Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov khoom lag luam thiab cov khoom lag luam ntawm neomycin sulphate hauv Suav teb. Txais tos rau kev lag luam wholesale ntau cov khoom lag luam zoo neomycin sulphate sulphate. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Neomycin Sulphate Sulphate Sulphateyog qhov ncauj aminoglycoside tshuaj tua kab mob uas ua lub luag haujlwm tseem ceeb hauv kev kho mob anti {{}} kev kho mob kis. Nws tau tsim muaj zog bactericidal kev ua feem ntau los ntawm irreveribly khi rau 30s subunit ntawm cov kab mob ribosomes, cuam tshuam nrog cov kab ke muaj protein proteination. Nws ua rau cov kabmob · - Tsis muaj tus kab mob uas tsis zoo rau qee qhov ua rau muaj qee tus kab mob. Tom qab cov thawj coj ntawm qhov ncauj, nws yog nqus tau ib qho me me thiab tswj hwm kev pom zoo hauv txoj hnyuv, ua rau nws xaiv qhov zoo tshaj plaws rau kev kho mob plab hnyuv. Nws tuaj yeem ua rau muaj cov tshuaj tiv thaiv kab mob hauv zos thaum txo qhov tshwm sim ntawm cov kev tsis zoo ntawm cov teeb meem.
Cov khoom ntiag tug
Cov yam ntxwv siv tshuaj thiab kev siv tshuaj ntau yam sib txawv:
Lub npe tshuaj lom neeg ntawm nomycn sulphate yog nibycn sulphate, nrog cov mis nyuj molecate ntawm c23h48n6o17s thiab txoj kev sib dhos ntawm 712.7222. Nws qhov kev npaj ntawm qhov ncauj yog tsuas yog cov ntsiav tshuaj, nrog cov kev qhia tshwj xeeb suav nrog 0.1g (100000 units thiab khaws cia rau hauv ib puag ncig qhuav los tiv thaiv kev nqus dej noo thiab kev txwv.
Muaj mob muaj cov kab mob:
Tsuas yog siv rau tus kab mob plab hnyuv los ua los ntawm cov kab mob uas rhiab, txo tus kab mob hauv txoj hnyuv thiab txo qis ntawm cov kab mob rhiab tseem muaj cov teebmeem tseem ceeb. Ntxiv rau, nws kuj tseem tuaj yeem siv ua ke nrog lwm cov tshuaj tiv thaiv cov tuberculosis tuberculosis rau kev coj ua ntawm tuberculant ntawm tuberculisation.
Cov ntaub ntawv ntxiv ntawm kev sib txuas lus:
| Khoom npe | Neomycin sulphate hmoov | Neomycin Sulphate Sulphate Sulphate | Neomycin sulphate txhaj | Noomycin sulpholog ointment |
| Khoom Yam | Hmoov | Phau ntawv | Kev txhaj tshuaj | Kua |
| Khoom Siv Purity | Ntau dua los yog sib npaug rau 99% | Ntau dua los yog sib npaug rau 99% | Ntau dua los yog sib npaug rau 99% | Ntau dua los yog sib npaug rau 99% |
| Cov Khoom Qhia Khoom Khoom | Tau sib kho | Tau sib kho | Tau sib kho | Tau sib kho |
| Khoom Pob | Tau sib kho | Tau sib kho | Tau sib kho | Tau sib kho |
Peb Cov Khoom
NOMYCIN SULPHATE +. coa
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Daim Ntawv Pov Thawj Kev Ntsuam Xyuas |
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Compound npe |
Neomycin Sulphate | |
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Cas Tsis tau. |
1405-10-3 | |
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Teem nqi |
Kws Tshuaj Ntsuam Xyuas | |
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Qho ntau |
Me nyuam | |
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Ntim txheem ntim |
Me nyuam | |
| Tus tsim | Shaanxi Bloom Tech Co., Ltd. | |
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Lauj tsis tau. |
20250109001 |
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Mfg |
Jan 12th 2025 |
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Tus txeeb |
Jan 8th 2029 |
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Lub tsev |
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| Kuaj Tus Qauv | GB / T24768-2009 kev lag luam. Stnndard | |
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Yam |
Kev Lag Luam Kev Lag Luam |
Kev tsom xam tau |
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Kev tshwm sim |
Dawb lossis yuav luag dawb hmoov |
Hloov |
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Dej Cov Ntsiab Lus |
Tsawg dua los yog sib npaug rau 4.5% |
0.30% |
| Poob rau ziab |
Tsawg dua los yog sib npaug rau 1.0% |
0.15% |
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Cov hlau hnyav |
PB tsawg dua lossis sib npaug rau 0.5ppm |
N.D. |
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Tsawg tsawg dua li lossis sib npaug rau 0.5ppm |
N.D. | |
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Hg tsawg dua lossis sib npaug rau 0.5ppm |
N.D. | |
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CD tsawg dua lossis sib npaug rau 0.5ppm |
N.D. | |
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Purity (hplc) |
Ntau dua los yog sib npaug rau 99.0% |
99.5% |
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Ib Leeg Cav |
<0.8% |
0.48% |
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Residue ntawm ignition |
<0.20% |
0.064% |
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TAG NRHO LICBIAL COUNT |
Tsawg dua li lossis sib npaug rau 750cfu / g |
80 |
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E. coli |
Tsawg dua los yog sib npaug rau 2mpn / g |
N.D. |
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Tus ntses siav |
N.D. | N.D. |
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Ethanol (los ntawm gc) |
Tsawg dua los yog sib npaug rau 5000ppm |
400ppm |
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Chaw ntim khoom |
Khaws rau hauv ib qho chaw sib khi, qhov chaw tsaus thiab qhuav ntawm-20 degrees |
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Ua ib tug sawv cev tshuaj ntawm aminoglyscoside tshuaj tua kab mob,Neomycin Sulphate Sulphate SulphateUa tiav cov txiaj ntsig kabmob uas tau ua tau zoo los ntawm kev ua yeeb yam ntawm ntau theem thiab cov hom phiaj, nrog cov yam ntxwv lom thiab muaj kev pheej hmoo txaus ntshai.
Cov txheej txheem tseem ceeb ntawm kev ua haujlwm ntawm cov txheej txheem ntawm cov txheej txheem ntawm cov txheej txheem sib txawv, thiab nws txoj kev sib tw "triple thaiv" nyhuv:
1. Thawj theem inhibition
Cov tshuaj tshwj xeeb khi mus rau lub xaib ntawm cov kab mob ribosome 30s subunit, tabking kev tsim ntawm kev pib ua haujlwm (30s mRAA fmpet trna). Cov txheej txheem no tso siab rau ntawm amino cyclic haus cawv hauv cov tshuaj molecuent thiab tshwj xeeb hauv Mrna codons tsis tuaj yeem paub txog kev pib ua lag luam, yog li thaiv kev txhais lus pib.
2. Kev cuam tshuam thaum lub sijhawm txuas ntxiv
Thaum lub sij hawm peptide saw elongation, nomycn sulphate cuam tshuam kev cuam tshuam cov protein synthesis hauv ob txoj kev:
Kev Siv Tshuaj Tsis Txaus Siab: Cov tshuaj molecules rau hauv qhov chaw txiav txim siab ntawm 30s subunit, hloov pauv cov khoom sib txuam ntawm cov pa roj hmab thiab mroconing rau hauv peptide cov saw thiab tsim cov protein tsis ua haujlwm.
Kev txiav tawm thaum ntxov ntawm txoj saw: Tshuaj siv yeeb tshuaj los rau Pite Rib
3. Hloov nyob hauv cell membrane permeability
Cov khoom siv protein ua rau cov kab mob tsis sib xws ntawm cov kab mob (xws li phospholipids (xws li phospholipids thiab to taub cov kab mob), thaum kawg ua rau cov kab mob sib cais thiab kev tuag. Cov nyhuv muaj txiaj ntsig tshwj xeeb tshaj yog nyob rau hauv gram cov kab mob tsis zoo, raws li qhov uas tsis muaj yeeb yam yeeb tshuaj (xws li OMPF) tuaj yeem ua rau memerbate puas.
Cov kabmob oocin sulphate zoo li cov kab mob uas muaj zog, thiab cov kab mob uas muaj txiaj ntsig zoo tshaj plaws rau cov kab mob ntawm phab ntsa ntawm phab ntsa thiab tshuaj lom neeg:
Cov kab ke nquag ua haujlwm
Gram cov kab mob tsis zoo: Escherichia coli, Klassiella, proteobacter, pseudomonas aerugina (qee hom sib tw), salmonella, shigella.
Ib nrab ntawm cov kab mob zoo: Meticillin Resistant Daphyrococcus xav tau), Staphylococcus EpidermiMidia, Streptococcus genus (rhiab).
Lwm yam: mycobacacterium tuberculosis (Inhibitib nyhuv).
Tsawg kev ua ub no lossis yeeb tshuaj - tsis kam rau cov kab mob
Anaerobic Bacteria: kab kab ntsig thiab kev sib txuas lus (vim tias qhov tsis muaj kev ua pa aerobic ua pa, yeeb tshuaj tsis tuaj yeem nquag thauj khoom hauv cov hlwb).
Gram cov kab mob zoo: Streptococcus pneumoniae, enterococcus genus (tuab ntawm phab ntsa phab ntsa thiab tsis muaj sab nraud membrane porin, cov tshuaj tsis zoo).
Tshwj xeeb hom ntaub ntawv: pseudomonas aeruginosa (qee hom kev tsim kho kev tiv thaiv aminoglycoside mapifyog enzymes lossis qhov tsis muaj o rov qab weein D2).
Cov khoom siv tsis zoo ntawm nomycn sulphate cov khoom pov thawj ntxiv, thiab cov khoom siv tshuaj lom neeg ua kom haum rau cov qauv ntawm cov tshuaj kho mob regimens
Kev xav tsis muaj menyuam tsis muaj menyuam
Cov tshuaj ntau dua, qhov tseem ceeb tshaj qhov inhibition ntawm cov kab ke protein proteisteres sai thiab sai sai Cov kev sim tau qhia tias thaum lub concentration ntawm neomycn sulphate ncav 8-10 feeb ntawm mic, 99.9% ntawm cov kab mob rhiab tsis raug 2-4 teev.
Cov tshuaj tua kab mob tom qab (Pae)
Txawm hais tias cov tshuaj muaj zog tso tawm hauv qab Mic, nws tseem tuaj yeem ua rau cov kab mob protein protein ntau txog li 2-4 teev. Muaj cov kev txhawb nqa PEE txhawb nqa ib qho "ib koob tshuaj ib hnub" regimen, uas tuaj yeem tswj cov tshuaj tiv thaiv ua tau zoo thaum txo txoj kev pheej hmoo ntawm kev pheej hmoo ntawm cov kev pheej hmoo ntawm cov kev pheej hmoo ntawm cov kev pheej hmoo ntawm cov kev pheej hmoo ntawm cov kev pheej hmoo ntawm cov kev pheej hmoo ntawm cov kev pheej hmoo ntawm cov kev pheej hmoo ntawm cov kev pheej hmoo.
Anti Tshuaj Sib Maub (MPC)
MPC ntawm neomycn sulphate yog li 4 {{- 8 zaug ntawm kev xaiv tshuaj ntsuam xyuas cov tshuaj tua hluav taws ntawm cov tshuaj-tiv taus mutant.
Qhov tsis kam ntawm nomycin sulphate yog qhov tsim los ntawm cov txheej txheem hauv qab no, thiab cov chaw kuaj mob yuav tsum tau them rau cov kev pheej hmoo ntawm Cross Crossistance thiab multidrug Kuj:
Kev Hloov Phaj
16s rrna methyltransferase: methylation hloov kho kho mob los ntawm RMTA, RMTB) tuaj yeem thaiv cov tshuaj uas muaj zog (mic ntau dua lossis sib npaug nrog 128 μ g / ml).
Ribosomal protein kev sib pauv, xws li S12 protein (RPSL Gene) hloov, tab sis feem ntau tsuas yog ua rau tsawg} qib}} μ-8 μ g / ml).
Tshuaj Inactivating enzyme
Aminoglycosyltratherase (AAC): catchalyzes cov acetylation ntawm cov amino pawg hauv cov tshuaj lwg me, txo lawv txoj kev duav muaj peev xwm ribosomes.
Aminoglycosyltratherase (aph): los ntawm phosphorylation hloov kho, hloov cov kev faib cov nqi tshuaj, tabkaub lawv cov kev nkag mus rau hauv lub cell membrane.
Aminoglycoside nucleoside hloov chaw (ntsaum): catalyzes cov tshuaj tiv thaiv, ua rau kev siv yeeb tshuaj tsis sib xws.
30 Overexurression Ntawm Cov Twj Tso Kua Mis
Lub caij nyoog rnd tsev neeg ntawm gram cov kab mob tsis zoo, xws li lub acrab tsis zoo, tuaj yeem nquag nqus tshuaj tawm ntawm lub xovtooj thiab txo cov tshuaj tiv thaiv hauv tshuaj.
Biofilm tsim
Cov kab mob hauv Biofilm Lub Xeev tau txo qis tshuaj permeability thiab cov kev ua haujlwm metabolic, uas yuav tsum muaj ntau qhov txiaj ntsig kom ua tiav cov kab mob tshwm sim.
Otoneoprotoxicity ntawm Neomycn sulphate yog ze rau nws txoj kev sib txuam hauv lub raum tub thiab cochlear plaub hau, tsuas yog koom nrog cov cuab yeej hauv qab no:
mitochondrial kev puas tsuaj
Cov tshuaj cuam tshuam nrog Mitochondrial protein synthesis los ntawm kev khi rau mitochondrial chartual accts, txo cov kev tsim tawm, thiab ua kom muaj zog ntawm cov kev kawm hauv xov tooj ntawm tes.
Oxidative Kev Nyuaj Siab
Tshuaj ua rau muaj kev nce siab ntawm cov oxygen cov pa roj (Ros)
Lysosomal Membrane Haus Yeeb
Nyob rau hauv lub raum tubular epithelial hlwb,Neomycin Sulphate Sulphate SulphateMuaj peev xwm cuam tshuam lysosomal membrane, tso cov kev tiv thaiv thiab lwm hydrolytic enzymes, thiab ua rau cell autolysis.
Cov tshuaj kho mob insights: cov tshuaj noj muaj txiaj ntsig thiab kev tiv thaiv toxicity thiab tswj
Raws li cov txheej txheem ntawm kev ua thiab cov yam ntxwv ntawm cov tshuaj ntsuam ntawm neomycin sulfphate yuav tsum ua raws li cov hauv qab no:
Indermation Xaiv
Ua ntej siv rau tus kab mob tsis zoo (xws li cov kab mob hnyuv thiab mob plab zom zaws), xws li cov kab mob streptococcal).
Koob tshuaj optimization
Txais yuav "high - koob tshuaj, ntev ntev" regimen "regimen (xws li feem ntau cov kev pheej hmoo ua kom muaj kev phom sij
Kev Kho Mob
Ua ke nrog {- Lactam lossis fluoroquinolone tshuaj, nws synoroquinolone voltans ntawm kev sib txawv ntawm kev nqis tes ua, txo qhov tshwm sim ntawm cov tshuaj tiv thaiv.
Kev soj ntsuam toxicity
Nquag saib cov ntshav creatin,
Kev nce qib thiab yav tom ntej cov lus qhia hauv kev tshawb fawb soj ntsuam
Kev tshawb nrhiav ntawm kev kho mob rau cov tshuaj -} tiv taus cov kab mob
Kev kho cov kev kho ntawmNeomycin Sulphate Sulphate SulphateNrog beta lactams (xws li amoxicillin thiab clavauranic acid poov tshuaj) lossis tau kawm fluorofloxacin) lossis tau kawm ua fluorofling Qhov txiaj ntsig ua ntej qhia tau tias kev cuam tshuam tau zoo tuaj yeem txhim kho kev ua tau zoo thiab txo cov tshuaj tiv thaiv kev pheej hmoo tiv thaiv.
Hauv zos tswj xyuas kev ua tau zoo
Tsim kev txhawb nqa - tso cov tov khoom thiab cov qauv sib xyaw los txo cov kev ua haujlwm ntawm Nepycin kom txo tau cov xeeb ntxwv ntawm NephroTOxicity los ntawm kev tawm tswv yim tso tawm. Piv txwv li, cov ntsiav tshuaj enteric npaj siv hydroxypropylulose txheej thev naus laus zis tuaj yeem ua tau cov tshuaj hnyuv tshuaj rau hauv cov hnyuv, txo cov ntshav kom muaj txiaj ntsig los ntawm 40% -60%.
Saib xyuas ntawm biomarkers
Kawm cov ntawv thov cov zis ntawm cov zis ntawm cov zis tshaj Next} acetyl {}!
Cim npe nrov: NOMYCIN SULPHATE ntsiav tshuaj, lwm tus neeg, chaw tsim tshuaj paus, Hoobkas, lag luam wholesale, yuav, nqe, loj, loj, rau muag