Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm compound febantel ntsiav tshuaj nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo febantel ntsiav tshuaj muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Compound febantel ntsiav tshuajyog ib qho dav -spectrum, muaj txiaj ntsig zoo tshuaj anthelmintic formulation. Nws cov khoom xyaw tseem ceeb, febantel (Non Bantyre), yog benzimidazole prodrug uas metabolizes hauv vivo rau hauv cov tshuaj lom neeg lom neeg fenbendazole (fenbendazole sulfoxide) thiab ofendazole. irreversibly inhibiting -tubulin polymerization hauv cov kab mob cab. Qhov no cuam tshuam lawv lub zog metabolism thiab cov qauv ntawm tes, thaum kawg ua rau cov kab mob tuag taus. Qhov kev sib xyaw ua ke no feem ntau yog co-formulated nrog praziquantel, ib qho tshuaj tua kab mob nrog cov txheej txheem sib txawv ntawm kev ua.
Praziquantel induces calcium ion permeability nyob rau hauv parasite cell membranes, ua rau tonic -clonic contractions nyob rau hauv parasite nqaij thiab epidermal puas, yog li ua rau lawv yooj yim rau tuav lub cev tiv thaiv kab mob. Qhov kev tsim kho dual -txheej txheem no ua tiav ntau- lub hom phiaj tshem tawm cov kab mob hauv lub cev, ua kom pom qhov tshwj xeeb ua ke ua haujlwm tawm tsam plab hnyuv nematodes (piv txwv li, roundworms, hookworms, whipworms) muaj nyob rau hauv dev thiab miv, tapeworms, thiab qee yam flukes. Txoj hauv kev no tsis tsuas yog nthuav dav cov kab mob parasitic tswj thiab txhim kho kev ua tau zoo tab sis kuj pab ncua kev txhim kho cov kab mob parasite. Yog li ntawd, nws yog ib qho tseem ceeb ntawm cov tshuaj kho tsiaj rau kev tiv thaiv thiab kho cov kab mob sib xyaw ua ke.
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Febantel COA
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| Certificate of Analysis | ||
| Compound npe | Febantel | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 58306-30-2 | |
| Ntau | Customized | |
| Ntim txheem | Customized | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090026 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.0054 |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.0042 |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.98% |
| Ib leeg impurity | <0.8% | 0.52% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 95 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree | |
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| Tshuaj Formula | C20H22N4O6S |
| Exact Mass | 446.13 |
| Molecular Luj | 446.48 |
| m/z | 446.13 (100.0%), 447.13 (21.6%), 448.12 (4.5%), 448.13 (2.2%), 447.12 (1.5%), 448.13 (1.2%) |
| Elemental Analysis | C, 53.80; H, 4.97; N, 12.55; O, 21.50; S, 7.18 |
Tshuaj Txheej txheem cej luam: Scientific Design of Compound Formulations
Compound febantel ntsiav tshuaj(ib tug dav -spectrum deworming tshuaj feem ntau siv nyob rau hauv veterinary clinical xyaum) yog tsim los ntawm lub ntsiab lub tswv yim ntawm kev ua tau zoo dual kev pab them nqi ntawm canine roundworms thiab tapeworms los ntawm kev sib koom ua ke ntawm peb cov khoom xyaw nquag. Qhov kev sib xyaw ua ke no tsis yog tsuas yog nthuav tawm cov kab mob deworming xwb tab sis kuj tseem txhim kho kev kho mob thiab txo qhov kev pheej hmoo ntawm cov tshuaj tiv thaiv los ntawm kev tsom mus rau ntau yam ntawm cov kab mob muaj sia nyob.
Synergistic Mechanism ntawm Compound Cheebtsam
Cov khoom muaj xws li Non Bantyre, Praziquantel, thiab Pyrantel Pamoate. Peb lub ntsiab lus siv lawv cov teebmeem los ntawm kev sib txawv mechanisms ua ke:
Tsis yog -bantel metabolic activation
Tsis yog -bantel belongs rau qib ua ntej -benzimidazole cov tshuaj. Tom qab kev tswj hwm qhov ncauj, nws tau nrawm nrawm los ntawm txoj hnyuv thiab hloov mus rau hauv fenbendazole thiab oxfendazole los ntawm kev ua haujlwm ntawm daim siab thiab plab hnyuv microorganisms. Ob lub metabolites no inhibit lub polymerization ntawm parasite microtubules, thaiv cov piam thaj uptake thiab lub zog metabolism, thaum kawg ua rau cov cab tuag. Piv txwv li, fenbendazole muaj kev tua tus nqi ntau dua 98% tawm tsam cov neeg laus whipworms, thiab nws kuj muaj qhov cuam tshuam tseem ceeb ntawm cov qe theem.
Kev puas tsuaj saum npoo ntawm praziquantel
Praziquantel yog ib qho pyrazine isoquinoline derivative. Nws yuav luag tag nrho absorbed tom qab noj qhov ncauj, thiab nws cov ntshav concentration siab tshaj li 2.5 teev. Nws ua rau cov calcium ion channels ntawm cov kab mob parasite, ua rau cov leeg nqaij tetanic contractions thiab tshem tawm sai ntawm focal vacuoles, ua rau cov kab mob tuag tes tuag taw thiab tuag tes tuag taw.
Neuroparalysis ntawm thiacetidine
Thiacetidine ua haujlwm ncaj qha rau hauv txoj hnyuv thiab ua rau cov neeg tuag tes tuag taw hauv cov nematodes los ntawm kev ua raws li kev khi ntawm acetylcholine rau nematode's choline receptor, ua rau lawv tshem tawm cov quav. Vim nws qhov nqus tau tsawg heev hauv cov hnyuv thiab cov ntshav qis heev, nws yuav luag tsis cuam tshuam rau tus tswv tsev (dub) lub paj hlwb, thiab muaj kev nyab xeeb heev.
Qhov zoo ntawm Compound Formula
Expanded spectrum ntawm deworming
Tib - cov tshuaj deworming feem ntau tsuas yog siv tau rau cov kab mob tshwj xeeb xwb, thaum cov tshuaj uas tsis yog -bantel ntsiav tshuaj, los ntawm kev sib xyaw ntawm peb yam, suav nrog cov kab mob nematodes (xws li cov kab mob roundworms, hookworms, thiab whipworms) thiab tapeworms (xws li Echinococcus tapeworms thiab Dipylidium tapeworms). Piv txwv li, tsis yog -bantel muaj kev tua tus nqi ntau dua 90% tawm tsam nematodes, praziquantel muaj qhov tshem tawm ntau dua 95% tawm tsam kab kab kab, thiab thiacetidine muaj cov txiaj ntsig tseem ceeb rau cov kab mob sib kis thiab kab mob sib kis.
Txo kev pheej hmoo ntawm kev siv tshuaj tiv thaiv
Cov kab mob muaj kab mob ua rau muaj kev tiv thaiv rau ib leeg - cov tshuaj deworming tshuaj. Cov mis nyuj sib xyaw tawm tsam ntau lub hom phiaj, txo qhov muaj peev xwm ntawm cov kab mob evading yeeb tshuaj los ntawm kev hloov caj ces. Piv txwv li, cov khoom lag luam metabolic uas tsis yog -bantel, fenbendazole thiab oxfendazole, muaj cov txheej txheem sib txawv ntawm kev ua los ntawm thiacetidine, thiab tuaj yeem cuam tshuam lub zog metabolism thiab paj hlwb ntawm cov kab mob parasites, yog li txo qhov tshwm sim ntawm cov tshuaj tiv thaiv.
Txhim kho kev kho mob
Cov tshuaj sib xyaw ua ke tuaj yeem ua tiav "ib zaug- kev tswj hwm lub sijhawm, ntau yam kev tiv thaiv", zam qhov nyuaj ntawm ntau qhov kev tswj hwm lossis kev sib xyaw ua ke uas yuav tsum tau ua los ntawm ib qho - cov tshuaj sib xyaw. Piv txwv li, hauv kev kho tus kab mob canine reoccurant tapeworm, cov tshuaj uas tsis yog -bantel ntsiav tshuaj tuaj yeem tshem tawm cov neeg laus thiab cov kab mob larval nyob rau hauv ib qho kev tswj hwm ib leeg, thaum ib leeg - cov khoom fenbendazole yuav tsum tau rov ua haujlwm kom ua tiav cov txiaj ntsig zoo ib yam.
Daim ntawv thov kev kho mob thiab kev nyab xeeb
CovFebantel ntsiav tshuajtau raug txheeb xyuas los ntawm ntau qhov kev tshawb fawb soj ntsuam rau nws cov txiaj ntsig thiab kev nyab xeeb. Hais txog kev nyab xeeb, qhov tshwm sim ntawm cov kev mob tshwm sim rau Cov Tshuaj Fenbendazole yog qhov tsawg. Cov tshuaj tiv thaiv muaj xws li ntuav me me, raws plab lossis txo qis qab los noj mov, uas feem ntau daws lawv tus kheej hauv 24 teev tom qab tswj hwm. Txawm li cas los xij, nws yog ib qho tseem ceeb kom tsis txhob siv ua ke nrog piperazine los yog cholinergic tshuaj los tiv thaiv kev sib cuam tshuam ntawm cov tshuaj uas yuav ua rau txo qis kev ua tau zoo los yog muaj zog toxicity.
Cov Ntsiab Cai Tseem Ceeb ntawm Tshuaj: Precise Dosage and Single Administration
Compound Fentanyl ntsiav tshuajua raws li lub hauv paus ntsiab lus ntawm qhov hnyav-raws li kev noj tshuaj, nrog rau tus qauv koob tshuaj ntawm 1 ntsiav tshuaj ib 10kg ntawm lub cev qhov hnyav (txhua ntsiav tshuaj muaj 150mg fentanyl, 50mg phenytoin, thiab 144mg dihydroxy-naphthoquinone thiazide).
Piv txwv li, tus dev 20kg yuav tsum tau 2 ntsiav tshuaj, thaum tus menyuam dev 5kg tsuas yog xav tau ib nrab ib ntsiav tshuaj xwb.
Cov qauv no ua kom muaj kev sib koom ua ke thoob plaws lub neej kab mob parasite: Fentazol metabolites (fenbendazole, ofendazole) cuam tshuam nematode zog metabolism; praziquantel tua kab mob sai sai los ntawm kev cuam tshuam cov calcium raws hauv lawv cov cuticle; thiab thiabendazole ncaj qha tuag tes tuag taw nematode neuromuscular systems.
Qhov kev sib xyaw ua ke triple no ua tiav ib zaug - koob tshuaj tshem tawm ntawm ob tus neeg laus thiab cov kab mob tsis paub tab, tshem tawm qhov xav tau kev kho dua.
Txoj kev tswj hwm: Siv tau yooj yim tuav thiab saib xyuas kev nyab xeeb
Kev tswj qhov ncauj qhov ncauj
Direct Feeding: Muab cov ntsiav tshuaj tso rau ntawm tus dev tus nplaig, maj mam kaw lub qhov ncauj, thiab ua rau lub caj pas ua rau nqos. Haum rau kev sib koom tes dev.
Khoom noj khoom haus-Masked Administration: Muab cov ntsiav tshuaj nrog me me ntawm cov zaub mov ntub lossis cheese los npog qhov saj. Tsis txhob noj cov zaub mov muaj roj ntau - kom tiv thaiv kom tsis txhob muaj kev nqus ntawm fenbendazole.
Kev Tswj Xyuas Kev Ruaj Ntseg: Rau cov dev refractory, siv cov tshuaj pub tsiaj los thawb cov ntsiav tshuaj tob rau hauv txoj hlab pas. Saib xyuas qhov ntuav tom qab-kev tswj hwm.
Ncej -Kev saib xyuas kev tswj hwm
Saib rau ntuav lossis regurgitation hauv 30 feeb. Yog tias cov ntsiav tshuaj raug tshem tawm, muab tshuaj hloov pauv.
Sau cov qauv defecation. Cov cim qhia muaj xws li tshem tawm cov kab mob tuag los yog cov qe tawg hauv 24-48 teev tom qab kev tswj hwm.
Teem caij kho mob: Kho kom zoo nkauj raws li Parasite Life Cycles
Kev kho mob niaj hnub
Ib koob tshuaj:Haum rau cov kab mob nematode (piv txwv li, roundworms, hookworms, whipworms) thiab kab mob neeg laus kab mob. Cov khoom xyaw nquag ib txhij tshem tawm cov kab mob ntawm txhua theem kev loj hlob hauv txoj hnyuv.
Rov ua dua:Rau cov kab mob tapeworm cysticerci los yog hookworm latent kab mob, rov muab tshuaj yog pom zoo 3-4 lub lis piam tom qab pib kho. Piv txwv li, lub voj voog ntawm Echinococcus multilocularis proglottids yog 21-28 hnub; rov txhaj tshuaj npog cov kab mob tshiab tshiab.
Kev Siv Tshwj Xeeb
Cov dev cev xeeb tub:Tej zaum yuav raug muab tshuaj thaum nruab nrab - mus rau - cev xeeb tub lig (tom qab 4 lub lis piam) nyob rau hauv kev saib xyuas ntawm kws kho tsiaj, tab sis cov koob tshuaj yuav tsum tau hloov nruj me ntsis los ntawm qhov hnyav kom tsis txhob noj ntau dhau thiab kev pheej hmoo nchuav menyuam.
Cov menyuam dev:Haum rau cov menyuam dev Loj dua lossis sib npaug li 3 lub lis piam thiab hnyav dua lossis sib npaug li 0.9kg, tab sis yuav tsum tau muab faib ua (piv txwv li, crushing ntsiav tshuaj thiab sib tov proportionally nrog zaub mov).
Clinical Application Cases: Translation theory to Practice
Kev kho mob sib xyaw
Ib tug 30kg German Shepherd co- kis Toxocara canis thiab Dipylidium caninum tau txais 3 ntsiav tshuaj raws li lub cev hnyav. Cov neeg laus tuag cov kab mob kab mob thiab kab kab kab mob tau kuaj pom hauv cov quav rau hnub 3. Ua raws li-Kev kuaj quav rau hnub 7 yog qhov tsis zoo, tsis muaj qhov tsis zoo thaum kho.
Kev Tswj Tshuaj Tiv Thaiv
Lub kennel muaj kev nce qib hookworm tsis kam vim kev siv ntev ntawm ib qho - cov khoom siv dewormers hloov mus raufebantel t
khoom. Hookworm clearance tus nqi nce los ntawm 68% mus rau 95%, uas tsis muaj rov tshwm sim hauv rau lub hlis.
Pharmacokinetics
Compound febantel ntsiav tshuajtau sai sai absorbed tom qab kev tswj qhov ncauj nrog siab bioavailability. Nws tus nqi nqus yog me ntsis cuam tshuam los ntawm lub plab zom mov ib puag ncig, thiab kev noj zaub mov tuaj yeem nce qhov nqus tau zoo. Tom qab kev tswj hwm qhov ncauj ntawm febantel, cov khoom tseem ceeb ntawm cov khoom no, lub sijhawm siab tshaj plaws ntawm cov ntshav plasma hauv cov dev yog kwv yees li 1.63 teev, nrog rau kev tshem tawm ib nrab - lub neej txog li 2.97 teev, qhia cov yam ntxwv ntawm kev nqus sai thiab kev tshem tawm nruab nrab.
Thaum nqus tau, cov tshuaj tau muab faib rau hauv cov ntaub so ntswg, tshwj xeeb tshaj yog nyob rau hauv lub plab hnyuv siab raum, daim siab thiab ob lub raum, thiab tuaj yeem nkag mus rau hauv cov hnyuv mucosa kom muaj kev cuam tshuam anthelmintic.
Cov khoom no tsuas yog metabolized hauv daim siab hauv vivo. Tsis yog Bantyre tuaj yeem ua ntxiv rau hauv cov metabolites nquag xws li oxfendazole los txhim kho kev ua haujlwm ntawm anthelmintic, thiab cov txheej txheem metabolic cuam tshuam nrog ntau yam tshuaj hepatic -metabolizing enzymes.
Cov metabolites feem ntau yog tawm los ntawm ob lub raum hauv cov zis, nrog me me tawm mus rau hauv cov hnyuv los ntawm cov kua tsib thiab tshem tawm hauv cov quav, uas qhia tsis pom tseeb hauv vivo tsub zuj zuj. Tus nqi excretion yog txo me ntsis hauv cov neeg mob lub raum tsis txaus, yuav tsum tau hloov kho kom haum; Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo tau txo qis cov peev txheej metabolic, uas tuaj yeem ua rau kom cov ntshav plasma ntau ntxiv thiab yog li yuav tsum tau ceev faj kev tswj hwm. Tag nrho cov tshuaj pharmacokinetic profile sib xws nrog cov kev cai thov kev kho mob ntawm nws qhov dav -spectrum anthelmintic cov cuab yeej.
Tsis yog Bantyre, cov khoom tseem ceeb ntawm cov khoom, yog synthesized los ntawm pheej yig thiab yooj yim muaj m-dichlorobenzene raws li cov khoom pib ntawm ntau- kauj ruam cov tshuaj tiv thaiv, uas yog tsim rau kev tsim khoom.
Thawj kauj ruam yog nitration: m-dichlorobenzene reacts nrog nitrating reagents nyob rau hauv kev tswj tej yam kev mob los tsim nitro- hloov intermediates.
Qhov thib ob theem yog condensation: lub nruab nrab reacts nrog thiophenol reagents nyob rau hauv ib tug haum hnyav nyob rau hauv potassium carbonate catalysis los tsim thioether derivatives.
Qhov thib peb kauj ruam yog amination, uas qhia txog cov amino pawg kom tau txais qhov tseem ceeb nruab nrab 4-phenylthio-o-phenylenediamine.
Cov kauj ruam thib plaub yog cyclization: sib tov 4-phenylthio-o-phenylenediamine nrog methyl N-(trichloromethyl)carbamate los tsim crude Non Bantyre ntawm lub nplhaib kaw nyob rau hauv me me. Optimizing cov tshuaj tiv thaiv tsis nyob rau hauv cov kauj ruam no yuav txo tau by-products thiab txhim kho yield.
Thaum kawg, refined Non Bantyre nrog purity tshaj 98% yog tau los ntawm cov txheej txheem purification nrog rau recrystallization, pom thiab ziab.
Cov uas tsis yog Bantyre refined yog proportionally blended nrog auxiliary cov ntaub ntawv xws li praziquantel thiab ivermectin, thiab ua tiav rau hauv cov khoom ntawm cov ntsiav tshuaj thiab txheej txheej txheem. Tag nrho cov txheej txheem synthesis tsom rau kev huv thiab kev ua haujlwm siab, txo tus nqi ntawm peb -kev kho cov khib nyiab.
FAQ
Cov tshuaj febantel siv rau dab tsi?
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Tsis yog Bantyre yog ib qho dav -spectrum Veterinary anthelmintic (dewormer) siv los kho cov kab mob plab hnyuv hauv cov dev, nees, yaj, thiab npua. Nws ua haujlwm los ntawm kev tawg mus rau hauv cov tebchaw uas cuam tshuam lub zog metabolism ntawm worms. Nws feem ntau ua ke nrog [praziquantel] thiab [pyrantel] los kho cov kab mob roundworms, hookworms, whipworms, thiab tapeworms.
Puas yog febantel thiab fenbendazole tib yam?
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Tsis yog Bantyre thiab fenbendazole yog cov muaj feem xyuam nrog benzimidazole anthelmintics siv los kho cov kab mob hauv plab hnyuv (cov kab mob sib kis, kab mob sib kis, kab mob npaws) hauv cov tsiaj, nrog febantel ua yeeb yam raws li cov tshuaj uas yog metabolized rau fenbendazole thiab oxfendazole hauv lub cev. Ob leeg muaj txiaj ntsig zoo, tab sis fenbendazole feem ntau siv ncaj qha rauGiardiaHauv cov dev, thaum febantel feem ntau ua ke nrog lwm tus neeg sawv cev (xws li, Drontal Plus) rau kev tswj hwm dav dav.
Vim li cas febantel tsis siv hauv miv?
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Tsis yog Bantyre tsis zoo rau cov miv thiabtus nqi ntawm pyrantel nyob rau hauv cov khoom tsis txaus los kho miv rau cov kab mob hauv plab.
Cim npe nrov: Compound Febantel ntsiav tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom