceeb, terbinafine hydrochloride, ua haujlwm los ntawm kev xaiv lub hom phiaj thiab inhibiting fungal enzyme squalene epoxidase. Qhov kev txwv tseem ceeb no cuam tshuam rau biosynthesis ntawm ergosterol, ib qho tseem ceeb ntawm cov txheej txheem ntawm cov kab mob fungal cell membrane, ua rau daim nyias nyias tsis ruaj khov thiab thaum kawg ua tiav cov txiaj ntsig ntawm fungicidal thiab fungistatic. Nws nthuav tawm cov haujlwm muaj zog tiv thaiv dermatophytes, thaum tseem ua kom pom qhov ua tau zoo tiv thaiv cov poov xab thiab lwm yam kab mob fungi. Cov tshuaj pleev no tau pom zoo rau kev kho mob ntawm ntau yam kab mob ntawm cov kab mob ntawm daim tawv nqaij, xws li tinea corporis, tinea cruris, tinea pedis, tinea versicolor, thiab cutaneous candidiasis. Raws li cov tshuaj pleev ib ce-raws li kev npaj, nws muaj cov txiaj ntsig kho mob sib txawv: nws kis tau sai thiab sib npaug thoob plaws ntawm daim tawv nqaij, tsim cov txheej txheem tiv thaiv uas txhawb nqa kev ua haujlwm tsis tu ncua; nws txhim kho permeability tso cai rau nws nkag mus tob rau hauv lub epidermal stratum corneum, ncaj qha mus txog qhov chaw ntawm tus kab mob kom zoo tshem tawm latent fungi; Tsis tas li ntawd, nws muaj lub teeb yuag, tsis yog - greasy zoo nkauj uas tsis muaj qhov seem ntawm daim tawv nqaij, yog li txhim kho cov neeg mob kev nplij siab thiab kev kho mob.
Thaum siv cov khoom, nws yog ib qho tsim nyog yuav tsum tau ua ntej ntxuav cov epidermis cuam tshuam thiab qhuav nws. Siv cov tshuaj ntxuav tes kom tsim nyog thiab siv nws sib npaug rau thaj chaw muaj kev cuam tshuam thiab ib puag ncig kev noj qab haus huv epidermis. Maj mam zaws kom txog thaum absorbed tag. Lub sijhawm ntawm cov tshuaj sib txawv nyob ntawm qhov chaw thiab qhov hnyav ntawm tus mob. Feem ntau, kev siv tas li yuav tsum tau siv rau 2-4 lub lis piam. Tom qab cov tsos mob ploj lawm, nws tseem pom zoo kom siv tshuaj ntxiv rau 1-2 lub lis piam txhawm rau txhim kho cov txiaj ntsig kho.
Cov ntaub ntawv ntxiv ntawm chemical compound:
Peb cov khoom tsim
terbinafine hydrochloride +. COA
1. Cov lus qhia
Epidermis ringworm kab mob:
Tinea corporis: ncig erythema nrog central regression thiab peripheral nplai
Tinea crus: ib ncig epidermis lesion nyob rau hauv lub puab tais, feem ntau nrog khaus
Tes thiab ko taw tinea: soaking thiab whitening ntawm ntiv tes / ntiv taw los yog ntau keratinization
Tinea capitis: scaly thaj ua rau ntawm tawv taub hau nrog cov plaub hau poob (yuav tsum tau kho qhov ncauj)
Kab mob poov xab:
Candidiasis ntawm epidermis: erythema thiab yaig ntawm qhov chaw rub
Malassezia folliculitis: Round papules ntawm lub hauv siab thiab nraub qaum
Lwm yam kab mob fungal:
Tinea versicolor: depigmentation lossis pigmentation me ntsis
Onychomycosis (yuav tsum tau kho pob): ntsia thawv thickening, discoloration, sib cais
2. Cov ntaub ntawv pov thawj ntawm kev kho tau zoo
Ntau qhov chaw randomized tswj kev sim tau pom tias tus nqi kho mob rau kev kho tinea corporis thiab pedis yog 85% -90% tom qab siv tas li rau 2 lub lis piam
Kev kho mob ntawm tinea pedis yuav tsum tau txuas ntxiv mus rau 4 lub lis piam, nrog kev kho tus nqi kwv yees li 75% -80%
Qhov txiaj ntsig zoo ntawm kev kho mob candidal papules yog 70% -75%
Raws li kev npaj ua kua sab nraud, cov tshuaj ntxuav tes tau siv dav hauv dermatology, gynecology thiab lwm yam. Nws cov txiaj ntsig kev tsim tawm tau cuam tshuam rau ntau yam xws li cov khoom sib xyaw, kev ua haujlwm, kev yooj yim ntawm kev siv, kev nyab xeeb thiab kev siv dav. Cov kev ntsuam xyuas hauv qab no yog ua los ntawm kev pom kev tshaj lij:
Cov tshuaj ntxhua khaub ncaws tuaj yeem tsim cov tshuaj, ncua kev kawm, lossis emulsion formulations siv dej los yog ethanol li dispersing media. Lub ncua kev kawm ntawv hom tshuaj detergent ntxiv glycerol thiab tshem tawm cov neeg sawv cev kom tusyees tshem tawm cov tshuaj hmoov nyob rau hauv cov kua, zam sedimentation thiab clumping. Piv txwv li, nyob rau hauv calamine lotion, zinc oxide thiab calamine hais yog stably dispersed nrog kev pab los ntawm tshem tawm cov neeg sawv cev, uas muaj peev xwm sib npaug ntawm cov epidermis thaum thov, kom ntseeg tau qhov kev tso tawm tsis tu ncua ntawm cov tshuaj active cov khoom xyaw. Qhov no dispersion system kuj optimizes tshuaj solubility los ntawm kev kho cov ethanol piv. Piv txwv li, ib lub xab npum uas muaj 20% ethanol tuaj yeem yaj tau ob qho tib si roj soluble thiab dej- cov khoom soluble ib txhij, txhim kho kev ruaj ntseg ntawm cov khoom sib xyaw.
1. Kev nkag mus sai thiab kev ua tiav
Cov kua dej ntawm cov tshuaj ntxuav tes tso cai rau nws nkag mus rau stratum corneum sai. nojTerbinafine Hydrochloride LotionRaws li ib qho piv txwv, nws cov acrylamide tivthaiv exerts bactericidal nyhuv los ntawm disrupting lub fungal cell membrane qauv. Cov neeg nqa khoom ua kua tuaj yeem nqa cov tshuaj ncaj qha mus rau qhov chaw muaj kab mob, thiab bioavailability ntawm cov khoom yog 15% -20% siab dua li cov tshuaj pleev ib ce thaum kho tinea pedis.
2.Multi nyhuv synergistic nyhuv
Cov tshuaj ntxhua khaub ncaws feem ntau muaj ntau yam khoom xyaw ua haujlwm:
Anti inflammatory thiab astringent: Zinc uas muaj cov khoom sib txuas (xws li zinc oxide) txo qhov tsim cov kab mob inflammatory los ntawm inhibiting histamine tso tawm, thaum tseem constricting cov hlab ntsha kom txo tau liab thiab o.
Antipruritic kev tiv thaiv: Menthol thiab lwm yam khoom xyaw txhawb rau cov tawv nqaij txias sensory receptors, cuam tshuam nrog khaus teeb liab kis tau tus mob, thiab tsim ib tug lub cev barrier los tiv thaiv sab nraud stimuli.
Antibacterial thiab bacteriostatic: Thaum cov ntsiab lus ethanol nce mus txog 15% -30%, nws tuaj yeem ua rau cov kab mob ntawm tes ua kom puas tsuaj thiab ua haujlwm sib xyaw ua ke sib xyaw nrog cov tshuaj tua kab mob.
3.Dynamically kho lub microenvironment
Cov evaporation ntawm cov dej hauv cov tshuaj ntxuav tes tuaj yeem tshem tawm cov cua sov thiab txo qhov kub ntawm cov kab mob epidermis los ntawm 0.5-1.5 degree. Nws yog tsim rau mob eczema, hu rau dermatitis thiab lwm yam kab mob ntawm tshav kub. Piv txwv li, Ganlin xab npum ua tiav lub cev txias los ntawm ethanol evaporation, thiab muab cov tshuaj suav tshuaj suav tshuaj los kho cov epidermis pH tus nqi rau 4.5-5.5, inhibiting kev loj hlob ntawm Staphylococcus aureus.
Cov txheej txheem ua haujlwm yooj yim
Cov tshuaj ntxuav tes siv ib kauj ruam tsim ntawm "siv nqus", uas yuav tsum tau zaws kom txog thaum absorbed tag piv rau qab zib. Cov tshuaj detergent yuav ib txwm evaporate los ua ib zaj duab xis tshuaj. Noj cov tshuaj gynecological ua piv txwv, patents tuaj yeem ua tiav kev tswj hwm cov tshuaj los ntawm qhov chaw mos irrigator, uas tsuas yog siv sijhawm 2-3 feeb, txuag 50% ntawm lub sijhawm piv rau suppositories.
Kev tswj tshuaj kom raug
Nruab nrog ntau lub nozzle lossis cov twj tso kua mis, nws tuaj yeem ua tiav kev tswj hwm ntawm 0.5-1mL ib koob. Piv txwv li, thaum kho tinea corporis thiab pedis, qhov pom zoo siv rau cov kab mob uas muaj txoj kab uas hla ntawm 3cm yog 0.5g ntawm xab npum, thiab cov qauv nozzle yog siv kom tsis txhob muaj qhov sib txawv ntawm qhov sib txawv los ntawm qhov sib txawv ntawm qhov sib txawv hauv cov tshuaj nplaum.
Kev txhim kho hauv kev huv huv
Dej raws li cov tshuaj ntxuav tau yooj yim los ntxuav thiab muaj qhov seem seem tsawg dua 5%, ua rau lawv tshwj xeeb rau cov plaub hau ntom ntom xws li tawv taub hau thiab caj dab. Tus nqi seem ntawm cov tshuaj pleev xim rau cov plaub hau tuaj yeem ncav cuag 30% -40%, thaum cov tshuaj detergents tuaj yeem txo qhov kev khaus ntawm kev ntxuav ntawm cov tawv nqaij.
1. Tsawg stimulus tsim
Txo kev ua xua rau cov epidermis ib txwm los ntawm kev ua kom zoo pH qhov tseem ceeb (5.0-7.0) thiab osmotic siab (280-320mOsm / kg). Piv txwv li, cov me nyuam cov tshuaj detergents yuav tsum tswj cov ethanol cov ntsiab lus hauv qab 10% kom tsis txhob muaj kev sib cuag dermatitis los ntawm cawv stimulation nyob rau hauv ib txwm tinctures.
2. Txo qhov kev tsis haum tshuaj
Cov tshuaj ntxhua khaub ncaws tsis muaj tshuaj tua kab mob lossis muaj cov tshuaj phenoxyethanol tsawg (0.1% -0.3%) muaj 60% -70% qis dua qhov tshwm sim ntawm kev ua xua piv rau cov tshuaj nplaum (muaj nipagin ester preservatives). Cov ntaub ntawv kho mob qhia tau hais tias qhov tshwm sim ntawm erythema hauv zos thiab khaus khaus hauv patents siv cov tshuaj phenoxyethanol tsuas yog 1.2%, txo qis dua li 4.8% hauv cov tshuaj qab zib.
3.System absorption yog tswj tau
Tus transdermal absorption tus nqi ntawm cov tshuaj nyob rau hauv detergents feem ntau yog tsawg tshaj li 5%, uas yog tshwj xeeb tshaj yog haum rau cov neeg tshwj xeeb xws li cov poj niam cev xeeb tub thiab cov me nyuam. Piv txwv li, thaum kho candidal vaginitis thaum cev xeeb tub, cov ntshav concentration ntawm cov tshuaj ntxuav tes tsuas yog 1/50 ntawm qhov ncauj, thiab qhov kev pheej hmoo ntawm kev kis tus menyuam hauv plab yog tsawg heev.
Compatibility ntawm kev sib xyaw ua ke
Lotion tuaj yeem siv ua ntu zus nrog cov tshuaj nplaum, gel thiab lwm yam tshuaj. Piv txwv li, hauv kev kho mob ntawm psoriasis, thawj zaug siv cov tshuaj ntxuav tes uas muaj salicylic acid kom tshem tawm cov nplai, thiab tom qab ntawd siv cov tshuaj pleev calcipotriol, uas ua rau kom cov tshuaj nqus tau los ntawm peb zaug.
Kev tswj tag nrho lub voj voog ntawm cov mob hnyav thiab mob ntev kab mob
Cov theem mob hnyav: Ethanol muaj cov tshuaj ntxuav tes ua kom lub cev txias los ntawm cov evaporation sai, ua ke nrog cov tshuaj tiv thaiv kab mob los txo qhov khaus. Piv txwv li, calamine lotion tsuas siv sijhawm 15-30 feeb los kho mob urticaria.
Lub sij hawm ntev: Los ntawm kev ncua lub voj voog tshuaj (xws li kev siv tshuaj pleev terfinabine tas li rau 6 lub hlis los kho onychomycosis) kom tswj tau cov tshuaj concentration, lub siab toxicity yog txo los ntawm 80% piv rau qhov ncauj formulations.
Kev kho kom zoo ntawm cov tshuaj rau thaj chaw tshwj xeeb
Mucosal cheeb tsam: Qhov chaw mos ntxuav siv cov mis isotonic (300mOsm / kg) kom tsis txhob mucosal edema tshwm sim los ntawm osmotic siab sib txawv nyob rau hauv ib txwm suppositories.
Wrinkle thaj tsam: Hauv kev kho pob khaus, cov tshuaj yeeb yaj kiab tsim los ntawm cov tshuaj ntxuav tes tuaj yeem txo kev sib txhuam thiab txo qhov rov ua dua ntawm 45% piv rau hmoov.
1. Tus nqi zoo tshaj -kev ua tau zoo piv
Tus nqi unit dose ntawmTerbinafine hydrochloride tshuaj pleevyog 20% -30% qis dua li cov qab zib, thiab lub sij hawm kho tau luv luv (xws li txo qhov kev kho lub voj voog ntawm tinea pedis los ntawm 4 lub lis piam mus rau 2 lub lis piam nrog qab zib). Cov kev tshawb fawb soj ntsuam tau pom tias cov patents uas siv cov tshuaj ntxuav tes muaj qhov txo qis ntawm 18% hauv tag nrho cov nqi kho mob.
2. Txhim kho kev ua raws li tus neeg mob
Kev siv cov tshuaj ntxuav kom huv ua rau tus neeg mob txaus siab ntawm 92%, ntau dua li 78% ntawm cov qab zib. Tshwj xeeb tshaj yog ntawm cov tub ntxhais hluas patents, qhov kev lees paub ntawm cov tshuaj ntxuav tes yog 40% siab dua li cov qauv tsim.
3. Kev cia thiab kev thauj mus los yooj yim
Cov tshuaj ntxuav tes yog ntim rau hauv lub raj mis yas, uas yog 60% sib dua li cov iav fwj tshuaj nplaum, thiab tsis tas yuav tsum tau tub yees, txo nqi logistics los ntawm 35%. Hauv thawj qhov chaw kho mob, tus nqi tawg ntawm cov tshuaj detergents (0.5%) yog qhov qis dua li cov tshuaj nplaum (3.2%).
Cim npe nrov: terbinafine hydrochloride lotion, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom