Bethanechol ntsiav tshuaj, Suav lub npe tuaj yeem txhais tau tias yog Bechlorpene ntsiav tshuaj, thiab cov npe khoom muaj xws li Duvoid, Myotonachol, Ureecholine, thiab lwm yam. Nws lub npe yog bethanechol lossis bethanechol chloride, thiab nws cov lus Suav zoo ib yam li "be ces e-kole". Los ntawm kev ua ntawm cholinergic receptors, nws exerts ib tug series ntawm pharmacological teebmeem, feem ntau nrog rau kev txhawb cov leeg nqaij contraction nyob rau hauv lub urinary thiab gastrointestinal systems, nce glandular secretion, thiab lwm yam Clinically, cov tshuaj yog tsuas yog siv los kho postoperative urinary retention, neurogenic zais zis, gastroparesis, functional dyspepsia. Txawm li cas los xij, Bethanchol kuj tseem tuaj yeem ua rau qee qhov tsis zoo, xws li kev mob plab hnyuv, kev mob plawv, thiab cuam tshuam nrog lwm yam tshuaj.
(1) Kev faib cov tshuaj
Nws yog nyob rau hauv qeb ntawm genitourinary cholinergic cov neeg ua haujlwm, feem ntau ua los ntawm activating cholinergic receptors.
(2) Formulation thiab Specifications
Cov tshuaj no yog muab rau hauv daim ntawv ntawm cov ntsiav tshuaj ntawm qhov ncauj, nrog rau cov kev qhia tshwj xeeb xws li 5mg, 10mg, 25mg, 50mg, thiab lwm yam. Cov ntsiav tshuaj sib txawv tuaj yeem ua tau raws li cov kev xav tau ntawm cov tshuaj ntawm cov neeg mob sib txawv, thiab cov kws kho mob yuav xaiv cov tshuaj kom tsim nyog raws li qhov xwm txheej tshwj xeeb ntawm tus neeg mob.
(3) Cia tej yam kev mob
Bethanechol ntsiav tshuajyuav tsum tau muab cia rau hauv chav sov li ntawm 68 ° F mus rau 77 ° F (kwv yees li 20 ° C mus rau 25 ° C). Cov kev cai cia tsim nyog tuaj yeem ua kom muaj txiaj ntsig zoo thiab ruaj khov ntawm cov tshuaj, kom ntseeg tau tias lawv siv lawv cov kev npaj kho mob hauv lawv hnub tas sijhawm
Peb cov khoom
Cov ntaub ntawv ntxiv ntawm chemical compound:
| Khoom npe | Bethanechol Cream | Kev txhaj tshuaj Bethanechol | Bethanechol ntsiav tshuaj |
| Yam khoom | Cream | Txhaj tshuaj | Cov ntsiav tshuaj |
| Khoom Purity | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% |
| Khoom Specifications | Customizable | Customizable | Customizable |
| Pob khoom | Customizable | Customizable | Customizable |
Peb Cov Khoom
Bethanechol +. COA
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Certificate of Analysis |
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Compound npe |
Bethanechol | |
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CAS Nr. |
590-63-6 | |
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Qib |
Pharmaceutical qib | |
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Ntau |
Customized | |
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Ntim txheem |
Customized | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
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Ntau No. |
20250109001 |
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MFG |
Jan 12th 2025 |
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EXP |
Jan 8th 2029 |
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Qauv |
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| TEST STANDARD | GB/T24768-2009 Kev lag luam. Stnndard | |
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Yam khoom |
Enterprise txheem |
Kev txheeb xyuas qhov tshwm sim |
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Qhov tshwm sim |
Dawb los yog yuav luag dawb hmoov |
Ua raws |
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Cov ntsiab lus dej |
Tsawg dua lossis sib npaug li 4.5% |
0.30% |
| Poob rau ziab |
Tsawg dua lossis sib npaug li 1.0% |
0.15% |
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Hnyav Hlau |
Pb Tsawg dua lossis sib npaug li 0.5ppm |
N.D. |
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Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Hg Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Cd Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Purity (HPLC) |
Ntau dua lossis sib npaug li 99.0% |
99.5% |
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Ib leeg impurity |
<0.8% |
0.48% |
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Residue ntawm ignition |
<0.20% |
0.064% |
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Tag nrho microbial suav |
Tsawg dua lossis sib npaug li 750cfu / g |
80 |
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E. Coli |
Tsawg dua lossis sib npaug li 2MPN / g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (los ntawm GC) |
Tsawg dua lossis sib npaug li 5000ppm |
400ppm ua |
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Cia |
Khaws rau hauv qhov chaw kaw, tsaus thiab qhuav ntawm -20 degrees |
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Cov kab mob ntawm cov urinary system
Postoperative urinary retention: Kev ua haujlwm yuav cuam tshuam rau kev ua haujlwm ntawm lub zais zis, ua rau tso zis. Nws tuaj yeem pab cov neeg mob tso zis, txo cov tsos mob ntawm qhov tso zis, thiab txo cov teeb meem tshwm sim los ntawm kev tso zis, xws li cov kab mob tso zis, los ntawm kev txhawb nqa lub zais zis detrusor.
Neurogenic zais zis dysfunction: Qee yam kab mob neurological, xws li kev raug mob ntawm tus txha caj qaum, ntau yam sclerosis, thiab lwm yam, tuaj yeem cuam tshuam rau cov paj hlwb innervation ntawm lub zais zis, ua rau lub zais zis tsis ua haujlwm. Nws tuaj yeem txhim kho lub zais zis ua haujlwm, txo cov neeg mob cov tsos mob nyuaj rau tso zis, thiab txhim kho lawv tus kheej - muaj peev xwm saib xyuas.
Kab mob plab
Postoperative plab hnyuv distension: Tom qab kev phais, cov neeg mob yuav ua rau lub plab zom mov qeeb vim kev siv tshuaj loog, cov txheej txheem phais, thiab lwm yam, ua rau mob plab.Bethanechol ntsiav tshuajtuaj yeem txhawb nqa cov leeg nqaij leeg hauv plab hnyuv, txhawb plab plab peristalsis, ua kom cov pa tawm, txo cov tsos mob plab, thiab pab txhawb kev rov qab ua haujlwm ntawm plab hnyuv hauv cov neeg mob.
Lwm yam ua rau lub plab zom mov tsis zoo xws li kev ua haujlwm dyspepsia, nws kuj tseem tuaj yeem txhim kho plab hnyuv motility, txo cov neeg mob cov tsos mob, thiab txhim kho plab hnyuv thiab nqus dej ua haujlwm.
Muaj ib hom tshuaj uas muaj cholinergic zog, thiab nws cov ntsiab lus tseem ceeb, betamethacoline (carbamoylcholine, chlorocholine), tuaj yeem ua raws li cov nyhuv ntawm acetylcholine ntawm cholinergic receptors, yog li ua rau muaj cov tshuaj pharmacological. Cov tshuaj no tsuas yog siv hauv kev kho mob los kho qee yam kab mob ntawm cov zis thiab plab hnyuv, txhim kho cov neeg mob cov tsos mob los ntawm kev tswj hwm cov haujlwm ntawm lub cev.
(1) Cholinergic receptor hom
Cholinergic receptors feem ntau suav nrog muscarinic receptors (mAChR) thiab nicotinic receptors (nAChR). MachR tuaj yeem muab faib ua subtypes xws li M1, M2, M3, M4, M5, thiab lwm yam., uas yog dav faib rau hauv nruab nrab lub paj hlwb thiab cov ntaub so ntswg ib puag ncig, xws li cov leeg du, qog, thiab lwm yam. Bethanchol feem ntau ua rau mAChR, tshwj xeeb tshaj yog M2 thiab M3 receptor subtypes.
(2) Kev khi thiab ua kom muaj zog nrog receptors
Tom qab khi rau mAChR, Bethanchol tuaj yeem ua raws li qhov kev txiav txim ntawm acetylcholine thiab qhib cov receptors. Thaum lub receptor yog qhib, nws ua rau ib tug series ntawm intracellular teeb liab transduction txheej txheem. Piv txwv li, nyob rau hauv cov leeg nqaij pob txha, activated mAChR activates phospholipase C (PLC) los ntawm G protein coupling mechanism, uas ntxiv catalyzes hydrolysis ntawm phosphatidylinositol diphosphate (PIP2) los tsim diacylglycerol (DAG) thiab inositol triphosphate (IP3). IP3 tuaj yeem tsim cov khw muag khoom calcium hauv lub cev kom tso cov calcium ions, ua rau muaj kev nce hauv cov calcium hauv lub cev thiab ua rau cov leeg nqaij leeg.
Kev cuam tshuam rau cov zis
(1) Smooth nqaij contraction ntawm lub zais zis
Hauv cov zis, Bethanchol tuaj yeem txhawb lub zais zis du cov leeg nqaij. Muaj ntau mAChRs faib rau ntawm cov leeg nqaij ntawm lub zais zis. Thaum Bethanchol khi rau cov receptors no, nws ua rau cov receptors thiab ua rau cov txheej txheem hloov pauv tau hais tseg, ua rau lub zais zis ntawm cov leeg nqaij. Cov nyhuv contraction no tuaj yeem ua rau lub zais zis siab thiab txhawb cov zis tawm. Rau qee cov kab mob xws li dysuria thiab tso zis tso zis tshwm sim los ntawm kev so ntawm lub zais zis ntawm cov leeg nqaij, Bethanchol tuaj yeem txhim kho cov zis tso zis los ntawm kev txhim kho lub zais zis ntawm cov leeg nqaij.
(2) Qhov cuam tshuam rau lub urethral sphincter
Ntxiv nrog rau nws cov txiaj ntsig ntawm lub zais zis cov leeg nqaij, Bethanchol kuj tseem muaj qee qhov cuam tshuam rau lub urethral sphincter.
Lub contraction thiab so ntawm lub urethral sphincter yog qhov tseem ceeb heev rau kev tso zis ntawm cov zis. Bethanchol tuaj yeem tswj xyuas qhov nro ntawm cov urethral sphincter, ua haujlwm ntawm lub zais zis thiab cov zis, thiab pab txhawb kev tso zis zoo. Txawm li cas los xij, kev tshawb fawb ntxiv yog xav tau los qhia meej txog nws cov txheej txheem tshwj xeeb ntawm kev ua haujlwm thiab qib ntawm kev cuam tshuam ntawm cov urethral sphincter.
(3) Kev siv tshuaj kho mob
Hauv tsev kho mob,Bethanechol ntsiav tshuajfeem ntau yog siv los kho postoperative urinary retention, neurogenic zais zis thiab lwm yam kab mob. Rau cov neeg mob tom qab phais tas, yam xws li tshuaj loog thiab kev phais mob yuav ua rau lub zais zis du cov leeg tuag tes tuag taw thiab tso zis nyuaj. Bethanchol tuaj yeem pab cov neeg mob rov qab tso zis ua haujlwm los ntawm kev txhawb lub zais zis cov leeg nqaij. Rau cov neeg mob uas muaj lub zais zis neurogenic, Bethanchol tuaj yeem tswj hwm lub zais zis neuromuscular, txhim kho cov zis cia thiab tso zis ua haujlwm ntawm lub zais zis, thiab txo qhov tshwm sim ntawm kev tso zis thiab khaws cia.
Kev cuam tshuam rau lub plab zom mov
(1) Smooth nqaij contraction ntawm plab hnyuv ib ntsuj av
Bethanchol kuj tseem muaj qhov cuam tshuam loj rau cov leeg nqaij ntawm txoj hnyuv. MachR kuj tau muab faib rau ntawm cov leeg du ntawm txoj hnyuv. Bethanchol khi rau cov receptors no, ua rau lawv ua haujlwm, thiab ua rau cov teeb liab hloov pauv hauv lub cev, ua rau cov nqaij ntshiv plab zom mov. Cov nyhuv no tuaj yeem txhawb lub peristalsis ntawm txoj hnyuv, ua kom lub plab zom mov thiab tshem tawm cov zaub mov. Rau qee qhov kev zom zaub mov thiab gastroparesis tshwm sim los ntawm kev ua tsis txaus ntawm plab hnyuv, Bethanchol tuaj yeem txhim kho plab hnyuv motility los ntawm kev txhim kho cov contractility ntawm cov nqaij ntshiv hauv plab hnyuv.
(2) Ua kom cov qog ua kua qaub
Ntxiv nrog rau kev txhawb nqa cov leeg nqaij leeg hauv plab hnyuv, Bethanchol kuj tseem tuaj yeem ua rau cov qog nqaij hlav hauv plab hnyuv.
Bethanchol activates mAChR ntawm glandular hlwb, txhawb kev tso tawm ntawm ntau yam digestive kua xws li qaub ncaug, gastric acid, plab hnyuv flGastrointestinal glands muaj xws li salivary glands, gastric glands, plab hnyuv glands, thiab lwm yam. Cov kua txiv hmab txiv ntoo tuaj yeem ua rau cov enzymes digestive thiab dej cov ntsiab lus hauv plab hnyuv, uas pab nrog kev zom zaub mov thiab kev nqus ntawm cov as-ham.
(3) Kev siv tshuaj kho mob
Hauv kev kho mob, nws tuaj yeem siv los kho cov kab mob xws li gastroparesis thiab kev ua haujlwm dyspepsia. Cov neeg mob uas muaj gastroparesis tuaj yeem ua rau lub plab zom mov qeeb vim muaj kev mob plab zom mov, ua rau cov tsos mob xws li xeev siab, ntuav, thiab tsam plab. Bethanchol tuaj yeem txhim kho plab hnyuv ua haujlwm thiab txo cov tsos mob hauv cov neeg mob los ntawm kev txhawb nqa cov leeg nqaij leeg thiab ua kom cov kua dej tso pa tawm. Rau cov neeg mob uas muaj kev ua haujlwm dyspepsia, Bethanchol tuaj yeem tswj cov kev txav mus los thiab kev tso tawm ntawm lub plab zom mov, txhim kho lub plab zom mov ntawm txoj hnyuv, thiab txo cov tsos mob ntawm kev zom zaub mov hauv cov neeg mob.
caj pas secretion
Bethanechol ntsiav tshuaj(chlorobutylcholine ntsiav tshuaj) raws li ib qho ncaj qha - ua yeeb yam anticholinergic, muaj kev cuam tshuam loj rau cov qog ua kua. Nws mechanism ntawm kev txiav txim thiab cov teebmeem feem ntau tshwm sim hauv cov hauv qab no:
Direct stimulating nyhuv ntawm glandular secretion
Chlorobutinecholine ncaj qha txhawb cov kev ua ub no ntawm cov qog exocrine los ntawm kev ua kom muscarinic acetylcholine receptors (M receptors). Tshwj xeeb, nws manifests li:
Cov qog ua kua qaub:Chlorobuculine tuaj yeem ua rau kom qaub ncaug ntau ntxiv thiab txo cov tsos mob ntawm qhov ncauj qhuav los ntawm kev siv xov tooj cua lossis tshuaj. Cov nyhuv no feem ntau yog siv rau hauv kev kho mob los txo cov qog ua kua qaub, xws li txo cov qaub ncaug tom qab siv hluav taws xob kho mob rau lub taub hau thiab caj dab.
Cov qog nqaij hlav:Chlorobuculine tuaj yeem txhawb nqa cov kua qaub ntawm lub plab los ntawm cov phab ntsa hauv plab thiab txhim kho cov kua dej hauv plab. Cov txiaj ntsig no tuaj yeem muaj txiaj ntsig zoo rau cov neeg mob uas muaj mob plab hnyuv lossis tsis txaus cov kua qaub hauv plab, tab sis nws yuav tsum tau muab sau tseg tias nws yuav ua rau mob plab hnyuv lossis cov tsos mob reflux.
Lwm cov qog:Chlorobuculine kuj tseem tuaj yeem txhawb kev tso tawm ntawm cov qog exocrine xws li qog hws thiab cov qog ua kua muag, tab sis nws daim ntawv thov kev kho mob tsis tshua tsom rau cov qog no ib leeg.
Kev sib piv nrog Acetylcholine (ACh) Mechanism
Chlorobuculine yog cov qauv zoo ib yam li acetylcholine (ACh), tab sis muaj qhov sib txawv hauv qab no:
Kev ruaj ntseg:Chlorobutylcholine yog quaternary ammonium compound thiab tsis yooj yim decomposed los ntawm cholinesterase, yog li nws lub sij hawm ntawm kev txiav txim yog ho ntev dua li ntawm acetylcholine. Cov yam ntxwv no ua rau nws ua rau lub caj pas tsis tu ncua tsis tas yuav tsum tau ua haujlwm ntau zaus.
Ntshav-b hlwb barrier permeability:Cov qauv quaternary ammonium ntawm chlorobutylcholine txwv tsis pub nws muaj peev xwm nkag mus rau hauv cov ntshav - lub hlwb teeb meem, ua rau muaj kev cuam tshuam me me rau hauv nruab nrab lub paj hlwb thiab txo cov kev mob tshwm sim hauv nruab nrab (xws li tshee, ntxhov siab) tshwm sim los ntawm acetylcholine.
Receptor Selectivity:Chlorobutylcholine feem ntau ua rau M receptors thiab muaj qhov tsis muaj zog ntawm nicotinic acetylcholine receptors (N receptors), yog li muab kev txhawb nqa tshwj xeeb ntawm qog qog.
Adenoid Secretion-Cov Lus Qhia ntsig txog hauv Kev Siv Tshuaj Kho Mob
Lub adenoid secretion stimulating nyhuv ntawm chlorobutylcholine yog tsuas yog siv nyob rau hauv cov nram no scenarios nyob rau hauv kev kho mob xyaum:
Salivary caj pas dysfunction
Piv txwv li, qhov ncauj qhuav tshwm sim los ntawm kev siv xov tooj cua lossis siv tshuaj, chlorobutynine tuaj yeem txhim kho lub neej zoo ntawm cov neeg mob los ntawm kev ua kom qaub ncaug ntau ntxiv.
Gastroparesis
Hauv cov neeg mob uas tsis muaj lub plab zom mov tsis txaus, chlorobutynine tuaj yeem cuam tshuam kev zom zaub mov los ntawm kev ua kom lub plab acid secretion thiab gastric peristalsis.
Postoperative urinary tuav
Txawm hais tias nws cov txiaj ntsig tseem ceeb yog lub zais zis detrusor nqaij contraction, qhov nce hauv glandular secretion (xws li qaub ncaug) tuaj yeem ua qhov qhia tsis ncaj ntawm cov tshuaj ua tau zoo.
FAQ
1. Vim li cas nws nqos tsis tau noj sublingually?
Tom qab kev tswj hwm qhov ncauj, betanechol yuav tsum tau nqus los ntawm txoj hnyuv kom tsis txhob cuam tshuam ncaj qha rau cholinergic receptors hauv caj pas, yog li tiv thaiv bronchospasm lossis bradycardia. Kev tswj hwm sublingual tuaj yeem ua rau muaj teeb meem cholinergic system.
2. Dab tsi yog qhov txaus ntshai ntawm kev noj nws ua ke nrog magnesium- muaj cov tshuaj hauv plab?
Noj magnesium-muaj cov tshuaj antacids ib txhij tuaj yeem ua rau cov plab hnyuv nqus ntawm bethanechol, ua kom cov leeg nqaij du, thiab ua rau mob plab -xws li mob plab lossis raws plab. Nws raug nquahu kom coj lawv tsawg kawg 2 teev sib nrug.
3. Vim li cas thiaj yuav muaj "kev xav txias" tom qab noj cov tshuaj?
Benzacine tuaj yeem qhib cov cholinergic receptors nyob rau hauv cov hlab ntsha peripheral, ua rau lub sijhawm hloov pauv ntawm cov hlab ntsha ntawm daim tawv nqaij thiab tso tawm hws qog, ua rau lub cev poob ntawm lub cev thiab ua rau lub siab txias. Cov nyhuv no tshwj xeeb tshaj yog thaum qhov kub ntawm ib puag ncig qis.
4. Dab tsi yuav tsum tau ceeb toom tshwj xeeb rau cov neeg mob glaucoma?
Txawm tias kaw -lub kaum sab xis glaucoma, cov teebmeem cholinergic ntawm Betahistine tuaj yeem hloov pauv cov dej lom zem thiab muaj feem cuam tshuam rau lub siab hauv lub cev. Thaum siv tshuaj, nws yog qhov yuav tsum tau ua tib zoo saib xyuas cov kev hloov pauv hauv lub siab, tsis yog tsuas yog tso siab rau "qhib-angle / kaw-angle" los txiav txim siab txog kev nyab xeeb.
Cim npe nrov: bethanechol ntsiav tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom