Citicoline Sodium ntsiav tshuaj 500mgyog cov tshuaj siv dav siv rau kev kho mob ntawm neurological tsis zoo, nrog nws cov tseem ceeb yog phosphadium ntsev ntawm choline cytidine diphosphate. Raws li nucleoside derivative, nws plays ntau lub luag haujlwm hauv kev txhim kho lub hlwb Metabolism, thiab txhim kho cov neurotransmitter synthesis. Txawm hais tias nws yog qhov nyuaj rau nkag mus rau lub hlwb puas hlwb yog li lub sijhawm lub hlwb puas siab dua, thiab cov pov thawj hwj txwv rau nws cov nyhuv tsim kho cov leeg.
Zog:
Dawb los yog tawm dawb ntsiav tshuaj, tsis muaj ntxhiab, soluble hauv dej, insoluble hauv ethanol thiab acetone.
DOSAGE DAIM DUAB:
Cov ntaub ntawv tshwj xeeb yog 0.1g / ntsiav tshuaj thiab ntsiav tshuaj thiab cov ntsiav tshuaj thiab cov ntsiav tshuaj, thiab cov ntsiav tshuaj ntim nrog cov ntawv siv tawv plet ntim ntim (10 ntsiav tshuaj / Board x 2 txiag / Box).
Cov Zej Tswm:
Kev coj cov tshuaj pom zoo hauv tebchaws H20100008 ua piv txwv (tshwj xeeb rau cov khoom tiag tiag).
Kev siv thiab kev nyab xeeb: qhov muag tshuaj yog feem ntau 0.2 grams rau ib koob tshuaj, noj 3 zaug ib hnub nrog dej sov. Qhov kev sib raug zoo no yog cov kev tsis ncaj ncees, qee zaum nrog kev tsis ncaj ncees, mob taub hau lossis insomnia, uas tuaj yeem raug tshem tawm ntawm lawv tus kheej tom qab ua haujlwm ntawm cov tshuaj. Thov nco ntsoov tias nws yog contraindicated rau cov uas ua xua rau cov khoom xyaw ntawm cov tshuaj. Cov poj niam cev xeeb tub thiab cov poj niam ua lactating yuav tsum siv cov tshuaj nrog kev ceev faj thiab yuav tsum tsis txhob siv ua ke nrog chlorhexidine.
Cov ntaub ntawv ntxiv ntawm kev sib txuas lus:
| Khoom npe | Citicoline Sodium hmoov | Citicoline Sodium ntsiav tshuaj | Citicoline sodium txhaj |
| Khoom Yam | Hmoov | Phau ntawv | Kev txhaj tshuaj |
| Khoom Siv Purity | Ntau dua los yog sib npaug rau 99% | Ntau dua los yog sib npaug rau 99% | Ntau dua los yog sib npaug rau 99% |
| Cov Khoom Qhia Khoom Khoom | Tau sib kho | Tau sib kho | Tau sib kho |
| Khoom Pob | Tau sib kho | Tau sib kho | Tau sib kho |
Peb Cov Khoom
Citicoline sodium +. coa
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Daim Ntawv Pov Thawj Kev Ntsuam Xyuas |
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Compound npe |
Citicoline sodium | |
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Cas Tsis tau. |
14769-73-4 | |
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Teem nqi |
Kws Tshuaj Ntsuam Xyuas | |
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Qho ntau |
Me nyuam | |
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Ntim txheem ntim |
Me nyuam | |
| Tus tsim | Shaanxi Bloom Tech Co., Ltd. | |
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Lauj tsis tau. |
20250109001 |
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Mfg |
Jan 12th 2025 |
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Tus txeeb |
Jan 8th 2029 |
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Lub tsev |
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| Kuaj Tus Qauv | GB / T24768-2009 kev lag luam. Stnndard | |
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Yam |
Kev Lag Luam Kev Lag Luam |
Kev tsom xam tau |
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Kev tshwm sim |
Dawb lossis yuav luag dawb hmoov |
Hloov |
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Dej Cov Ntsiab Lus |
Tsawg dua los yog sib npaug rau 4.5% |
0.30% |
| Poob rau ziab |
Tsawg dua los yog sib npaug rau 1.0% |
0.15% |
|
Cov hlau hnyav |
PB tsawg dua lossis sib npaug rau 0.5ppm |
N.D. |
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Tsawg tsawg dua li lossis sib npaug rau 0.5ppm |
N.D. | |
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Hg tsawg dua lossis sib npaug rau 0.5ppm |
N.D. | |
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CD tsawg dua lossis sib npaug rau 0.5ppm |
N.D. | |
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Purity (hplc) |
Ntau dua los yog sib npaug rau 99.0% |
99.5% |
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Ib Leeg Cav |
<0.8% |
0.48% |
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Residue ntawm ignition |
<0.20% |
0.064% |
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TAG NRHO LICBIAL COUNT |
Tsawg dua li lossis sib npaug rau 750cfu / g |
80 |
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E. coli |
Tsawg dua los yog sib npaug rau 2mpn / g |
N.D. |
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Tus ntses siav |
N.D. | N.D. |
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Ethanol (los ntawm gc) |
Tsawg dua los yog sib npaug rau 5000ppm |
400ppm |
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Chaw ntim khoom |
Khaws rau hauv ib qho chaw sib khi, qhov chaw tsaus thiab qhuav ntawm-20 degrees |
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Citicoline Sodium ntsiav tshuaj 500mg, raws li lub nucleoside derivative tshuaj, tau siv dav hauv kev kho mob ntawm cov kab mob neurological xws li kev mob siab rau lub hlwb. Nrog rau kev loj hlob ntawm cov kws kho tsiaj, nws cov peev txheej thov tau yooj yim tau txaus nyiam ntawm cov kws kho tsiaj teb.
Daim Ntawv Thov Qhia:
Pob txha pob txha pob txha thiab lub hlwb cov ntsiab lus tshwm sim los ntawm dev thiab miv cov tsheb sib nraus, poob ntawm qhov siab.
Rov qab ntawm kev txawj xav tsis meej tom qab lub hlwb qog rov, intracranial Hematoma tshem tawm, thiab lwm yam kev phais mob.
Mechanism ntawm Kev Ua:
Los ntawm kev ua kom nce siab kom ua haujlwm ntawm lub paj hlwb rov ua tiav, lub sijhawm coma yog luv thiab txaus siab tau nce qib.
Txhim kho txoj haujlwm ntawm cov pyramidal, txhim kho cov tuag taw tuag tes tuag taw, thiab ua kom muaj zog ua kom muaj zog thiab kev sib koom tes.
Txo lub hlwb edema, qis intracranial siab siab, thiab alleviate kaum ob lub hlwb kev raug mob.
Kho rooj plaub:
Txoj kev tshawb fawb tau ua rau 12 tus dev nrog kev raug mob lub hlwb raug mob hauv tsev kho mob tsiaj. Cov pab pawg kho mob (kho nrog 0.2g sodium phosphatidcholine ob zaug hauv kev sib xyaw ua ke nrog cov qhab nia<0.05) compared to the control group.
Daim Ntawv Thov Qhia:
Lub sijhawm rov qab rau stroke hauv dev thiab miv (xws li vertebrality arracity, xws li los ntshav indacereftbral hemorrhage, los ntshav theem nrab los ntawm kev mob siab).
Kev txawj yuam kev los ntawm lub hlwb atrophy nyob hauv cov tsiaj laus.
Mechanism ntawm Kev Ua:
Kev nce Cerebral ntshav txaus, txhim kho metabolism hauv thaj chaw yog penumbra penumbra, thiab txhawb kev ua haujlwm tshiab ntawm neurological rov qab.
Inhibit neuronal neuronal apoptosis thiab txo cov ntaub so ntswg hlwbcros.
Kev tswj hwm cov cholinergic system thiab txhim kho kev taw qhia kev txawj ntse xws li nco thiab mloog.
Cov kev tshawb fawb soj ntsuam:
Cov kev tswj hwm kev sib tw ntawm 20 leeg mob stroke tau qhia tias cov ntawv sau ua ke hauv cov haujlwm ntawm kev ua haujlwm txhua hnub (0/30 lub lis piam<0.01).
Tom qab kev ua haujlwm rau cov dev cov dev uas pom tau tias tom qab cov tshuaj sib txuas ntxiv tau nce los ntawm qhov nruab nrab ntawm 2.8 ntsiab lus tau pom cov nyom tshwm sim.
Daim Ntawv Thov Qhia:
Kev puas lub hlwb los ntawm cov pa roj carbon monoxide, organophosphaate tshuaj lom rau cov tshuaj, lom cov hlau hnyav, thiab lwm yam.
Central Kev Nyuaj Siab Kev nyuaj siab tshwm sim los ntawm kev haus yeeb tshuaj ntau dhau (xws li Sedatives, antiepileptic tshuaj).
Mechanism ntawm Kev Ua:
Tshem tawm cov radicals dawb thiab txo cov oxidative oxidative kev puas tsuaj.
Txhawb nqa kev kho ntawm lub hlwb ntawm lub hlwb daim duab phosprane phosprane phospholipids thiab kho cov neuronal muaj nuj nqi.
Kev tswj hwm neurottransmitter tshuav nyiaj li cas thiab daws cov kev mob tshwm sim xws li kev nco qab thiab qaug dab peg los ntawm kev lom.
Pab Txhawb Nqa:
Ib qho qee lub tsev kho tsiaj kho 8 tus dev nrog cov pa roj carbon monoxide. Cov pab pawg kho nrog phosphatidylacy sodium (0.2g / sijhawm, ob zaug ib hnub, sib xyaw ua ke nrog cov pa roj oxygen ib leeg, thiab tsis muaj kev ncua cov hlab ntsha tau tshwm sim.
Kev Tsim Kho Kom Haum Rau Cov Kab Mob Nurodegenerative
Daim Ntawv Thov Qhia:
Canine Caws kev txawj ntse kawg li (CCDs), Feline Alzheimer tus kab mob (FAD), thiab lwm yam.
Degenerive txha caj qaum kev mob hlwb thiab theem ob raug mob vim yog cuam tshuam nrog kev sib txuas lus disvertebral.
Mechanism ntawm Kev Ua:
Txhawb cov kev qhia ntawm cov leeg ntawm kev loj hlob ntawm cov leeg loj hlob (NGF), txhawb nqa synaptic remodeling thiab cov hlab refenteration.
Txhim kho theem acetylcholine hauv lub hlwb thiab ncua kev txawj xav.
Txhim khu negority neural thiab txhawb kev ua haujlwm kom rov zoo.
Kev Tshawb Fawb Kev Tshawb Fawb:
Kev Kho Mob Ua Ntej PhcDSidylchoy Sodium thiab Mecobalamin Kev Kho Mob Hauv CCS tau tshwm sim (CDS)
Tsiaj Kho Tshuaj thiab Kev Nyab Xeeb
Muab thiab Cov Qauv Txheej Txheem
Pom zoo siv:
Cov dev: 0.1-0.2g / Time, 2-3 zaug nyob rau ib hnub (kho kom zoo li tus dev, me me dev 0.1g / cov dev loj 0.2g / sijhawm).
Miv: 0.05-0.1g / Time, ob zaug ib hnub (0.05G / Time rau qhov hnyav<5kg, 0.1g/time for weight ≥ 5kg).
Droute ntawm kev tswj hwm:
Kev Tswj Xyuas Qhov Ncauj: Tsim nyog rau kev kho mob me me lossis kev kho mob ntev los yog kev noj haus ntev, yuav tsum tau noj tom qab noj mov kom txo cov plab zom mov.
Kev txhaj tshuaj: rau cov neeg mob tsis tshua muaj mob lossis cov neeg muaj kev cuam tshuam ceev ceev, diluted rau 250ml ntawm 5% kev txhaj tshuaj zoo nkauj).
Kev tawm tsam kev kho mob
Cov Kev Sib Koom Tes:
Cov plab zom mov: xeev siab (5% -10%), ntuav (3% -5%), feem ntau yuav tau txais kev pab los ntawm kev noj tom qab noj mov.
Lub siab xav: mob taub hau (2% -4%), insomnia (1% -2%), tuaj yeem cuam tshuam nrog nruab nrab ntawm cov hlab ntsha expitability expitability expitability expitability excitility.
Qhov kev pheej hmoo loj:
Ntshav siab hloov pauv: Tshuaj tswj hwm kev txhaj tshuaj yuav ua rau cov neeg hypient hypotension (nrog tus nqi ntawm 0.1%, uas yuav tsum tau saib xyuas.
Kev ua xua: pob khaus (0.5% -1%), khaus (0.3%), thiab tsis tshua muaj tshwm sim ntawm anaphylvactic poob siab.
Taboos thiab ceev faj
Tsis Tab Qab Tabe:
Cov tib neeg ua xua rauCiticoline Sodium ntsiav tshuaj 500mglossis excipients.
Cov tib neeg muaj keeb kwm ntawm kev tsis haum hnyav rau chloroesters.
Tus txheeb ze tab sis
Mob theem ntawm Cerebral hemorrhage (hauv 72 teev).
Kev tswj tsis tau ntawm Intracranial siab nce.
Cov neeg mob uas muaj arhythmia hnyav.
Chaw Tsim Tshuaj Cov Yam ntxwv: Dynamic faib ntawm Lub Cim Rau Lub Hlwb
Cov tswj hwm tau: Cov tshuaj sai tau nkag rau hauv cov hlab ntshav, thiab cov tshuaj hauv qab ntawm lub neej li ntawm 15 feeb, beta theem ib nrab-lub neej ntawm 3.5 teev).
Kev nkag rau cov ntshav-lub hlwb barrier: Hais txog 1% ntawm cov tshuaj muaj peev xwm nce hlwb (txog li 5-10 zaug ntxiv tuaj yeem pom tau tom qab 24 teev).
Cov kev ntsuas metabolic: feem ntau yog los ntawm daim siab dephospermation los tsim choligsylamine (TRItidine diphosphate, thaum Cytidine diphosphate ntxiv rau hauv uric acid thiab tawm hauv cov zis.
Cov yam ntxwv zoo: 70% -80% -80% ntawm cov tshuaj tau ua tiav nyob rau hauv daim ntawv ntawm cov metabolites los ntawm bile, thiab tsawg dua 1% ntawm cov tshuaj qub yog tawm.
Cov tib neeg laus: Cov neeg laus thiab raum ua haujlwm ua rau 30% nce rau hauv AUC, nrog ib nrab-lub neej txuas ntxiv rau 5 teev. Cov tshuaj yuav tsum tau hloov kho rau 0.1-0.2g / hnub.
Cov menyuam yaus: Thaj chaw thaj ntawm lub cev yog qhov me me thiab cov khoom xa tawm yog txo. Nws raug nquahu kom ua hwm 0.02-0.05g / kg / hnub.
Mob siab thiab raum tsis sib haum: Thaum cov AUC ntawm cov neeg mob hnyav nce qis dua 30ml / min, lub neej muaj kev sib tw tau txo 8 teev thiab xav tau txo los ntawm 50%.
Kev thov kev sib koom tes nrog lwm cov tshuaj
Kev kho kev kho mob ntawm cov tshuaj tua kab mob rau kev mob encephanathy
Cov ntaub ntawv: Tshuaj tua kab mob tshwm sim los ntawm kev kis tus mob meningococcal, kev sib xyaw ua ke (50mg / kg, ib hnub twg ib hnub) tuaj yeem kho cov leeg puas.
Mechanism: tshuaj tua kab mob ntshiab pathogens, thiab phosphatidylcholine sodium txo cov kev puas tsuaj theem nrab tshwm sim los ntawm kev mob o.
Siv hauv kev sib xyaw nrog cov neeg sawv cev neuroprotrive
Kev daws: Sodium phosphly (0.2g / Time, ob zaug ib hnub) + Mecobalamin (0.5mg / sijhawm, ib hnub txhua hnub).
Cov txiaj ntsig zoo: Mecobalamin txhawb nqa Myelin kho, thaum sodium phosphatidyidcholine txhim kho cov metabolism thiab symergistically txhim kho cov kev lom zem neurological.
Synergy nrog cov tshuaj antiepilepticic
Daim Ntawv Thov:
Tom qab cov xwm txheej epileptus ua rau lub hlwb raug mob, ua ke phosphatidylchoy sodium (2-4 xyoos
Kev txwv thiab yav tom ntej cov lus qhia ntawm kev tshawb fawb
Cov kev twb muaj lawm
Tsis muaj cov tsiaj muaj tshuaj tiv thaiv tsiaj:
Tam sim no, cov tshuaj specifications (0.1g / ntsiav tshuaj, 0.2g / ntsiav tshuaj
Cov ntaub ntawv kev nyab xeeb ntev ntev yog ploj lawm:
Cov kev tshawb fawb muaj feem ntau tau tsom rau kev ua tau zoo luv luv, thiab kev ntsuas ntxiv yog xav tau kev ntsuas ncua ntev ntawm daim siab thiab lub raum ua haujlwm, thiab lwm yam.
Chaw sib txawv ntawm chaw muag tshuaj:
Muaj cov kev sib txawv hauv kev ua yeeb yam metabolic enzyme thiab ntshav protein khi cov nqi ntawm cov tsiaj thiab cov tib neeg, thiab lub hom phiaj ua kom zoo ntawm cov dosing regimen yog xav tau.
Kev Tshawb Fawb Yav Tom Ntej
Lub hom phiaj xa khoom:
Kev kawm cov neeg nqa khoom xws li liposomes thiab nanoparticles kom nce cov tshuaj hauv cov tshuaj hauv cov tshuaj kho lub hlwb.
Kev loj hlob ntawm cov lus sib xyaw ua ke:
Tshawb cov kev ua ke ntawm kev npaj ua ke nrog Methylcobalamin, cov leeg ntawm kev loj hlob ntawm kev txhim kho kho kom zoo.
Qhia Qhia nthuav dav:
Campical sim cov kab mob nurodegenerative xws li cov kab mob Parkinson hauv cov dev thiab ntau yam sclerosis hauv miv.
Citicoline Sodium ntsiav tshuaj 500mgmuaj kev cia siab thov kev cia siab hauv cov tsiaj, tshwj xeeb tshaj yog nyob rau hauv kev kho mob ntawm kev raug mob hlwb, cov kab mob lom, thiab neurodegenerative cov kab mob, thiab neurodegenerative cov kab mob, thiab neurodegenerative cov kab mob, thiab neurodegenerative cov kab mob, thiab neurodegenerative cov kab mob, thiab neurodegenerative
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