Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm furosemide tov khoom hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo furosemide tov rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Lub npe tshuaj ntawmtshuaj furosemideyog 2- [(2-furanmethyl) amino] -5- (sulfamoyl) -4-chlorobenzoic acid, nrog ib tug molecular mis ntawm C₁₂H₁₁ClN₂O₅S thiab molecular hnyav ntawm 330.75. Nws cov qauv suav nrog furan nplhaib, chlorobenzoic acid pawg, thiab sulfamoyl pawg, uas ua ke txiav txim siab txog kev solubility thiab lom ntawm cov tshuaj. Nws yog haum rau cov neeg mob uas muaj refractory hypertension los yog concomitant edema.
Feem ntau, cov koob tshuaj tsawg (20-40mg / hnub) yog siv ua ke nrog lwm cov tshuaj tiv thaiv hypertensive (xws li ACEIs, ARBs) los txhim kho cov nyhuv antihypertensive thiab txo cov kev mob tshwm sim. Cov tshuaj no muaj 10mg / mL lossis 40mg / 5mL ntawm furosemide, ntxiv nrog D&C Yellow No.10, FD&C Yellow No.6 (xim xim), potassium carbonate (pH regulator), propylene glycol (cosolvent), purified dej, thiab sorbitol tov (sweetener). Kev txhim kho saj (txiv kab ntxwv lossis txiv duaj txiv duaj tsw), yooj yim rau cov menyuam yaus thiab cov neeg mob nqos nyuaj siv. Siv cov cuab yeej ntsuas tshwj xeeb (xws li cov koob txhaj tshuaj hauv qhov ncauj) txhawm rau ntsuas qhov ntau npaum li cas.
Peb cov khoom
Furosemide COA
Molecular Stage of Gas Liquid Interface: Interface Self Assembly of Furosemide
Nyob rau hauv kev sib tshuam ntawm nanotechnology thiab kev xa tshuaj, roj-kua interface tus kheej-sembly thev naus laus zis tau dhau los ua lub tswv yim tshiab. Cov thev naus laus zis no simulates cov txheej txheem sibtham ntau- nplai sib dhos txheej txheem ntawm cov molecules nyob rau hauv qhov, orienting functional molecules los yog nanoparticles rau hauv cov qauv txiav txim, yog li endowing cov ntaub ntawv nrog lub cev thiab tshuaj muaj pes tsawg leeg.Furosemide daws, raws li ib tug classic voj diuretic, yog endowed nrog tshwj xeeb hydrophilicity thiab hydrophobicity los ntawm furan nplhaib, sulfamoyl pawg, thiab chlorobenzoic acid pab pawg neeg nyob rau hauv nws cov qauv molecular, ua rau nws yog ib tug zoo tagnrho qauv molecule rau kev kawm roj{0}} kua interface nws tus kheej -assembly.
Furosemide yog cov tshuaj tsis muaj zog acidic (pKa ≈ 3.9), thiab nws cov℃dissociation yog cuam tshuam ncaj qha los ntawm pH ntawm cov tshuaj. Hauv kev daws qhov ncauj, pH regulators (xws li poov tshuaj carbonate) tsis tsuas yog cuam tshuam rau cov tshuaj stability tab sis kuj tswj kev nqus tau los ntawm kev hloov lub xeev dissociation. Cov kev tshawb fawb tau pom tias thaum pH ntawm cov tshuaj tau khaws cia ntawm 7.4-8.0, qhov feem pua ntawm furosemide hauv nws daim ntawv uas tsis yog-dissociated (lipid-}soluble)) nce 30%, ua kom nws cov permeability los ntawm cov kab mob hauv plab hnyuv me thiab nce bioavailability ntawm 5% mus rau 6%. Qhov "pH-dependent absorption" tshwm sim muab lub hauv paus theoretical rau optimizing cov tshuaj formulations.
Molecular Properties thiab interface tus kheej - sib dhos hauv paus ntawm furosemide
Molecular Structure thiab Hydrophobicity
Cov tshuaj formula ntawm furosemide yog C ₁₂ H ₁₁ ClN ₂ O ₅ S, thiab nws cov qauv molecular muaj peb lub luag haujlwm tseem ceeb: Furan nplhaib: Raws li lub taub hau hydrophilic, nws tuaj yeem cuam tshuam nrog cov dej molecules los ntawm hydrogen bonding; Aminosulfonyl pawg: muab cov polar functional pab pawg Cov kuab tshuaj; Chlorobenzoic acid pawg: Raws li tus Tsov tus tw hydrophobic, nws tsav lub aggregation ntawm molecules nyob rau hauv uas tsis yog -polar ib puag ncig.Cov qauv amphiphilic no ua rau cov molecules ntawm furosemide.
Thaum cov molecules diffuse mus rau cov pa roj-kua interface, lub nplhaib furan nyiam mus rau lub ntsej muag ntawm lub aqueous theem, thaum cov chlorobenzoic acid pawg taw tes rau cov roj theem, tsim ib qho kev npaj monolayer. Txoj kev taw qhia no yog lub hauv paus ntawm tus kheej- kev sib dhos, zoo ib yam li kev sib dhos ntawm phospholipid molecules hauv cell membrane.
Cov pa roj-kua interface yog lub zog sib npaug, thiab nws qhov nro ( ) thiab qhov siab (π) ua lub luag haujlwm tseem ceeb hauv kev sib dhos molecular.
Rau furosemide molecules:
Kev txo qhov nro: Lub adsorption ntawm furosemide ntawm lub interface ua rau txo qhov nro ntawm dej.
Kev sim tau pom tias thaum qhov concentration ntawm furosemide yog 0.1 mM.
Qhov nro saum npoo tuaj yeem raug txo los ntawm 72 mN / m mus rau 55 mN / m, qhia txog kev tsim cov monolayer ntom ntom ntawm cov molecules ntawm lub interface.
Kev tswj qhov siab saum npoo:
Los ntawm Langmuir Blodgett (LB) zaj duab xis thev naus laus zis, qhov chaw siab tuaj yeem tswj tau meej (feem ntau nyob rau hauv thaj tsam ntawm 10-40 mN / m), yog li tswj cov ntim ntim ntawm cov molecules. Piv txwv li, ntawm qhov siab ntawm 20 mN / m, furosemide molecules tsim ib hexagonal kaw packed qauv; Thaum lub siab saum npoo nce mus txog 35 mN / m, nws hloov mus rau hauv cov qauv tilted.
Kev sib dhos tus kheej ntawm furosemide ntawm cov pa roj - kua interface
Spontaneous adsorption thiab monolayer tsim
Cov txheej txheem ntawm diffusion ntawmtshuaj furosemidemolecules los ntawm bulk tov rau roj-kua interface yuav muab faib ua peb theem:
Diffusion theem: molecules ncav cuag thaj tsam ntawm qhov sib cuam tshuam los ntawm Brownian motion; Adsorption theem: Hydrophobic pawg (chlorinated benzoic acid) nyiam tso rau hauv cov roj theem.Thaum cov pab pawg hydrophilic (furan nplhaib) cuam tshuam nrog cov dej theem los tsim cov adsorption instantaneous.
Rearrangement theem:
Cov molecules optimize intermolecular rog (xws li van der Waals rog thiab π - π stacking) los ntawm lateral txav thiab rotation.Thaum kawg tsim ib tug ruaj khov monolayer.Cov txheej txheem no tuaj yeem ua tus yam ntxwv ntawm thaj chaw siab isotherm (π - Ib qho nkhaus). Ib tug raug π - Ib tug nkhaus qhia tau hais tias thaum lub molecular cheeb tsam yog compressed mus txog 0.8 nm ² / molecule, lub nto siab sharply nce, qhia tau hais tias cov molecules yog compressed los ntawm cov roj theem mus rau lub kua theem, tsim ib tug incompressible monolayer.
Los ntawm kev rov ua cov txheej txheem LB rub tawm, ib txheej ntawm furosemide tuaj yeem hloov mus rau hauv cov khoom siv substrate kom ua tiav ntau- txheej txheej. Kev tshawb nrhiav pom:
Interlayer kev sib cuam tshuam: Cov khaubncaws sab nraud povtseg yog txuas nrog hydrogen bonds thiab π - π stacking (benzene nplhaib benzene nplhaib), nrog rau interlayer spacing ntawm kwv yees li 1.2 nm;
Kev tswj hwm crystallinity: Nyob rau hauv kev ua kom qhuav qeeb, cov yeeb yaj kiab multilayer tuaj yeem tsim cov qauv crystalline heev. X-ray diffraction (XRD) qhia tau hais tias qhov interplanar spacing ntawm (001) yog 1.2 nm, uas yog raws li cov thickness ntawm molecular txheej;
Kev tswj tsis raug: Los ntawm kev kho qhov nrawm nrawm (0.1-10 mm / min) thiab kub (20-40 degree), cov qoob loo ciam teb tuaj yeem tswj tau. Thaum rub ntawm qhov ceev ceev (0.5 mm / min), cov qoob loo ciam teb txo qis mus rau 5% / μ m ², txhim kho cov neeg kho tshuab ruaj khov ntawm zaj duab xis.
Tswj kev ua tau zoo ntawm furosemide los ntawm kev sib txuas ntawm tus kheej - sib dhos
Solubility thiab tso tawm Dynamics
Tus kheej-cov qauv sib dhos ua rau muaj kev cuam tshuam rau kev sib cais thiab tso tawm tus cwj pwm ntawm furosemide: Ib txheej txheej membrane: Hauv pH 7.4 phosphate buffered saline (PBS), qhov kev sib cais ntawm ib txheej membrane (k=0.02 min ⁻¹) raug txo los ntawm 8 npaug piv rau cov qauv dawb molecules sib dhos los ntawm kev ncua, steric hindrance; Multilayer zaj duab xis: Qhov tso tawm nkhaus ntawm peb - txheej txheej txheej zaj duab xis nthuav tawm cov yam ntxwv biphasic: thawj zaug tso tawm sai, ua raws li kev tso tawm qeeb (tseem tshuav 80% hauv 72 teev). Cov qauv no haum rau cov xwm txheej uas yuav tsum tau ua kom muaj txiaj ntsig zoo, xws li kev kho mob plawv tsis ua haujlwm.
Kev ua haujlwm lom neeg thiab lub hom phiaj
Kev sib dhos tus kheej tuaj yeem txhim kho qhov bioavailability ntawm furosemide thiab ua tiav lub hom phiaj xa khoom: Cell uptake: Hauv Caco-2 qauv ntawm tes, kev nce ntawm tus kheej- sib dhos nanosheets (diameter 200 nm, thickness 5 nm) yog 3.2 npaug siab dua li ntawm cov dawb molecules, ntaus nqi ntawm cov ntaub ntawv xov xwm los ntawm cov ntaub ntawv tsis muaj txiaj ntsig. endocytosis; Lub raum lub hom phiaj: Hauv cov qauv nas, kev faib tawm ntawm tus kheej sib sau ua ke furosemide hauv ob lub raum (AUC=12.5 μ g · h / mL) yog 2.6 npaug ntau dua li cov tshuaj dawb (AUC=4.8 μ g · h / mL), ua tsaug rau qhov tshwj xeeb khi ntawm nanostructure ntawm cov kab mob ntawm cov kab mob ntawm cov kab mob ntawm cov kab mob heparlican. hlwb.
Kev ruaj ntseg thiab kev cia khoom
Tus kheej- kev sib dhos ua tau zoo txhim kho cov tshuaj lom neeg ruaj khov ntawm furosemide: Lub teeb ruaj khov: Nyob rau hauv cov xwm txheej ntawm 40℃thiab lub teeb raug (4500 lx), dawb furosemide degrades los ntawm 35% hauv 72 teev, thaum nws tus kheej- sib dhos nanosheets tsuas yog degrade los ntawm 8%, qhov qhia tau hais tias lub teeb pom kev zoo Qhov chaw; Cov thermal stability: Differential scanning calorimetry (DSC) qhia tau hais tias qhov kub ntawm lub melting ntawm tus kheej - sib dhos zaj duab xis (Tm=185 degree) yog 23℃siab dua li cov dawb molecules (Tm{10}}℃), ntaus nqi rau kev txhim kho ntawm muaj zog intermolecular kev sib txuas lus (xws li hydrogen network).
Biomedical daim ntaub ntawv ntawm tus kheej - sib dhos furosemide ntawm roj - kua interface
Ua tau zoo Diuretics thiab Electrolyte Balance
Kev sib sau ua tus kheej furosemide nthuav tawm cov txiaj ntsig zoo diuretic hauv cov qauv tsiaj:
Rat mob plawv tsis ua hauj lwm qauv: Tom qab txhaj tshuaj ntawm tus kheej - sib dhos nanosheets ( koob tshuaj 2 mg / kg), tso zis mus txog 8.5 mL / kg hauv 30 feeb, nce 63% piv rau cov tshuaj dawb (5.2 mL / kg), Thaum cov ntshav potassium concentration tau khaws cia ntawm 4.0 ± 0.3 pawg (2 mmol / 0.2 mmol). mmol / L), txo qis kev pheej hmoo ntawm hypokalemia.
Tus qauv kab mob raum ntev: Tom qab kev tswj hwm qhov ncauj ntawm tus kheej- cov ntsiav tshuaj sib sau ua ke ( koob tshuaj 10 mg / kg / hnub) rau 4 lub lis piam sib law liag, cov ntshav creatinine poob qis ntawm 2.1 mg / dL mus rau 1.5 mg / dL, thaum pab pawg tshuaj dawb tsuas yog txo mus rau 1.8 mg / dL, qhia tias kev ua haujlwm tsis tu ncua los ntawm kev sib sau ua ke.
Kev tshoov siab los ntawm ntau lub enzyme synergistic antibacterial system, cov kws tshawb fawb tau sib sau ua ke furosemide nrog lysozyme thiab qabzib oxidase los tsim kom muaj "diuretic antibacterial" dual functional nanosheet-Antibacterial mechanism: Furosemide txhim kho qhov permeability ntawm lysozyme los ntawm kev cuam tshuam cov kab mob ntawm cov kab mob.
While H ₂ O ₂ produced by glucose oxidase further oxidizes bacterial proteins;In vitro experiment: The minimum inhibitory concentration (MIC) against methicillin-resistant Staphylococcus aureus (MRSA) is 16 μ g/mL, which is significantly lower than the use of furosemide (MIC>128 μ g / mL) lossis lysozyme ib leeg (MIC=64 μ g / mL);
Hauv kev sim vivo: Hauv tus qauv nas kab mob ntawm daim tawv nqaij, ob chav ua haujlwm nanosheets txo cov kab mob hnyav los ntawm 4 log ₁₀ CFU / g, thaum pawg monotherapy tsuas txo nws los ntawm 1.5 teev ₁₀ CFU / g.
Cov tshuaj sib xyaw ua ke thiab kev kho mob sib koom ua ke
Kev sib dhos ntawm tus kheej tuaj yeem ua tiav kev sib koom ua ke ntawm furosemide thiab lwm yam tshuaj: Ua ke nrog angiotensin receptor enkephalin inhibitor (ARNI):
Kev sib xyaw furosemide thiab sacubitril hauv nanosheets tuaj yeem ua rau tib lub sijhawm inhibit renin -angiotensin system thiab txhawb kev diuresis. Hauv cov qauv nas hypertensive, kev sib xyaw ntawm nanosheets txo cov ntshav siab los ntawm 35 mmHg, thaum pawg monotherapy tsuas yog txo nws los ntawm 18 mmHg; Ua ke nrog SGLT2 inhibitor:tshuaj furosemidetau sib sau ua ke nrog dagelin kom txhim kho cov proteinuria (urinary albumin / creatinine piv txo qis los ntawm 1200 mg / g mus rau 350 mg / g) ntawm cov kab mob ntshav qab zib nephropathy qauv nas los ntawm kev tswj cov txheej txheem ntawm ob lub raum tubular sodium reabsorption thiab qabzib excretion.
Cov lus nug nquag
furosemide 20mg 5ml yog dab tsi?
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Furosemide qhov ncauj daws yogqhia nyob rau hauv tag nrho cov mob uas yuav tsum tau tam sim diuresis nyob rau hauv cov neeg mob uas tsis muaj peev xwm mus noj cov ntaub ntawv tshuaj. Indications muaj xws li mob plawv, pulmonary, hepatic thiab lub raum oedema, peripheral edema vim mechanical obstruction los yog venous insufficiency thiab kub siab.
Vim li cas IV furosemide muab maj mam?
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Txhawm rau kom tsis txhob muaj qhov nce sai hauv cov ntshav siab concentration, koob tshuaj ntau dua 80mg ntawm furosemide yuav tsum tau maj mam infused. Thaum kawg, furosemide tuaj yeem tshem tawm warfarin los ntawm nws qhov chaw khi ntawm cov ntshav proteins. Yog li, yuav tsum tau txhaj tshuaj tsawg dua ntawm warfarin thaum siv warfarin nrog furosemide.
Yuav ua li cas yog tias koj thawb IV lasix sai heev?
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Kev tswj hwm tus nqi ntawm Lasix yog qhov tseem ceeb vim tias kev thawb nws nrawm dhau tuaj yeem ua rau muaj teeb meem loj, suav nrogototoxicity thiab lub raum puas.
Puas yog furosemide muaj nyob rau hauv daim ntawv ua kua?
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Furosemide tsuas yog muaj nyob rau hauv cov tshuaj.Nws los ua cov ntsiav tshuaj thiab cov kua uas koj nqos. Nws tuaj yeem muab tau los ntawm kev txhaj tshuaj, tab sis qhov no feem ntau tsuas yog ua hauv tsev kho mob.
Kuv puas tuaj yeem yaj furosemide hauv dej?
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Furosemide yog xim dawb rau me ntsis daj, tsis muaj ntxhiab, 14 crystalline hmoov.Xyaum insoluble hauv dej; dawb do soluble nyob rau hauv acetone, nyob rau hauv 15 dimethylformamide, thiab nyob rau hauv kev daws ntawm alkali hydroxides; soluble hauv methanol; sparingly 16 soluble hauv cawv; me ntsis soluble hauv ether; me ntsis soluble hauv chloroform.
Cim npe nrov: furosemide tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom