Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm bismuth subcarbonate ntsiav tshuaj nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo bismuth subcarbonate ntsiav tshuaj muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Bismuth subcarbonate ntsiav tshuajyog ib tug kws tshuaj formulation feem ntau muaj xws li dibismuth subnitras (tshuaj formula (BiO) 2CO3) raws li active ingredient. Nws cov tsos mob feem ntau yog cov ntsiav tshuaj dawb lossis lub teeb daj, tshuaj lom neeg ruaj khov, tsis muaj dej hauv dej, tab sis nws tuaj yeem maj mam tso cov dibismuth ions (Bi ³ ⁺) nyob rau hauv ib puag ncig gastric acid, yog li ua rau cov tshuaj pharmacological. Raws li tus tswv cuab tseem ceeb ntawm dibismuth tebchaw, dibismuth carbonate yog dav siv hauv kev kho mob, kev lag luam, thiab cov ntaub ntawv tshawb fawb. Nws yog ib tug classic kws tshuaj formulation nrog dibismuth carbonate (BiO) 2CO3 raws li lub ntsiab tivthaiv, lug siv nyob rau hauv kev kho mob ntawm digestive system kab mob.
Kev npaj
Qhov kev npaj feem ntau yog siv txoj kev compression ncaj qha los yog txoj kev ntub dej granulation. Cov kauj ruam tseem ceeb muaj xws li:
Raw khoom mixing:
Sib tov dibismuth carbonate hmoov nrog cov khoom siv (xws li cov hmoov txhuv nplej siab, lactose, microcrystalline cellulose) hauv kev faib ua feem kom ntseeg tau cov ntsiab lus sib xws.
Granulation thiab ziab:
Txhim kho hmoov flowability los ntawm ntub granulation technology, ua raws li los ntawm kev ziab kom tshem tawm noo noo.
Tablet nias thiab txheej:
Cov khoom yog compressed rau hauv cov ntsiav tshuaj thiab coated nrog qab zib txheej los yog zaj duab xis txheej raws li xav tau los npog cov ntxhiab tsw los yog tswj cov tshuaj tso tawm.
Cov ntaub ntawv ntxiv ntawm chemical compound:
| Khoom npe | Bismuth Subcarbonate hmoov | Bismuth Subcarbonate Tablets |
| Yam khoom | Hmoov | Cov ntsiav tshuaj |
| Khoom Purity | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% |
| Khoom Specifications | Customizable | Customizable |
| Pob khoom | Customizable | Customizable |
Peb cov khoom tsim
bismuth subcarbonate +. COA
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Certificate of Analysis |
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Compound npe |
Bismuth subcarbonate | |
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CAS Nr. |
5892-10-4 | |
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Qib |
Pharmaceutical qib | |
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Ntau |
Customized | |
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Ntim txheem |
Customized | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
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Ntau No. |
20250109001 |
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MFG |
Jan 12th 2025 |
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EXP |
Jan 8th 2029 |
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Qauv |
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| TEST STANDARD | GB/T24768-2009 Kev lag luam. Stnndard | |
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Yam khoom |
Enterprise txheem |
Kev txheeb xyuas qhov tshwm sim |
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Qhov tshwm sim |
Dawb los yog yuav luag dawb hmoov |
Ua raws |
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Cov ntsiab lus dej |
Tsawg dua lossis sib npaug li 4.5% |
0.30% |
| Poob rau ziab |
Tsawg dua lossis sib npaug li 1.0% |
0.15% |
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Hnyav Hlau |
Pb Tsawg dua lossis sib npaug li 0.5ppm |
N.D. |
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Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Hg Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Cd Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Purity (HPLC) |
Ntau dua lossis sib npaug li 99.0% |
99.5% |
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Ib qho impurity |
<0.8% |
0.48% |
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Residue ntawm ignition |
<0.20% |
0.064% |
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Tag nrho microbial suav |
Tsawg dua lossis sib npaug li 750cfu / g |
80 |
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E. Coli |
Tsawg dua lossis sib npaug li 2MPN / g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (los ntawm GC) |
Tsawg dua lossis sib npaug li 5000ppm |
400ppm ua |
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Cia |
Khaws rau hauv qhov chaw kaw, tsaus thiab qhuav ntawm -20 degrees |
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Bismuth Subcarbonate Tabletsyog ib hom tshuaj classic nrog dibismuth subnitras (BiO) ₂ CO3 ua nws cov ntsiab lus tseem ceeb. Nrog nws ntau- lub hom phiaj ntawm kev ua haujlwm, nws ua lub luag haujlwm tseem ceeb hauv kev kho cov kab mob digestive. Nws cov lus qhia suav nrog peb qhov tseem ceeb: kev tiv thaiv plab hnyuv, kev kho kab mob tua kab mob, acid tsis kam thiab astringency, thiab txuas ntxiv mus rau kev pab cuam xws li kev tiv thaiv tawv nqaij. Cov hauv qab no muab cov ncauj lus kom ntxaws los ntawm peb qhov loj: daim ntawv thov kev kho mob, kev ua haujlwm, thiab kev ceev faj txog tshuaj.
Daim ntawv thov ntawm dibismuth carbonate ntsiav tshuaj nyob rau hauv lub tshav pob ntawm gastric mucosal tiv thaiv yog raws li nws cov cim lub cev thiab tshuaj synergistic nyhuv:
Kev kho qhov txhab: Dibismuth carbonate txo qhov khaus ntawm qhov chaw ntawm qhov txhab los ntawm neutralizing gastric acid (nce pH los ntawm 0.5-1.0 units) thiab adsorbing pepsin. Nyob rau tib lub sijhawm, Dibismuth ions (Bi ³ ⁺) ua ke nrog collagen nthuav tawm ntawm lub hauv paus ntawm lub qhov txhab los tsim cov yeeb yaj kiab tiv thaiv nrog lub thickness ntawm li 50-100 μ m, uas tuaj yeem ua rau lub plab acid ib puag ncig nrog pH 1-3 thiab nyob rau 6-8 teev. Cov daim nyias nyias no tsis tsuas yog cais cov stimuli sab nraud, tab sis kuj txhawb cov mucosal epithelial regeneration los ntawm stimulating lub secretion ntawm prostaglandin E2 (PGE2) thiab epidermal loj hlob yam (EGF).
Cov kev tshawb fawb soj ntsuam tau pom tias tom qab 4 lub lis piam ntawm kev kho mob nrog dibismuth carbonate, qhov kev kho mob ntawm cov kab mob plab nce mus txog 85%, ntau dua li sucralfate (60%) thiab placebo (30%).
Kev kho mob plab: Mob plab feem ntau tshwm sim los ntawm tus kab mob Helicobacter pylori lossis kev puas tsuaj los ntawm nonsteroidal anti-cov tshuaj tiv thaiv kab mob (NSAIDs). Bismuth carbonate alleviates gastric mucosal o los ntawm neutralizing gastric acid thiab adsorbing bile acids. Rau cov neeg mob Helicobacter pylori zoo, dibismuth carbonate ua ib qho tseem ceeb ntawm kev kho plaub hau plaub hau (dibismuth tus neeg saib xyuas + proton twj tso kua mis inhibitor + ob cov tshuaj tua kab mob) tuaj yeem ua rau nce qhov kev tshem tawm ntawm 70% mus rau ntau dua 90%. Nws cov txheej txheem suav nrog kev ua kom tsis muaj menyuam ncaj qha (MIC 8-32 μ g / mL), cuam tshuam ntawm biofilms, thiab txhim kho cov tshuaj tua kab mob permeability.
Cov nyhuv antibacterial ntawm dibismuth carbonate yog qhov tseem ceeb nthuav dav ntawm nws daim ntawv thov kev kho mob:
Helicobacter pylori eradication: Dibismuth carbonate inhibits Helicobacter pylori los ntawm ntau yam - lub hom phiaj:
Kev puas tsuaj ntawm phab ntsa ntawm tes: Dibismuth ions khi rau phosphoric acid nyob rau hauv cov kab mob cell phab ntsa peptidoglycan, cuam tshuam rau tus ntoo khaub lig-txoj kev txuas thiab ua rau kev puas tsuaj rau cov phab ntsa ntawm tes.
Inhibition ntawm enzyme kev ua si: Chelate hlau cofactors (xws li zinc thiab magnesium) nyob rau hauv cov enzymes tseem ceeb ntawm cov kab mob metabolism hauv inactivate enzyme. Piv txwv li, inhibiting urease kev ua ntawm Helicobacter pylori, thaiv cov ammonia ntau lawm, thiab ua rau nws muaj peev xwm ciaj sia nyob rau hauv gastric acid ib puag ncig.
Inducing oxidative kev nyuaj siab: tsim cov reactive oxygen hom (ROS) uas ua rau puas cov kab mob DNA thiab cov proteins, nce DNA breakage tus nqi los ntawm 30% -50%.
Blocking adhesion: Hloov qhov chaw them nqi ntawm lub plab mucosa, txo qhov kev sib txuas ntawm cov kab mob thiab cov mucosal receptors, thiab txo qhov adhesion ntawm 60% -70%.
Combination therapy optimization: Dibismuth carbonate is often used in combination with antibiotics such as clarithromycin, amoxicillin, and metronidazole to form a quadruple therapy. Its advantages lie in reducing antibiotic resistance (reducing mutation probability through multi-target action) and enhancing therapeutic efficacy (breaking biofilms and improving antibiotic permeability). For example, in areas with clarithromycin resistance rates>15%, qhov kev tshem tawm ntawm dibismuth quadruple therapy tseem tuaj yeem ncav cuag 85% -90%.
Daim ntawv thov ntawm dibismuth carbonate ntsiav tshuaj hauv thaj tsam ntawm cov kua qaub tiv thaiv thiab kev tiv thaiv kab mob raws plab yog raws li lawv ob lub cev thiab tshuaj lom neeg cov teebmeem:
Cov nyhuv nrawm nrawm: Cov khoom tsis muaj zog alkaline ntawm dibismuth carbonate (pKa ≈ 8.5) tuaj yeem ua rau lub plab acid ib ntus, txo cov tsos mob xws li mob plab, kua qaub reflux, thiab kub siab. Nws lub sijhawm pib tsawg dua lossis sib npaug li 30 feeb thiab nws lub sijhawm ua haujlwm ntev txog 8 teev, tsim nyog rau kev txo qis cov tsos mob tshwm sim los ntawm plab acid ntau dhau.
Converge thiab nres raws plab: Dibismuth carbonate alleviates raws plab raws li hauv qab no:
Adsorption ntawm co toxins: khi nrog cov kab mob co toxins (xws li endotoxins) hauv cov hnyuv los tsim cov complexes insoluble, txo cov co toxins. Piv txwv li, nyob rau hauv Vibrio cholerae tus kab mob, lub tso zis ntawm txoj hnyuv yuav txo tau los ntawm 30% -50%.
Inhibit plab hnyuv peristalsis: txo cov concentration ntawm calcium ions nyob rau hauv cov hnyuv du nqaij hlwb, thiab tsis muaj zog lub amplitude thiab zaus ntawm plab hnyuv peristalsis. Cov kev tshawb fawb soj ntsuam tau pom tias nws tuaj yeem txo qhov zaus ntawm lub plab zom mov los ntawm 60% -70% thiab qis cov dej hauv plab los ntawm 40% hauv cov neeg mob raws plab.
Kev tswj cov electrolyte tshuav nyiaj li cas: inhibiting kev ua ntawm plab hnyuv sodium glucose cotransporter protein (SGLT1), txo cov reabsorption ntawm sodium thiab dej, thiab txo cov hnyuv osmotic siab.
Cov lus qhia ntxiv: Dibismuth carbonate ntsiav tshuaj yog tsim los kho cov tsos mob ntawm tus kab mob me mus rau nruab nrab raws plab (xws li cov neeg taug kev raws plab thiab kab mob raws plab). Ib koob tshuaj ib zaug ntawm 250 mg tuaj yeem ua rau lub sijhawm zawv plab mus rau 24-48 teev, thiab qhov kev txhim kho ntawm cov quav quav tuaj yeem ncav cuag 70%. Tsis tas li ntawd, nws cov nyhuv astringent kuj tuaj yeem siv los txo cov tsos mob xws li tsam plab thiab xeev siab los ntawm kev ua haujlwm dyspepsia.
Bismuth subcarbonate ntsiav tshuaj, raws li dibismuth uas muaj cov tshuaj sib xyaw ua ke, muaj nws cov ntsiab lus tseem ceeb dibismuth Bicarbonate (BiO) ₂ CO3, uas yog siv dav hauv kev kho mob ntawm cov kab mob hauv plab. Nws astringent, antibacterial, thiab barrier tiv thaiv cov khoom kuj ua rau nws muaj peev xwm adjuvant tshuaj nyob rau hauv kev kho mob ntawm daim tawv nqaij.
Cov txheej txheem tseem ceeb ntawm bismuth carbonate rau kev tiv thaiv tawv nqaij
Dibismuth carbonate muab ntau- qhov ntev tiv thaiv rau ntawm daim tawv nqaij los ntawm peb lub tswv yim ntawm kev tsim lub cev, kev sib koom ua ke ntawm cov kab mob, thiab cov tshuaj astringent los tiv thaiv khaus.
Tom qab dibismuth carbonate dissolves nyob rau saum npoo ntawm daim tawv nqaij, dibismuth ions (Bi ³ ⁺) ua ke nrog dawb fatty acids nyob rau hauv sebum los ua ib tug hydrophobic tiv thaiv zaj duab xis nrog ib tug tuab ntawm txog 10-20 μ m. Cov daim nyias nyias no tuaj yeem sib cais ncaj qha ntawm cov stimuli sab nraud (xws li ammonia hauv cov zis thiab quav, ntsev hauv hws) thiab daim tawv nqaij, txo qhov kev pheej hmoo ntawm kev sib txhuam. Cov kev sim tau pom tias cov tshuaj nplaum uas muaj 2% dibismuth carbonate tuaj yeem ua rau kom ceev ntawm daim tawv nqaij barrier muaj nuj nqi rov qab los ntawm 40% thiab txo cov dej tsis zoo (TEWL) los ntawm 35%.
Dibismuth carbonate muaj qhov cuam tshuam ncaj qha rau cov kab mob pathogenic ntawm daim tawv nqaij, xws li Staphylococcus aureus, Escherichia coli, thiab Candida albicans.
Kev puas tsuaj ntawm cell phab ntsa:
Dibismuth ions khi rau phosphoric acid nyob rau hauv cov kab mob cell phab ntsa peptidoglycan, cuam tshuam rau tus ntoo khaub lig-txoj kev txuas, ua rau kev puas tsuaj rau cov phab ntsa ntawm tes thiab qhov nce ntawm cov kab mob sib kis los ntawm 20% -30%.
Inhibition ntawm kev ua haujlwm enzyme:
Chelate hlau cofactors nyob rau hauv cov enzymes tseem ceeb ntawm cov kab mob metabolism (xws li urease thiab catalase), inactivate cov enzymes, thiab thaiv cov kab mob lub zog metabolism thiab co toxins synthesis.
oxidative kev nyuaj siab induction:
Kev tsim cov pa oxygen reactive hom (ROS) ua rau cov kab mob DNA puas, txo cov kev hloov pauv los ntawm 50% thiab txhawb kev sib tw kom zoo dua ntawm cov kab mob ntawm daim tawv nqaij (xws li Staphylococcus epidermidis), tswj microbial ecological tshuav nyiaj li cas.
Dibismuth carbonate alleviates daim tawv nqaij o thiab khaus los ntawm cov hauv qab no:
Contraction ntawm cov hlab ntsha:
txo cov permeability ntawm daim tawv nqaij capillaries, txo inflammatory exudation, thiab txo cov cheeb tsam ntawm lub zos redness thiab o los ntawm 30% -50%.
Inhibition ntawm neural signal transduction:
Thaiv cov histamine H1 receptor thiab TRPV1 channel (mob thiab kub receptors) ua rau kom khaus qhov pib ntawm 60% -70%.
Tswj lub cev tiv thaiv kab mob:
Inhibiting lub secretion ntawm Th2 cytokines xws li IL-4 thiab IL-13, thiab alleviating chronic o nyob rau hauv atopic dermatitis (AD).
Kev siv tshuaj dibismuth carbonate hauv kev tiv thaiv tawv nqaij
Dibismuth carbonate ntsiav tshuaj (los yog lawv cov tshuaj pleev ib ce) muab kev tiv thaiv kev tiv thaiv rau ntau yam teeb meem ntawm daim tawv nqaij los ntawm kev thov hauv zos lossis kev kho qhov ncauj:
Tus menyuam pob khaus yog tshwm sim los ntawm kev txhawb nqa ntawm cov tshuaj ammonia hauv cov zis / quav. Dibismuth carbonate txo qhov hnyav ntawm cov pob liab liab los ntawm kev tsim cov yeeb yaj kiab tiv thaiv, neutralizing ammonia tshuaj (nce pH los ntawm 0.5-1.0 units), thiab inhibiting kev loj hlob ntawm Escherichia coli. Cov kev tshawb fawb soj ntsuam tau pom tias lub pob tw qab zib muaj 1% dibismuth carbonate tuaj yeem txo lub sijhawm kho cov pob khaus ntawm 72 teev mus rau 48 teev thiab txo qhov rov tshwm sim ntawm 50%.
Cov nyhuv astringent ntawm dibismuth carbonate tuaj yeem txhawb qhov mob kom qhuav, txo cov exudate tsub zuj zuj, thiab txo qhov kev pheej hmoo ntawm kev kis kab mob. Piv txwv li, hauv thawj qib kub hnyiab, dibismuth carbonate gel tuaj yeem ua tiav lub sijhawm kho qhov txhab los ntawm 2-3 hnub thiab txo qhov mob ntawm 40%.
Kev puas tsuaj ntawm daim tawv nqaij los ntawm kev siv hluav taws xob, xws li erythema thiab scaling, yog txuam nrog dawb radical puas. Dibismuth carbonate txo cov tawv nqaij fibrosis los ntawm kev tshem ROS thiab inhibiting MMP-9 (matrix metalloproteinase) kev ua. Cov kev sim tsiaj tau pom tias hauv zos daim ntawv thov ntawm dibismuth carbonate tuaj yeem txo cov hluav taws xob dermatitis cov qhab nia los ntawm 60% thiab nce qhov ceev ntawm epidermal thickness rov qab los ntawm 30%.
Kev sib xyaw ua ke ntawm dibismuth carbonate thiab tshuaj tua kab mob (xws li mupirocin) tuaj yeem txhim kho cov nyhuv tshem tawm ntawm cov tshuaj - tiv thaiv Staphylococcus aureus. Piv txwv li, nyob rau hauv kev kho mob ntawm pustules, ib tug composite npaj uas muaj dibismuth carbonate tuaj yeem ua rau kom cov kab mob tshem tawm ntawm 75% mus rau 90% thiab txo cov kev kho mob los ntawm 2 hnub.
Bismuth subcarbonate ntsiav tshuajmuab ntau- txheej tiv thaiv rau daim tawv nqaij los ntawm kev tiv thaiv kab mob, tshuaj tua kab mob, thiab tiv thaiv- cov txheej txheem inflammatory, ua rau lawv tshwj xeeb tshaj yog haum rau kev kho mob ntawm daim di ncauj, mob me me, thiab kab mob ntawm daim tawv nqaij. Kev tshawb fawb yav tom ntej tuaj yeem tsom mus rau kev txhim kho ntawm nanomaterials (xws li kev txhim kho lub hom phiaj tso tawm kev ua haujlwm ntawm dibismuth ions), kev kho photodynamic ua ke (txhim kho cov kab mob los tiv thaiv kab mob), thiab nthuav qhia (xws li pob txuv thiab rosacea) txhawm rau txhim kho lawv daim tawv nqaij tiv thaiv tus nqi. Lub caij no, ntxiv dag zog rau kev kawm ntawm tus neeg mob (xws li zam kev siv ntev - lub sij hawm loj-}) thiab kev saib xyuas kev nyab xeeb yog qhov tseem ceeb rau kev ua kom muaj kev nyab xeeb thiab kev ua tau zoo ntawm daim tawv nqaij ntawm dibismuth carbonate.
Cim npe nrov: bismuth subcarbonate ntsiav tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom