KPV Peptide Creamyog ib lub ntsej muag cream hom kev npaj ntxiv nrog KPV peptid (tripeptide muaj li ntawm lysine proline valine), uas qhia tau hais tias muaj peev xwm nyob rau hauv kev kho mob ntawm daim tawv nqaij thiab o. Los ntawm qhov kev xav ntawm cov yam ntxwv muaj pes tsawg leeg, KPV peptid yog ib feem ntawm alpha MSH (melanocyte stimulating hormone), uas muaj cov kev ua ub no xws li tiv thaiv -inflamatory, antibacterial, thiab qhov txhab kho qhov txhab. Nws ua haujlwm los tiv thaiv - cov teebmeem tshwm sim los ntawm kev khi rau melanocortin receptors (MC-Rs), inhibiting qhov tso tawm ntawm cov kab mob inflamatory mediators, thaiv cov NF - κ B signaling pathway, thiab txo cov kev tsim tawm ntawm pro-inflamatory yam xws li IL-1 . PV cov teebmeem tshwm sim, xws li cov kab mob sib kis. Staphylococcus aureus thiab Candida albicans, uas tuaj yeem txo qhov kev pheej hmoo ntawm kev kis kab mob.
Hauv kev siv tshuaj kho mob, alpha msh yog tsim rau kev kho mob ntawm ntau yam kab mob ntawm daim tawv nqaij, xws li atopic dermatitis, psoriasis, thiab hu rau dermatitis. Tom qab siv, cov tsos mob khaus tuaj yeem txo qis hauv cov sij hawm mus rau hnub, thiab qhov chaw pob khaus thiab cov qhab nia hnyav tau txo qis. Tsis tas li ntawd, lub ntsej muag cream kuj tuaj yeem siv los txhawb kev kho qhov txhab, ua kom cov txheej txheem kho mob ntawm kev phais thiab hlawv qhov txhab, thiab txo cov caws pliav.
Hais txog kev nyab xeeb, kev siv hauv zos ntawm KPV muaj qhov cuam tshuam me me, feem ntau yog stinging ib ntus lossis erythema, thiab tsis muaj kev phiv xws li pigmentation. Nws cov tshuaj lom neeg ruaj khov yog superior rau niam txiv cov tshuaj hormone alpha MSH, ua rau nws yooj yim khaws thiab siv. Tam sim no, kev tshawb fawb tab tom tshawb nrhiav nws daim ntawv thov ua ke nrog cov tshuaj xws li glucocorticoids thiab tshuaj tua kab mob, txhawm rau nthuav nws cov txiaj ntsig kho mob hauv ntau thaj chaw ntawm cov kab mob ntawm daim tawv nqaij.
Peb cov khoom
Cov ntaub ntawv ntxiv ntawm chemical compound:
Peb Cov Khoom
Ceftiofur +. COA
Cov yam ntxwv thiab qhov zoo
1. Kev tsim qauv tsim tshiab
KPV Peptide Creamsiv liposome encapsulation technology los encapsulate KPV peptids nyob rau hauv phospholipid bilayer microspheres. Qhov kev tsim no ua rau kev tswj kev tso tawm ntawm cov khoom xyaw nquag thiab ua rau lub sijhawm ntev ntawm cov tshuaj ua haujlwm hauv txheej txheej ntawm daim tawv nqaij. Cov kev sim tshuaj ntsuam xyuas tau pom tias liposome encapsulation tuaj yeem ua rau nce qhov transdermal absorption tus nqi ntawm KPV peptids ntau dua 40%.
2. Kev tswj xyuas zoo
Kev tsim cov qauv tsim yuav tsum ua raws li cov qauv cGMP, nrog rau kev ua kom huv huv ntawm ntau dua lossis sib npaug li 98%. Txhua pawg ntawm cov khoom yuav tsum tau kuaj xyuas cov ntsiab lus tseem ceeb los ntawm HPLC thiab tau lees paub rau cov kev txwv microbial, cov hlau hnyav, thiab lwm yam ntsuas. Cov kev tshawb fawb kev ruaj ntseg tau pom tias qhov degradation tus nqi ntawm cov khoom xyaw nquag hauv cov khoom yog tsawg dua 5% tom qab khaws cia ntawm 25℃/ 60% RH rau 12 lub hlis.
3. Kev nyab xeeb thiab kam rau ua
The acute toxicity test showed that the maximum tolerated dose (MTD) of alpha msh to experimental animals was>5000mg / kg. Kev kuaj mob ntawm tib neeg daim tawv nqaij pom tau tias 0.5% concentration formulation tsis ua rau muaj kev phiv xws li erythema thiab edema tom qab siv tas li rau 28 hnub. Kev kam rau hauv zos yog superior rau cov tshuaj glucocorticoid tshuaj.
4. Txoj kev tswj hwm thiab kev noj tshuaj kom zoo
Kev pom zoo siv yog ob zaug ib hnub. Siv cov tshuaj nplaum tsim nyog rau thaj chaw muaj kev cuam tshuam thiab maj mam zaws kom txog thaum nqus tau tag nrho. Qhov pom zoo ib koob tshuaj yog 0.1-0.2g / cm ², thiab cov koob tshuaj tshwj xeeb yuav tsum tau hloov kho raws li qhov chaw mob. Cov chav kawm ntawm kev kho mob feem ntau yog tsim los rau 4-8 lub lis piam thiab yuav tsum tau txhaj tshuaj titration ua ke nrog kev ntsuas kev ua tau zoo.
Anti-inflammatory nyhuv
Tiv thaiv kev tso tawm ntawm cov kab mob inflamatory mediators
alpha msh peptid nyob rau hauv alpha msh muaj qhov tseem ceeb los tiv thaiv - kev ua mob, uas inhibits kev tso tawm ntawm cov kab mob sib kis los ntawm ntau lub tshuab. Thaum lub sij hawm inflammtory teb, hlwb tso tawm ntau yam inflammtory mediators xws li prostaglandins, leukotrienes, thiab lwm yam. Cov neeg kho kom haum xeeb no ntxiv exacerbate tus mob teb, ua rau cov tsos mob xws li lub zos redness, o, thiab mob. KPV peptid tuaj yeem ua rau cov hlwb mob xws li macrophages, neutrophils, thiab lwm yam., inhibiting lawv tso tawm cov kab mob sib kis.
Piv txwv li, alpha msh peptids tuaj yeem cuam tshuam nrog intracellular signaling txoj hauv kev los ntawm kev khi rau cov receptors tshwj xeeb ntawm lub xovtooj ntawm tes, yog li tiv thaiv kev sib txuas thiab tso tawm cov kab mob sib kis. Qhov no mechanism ntawm kev txiav txim uaKPV Peptide CreamNws muaj txiaj ntsig zoo hauv kev txo cov tsos mob ntawm daim tawv nqaij, xws li liab, khaus, thiab lwm yam tsos mob ntawm daim tawv nqaij mob xws li psoriasis thiab atopic dermatitis.
Tswj lub cev tiv thaiv kab mob ua haujlwm
alpha msh peptids tseem tuaj yeem tswj hwm lub luag haujlwm ntawm lub cev tiv thaiv kab mob thiab tswj lub cev tiv thaiv kab mob. Nyob rau hauv cov lus teb inflammtory, lub cev tiv thaiv kab mob xws li T lymphocytes thiab B lymphocytes koom rau hauv lub cev tiv thaiv kab mob, thiab overactivated lub cev tiv thaiv kab mob tuaj yeem ua rau tsis muaj kev tiv thaiv kab mob. KPV peptid tuaj yeem cuam tshuam rau kev ua kom thiab sib txawv ntawm T hlwb, thiab tswj qhov sib npaug ntawm Th1 / Th2 hlwb.
Th1 hlwb feem ntau zais cytokines xws li IFN - , uas koom nrog hauv cov lus teb ntawm tes; Th2 hlwb feem ntau zais cov cytokines xws li IL-4 thiab IL-5, uas koom nrog cov lus teb humoral. Hauv cov kab mob ua xua xws li atopic dermatitis, kev ua kom ntau dhau ntawm Th2 hlwb ua rau muaj qib IgE siab thiab ua rau muaj kev fab tshuaj. alpha msh peptid tuaj yeem txo cov tsos mob tsis haum los ntawm kev tswj hwm qhov sib npaug ntawm Th1 / Th2 hlwb thiab txo qis kev ua kom ntau dhau ntawm Th2 hlwb. Lub caij no, alpha msh peptid tseem tuaj yeem cuam tshuam qhov kev loj hlob ntawm B hlwb thiab cov tshuaj tiv thaiv kab mob, ntxiv kom txo qis kev siv lub cev tiv thaiv kab mob.
1. Inhibition ntawm cov kab mob
KPV peptids muaj inhibitory cuam tshuam rau ntau yam kab mob, nrog rau cov kab mob thiab fungi. Kev tshawb fawb tau pom tias alpha msh peptids muaj cov tshuaj tua kab mob tseem ceeb tiv thaiv kab mob xws li Staphylococcus aureus thiab Candida albicans. Staphylococcus aureus yog ib hom kab mob kis tau zoo uas tuaj yeem ua rau ntau yam kab mob xws li kab mob ntawm daim tawv nqaij thiab kab mob ua pa; Candida albicans yog ib hom kab mob uas ua rau fungal vaginitis, qhov ncauj candidiasis, thiab lwm yam kab mob.
Cov tshuaj tua kab mob ntawm alpha msh peptid feem ntau cuam tshuam rau cov cell membrane ntawm cov kab mob, ua kom cov permeability ntawm cov cell membrane, ua rau cov to ntawm intracellular tshuaj, yog li inhibiting kev loj hlob thiab kev loj hlob ntawm pathogens. Piv txwv li, alpha msh peptids tuaj yeem cuam tshuam nrog phospholipid molecules ntawm cov kab mob ntawm cov kab mob hauv cov kab mob, ntxig rau hauv cov cell membrane, tsim cov pores, cuam tshuam kev ncaj ncees ntawm cov cell membrane, thiab ua rau cov kab mob tuag. Rau cov fungi, alpha msh peptids kuj tuaj yeem cuam tshuam nrog kev sib txuas ntawm cov phab ntsa ntawm tes, cuam tshuam rau kev loj hlob ib txwm thiab cov metabolism ntawm cov fungi.
2. Kev tiv thaiv thiab kho kab mob
Vim nws cov tshuaj tua kab mob, alpha msh tuaj yeem siv rau kev tiv thaiv thiab kho cov kab mob ntawm daim tawv nqaij thiab mucosal. Nyob rau hauv cov ntaub ntawv ntawm daim tawv nqaij raug mob, phais incision, thiab lwm yam., daim tawv nqaij barrier functon yog impaired thiab susceptible rau pathogen ntxeem tau. Kev siv alpha msh tuaj yeem tsim cov kab mob tiv thaiv kab mob hauv zos, txo qhov kev pheej hmoo ntawm kab mob colonization thiab kab mob.
Rau cov kab mob uas twb tau tshwm sim lawm, xws li kab mob ntawm daim tawv nqaij thiab cov nqaij mos, kab mob ntawm qhov ncauj mucosal, thiab lwm yam, alpha msh tuaj yeem pab kho mob, txo cov tsos mob ntawm tus kab mob, thiab txhawb kev kho qhov txhab. Piv txwv li, hauv kev kho mob ntawm qhov ncauj mucositis, alpha msh tuaj yeem cuam tshuam kev loj hlob ntawm cov kab mob pathogenic hauv lub qhov ncauj kab noj hniav, txo qhov mob ntawm qhov ncauj mucosa, thiab txo qhov mob thiab tsis xis nyob.
1. Txhawb nqa cell proliferation thiab migration
KPV peptid tuaj yeem txhawb kev loj hlob thiab kev tsiv teb tsaws ntawm ntau lub hlwb, suav nrog fibroblasts, keratinocytes, thiab lwm yam. Fibroblasts yog hom cell tseem ceeb hauv cov txheej txheem ntawm qhov txhab kho. Lawv tuaj yeem ua ke thiab tso tawm cov khoom sib txuas ntawm cov khoom sib txuas xws li collagen thiab elastin, txhawb qhov txhab mob thiab kho. KPV peptids tuaj yeem qhib txoj hauv kev hauv lub cev los ntawm kev khi rau cov receptors ntawm qhov chaw ntawm fibroblasts, txhawb nqa fibroblast proliferation thiab collagen synthesis.
Keratinocytes yog hom cell tseem ceeb ntawm daim tawv nqaij epidermis, uas tsiv mus rau qhov chaw ntawm lub qhov txhab thaum lub sij hawm kho, npog lub qhov txhab thiab tsim ib tug tshiab epidermis. KPV peptid tuaj yeem txhawb nqa kev tsiv teb tsaws ntawm keratinocytes, ua kom cov txheej txheem rov ua dua tshiab thiab kho dua tshiab. Piv txwv li, nyob rau hauv kev kho mob ntawm qhov txhab hlawv,KPV Peptide Creamtuaj yeem txhawb kev loj hlob thiab tsiv teb tsaws ntawm fibroblasts thiab keratinocytes nyob ib ncig ntawm lub qhov txhab, ua kom lub qhov txhab zoo.
2. Kev tswj cov txheej txheem extracellular matrix synthesis
Extracellular matrix yog ib qho tseem ceeb ntawm cov txheej txheem kho qhov txhab, muab scaffold thiab khoom noj khoom haus pab txhawb kev loj hlob ntawm tes thiab tsiv teb tsaws. alpha msh peptids tuaj yeem tswj cov synthesis thiab degradation ntawm extracellular matrix, txhawb qhov txhab kho. alpha msh peptid tuaj yeem txhawb nqa cov synthesis ntawm extracellular matrix Cheebtsam xws li collagen thiab elastin, ua kom cov extracellular matrix cov ntsiab lus ntawm lub qhov txhab, thiab txhim kho lub zog thiab toughness ntawm lub qhov txhab.
Lub caij no, alpha msh peptids tseem tuaj yeem cuam tshuam cov kev ua ntawm matrix metalloproteinases (MMPs) thiab txo qhov degradation ntawm extracellular matrix. MMPs yog cov enzymes uas tuaj yeem degrade extracellular matrix. Thaum lub sij hawm o thiab cov txheej txheem kho qhov txhab, kev ua haujlwm ntau dhau ntawm MMPs tuaj yeem ua rau muaj kev degradation ntawm extracellular matrix, cuam tshuam rau qhov txhab zoo. alpha msh peptid tswj kev ruaj ntseg ntawm extracellular matrix thiab txhawb lub qhov txhab kho los ntawm inhibiting qhov kev ua ntawm MMPs.
1. Tshem tawm cov dawb radicals
Oxidative stress yog ib qho tseem ceeb ntawm cov tawv nqaij laus thiab ntau yam kab mob ntawm daim tawv nqaij. Nyob rau hauv ib txwm muaj xwm txheej, lub cev tsim muaj qee yam ntawm cov dawb radicals, tab sis cov kab mob antioxidant tuaj yeem tshem tawm cov dawb radicals tam sim ntawd thiab tswj cov redox tshuav nyiaj li cas hauv lub cev. Thaum muaj ntau dhau ntawm cov dawb radicals los yog txo qis hauv cov kab mob antioxidant, nws tuaj yeem ua rau oxidative kev nyuaj siab, kev puas tsuaj rau cov macromolecules xws li DNA, proteins, thiab lipids hauv hlwb, thiab ua rau daim tawv nqaij mob, laus, thiab lwm yam teeb meem.
alpha msh peptids muaj antioxidant zog thiab tuaj yeem tshem tawm cov dawb radicals hauv lub cev. alpha msh peptids tuaj yeem cuam tshuam nrog cov dawb radicals los hloov lawv mus rau hauv cov molecules ruaj khov, yog li txo qhov kev puas tsuaj ntawm cov dawb radicals rau cov hlwb. Piv txwv li, alpha msh peptids tuaj yeem tshem tawm cov dawb radicals xws li superoxide anion radicals thiab hydroxyl radicals, tiv thaiv cov hlwb los ntawm kev puas tsuaj oxidative.
2. Tiv thaiv cellular qauv thiab muaj nuj nqi
Los ntawm kev tshem tawm cov dawb radicals, alpha msh peptids tuaj yeem tiv thaiv cov qauv thiab kev ua haujlwm ntawm cov hlwb. Dawb radicals tua lipids ntawm lub cell membrane, ua rau lipid peroxidation thiab cuam tshuam kev ncaj ncees thiab fluidity ntawm cell membrane. Cov nyhuv antioxidant ntawm alpha msh peptid tuaj yeem txo qhov tshwm sim ntawm lipid peroxidation thiab tswj lub cev ua haujlwm ntawm cell membrane. Lub caij no, cov dawb radicals kuj tuaj yeem ua rau cov protein thiab DNA hauv cov hlwb puas, cuam tshuam rau lawv cov metabolism thiab ua haujlwm. KPV peptids tuaj yeem tiv thaiv cov biomolecules los ntawm kev puas tsuaj dawb radical, ua kom lub cev muaj zog ntawm cov hlwb.
1. Txhim khu kev ncaj ncees ntawm stratum corneum
Cov tawv nqaij barrier functon feem ntau yog muab los ntawm stratum corneum, uas yog cov qauv ntom ntom tsim los ntawm keratinocytes thiab intercellular lipids. alpha msh peptid tuaj yeem txhawb kev sib txawv thiab kev loj hlob ntawm keratinocytes, nce lub thickness thiab kev ncaj ncees ntawm stratum corneum. alpha msh peptid tuaj yeem tswj hwm cov noob qhia hauv keratinocytes, txhawb kev sib txuas thiab tso tawm cov txheej txheem ntawm cov proteins xws li keratin, txhim kho lub peev xwm adhesion ntawm keratinocytes, thiab ua rau stratum corneum tighter.
2. Tswj kev sib txuas ntawm lipid synthesis
Intercellular lipids yog ib qho tseem ceeb ntawm cov stratum corneum, sau qhov khoob ntawm keratinocytes los tsim cov dej tsis sib haum, tiv thaiv dej poob thiab kev cuam tshuam ntawm cov khoom tsis zoo los ntawm lub ntiaj teb sab nraud. alpha msh peptid tuaj yeem tswj cov synthesis thiab tso tawm ntawm intercellular lipids, nce cov ntsiab lus ntawm intercellular lipids. Piv txwv li, alpha msh peptids tuaj yeem txhawb kev sib txuas ntawm cov lipids hauv intercellular xws li ceramides, cholesterol, thiab cov roj fatty acids dawb, txhim kho qhov cuam tshuam ntawm stratum corneum, txo cov dej tsis zoo (TEWL), thiab txhim kho daim tawv nqaij muaj peev xwm moisturizing.
Kev sib cuam tshuam nrog melanocortin receptors
1. Kev sib txuas ntawm melanocortin receptors
KPV peptid yog ib feem ntawm alpha melanocyte stimulating hormone (- MSH) uas tuaj yeem khi rau melanocortin receptors (MC-Rs). MC-Rs yog ib chav kawm ntawm G protein ua ke receptors, suav nrog ntau yam subtypes xws li MC1R, MC2R, MC3R, MC4R, thiab MC5R. alpha msh peptid feem ntau khi rau MC1R, uas tau nthuav dav hauv cov ntaub so ntswg xws li tawv nqaij thiab cov hauv paus hniav.
2. Tswj cov kev taw qhia hauv qab
Tom qab khi rau MC1R,KPV peptide creamtuaj yeem qhib cov kev taw qhia hauv qab, xws li adenylate cyclase (AC) - cyclic adenosine monophosphate (cAMP) - protein kinase A (PKA) qhia txoj hauv kev. Kev ua kom lub cev muaj zog ntawm txoj kev taw qhia no tuaj yeem tswj hwm ntau yam kev ua haujlwm ntawm lub cev ntawm lub hlwb, xws li tiv thaiv -inflamatory, antioxidant, txhawb kev loj hlob ntawm tes thiab kev sib txawv, thiab lwm yam. Piv txwv li, nyob rau hauv cov nqe lus ntawm kev tiv thaiv -inflammtory cuam tshuam, nce qib cAMP tuaj yeem cuam tshuam qhov ua kom muaj mob ntawm cov kab mob B6} xws li cov teeb liab ntawm {6} txo cov kab mob B. inflammtory mediators; PKA tuaj yeem phosphorylate ntau yam kev hloov pauv, tswj cov noob qhia, thiab txhawb kev loj hlob ntawm tes thiab kev loj hlob hauv kev txhawb nqa cell proliferation thiab sib txawv.
KPV peptide, ib qho me me tripeptide uas muaj kev cuam tshuam loj heev, ua piv txwv lub zog ntawm cov qauv tsim me me hauv kev kho tshiab. Los ntawm kev tuav cov tshuaj tiv thaiv - mob thiab tshuaj tua kab mob ntawm -MSH thaum tshem tawm nws cov teebmeem tsis xav tau, KPV muab txoj hauv kev tsom thiab nyab xeeb rau kev kho mob ntev, mob ntawm daim tawv nqaij, teeb meem kev noj qab haus huv hauv plab, thiab vascular calcification. Nws lub peev xwm los hloov kho txoj hauv kev tseem ceeb, txhawb nqa cov kab mob epithelial, thiab qhib autophagy txoj haujlwm nws ua ntau yam cuab yeej hauv cov tshuaj niaj hnub. Txawm hais tias kev tshawb fawb ntxiv yog xav tau los txhais nws cov lus cog tseg ua ntej rau hauv qhov chaw kho mob, KPV sawv ua pov thawj rau lub peev xwm ntawm cov molecules me me los daws qee qhov kev txhawj xeeb txog kev noj qab haus huv ntawm tib neeg. Raws li thaj chaw ntawm kev kho peptide txuas ntxiv mus, KPV tuaj yeem tshwm sim zoo li lub hauv paus ntawm cov tshuaj precision, muab kev cia siab rau ntau lab thoob ntiaj teb.
Cov lus nug nquag
Cov txiaj ntsig ntawm KPV peptides yog dab tsi?
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Cov kev tshawb fawb tau pom tias KPV tuaj yeem ua tautxo cov kab mob hauv cov hnyuv, khaws cov kab mob hauv plab, thiab pab txhawb kev sib npaug hauv microbiome. Nws kuj tshwm sim los txhawb kev kho sai ntawm cov ntaub so ntswg puas thiab tiv thaiv kev puas tsuaj ntawm txoj hnyuv, uas yog qhov tseem ceeb rau kev tswj xyuas tag nrho plab hnyuv.
Puas yog KPV peptide muaj kev nyab xeeb noj?
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Cov kev tshawb fawb qhia tias KPV tau txais txiaj ntsig zoo -thiab tej zaum yuav muab cov txiaj ntsig tsis tu ncua rau inflammatory thiab tiv thaiv kab mob -txog yam mob. Ntawm Evolve Aesthetics thiab Regenerative Medicine, dosing protocols tau ua tib zoo kho kom muaj kev nyab xeeb thiab ua haujlwm tau zoo.
KPV puas tsim nyog?
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Xaus. Thaum KPV peptides qhia tau hais tias muaj txiaj ntsig los tiv thaiv- cov teebmeem inflammatory hauv kev tshawb fawb ua ntej, tshwj xeeb tshaj yog rau cov kab mob plab hnyuv thiab muaj peev xwm ua rau cov kab mob cutaneous zoo,tam sim no tsis muaj pov thawj kho mob txaus los pom zoo siv rau tib neeg.
Cim npe nrov: kpv peptide cream, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom