Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm levamisole ntsiav tshuaj nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo levamisole ntsiav tshuaj muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Levamisole ntsiav tshuajyog ib qho tshuaj classic nrog cov teebmeem pharmacological dual, nrog nws cov ntsiab lus tseem ceeb yog Levamisole. Thaum xub thawj tsim los ua ib qho dav -spectrum deworming tshuaj, tom qab ntawd nws tau pom tias muaj cov haujlwm immunomodulatory thiab tau pom muaj txiaj ntsig tshwj xeeb hauv kev siv tshuaj kho mob. Nws yog ib tug derivative ntawm thiazole tebchaw thiab ib tug dav - spectrum anthelmintic tshuaj feem ntau yog siv los tsav roundworms thiab hookworms. Cov txiaj ntsig kho mob ntawm cov kab mob hauv plab hnyuv xws li kab mob sib kis, kab mob sib kis, thiab tus kab mob pinworms yog qhov tseem ceeb, tshwj xeeb tshaj yog nrog cov kab mob deworming ntau dua 90% rau roundworms. Nws cov txheej txheem ntawm kev ua haujlwm suav nrog kev xaiv inhibiting succinate dehydrogenase hauv cov leeg ntawm cov kab mob cab, thaiv lub zog metabolism hauv txoj hauv kev, ua rau tuag tes tuag taw thiab tuag ntawm cov cab, thaum cov teebmeem cholinergic txhawb cov cab cab. Piv nrog rau tetraimidazole (racemic daim ntawv), levamisole muaj zog dua kev ua si thiab muaj kev phiv tsawg dua, ua rau nws yog ib qho ntawm cov tshuaj nyiam rau kev kho deworming.
Cov ntaub ntawv ntxiv ntawm chemical compound:
| Khoom npe | Levamisole hmoov | Levamisole ntsiav tshuaj | Kev txhaj tshuaj Levamisole | Levamisole Hcl |
| Yam khoom | Hmoov | Tablet | Txhaj tshuaj | Hmoov |
| Khoom Purity | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% |
| Khoom Specifications | Customizable | Customizable | Customizable | Customizable |
| Pob khoom | Customizable | Customizable | Customizable | Customizable |
Peb Cov Khoom
Levamisole +. COA
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Certificate of Analysis |
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Compound npe |
Levamisole | |
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CAS Nr. |
14769-73-4 | |
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Qib |
Pharmaceutical qib | |
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Ntau |
Customized | |
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Ntim txheem |
Customized | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
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Ntau No. |
20250109001 |
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MFG |
Jan 12th 2025 |
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EXP |
Jan 8th 2029 |
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Qauv |
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| TEST STANDARD | GB/T24768-2009 Kev lag luam. Stnndard | |
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Yam khoom |
Enterprise txheem |
Kev txheeb xyuas qhov tshwm sim |
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Qhov tshwm sim |
Dawb los yog yuav luag dawb hmoov |
Ua raws |
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Cov ntsiab lus dej |
Tsawg dua lossis sib npaug li 4.5% |
0.30% |
| Poob rau ziab |
Tsawg dua lossis sib npaug li 1.0% |
0.15% |
|
Hnyav Hlau |
Pb Tsawg dua lossis sib npaug li 0.5ppm |
N.D. |
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Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Hg Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Cd Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
|
Purity (HPLC) |
Ntau dua lossis sib npaug li 99.0% |
99.5% |
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Ib leeg impurity |
<0.8% |
0.48% |
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Residue ntawm ignition |
<0.20% |
0.064% |
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Tag nrho microbial suav |
Tsawg dua lossis sib npaug li 750cfu / g |
80 |
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E. Coli |
Tsawg dua lossis sib npaug li 2MPN / g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (los ntawm GC) |
Tsawg dua lossis sib npaug li 5000ppm |
400ppm ua |
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Cia |
Khaws rau hauv qhov chaw kaw, tsaus thiab qhuav ntawm -20 degrees |
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Levamisole ntsiav tshuaj, raws li cov tshuaj classic uas sib xyaw ua ke deworming thiab kev tiv thaiv kab mob kev ua haujlwm, tau ua lub luag haujlwm tseem ceeb hauv cov tshuaj kho mob txij thaum lawv pib. Nws cov ntsiab lus tseem ceeb yog levamisole hydrochloride. Raws li sab laug-muab daim ntawv ntawm tetraimidazole, nws cov haujlwm yog kwv yees li 1-2 npaug ntawm daim ntawv racemic, tab sis nws cov kev phiv tshuaj lom tau txo qis.
Nws muaj zog tua cov nyhuv ntawm ntau yam nematodes, thiab nws cov txheej txheem ntawm kev ua haujlwm yog xaiv inhibit succinate dehydrogenase hauv cov leeg nqaij, thaiv cov txheej txheem ntawm txo fumarate rau succinic acid, ua rau muaj kev cuam tshuam ntawm anaerobic metabolism hauv kab mob, cuam tshuam ntawm lub zog mov, thiab thaum kawg excretion nrog cov quav vim cov leeg. Cov txheej txheem no ua rau nws nyiam tshuaj rau kev kho cov kab mob cab hauv qab no:
1. Kab mob plab hnyuv nematode
Tus kab mob Ascaris: Qhov txiaj ntsig zoo ntawm ib koob tshuaj ntawm qhov ncauj ntau tshaj 90%, nrog rau cov neeg laus koob ntawm 1.5-2.5mg / kg thiab ib koob tshuaj me nyuam ntawm 2-3mg / kg, noj ntawm lub plab khoob lossis ua ntej yuav mus pw.
Kab mob Hookworm: Nws yuav tsum tau noj tsis tu ncua rau 3 hnub, nrog rau kev noj tib yam li tus kab mob roundworm. Qhov ua tau zoo ntawm kev tshem tawm American hookworms tuaj yeem txhim kho ntxiv los ntawm kev sib txuas nrog thiacloprid.
Kab mob Pinworm thiab kab mob fecal roundworm: Kev kho ib koob tshuaj tuaj yeem txo qhov zoo ntawm cov qe qe, thiab cov txiaj ntsig tshwj xeeb yog qhov tshwj xeeb tshaj yog thaum kho ua ke.
2. Filariasis
Kev ua haujlwm ntawm Ban's filarial worm, Malay filarial worm cov neeg laus, thiab microfilaments yog qhov zoo tshaj rau cov tshuaj ib txwm siv xws li ethambutol, tab sis ntev - kev ua tau zoo tsis zoo. Cov koob tshuaj pom zoo yog 4-6mg / kg, noj hauv 2-3 koob tshuaj rau 3 hnub sib law liag.
Kev kho mob txuas ntxiv nrog amiodarone citrate tuaj yeem txhim kho kev ua tau zoo thiab txo qhov kev pheej hmoo ntawm kev tiv thaiv tshuaj.
3. Cov kab mob parasitic tshwj xeeb
Onchocerciasis: Nws muaj cov nyhuv tua ncaj qha ntawm microfilaments, tab sis nws yuav tsum tau muab sau tseg tias nws yuav ua rau muaj kev tsis haum tshuaj loj.
Taenia solium: Ua ke nrog thiabendazole, nws tuaj yeem kho cov kab mob sib xyaw ntawm cov hnyuv nematodes thiab nthuav cov kab mob tua kab mob.
Cov ntaub ntawv kho mob: Hauv thaj chaw African filariasis endemic, kev kho mob ua ke ntawm levamisole thiab ethambutol txo qhov zoo ntawm microfilaments los ntawm 62% mus rau 8%, thiab tus nqi rov qab qis dua li ntawm pawg kws kho mob monotherapy.
Cov nyhuv immunomodulatory ntawm levamisole yog bidirectional: nws txhim kho cov lus teb thaum lub cev tsis muaj zog thiab inhibits overreaction hauv cov kab mob autoimmune. Cov txheej txheem cuam tshuam nrog T cell ua kom, txhim kho macrophage phagocytic muaj nuj nqi, thiab kev tswj hwm ntawm cytokine secretion.
1. Cov kab mob autoimmune
Rheumatoid mob caj dab: Raws li cov tshuaj tiv thaiv rheumatic qeeb, nws tuaj yeem txo qhov tsim cov autoantibodies thiab txo cov tsos mob sib koom ua ke. Thawj koob tshuaj yog 50mg / hnub, maj mam nce mus rau 150mg / hnub, thiab yuav tsum tau saib xyuas cov ntshav kom zoo los tiv thaiv granulocyte deficiency.
Systemic lupus erythematosus: Los ntawm inhibiting kev ua kom ntau dhau ntawm B hlwb, txo cov qib ntawm cov tshuaj tiv thaiv dsDNA, thiab txhim kho daim tawv nqaij thiab cov tsos mob sib koom.
2. Lub xeev ntawm lub cev tsis muaj zog
Mob kab mob siab B: Kev sib xyaw nrog interferon tuaj yeem ua rau cov ntshav hloov pauv ntawm HBeAg, thiab nws cov txheej txheem cuam tshuam txog kev txhim kho Th1 cell teb.
AIDS opportunistic kab mob: los ntawm stimulating proliferation ntawm cov pob txha pob txha hematopoietic stem cells, nce CD4+T cell suav, thiab txo qhov tshwm sim ntawm Kaposi's sarcoma.
Tom qab hloov khoom nruab nrog cev: Kev sib xyaw nrog qis - koob tshuaj glucocorticoids tuaj yeem txo qhov koob tshuaj tiv thaiv kab mob thiab txo qis kev pheej hmoo kis mob.
3. Tus kab mob tseem ceeb tiv thaiv kab mob
Rau cov neeg mob uas muaj kab mob sib txawv ntawm cov kab mob sib txawv (CVID), levamisole tuaj yeem nce qib IgG thiab txo qhov zaus ntawm cov kab mob ua pa.
Cov ntaub ntawv tshawb fawb: Ib qho kev sim tshuaj ntsuam xyuas randomized tsom rau kev mob rheumatoid mob caj dab tau pom tias 2-xyoo kev nce qib ntawm kev sib koom ua ke hauv pawg kho mob levamisole yog 43% qis dua li hauv pawg placebo, tab sis yuav tsum ceev faj tiv thaiv granulocyte deficiency (qhov tshwm sim ntawm kwv yees li 2.8%).
Lub luag haujlwm ntawm levamisole hauv kev kho mob qog nqaij hlav yog maj mam hloov los ntawm kev kho adjuvant mus rau ntau yam - lub hom phiaj kev kho mob, nrog rau cov txheej txheem suav nrog kev tiv thaiv kab mob, tiv thaiv angiogenesis, thiab kev tswj hwm epigenetic.
1. Adjuvant therapy rau cov qog nqaij hlav
Mob qog noj ntshav: Kev kho mob tom qab kev sib xyaw ua ke tuaj yeem ua kom ntev li nruab nrab txoj sia nyob (MST) los ntawm 3.2 lub hlis thiab nce 5-xyoo kev ciaj sia los ntawm 12%.
Mob qog noj ntshav mis: ua ke nrog cyclophosphamide thiab methotrexate (CMF scheme) tuaj yeem txo qhov kev pheej hmoo rov qab los ntawm 19%.
Mob qog nqaij hlav hauv plab: Txhim kho qhov kev mob tshwm sim ntawm theem III cov neeg mob los ntawm kev txhim kho qhov ntom ntom ntawm cov qog infiltrating lymphocytes (TILs).
2. Hematological malignancies
Cov kab mob lymphocytic leukemia ntev: Cov koob tshuaj tsawg levamisole (25-50mg / hnub) tuaj yeem ncua kev kis tus kab mob, thiab nws cov txheej txheem cuam tshuam nrog inhibition ntawm Bcl-2 protein qhia.
Ntau myeloma: Kev siv ua ke nrog thalidomide tuaj yeem txhim kho dendritic cell antigen kev nthuav qhia muaj nuj nqi thiab txhim kho tus nqi tso tawm kom tiav.
Direct anti- qog nyhuv
Kev sim hauv vitro tau pom tias levamisole tuaj yeem ua rau apoptosis hauv leukemia HL-60 hlwb, thiab nws cov txheej txheem cuam tshuam nrog caspase-3 ua kom muaj zog thiab mitochondrial membrane tuaj yeem tawg.
Cov txheej txheem kho mob: NCCN cov lus qhia pom zoo rau levamisole raws li kev xaiv kev kho mob rau kev kho mob tom qab kev kho mob ntawm theem III mob qog noj ntshav, tshwj xeeb tshaj yog rau cov neeg mob uas tsis tuaj yeem zam oxaliplatin.
Daim ntawv thov ntawm levamisole nyob rau hauv dermatology yog raws li nws ob yam teebmeem ntawm kev tiv thaiv kab mob thiab tshuaj tua kab mob, ua rau nws muaj kev kho mob rau ntau yam kab mob ntawm daim tawv nqaij refractory.
1. Kab mob ntawm daim tawv nqaij
Flat warts: Hauv zos daim ntawv thov ntawm levamisole ointment ua ke nrog vitamin A yogurt cream muaj kev kho tus nqi ntawm 78% nyob rau hauv 4 lub lis piam, thiab nws cov txheej txheem muaj feem xyuam rau kev txhim kho lub zos cellular tiv thaiv ntawm daim tawv nqaij.
Condyloma acuminatum: ua ke nrog interferon -2b gel tuaj yeem txo tus nqi rov qab, tshwj xeeb tshaj yog rau cov kab mob hauv tsev menyuam.
2. Cov kab mob autoimmune ntawm daim tawv nqaij
Mob urticaria: Hauv cov neeg mob uas muaj cov tshuaj tiv thaiv histamine, levamisole (50mg / hnub) tuaj yeem txo qhov zaus ntawm kev tawm tsam wheal, thiab nws cov txiaj ntsig cuam tshuam rau kev tswj hwm Th1 / Th2 tshuav nyiaj li cas.
Bullous pemphigoid: Tsawg koob tshuaj levamisole (25mg / txhua hnub) tuaj yeem txo qhov koob tshuaj ntawm glucocorticoids thiab txo qhov kev pheej hmoo ntawm pob txha.
3. Kab mob ntawm daim tawv nqaij
Cov kab mob ntawm daim tawv nqaij ntev: Levamisole tuaj yeem ua kom lub qhov txhab zoo los ntawm kev txhawb nqa fibroblast proliferation thiab angiogenesis, tshwj xeeb tshaj yog rau cov mob ntshav qab zib ko taw.
Kev tshawb fawb pov thawj: Ib qho kev sim qhib rau ntawm qhov chaw mos herpes rov tshwm sim tau pom tias pab pawg kho mob levamisole muaj 61% qis dua tus nqi ntawm 6 lub hlis piv rau pawg tswj hwm, thiab tsis ua rau muaj kev pheej hmoo ntawm kev tsim tshuaj - tiv thaiv kab mob.
Kev tiv thaiv kev tiv thaiv kab mob ntawm levamisole ua rau nws muaj txiaj ntsig tshwj xeeb hauv kev tiv thaiv kab mob, tshwj xeeb tshaj yog rau cov neeg tiv thaiv kab mob.
1. Tshuaj tiv thaiv adjuvant nyhuv
Tshuaj tiv thaiv kab mob khaub thuas: Ua ke nrog aluminium adjuvant,levamisole ntsiav tshuajtuaj yeem ua kom cov ntshav tiv thaiv cov neeg laus mus rau 82%, thiab nws cov txheej txheem muaj feem xyuam rau kev txhim kho dendritic cell antigen kev nthuav qhia muaj nuj nqi.
Tshuaj tiv thaiv kab mob siab B: Rau cov neeg tsis teb, kev kho mob ua ntej nrog levamisole tuaj yeem ua rau cov tshuaj tiv thaiv zoo hloov pauv ntawm 31% mus rau 67%.
2. Kev tswj cov tshuaj - tiv thaiv kab mob
Methicillin resistant Staphylococcus aureus (MRSA): Levamisole restores rhiab heev rau - lactam tshuaj tua kab mob los ntawm downregulating cov kev qhia ntawm penicillin binding protein 2a (PBP2a).
Multidrug resistant Mycobacterium tuberculosis: Kev sim hauv vitro tau pom tias levamisole tuaj yeem txhim kho cov kab mob bactericidal ntawm rifampicin, thiab nws cov txheej txheem cuam tshuam txog kev puas tsuaj ntawm cov kab mob biofilms.
Kev xyaum kho mob: Hauv kev txhaj tshuaj tiv thaiv kab mob qhua pias rau cov menyuam yaus African, levamisole adjuvant nce cov ntshav hloov pauv los ntawm 29% yam tsis muaj qhov tshwm sim tsis zoo.
Cov teebmeem lom ntawm levamisole txuas mus rau ntau qhov chaw kho mob, thiab nws cov peev txheej tseem tab tom tshawb nrhiav.
1. Kev txhawb nqa menyuam txoj kev loj hlob thiab kev loj hlob
Rau cov menyuam yaus nrog idiopathic luv stature, kev sib xyaw ntawm levamisole (0.5mg / kg / hnub) thiab kev kho cov tshuaj hormones loj hlob tuaj yeem nce qhov kev loj hlob txhua xyoo (8.2cm vs 6.5cm), thiab nws cov txheej txheem cuam tshuam txog kev txhawb nqa ntawm IGF-1 qhia.
2. Kev tshawb fawb los tiv thaiv kev laus
Cov kev sim tsiaj tau pom tias levamisole tuaj yeem txuas ntxiv lub neej ntawm cov txiv hmab txiv ntoo yoov los ntawm 18%, thiab nws cov txheej txheem cuam tshuam nrog kev ua kom lub neej ntev ntawm SIRT1, tab sis tib neeg kev tshawb fawb tseem tsis muaj.
3. Cov tshuaj tua kab mob
Rau cov neeg mob infertile nrog rov implantation tsis ua hauj lwm, levamisole txhim kho embryo implantation tus nqi (los ntawm 28% mus rau 41%) los ntawm kev tswj cov Th1 / Th2 tshuav nyiaj li cas hauv endometrium.
Raws li "ntau yam" hauv keeb kwm ntawm cov tshuaj, tus nqi ntawmlevamisole ntsiav tshuajtsis yog tsuas yog xav txog hauv kev siv tshuaj kho mob tam sim no, tab sis kuj tseem muaj peev xwm txuas ntxiv txhawb kev kho mob tshiab. Nyob rau hauv lub neej yav tom ntej, nrog rau kev txhim kho ntawm tus kheej txoj kev kho thiab kev txhais cov tshuaj, levamisole yuav tsum ua kom pom cov kev kho mob tshwj xeeb hauv cov kab mob ntau dua thiab ua rau muaj zog ntau dua rau tib neeg kev noj qab haus huv.
Cov lus nug nquag
Leej twg yog tus muaj peev xwm "stability killer" nyob rau hauv nws cov ntsiav tshuaj excipients?
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Lactose. Lactose, uas feem ntau siv rau hauv cov ntsiav tshuaj levamisole, tuaj yeem ua rau Maillard cov tshuaj tiv thaiv nrog cov tshuaj tseem ceeb thaum lub sijhawm khaws cia, ua rau cov ntsiav tshuaj tsis zoo thiab tsim cov kab ntau ntawm cov impurities. Qhov no piav qhia vim li cas qhov kev ruaj ntseg ntawm qee qhov kev npaj ua ke (tshwj xeeb tshaj yog thaum ua ke nrog macrolides) txo qis - lwm yam API concentrations uas ntau dua 10 npaug tuaj yeem cuam tshuam rau kev ruaj ntseg ntawm kev npaj, ua rau tsis paub impurities tshaj tus qauv.
Vim li cas cov kua hauv qhov ncauj tau npaj "ruaj khov hauv cov tshuaj qub tab sis ua rau cov ntsiav tshuaj tawg"?
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90 day stability: Original drug powder>96%, ntsiav tshuaj kua tsuas yog 64% tshuav.
The key experiment showed that the levamisole solution (25 mg/mL) prepared with pure powder still retained>96% tom qab khaws cia ntawm 25 ° C rau 90 hnub, tab sis tsuas yog 63.56% ntawm tib cov tshuaj concentration npaj nrog cov ntsiav tshuaj tseem nyob. Txias mechanism: Cov extract ntawm ntsiav tshuaj excipients hloov pH (los ntawm 5.3 mus rau 6.87), thaum lub degradation ntawm levamisole accelerates ntawm pH 5-7, nrog ib tug degradation tus nqi 70 lub sij hawm sai dua ntawm pH 8 tshaj pH 2.
Vim li cas cov tshuaj pharmacopoeia yuav tsum tau saib xyuas qhov 'invisible impurity ncov'?
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Vim tias cov txheeb ze tuav lub sijhawm ntawm cov khoom raug yuam kom degradation yog li ntawm 1.3, thiab qhov kev xav tau ntawm kev sib cais yog ntau dua lossis sib npaug rau 6.0.
Lub International Pharmacopoeia tau hais tias tom qab yuam kev degradation nyob rau hauv alkaline tej yam kev mob (0.1 mol / L NaOH) ntawm 100℃C rau 5 teev, lub ntsiab ncov thiab lub ntsiab degradation ncov yuav tsum tau muab sib cais tag nrho (kev sib cais℃siab tshaj los yog sib npaug rau 6.0). Qhov no 'invisible' ncov yog tus yuam sij rau kev txheeb xyuas seb txoj kev tshuaj ntsuam xyuas puas tuaj yeem ntes cov impurities.
Nws qhov ncauj bioavailability siab npaum li cas?
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Txog li 92.3%, yuav luag tau txais kev txhaj tshuaj.
Cov ntaub ntawv pharmacokinetic tshiab qhia tau hais tias qhov tseeb bioavailability (F) ntawm qhov ncauj kev tswj hwm ntawm levamisole yog 92.3%, uas yuav luag tsis paub qhov txawv ntawm kev txhaj tshuaj intramuscular. Tab sis qhov nqus nqus tau txawv txav: lub sijhawm siab tshaj plaws rau kev tswj hwm qhov ncauj (Tmax) yog 2.63 teev, thaum txhaj tshuaj intramuscular tsuas yog siv sijhawm 1.41 teev.
Vim li cas cov milligrams ntawm cov ntsiav tshuaj daim ntawv lo tsis sib haum?
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50 mg levamisole ≈ 58 mg hydrochloride.
Lub International Pharmacopoeia tau txiav txim siab tias cov ntawv yuav tsum qhia cov ntsiab lus hauv paus ntawm levamisole, tab sis cov khoom xyaw tiag tiag yog nws cov ntsev hydrochloride. Cov mis hloov pauv yog: 1 mg ntawm levamisole hydrochloride =0.848 mg ntawm levamisole. Qhov no ua rau muaj ntau tshaj 18% thaum pub mis rau cov qauv kom paub meej tias lub hauv paus daim ntawv lo ua tau raws li tus qauv.
Cim npe nrov: levamisole ntsiav tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom