Cimetidine ntsiav tshuaj 400 mgyog ib qho classic H2 receptor antagonist uas cuam tshuam lub plab acid secretion los ntawm thaiv H2 receptors ntawm lub plab phab ntsa hlwb. Txij li thaum nws tso tawm xyoo 1976, nws tau dhau los ua ib qho ntawm cov tshuaj tseem ceeb rau kev kho mob plab acid ntsig txog cov kab mob vim nws qhov kev ua tau zoo thiab kev nyab xeeb. Cov tshuaj no tsim nyog rau kev tso tawm ntau dhau ntawm cov kua qaub hauv cov kab mob xws li gastric ulcer, duodenal ulcer, gastroesophageal reflux disease (GERD), Zollinger Ellison syndrome, thiab lwm yam. Nws tuaj yeem txo tus kheej txwv cov tsos mob xws li mob plawv thiab kua qaub reflux.
Cov ntaub ntawv ntxiv ntawm chemical compound:
| Khoom npe | Cimetidine hmoov | Cimetidine ntsiav tshuaj | Kev txhaj tshuaj Cimetidine | Cimetidine Capsules | Cimetidine Cream |
| Yam khoom | Hmoov | Cov ntsiav tshuaj | Txhaj tshuaj | Capsules | Cream |
| Khoom Purity | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% |
| Khoom Specifications | Customizable | Customizable | Customizable | Customizable | Customizable |
| Pob khoom | Customizable | Customizable | Customizable | Customizable | Customizable |
Peb cov khoom tsim
Cimetidine +. COA
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Certificate of Analysis |
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Compound npe |
Cimetidine | |
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CAS Nr. |
51481-61-9 | |
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Qib |
Pharmaceutical qib | |
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Ntau |
Customized | |
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Ntim txheem |
Customized | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
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Ntau No. |
20250109001 |
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MFG |
Jan 12th 2025 |
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EXP |
Jan 8th 2029 |
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Qauv |
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| TEST STANDARD | GB/T24768-2009 Kev lag luam. Stnndard | |
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Yam khoom |
Enterprise txheem |
Kev txheeb xyuas qhov tshwm sim |
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Qhov tshwm sim |
Dawb los yog yuav luag dawb hmoov |
Ua raws |
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Cov ntsiab lus dej |
Tsawg dua lossis sib npaug li 4.5% |
0.30% |
| Poob rau ziab |
Tsawg dua lossis sib npaug li 1.0% |
0.15% |
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Hnyav Hlau |
Pb Tsawg dua lossis sib npaug li 0.5ppm |
N.D. |
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Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Hg Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Cd Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Purity (HPLC) |
Ntau dua lossis sib npaug li 99.0% |
99.5% |
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Ib qho impurity |
<0.8% |
0.48% |
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Residue ntawm ignition |
<0.20% |
0.064% |
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Tag nrho microbial suav |
Tsawg dua lossis sib npaug li 750cfu / g |
80 |
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E. Coli |
Tsawg dua lossis sib npaug li 2MPN / g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (los ntawm GC) |
Tsawg dua lossis sib npaug li 5000ppm |
400ppm ua |
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Cia |
Khaws rau hauv qhov chaw kaw, tsaus thiab qhuav ntawm -20 degrees |
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Cimetidine ntsiav tshuaj 400 mg, raws li ib tug classic H2 receptor antagonist, ho inhibit gastric acid secretion los ntawm thaiv H2 receptors ntawm lub plab phab ntsa hlwb. Lawv tau siv dav hauv tib neeg cov tshuaj rau kev kho mob gastric acid ntsig txog kab mob. Nrog rau kev txhim kho cov tshuaj kho tsiaj, Cimetidine ntsiav tshuaj tau maj mam dhau los ua cov tshuaj tseem ceeb rau kev kho cov kab mob gastric acid thiab lwm yam kab mob hauv cov tsiaj txhu hauv cov tsiaj txhu hauv kev kho tsiaj kho tsiaj vim lawv qhov ua tau zoo thiab kev nyab xeeb.
1.1 Ua rau thiab pathological mechanisms
Gastric ulcer thiab duodenal ulcer yog cov kab mob hauv plab zom mov hauv cov tsiaj (tshwj xeeb yog dev thiab miv), feem ntau tshwm sim los ntawm kev tso kua qaub ntau dhau, kev puas tsuaj rau lub plab mucosal tiv thaiv mechanisms, lossis Helicobacter pylori kab mob (tsawg dua hauv cov tsiaj). Kev siv cov tshuaj nonsteroidal los tiv thaiv -cov tshuaj inflammatory (NSAIDs), kev ntxhov siab (xws li kev phais, kev raug mob, kev kis kab mob), lossis kev noj zaub mov tsis zoo yog qhov tshwm sim.
1.2 Clinical manifestations
Cov dev: ntuav (tej zaum los ntshav), mob plab, tsis qab los noj mov, poob phaus, quav dub (los ntshav hauv plab).
Miv: ntuav, tsis qab los noj mov, plab nruj, plaub hau ntxhib, poob phaus.
1.3 Cov nyhuv kho
Cimetidine ntsiav tshuaj txhawb kev kho mob los ntawm inhibiting gastric acid secretion, txo tus nqi pH hauv plab, txo cov stimulation ntawm gastric acid nyob rau ntawm qhov chaw ntawm qhov txhab. Lub caij no, nws cov nyhuv antihistamine tuaj yeem txo cov tsos mob xws li xeev siab thiab ntuav los ntawm gastric acid stimulation.
1.4 Kev npaj tshuaj
Cov dev: 5-10mg / kg lub cev qhov hnyav, qhov ncauj lossis tso zis, 3-4 zaug hauv ib hnub; Los yog 10-20mg / kg lub cev hnyav, hais lus, ob zaug ib hnub.
Miv: 5mg / kg lub cev hnyav, hais lus, ib zaug txhua 8-12 teev.
Kev kho mob: feem ntau yuav kav li 4-8 lub lis piam kom txog thaum lub rwj zoo.
1.5 Cov Kev Kho Mob
Case 1: Ib tug 8-xyoo- laus txiv neej German Shepherd aub tau kuaj pom tias muaj mob plab los ntawm kev siv tshuaj endoscopy vim ntuav thiab cov quav dub tshwm sim los ntawm kev siv NSAIDs mus ntev los kho mob caj dab. Siv 8 mg / kg lub cev qhov hnyav ntawm Cimetidine ntsiav tshuaj ntawm qhov ncauj, peb zaug hauv ib hnub, thaum txiav NSAIDs thiab muab cov tshuaj tiv thaiv plab hnyuv. Tom qab 2 lub lis piam ntawm kev kho mob, ntuav nres thiab cov quav dub ploj; Plaub lub lis piam tom qab, endoscopic rov kuaj pom pom kev kho mob.
Case 2: Ib tug 5-xyoo- tus poj niam laus hauv tsev miv tau poob qab los noj mov thiab ntuav vim muaj kev ntxhov siab (tsiv), thiab kev kuaj X-ray qhia pom cov kab mob duodenal. Siv Cimetidine ntsiav tshuaj 5mg / kg lub cev qhov hnyav ntawm qhov ncauj, ib zaug txhua 12 teev, thiab muab kev kho mob txhawb nqa. Tom qab ib lub lim tiam ntawm kev kho mob, cov tsos mob zoo heev; Zoo zoo tom qab 2 lub lis piam.
2.1 Ua rau thiab pathological mechanisms
GERD yog tshwm sim los ntawm kev ua haujlwm tsis zoo ntawm txoj hlab pas esophageal sphincter (LES) los yog qeeb ntawm lub plab khoob, ua rau cov kua qaub reflux mus rau hauv txoj hlab pas thiab ua rau mob, rwj, thiab txawm nqaim ntawm txoj hlab pas. Feem ntau pom hauv cov dev luv luv ntawm cov dev (xws li bulldogs, Boston Terriers) thiab cov tsiaj rog rog.
2.2 Clinical manifestations
Cov dev: Reflux, ntuav (tej zaum muaj ntshav), nqos nyuaj, poob phaus, qaub ncaug ntau dhau.
Miv: Reflux, tsis qab los noj mov, poob phaus, hnoos (vim khaus ntawm lub plab los ntawm plab acid).
2.3 Cov nyhuv kho
Cimetidine ntsiav tshuaj txo cov kua qaub hauv plab, txo qis reflux acidity, alleviate esophageal mucosal puas, txhawb kev kho mob, thiab kho rwj. Lub caij no, nws cov nyhuv antihistamine tuaj yeem txo cov tsos mob xws li hnoos thiab ntuav los ntawm gastric acid stimulation.
2.4 Kev npaj tshuaj noj
Cov dev: 5-10mg / kg lub cev qhov hnyav, qhov ncauj lossis tso zis, 3-4 zaug hauv ib hnub; Los yog 10-20mg / kg lub cev hnyav, hais lus, ob zaug ib hnub.
Miv: 5mg / kg lub cev hnyav, hais lus, ib zaug txhua 8-12 teev.
Hoob kev kho mob: feem ntau kav ntev li 8-12 lub lis piam, thiab tuaj yeem hloov mus rau kev noj tshuaj (xws li ib hnub ib zaug) tom qab cov tsos mob zoo dua.
2.5 Cov Kev Kho Mob
Case 1: Ib tug 3-xyoo- tus txiv neej Fabkis txoj bulldog tau kuaj pom tias muaj tus mob reflux esophagitis los ntawm kev kuaj endoscopic vim nquag reflux thiab ntuav. Muab 10mg / kg lub cev hnyav ntawm Cimetidine ntsiav tshuaj ntawm qhov ncauj, peb zaug hauv ib hnub, thaum kho cov khoom noj (me me rau ntau pluas noj, muaj protein ntau thiab rog tsawg) thiab tsa lub tais. Tom qab 4 lub lis piam ntawm kev kho mob, reflux thiab ntuav nres; Tom qab 8 lub lis piam, endoscopic rov kuaj pom pom kev kho mob ntawm esophageal mucosa.
Case 2: Ib tug 7-xyoo- tus poj niam laus Maine Coon miv tau kuaj pom tias muaj tus mob reflux esophagitis ntawm kev kuaj X-ray vim hnoos thiab tsis qab los noj mov. Siv Cimetidine ntsiav tshuaj 5mg / kg lub cev qhov hnyav ntawm qhov ncauj txhua 12 teev, nrog rau cov tshuaj tiv thaiv hnoos thiab txhawb kev kho mob. Tom qab 2 lub lis piam ntawm kev kho mob, hnoos tau zoo; Ua kom rov zoo tom qab 4 lub lis piam.
3.1 Ua rau thiab pathological mechanisms
Kev ntxhov siab rwj yog tshwm sim hauv cov xeev kev ntxhov siab xws li kev saib xyuas hnyav, kev phais, kev raug mob, lossis kev kis kab mob, qhov uas ua rau cov kua qaub ntau ntxiv thiab txo qis hauv plab mucosal cov ntshav ntws ua rau lub plab puas. Drug induced gastritis feem ntau yog tshwm sim los ntawm kev siv sijhawm ntev ntawm -NSAIDs, glucocorticoids, lossis qee yam tshuaj tua kab mob (xws li tetracycline).
3.2 Clinical manifestations
Stress ulcer: ntuav (tej zaum los ntshav), quav dub, mob plab, poob siab (thaum los ntshav hnyav).
Tshuaj induced gastritis: ntuav, tsis qab los noj mov, mob plab, quav dub.
3.3 Cov nyhuv kho
Cimetidine ntsiav tshuaj inhibit gastric acid secretion, txo gastric acid puas rau lub plab mucosa, thiab txhawb ulcer kho. Lub caij no, nws cov nyhuv antihistamine tuaj yeem txo cov tsos mob xws li xeev siab thiab ntuav los ntawm gastric acid stimulation.
3.4 Kev npaj tshuaj
Tiv thaiv kom tsis txhob muaj kev ntxhov siab: Cov tsiaj txhu muaj kev pheej hmoo siab (xws li kev kho mob tom qab phais thiab mob hnyav) yuav tsum tau muab Cimetidine ntsiav tshuaj ntawm koob tshuaj 3-5mg / kg lub cev qhov hnyav, qhov ncauj lossis tso zis, 3-4 zaug hauv ib hnub.
Kev kho mob ntawm kev ntxhov siab rwj / tshuaj-induced gastritis: 5-10mg / kg lub cev hnyav, qhov ncauj los yog tso zis, 3-4 zaug hauv ib hnub; Los yog 10-20mg / kg lub cev hnyav, hais lus, ob zaug ib hnub.
Kev kho mob: feem ntau yuav kav li 7-14 hnub kom txog thaum cov tsos mob zoo dua.
3.5 Cov Kev Kho Mob
Case 1: Ib tug txiv neej 10-xyoo-laus Golden Retriever tau kuaj pom tias muaj mob qog nqaij hlav los ntawm kev kuaj mob endoscopic vim ntuav thiab cov quav dub tom qab phais femoral taub hau hloov. TswjCimetidine ntsiav tshuaj 400 mgntawm ib koob ntawm 8mg / kg lub cev qhov hnyav ntawm qhov ncauj, peb zaug hauv ib hnub, nrog rau cov tshuaj hemostatic thiab kev txhawb nqa. Tom qab 3 hnub ntawm kev kho mob, ntuav nres thiab cov quav dub poob; Zoo zoo nyob rau hauv 7 hnub.
Case 2: Ib tug 4-xyoo- poj niam poodle tau kuaj pom tias muaj tshuaj-induced gastritis los ntawm kev kuaj endoscopic vim ntuav thiab poob qab los ntawm kev siv NSAIDs mus ntev los kho mob caj dab. Siv Cimetidine ntsiav tshuaj 5mg / kg lub cev qhov hnyav ntawm qhov ncauj txhua 12 teev, thaum txiav NSAIDs thiab muab cov tshuaj tiv thaiv plab hnyuv. Tom qab 5 hnub ntawm kev kho mob, cov tsos mob zoo heev; Ua kom rov qab ua tiav hauv 10 hnub.
4.1 Ua rau thiab pathological mechanisms
Gastrinoma yog ib yam kab mob uas tsis tshua muaj endocrine uas secretes ntau ntawm gastrin, nkoos ntau secretion ntawm gastric acid, thiab ua rau refractory gastric ulcers thiab raws plab. Systemic mastocytosis yog tshwm sim los ntawm kev tso tawm ntawm histamine thiab lwm yam kev kho mob los ntawm mast hlwb, ua rau muaj zog gastric acid secretion thiab gastrointestinal tsos mob.
4.2 Clinical manifestations
Gastrinoma: refractory gastric ulcer, raws plab, poob phaus, mob plab.
Systemic mastocytosis: ntuav, raws plab, daim tawv nqaij erythema, khaus, mob plab.
4.3 Cov nyhuv kho
Cimetidine ntsiav tshuaj alleviate cov tsos mob xws li rwj thiab raws plab los ntawm gastric acid ntau dhau los ntawm inhibiting gastric acid secretion thiab txo tus nqi pH hauv plab. Lub caij no, nws cov nyhuv antihistamine tuaj yeem txo cov kev tsis haum tshuaj tshwm sim los ntawm mast cell tso mediators.
4.4 Kev npaj tshuaj noj
Gastrinoma: Thawj koob tshuaj ntawm 600-1200mg / hnub, noj hauv qhov ncauj hauv cov koob tshuaj sib faib, hloov kho raws li kev tso pa tawm ntawm gastric acid (txog 2400mg / hnub).
Systemic mastocytosis: 5-10mg / kg lub cev qhov hnyav, qhov ncauj los yog tso zis, 3-4 zaug hauv ib hnub.
Hoob kho mob: yuav tsum tau kho lub sij hawm ntev, nrog rau kev saib xyuas ntawm gastric acid secretion thiab cov tsos mob nyem.
4.5 Cov Kev Kho Mob
Case 1: Ib tug 6-xyoo-laus txiv neej Border Collie tau kuaj pom tias muaj gastrinoma vim yog mob plab hnyuv thiab raws plab, nrog rau qib siab gastrin. Siv Cimetidine ntsiav tshuaj 800mg / hnub ntawm qhov ncauj hauv kev faib cov koob tshuaj, nrog rau cov tshuaj tiv thaiv kab mob thiab kev kho mob txhawb nqa. Tom qab 2 lub lis piam ntawm kev kho mob, raws plab tau txo qis; Tom qab 4 lub lis piam, lub rwj ntawm lub qhov txhab kho thiab gastrin qib txo.
Case 2: Ib tug 5-xyoo-laus poj niam Labrador Retriever tau kuaj pom tias muaj cov kab mob mastocytosis los ntawm daim tawv nqaij biopsy vim yog ntuav ntuav, raws plab, thiab daim tawv nqaij erythema. Siv 10mg / kg lub cev hnyav ntawm Cimetidine ntsiav tshuaj ntawm qhov ncauj, peb zaug ib hnub, nrog rau cov tshuaj tiv thaiv kab mob thiab kev txhawb nqa. Tom qab ib lub lim tiam ntawm kev kho mob, cov tsos mob zoo heev; Zoo zoo tom qab 2 lub lis piam.
5.1 Ua rau thiab pathological mechanisms
Cov kab mob gastritis tuaj yeem tshwm sim los ntawm kev noj zaub mov tsis tu ncua, kev kis kab mob (xws li Helicobacter pylori, uas tsis tshua muaj nyob hauv tsiaj), kab mob autoimmune, lossis ntev - siv cov tshuaj (xws li NSAIDs). Cov tsos mob ntuav yog hais txog ntuav ntuav hauv cov tsiaj tsis muaj qhov pom tseeb ntawm cov kab mob organic, uas tej zaum yuav cuam tshuam nrog kev ua rau lub plab acid, ncua lub plab zom mov, lossis cov hlab ntsha hauv nruab nrab.
5.2 Clinical manifestations
Mob plab gastritis: ntuav, tsis qab los noj mov, poob phaus, mob plab, qaub ncaug ntau dhau.
Cov tsos mob ntuav: ntuav ntuav (tej zaum nrog ntshav), mob plab, thiab ntxhov siab.
5.3 Cov nyhuv kho
Cimetidine ntsiav tshuaj txo cov tsos mob ntuav los ntawm inhibiting gastric acid secretion, txo cov stimulation ntawm gastric acid ntawm lub plab mucosa. Lub caij no, nws cov nyhuv antihistamine tuaj yeem txo qhov xeev siab thiab ntuav reflex tshwm sim los ntawm gastric acid stimulation.
5.4 Kev npaj tshuaj
Mob plab hnyuv: 5-10mg / kg lub cev hnyav, qhov ncauj lossis tso zis, 3-4 zaug hauv ib hnub; Los yog 10-20mg / kg lub cev hnyav, hais lus, ob zaug ib hnub.
Cov tsos mob ntuav: 5mg / kg lub cev hnyav, noj qhov ncauj, txhua 8-12 teev.
Kev kho mob: feem ntau kav ntev li 2-4 lub lis piam, thiab tuaj yeem txo qis tom qab cov tsos mob zoo dua.
5.5 Cov Kev Kho Mob
Case 1: Ib tug 7-xyoo- tus txiv neej laus corgi dev tau kuaj pom tias mob plab hnyuv los ntawm kev siv tshuaj endoscopy vim ntuav mus ntev thiab anorexia. TswjCimetidine ntsiav tshuaj 400 mgntawm ib koob ntawm 8mg / kg lub cev qhov hnyav ntawm qhov ncauj, peb zaug hauv ib hnub, thaum kho cov khoom noj (me me rau ntau yam zaub mov, yooj yim digestible) thiab muab cov tshuaj tiv thaiv plab hnyuv. Tom qab 2 lub lis piam ntawm kev kho mob, ntuav nres thiab qab los noj mov; Ua kom rov zoo tom qab 4 lub lis piam.
Case 2: Ib tug 3-xyoo-laus poj niam Siamese miv tau kuaj pom tias muaj ntuav ntuav vim ntuav ntuav thiab tsis muaj qhov pom tseeb ntawm cov kab mob. Siv Cimetidine ntsiav tshuaj 5mg / kg lub cev qhov hnyav ntawm qhov ncauj txhua 12 teev, nrog rau cov tshuaj tiv thaiv kev ntxhov siab thiab kev txhawb nqa. Tom qab ib lub lim tiam ntawm kev kho mob, qhov ntuav ntuav txo qis; Ua kom tiav tom qab 2 lub lis piam.
Cov lus nug nquag
Vim li cas cimetidine tsis siv lawm?
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Cimetidine tuaj yeem ua rau cov ntshav ntau ntxiv ntawm loperamide, uas tuaj yeem ua rau muaj teeb meem loj thiab muaj peev xwm ua rau tuag taus xws li mob plawv arrhythmias thiab mob plawv, tshwj xeeb tshaj yog tias loperamide tau noj ntau dhau.
Puas yog cimetidine thiab omeprazole tib yam?
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Cimetidine (Tagamet HB) thiab omeprazole (Prilosec) yog ob qho tib si siv los kho mob plawv thiab lwm yam teeb meem plab acid, tab sis lawv koom nrog ntau hom tshuaj.
Dab tsi yuav tsum zam thaum noj cimetidine?
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Cov tshuaj no kuj tseem cuam tshuam nrog cov hauv qab no:
Caffeine.
Carbamazepine.
Carmustin.
Delavirdine.
Estrogen los yog progestin cov tshuaj hormones.
Itraconazole.
Ketoconazole.
Cov tshuaj rau lub plawv dhia tsis xwm yeem.
Dab tsi yog qhov teeb meem nrog cimetidine?
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Cimetidine feem ntau ua tau zoo. Tab sis cov kev mob tshwm sim me me, xws li raws plab, mob taub hau, thiab siab enzyme siab, tseem tuaj yeem tshwm sim. Cimetidine tuaj yeem ua rau muaj kev phiv tsawg dua, suav nrog kev tsis meej pem, lub mis loj rau cov txiv neej, thiab mob pob qij txha thiab cov leeg.
Cimetidine puas tuaj yeem kho cov kua qaub reflux?
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Cimetidine yog lub plab acid reducer siv nyob rau hauv luv luv -kev kho mob duodenal thiab gastric ulcers. [1] Yog li ntawd, cov tshuaj muaj txiaj ntsig zoo tswj lub plab hypersecretion thiab siv los tswj cov kab mob reflux esophagitis thiab tiv thaiv kev ntxhov siab- ntsig txog plab hnyuv.
Cim npe nrov: Cimetidine ntsiav tshuaj 400mg, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom