Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom lag luam thiab cov neeg muab khoom ntawm cov cim tau nyiaj tsawg. Txais tos rau kev lag luam wholesale mis muaj txiaj ntsig zoo lees paub cov peev txheej rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Credelio Lotilaner, Lub npe lag luam Counyinio, yog qhov tshiab cabiciticide tsim los ntawm Eli Lilly thiab tuam txhab hauv 2017 rau kev kho mob sai ntawm zuam thiab dev kis dev hauv dev. Nws cov tshuaj lom neeg lub npe yog 5 - [{}}}}}}}}}}}}}. Isoxazol-3-YL] -3-Methyl-Thiophene-2-carboxylic acid - [2,2,2-trifluoroethyl-aminoform) - Methyl] - nyob. Lotelana yog qhov ua tau zoo thiab tsis muaj txiaj ntsig stroseptor uteptor thiab tsis muaj cov txiaj ntsig zoo ntawm GAMMA aminobutyric acid hom ib tug receptor hauv cov dev hauv tsev. Nws tuaj yeem tshem tawm cov cab xws li zuam, cov zuam muaj kab mob siab, thiab cov phom sij ntawm cov zuam no tseem nyob hauv ib hlis.
Peb Cov Khoom
Ua ib tus sawv cev ntawm isoxazoline cov tshuaj tua kab, txij li nws daim ntawv thov thawj zaug hauv 2017, Lopinal tau sai sai los ua kev ua tus tsiaj sib tw rau kev ua thiab dav} {{1} {{1} {{1} {{1} {{1} {{1} {{1} {{1} {{1} {{ Nws ua tiav kev tua sai sai los ntawm kev sib tw cov parasitic hlab, ua ke nrog cov nyhuv synasendic, muab kev tiv thaiv zoo tshaj plaws rau cov cab sab nraud. Cov kev siv tshwj xeeb ntawmCredelio LotilanerHauv kev kho mob tsiaj yog cov kab ke piav qhia los ntawm plaub qhov ntev: Kev tiv thaiv thiab kev tswj hwm ntawm tus tsiaj cab sab nraud, kev nthuav dav ntawm kev ntsuas tshwj xeeb, thiab kev siv tshuaj tshwj xeeb.
1.1 kev sib tua ntawm Flea Frea
Lotelana muaj ib qho kev tua neeg tseem ceeb rau cov neeg tua tsiaj laus, thiab cov txheej txheem deva, ua rau Neuronal overexccitation thiab ua rau tuag tes tuag taw thiab kev tuag. Cov kev tshawb fawb soj ntsuam tau pom tias:
Kev ua yeeb yam nrawm: Tus kabmob mub tua tus nqi ntau dua 99% hauv 8 teev tom qab kev tswj hwm thiab mus txog 100% hauv 24 teev.
Kev thaiv lub neej dhau los: los ntawm inhibiting kev loj hlob ntawm cov qe thiab cov kab menyuam dev, cov dev mub rised saw txiav txiav. Kev tshawb fawb hauv Tebchaws Meskas tau lees paub tias tom qab siv cov dev ntsuab txuas ntxiv rau 99.5% -100%, thiab tsiaj cov nqaij daim tawv (erhathema, dentquamation) txhim kho.
Kev tiv thaiv thiab tswj cov kev pheej hmoo ua npaws: mub tuaj yeem kis cov kab mob xws li miv kiav txhab thiab spines bacillus. Lotilana txo kev pheej hmoo ntawm tib neeg kis tau los ntawm kev tua huab cua nrawm.
1.2 Kev tiv thaiv dav dav thiab tswj cov zuam zuam
Lotelana muaj lub zog tua tau rau siab - Cov zuam luas uas tau zuam,
Broad spectrum activity: Laboratory studies have shown that it has a killing rate of over 97% against ticks such as Tetranychus, Tetranychus, Tetranychus, and Tetranychus within 48 hours after administration.
Kev ua tau zoo sai: Cov zuam yuav raug tua 4 teev tom qab kev tua neeg, nrog kev tua tus nqi ntau dua lossis sib npaug ntawm 48 teev.
Kev tiv thaiv kab mob: Los ntawm cov blocking zuam, txoj kev pheej hmoo ntawm zuam cov kab mob xws li tus kab mob Lyme (kis los ntawm cov zuam dub) tuaj yeem raug txo. Lub CAPC (tus khub tsiaj Parasitic Committee) hauv Tebchaws Meskas pom zoo cov tswv tsiaj siv cov LOILANA tiv thaiv kev kis ntawm pathogens.
1.3 kev txhim kho kev txhim kho ntawm kev tsim cov kev npaj
Noj cov qhab nia quattro (compound ntsiav tshuaj
Lothilana: Ceev tua cov neeg dev mub thiab zuam.
Moxibustin: Kills Deg Parasites los ntawm qhib Gaba raws thiab ua ib qho kev thaiv dual nrog Lopina.
Kev kho mob kom tau txais txiaj ntsig: Kev ntsuas kev sib piv qhia tau tias Credelio Quattro Refoat Picks (Sarorana / Piamitox) thiab Nexgard (Afurana).
Kev tiv thaiv ntawm Endoparasites: muaj cov ntaub thaiv npog nruab nrab ntawm cov hospectworm thiab hnyuv hnyuv
2.1 Kev Tiv Thaiv Lymphatic
Kab mob ntawm lub plawv yog tshwm sim los ntawm canine filariasis thiab tuaj yeem ua rau lub plawv tsis ua tiav hauv cov tsiaj. Yoov tshaj cum tuaj yeem kis cov tsiaj thiab kis tau rau tib neeg (txawm hais tias tsis tshua muaj, kev ceev faj yuav tsum tau ua). Lotelana ua tiav kev txuag hluav taws xob ua haujlwm los ntawm kev sib txuas ua qauv tsim:
Txoj haujlwm ntawm Moxifoxacin: Raws li Macrolide koob: Moxifloxacin ua rau cov neeg tuag tes tuag taw thiab kev tuag hauv lub plawv ntawm kev qhib glutamate gated chloride ion channel.
Cov ntaub ntawv kuaj mob: Kev tshawb nrhiav tau pom tias 100% tiv thaiv cov neeg foob tuaj yeem ua tiav los ntawm thawj thawj coj.
Kev Nyab Xeeb: Credelio quattro muaj kev tiv thaiv dev muaj kev tiv thaiv zoo nkauj, tsis muaj kev cuam tshuam nrog cov kev tiv thaiv microfilament ntau tau raug pom.
2.2 Kev kho mob ntawm cov hnyuv hnyuv
Lotelana compound npaj muaj lub zog tua cov txiaj ntsig ntawm cov kab mob plab zom mov xws li cov hloov chaw, hookworms, thiab cov sib tw ua ke:
Prazatiquantel: rhuav tshem cov tapeworm cortex, ntxias cov leeg mob plab, thiab ua rau tuag taus.
Thiamethoxam: raws li neuromuscular blocker, nws ua rau tuag tes tuag taw hauv roundworms thiab hookworms.
Cov kho mob efficacy: kev tua tus nqi ntawm cov runes hlau, thiab nqaim taub hau nematege yog ntau dua los yog sib npaug ntawm kev sib npaug thiab cov tapworm yog qhov tseem ceeb.
2.3 tshuaj kho cov tshuaj thiab ua raws
Kev siv thiab kev siv tshuaj: Credelio quattro yog cov tshuaj tsw qab, tsis muaj kev sib xyaw ntawm 20mg / kg moxatanteltel, thiab 5mg / kg thiazide.
Cov Qauv Tswj Qauv: Yuav tsum tau noj nrog zaub mov noj lossis hauv 30 feeb tom qab noj mov, nrog txo qis bioavailability ntawm ib lub plab khoob.
Ua raws li cov txiaj ntsig: tswj noj tshuaj ib hlis ib hlis, ua ke nrog cov ntsiav tshuaj chewable, txhawm rau txhim kho cov tswv tsiaj kev ua raws.
3.1 Kev Kho Mob ntawm Demodex Bypharitis
Credelio LotilanerQhov muag poob (XDEMVY, 0.25%) tau pom zoo los ntawm FDA hauv Lub Xya Hli 2023, dhau los ua cov yeeb tshuaj ua ntej lub hauv paus ua rau Demodex Blinearitis:
Mechanism ntawm Kev Ua: Los ntawm xaiv Inhibiting Lub Gaba CL Channel hauv lub cev ntawm Demodex Mites, tus cab yog tuag tes tuag taw thiab tua.
Kev Kawm Txuj Ci: Ob txoj kev tshawb fawb tseem ceeb cuv npe ntau dua 800 tus neeg mob, tus kab mob uas tsis muaj tus kab mob Demodex yog cov ntsiab lus tseem ceeb (P<0.001), and the cure rate of eyelid sleeve secretion showed a positive trend (p=0.15).
Kev lag luam kev ua lag luam: Yuaanda cov khoom yuav ua rau pom cov khoom no hauv 2024, thiab nws theem 2 lub tsev kho mob tsom mus rau ntawm Demodex Mites yog tam sim no.
3.2 Cov ntawv thov cov tshuaj Lyme tiv thaiv
TP-05 (Qhov ncauj Lotilana npaj) tab tom ua haujlwm hauv chaw kuaj mob los tiv thaiv kab mob Linhochetes ua ntej lawv tau kis tus kab mob.
Txheej txheem kev txhim kho tshuaj thiab kev taw qhia
Lotelana yog Ameslikas tau tsim los ntawm Eli Lilly tsim los ntawm Eli Lilly tsim los ntawm Eli Lilly tsim los ntawm Eli Lilly tsim los ntawm Eli Lilly thiab lub tuam txhab ua lag luam Credelio) rau kev kho tus zuam thiab dev tua tsiaj hauv cov dev. Qhov nyuaj ntawm nws cov tshuaj lom neeg tau hais txog qhov tsis zoo ntawm nws cov qauv, uas yog 5 {{{{- tichlorophenyl) -}} {-}}}}}}} {21-{ Hauv kev kho mob tsiaj, Lotelana tau sai dhau los ua ib qho tshuaj tseem ceeb rau kev kho tus mob cabination passitic vim nws qhov kev ua haujlwm siab thiab muaj kev nyab xeeb. Nws tuaj yeem tshem tawm cov cab ntawd xws li zuam, cov zuam muaj kab mob siab, thiab cov nyhuv muaj txiaj ntsig tsis pub dhau ib hlis.
Thaum Lub Xya Hli 25, 2023, Lothilana ncav cuag lub peev xwm tseem ceeb hauv nws txoj kev tsim kho. Teb Chaws Asmeskas Khoom Noj thiab Tshuaj Siv (FDA) tau pom zoo ua lag luam ntawm Landelana qhov muag xdemvy (R & D Code TP-03) Tsim los ntawm Tarsus Corporation rau kev kho mob ntawm Demodex Bleepharitis. Qhov no yog thawj zaug DepydE kev tshuaj xyuas tau pom zoo los ntawm cov hauv paus cag ua rau muaj tus kab mob, khij ib qho kev sib tw tseem ceeb rau hauv cov neeg noj qab haus huv.
Demodex ua rau cov kab mob bleepharitis yog mob mob ntev los ntawm cov tib neeg ectoparasite Demodex Mites Sib kis tau daim tawv muag daj. Nws cov kws kho mob raug mob xws li khaus, qhov muag txawv txawv, tawv muag, thiab tes tsho zoo li cov plaub muag ntawm cov plaub muag. Thaum muaj mob hnyav, tus kab mob tuaj yeem ua rau muaj kev cuam tshuam nrog lub conjunctiva thiab corna, thiab muaj qee qib kis. Ib qho ntxiv, Demodex Mites kuj yog ib qho muaj kev pheej hmoo rau meibm Yog tias tsis kho, nws yuav ua rau hloov kev hloov mus tas li hauv cov kua muag zaj duab xis thiab ploj zuj zus mus.
Lotelana qhov muag poob views inhibit Lub Gaba Cl Channel hauv Demodex Mites, ua rau tuag tes tuag taw thiab kev tuag ntawm cov demodex bleephaititis. Nws lub siab Lipophilicity pab kom nqus roj los ntawm cov plaub muag plaub hau uas mites nyob, txhim kho cov tshuaj hauv zos ua tau zoo.
Nyob rau hauv lub Peb Hlis 2024, Yuanda Pharmaceutical tau pom txog cov txheej txheem kev sib koom tes ntawm TP-03 ntau yam ntawm cov chaw sau npe, thiab cov neeg ua haujlwm qis dua qub (Suav Mainland, Hong Kong, Macao, Taiwan). Qhov kev ntsuas no tau kos npe ntawm cov ntawv tshaj tawm ntawm Lotelana qhov muag rau hauv Suav lag luam, muab cov kev kho tshiab rau cov neeg mob tshiab.
Yav dhau los, ob lub tsev kho mob tseem ceeb tau ua tiav hauv Tebchaws MeskasCredelio LotilanerQhov muag poob, cuam tshuam nrog tshaj 800 tus neeg mob nrog Demodex Bleephaitis. Cov kev kuaj mob ua rau pom tias ob qho tib si kev tshawb fawb tau ua tiav qhov kev xaus theem siab thiab tag nrho cov ntsiab lus tseem ceeb uas muaj qhov tseem ceeb ntawm kev sib raug zoo tshwm sim. Hauv Suav teb, cov tshuaj kuj tau ua tiav theem 3 kuaj mob ntawm kev tswj hwm tus kab mob ntawm cov neeg mob<0.001), and the cure rate of eyelid sleeve secretion also showed a positive but not statistically significant trend (p=0.15). In addition, TP-03 has good tolerability and its safety features are similar to those observed in other large-scale clinical trials, with no treatment-related discontinuation.
Cim npe nrov: Cruelelio Lotilaner, Cov chaw muag khoom, chaw tsim tshuaj paus, Hoobkas, lag luam wholesale, yuav, nqe, loj, loj, rau muag