Ivermectin stromectol ntsiav tshuajyog ib hom tshiab ntawm dav -spectrum, muaj txiaj ntsig zoo, thiab muaj tshuaj lom tsis tshua muaj tshuaj tua kab mob tshuaj tua kab mob, uas muaj txiaj ntsig zoo tua kab mob, tshwj xeeb tshaj yog nematodes thiab arthropods, sab hauv thiab sab nraud lub cev. Tab sis nws tsis muaj txiaj ntsig tiv thaiv kab mob kab mob, kab mob, thiab protozoa. Kev tua cov nyhuv ntawm macrolide antiparasitic tshuaj ntawm nematodes thiab arthropods yog txhawm rau tso tawm cov inhibitory neurotransmitter gamma aminobutyric acid (GABA) hauv cov cab, nrog rau qhib glutamate tswj Cl ion channel, txhim kho cov permeability ntawm cov paj hlwb mus rau Cl, yog li thaiv cov hlab ntsha ntawm cov leeg nqaij, ua rau lub cev tsis muaj zog. muaj peev xwm cog lus, ua rau tus kab mob tuag taus.
Stromectol yog lwm lub npe rau ivermectin, thiab nws cov khoom tseem ceeb ntawm lub cev yog cov hmoov dawb crystalline tsis muaj saj. Cov khoom no yog nyob rau hauv ib qho thaiv zoo li lub cev lub cev thiab yooj yim soluble hauv methanol, ethanol, acetone, thiab ethyl acetate. Nws yuav luag insoluble hauv dej thiab muaj me ntsis hygroscopicity. Ivermectin yog ib qho tshuaj tua kab mob macrocyclic lactone nrog kaum rau lub nplhaib. Nws cov qauv tsim muaj lub nplhaib loj ester ntawm cov pa roj carbon 16 txoj haujlwm thiab peb pawg loj hloov pauv, uas yog hexahydrophenylpropanofuran ntawm C2 rau C8 txoj haujlwm, disaccharide ntawm C13 txoj haujlwm, thiab ketone ntawm C17 mus rau C18 txoj haujlwm.
Nyob rau tib lub sijhawm, peb lub tuam txhab tsis tsuas yog muab ivermectin stromectol ntsiav tshuaj, tab sis kuj qab zib, muab tshuaj txhuam thiab hmoov. Yog tias xav tau, thov koj xav tiv tauj peb txhua lub sijhawm.
Peb cov khoom
Cov ntaub ntawv ntxiv ntawm chemical compound:
| Khoom npe | Ivermectin stromectol hmoov | Ivermectin stromectol ntsiav tshuaj |
| Yam khoom | Hmoov | Cov ntsiav tshuaj |
| Khoom Purity | HPLC Ntau dua lossis sib npaug rau 99.0% | Ntau dua lossis sib npaug li 99% |
| Khoom Specifications | 100g / 1kg / thiab lwm yam. | 360 mg/tab |
| Pob khoom | PE / Al foil hnab / ntawv lub thawv rau Pure hmoov |
100 ntsiav tshuaj / lub raj mis 80 fwj / thawv |
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Ivermectin Stromectol +. COA
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Certificate of Analysis |
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Compound npe |
Ivermectin | |
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CAS Nr. |
70288-86-7 | |
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Qib |
Veterinary qib |
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Ntau |
3 39,3kg |
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Ntim txheem |
25kg / nruas |
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| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
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Ntau No. |
20250109001 |
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MFG |
Jan 9th 2025 |
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EXP |
Jan 8th 2028 |
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Qauv |
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| TEST STANDARD | GB/T24768-2009 Kev lag luam. Stnndard | |
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Yam khoom |
Enterprise txheem |
Kev txheeb xyuas qhov tshwm sim |
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Qhov tshwm sim |
Dawb los yog yuav luag dawb hmoov |
Ua raws |
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Cov ntsiab lus dej |
Tsawg dua lossis sib npaug li 5.0% |
0.31% |
| Poob rau ziab |
Tsawg dua lossis sib npaug li 1.0% |
0.15% |
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Hnyav Hlau |
Pb Tsawg dua lossis sib npaug li 0.5ppm |
N.D. |
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Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Hg Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Cd Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
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Purity (HPLC) |
Ntau dua lossis sib npaug li 99.0% |
99.4% |
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Ib qho impurity |
<0.8% |
0.48% |
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Residue ntawm ignition |
<0.20% |
0.064% |
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Tag nrho microbial suav |
Tsawg dua lossis sib npaug li 750cfu / g |
80 |
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E. Coli |
Tsawg dua lossis sib npaug li 2MPN / g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (los ntawm GC) |
Tsawg dua lossis sib npaug li 5000ppm |
400ppm ua |
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Cia |
Khaws rau hauv qhov chaw kaw, tsaus thiab qhuav ntawm -20 degrees |
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Ivermectin stromectol ntsiav tshuajyog dav siv rau gastrointestinal nematodes, pulmonary nematodes, thiab parasitic arthropods nyob rau hauv nyuj, yaj, nees, thiab npua, plab hnyuv nematodes nyob rau hauv dev, pob ntseg mites, scabies mites, heartworms, thiab microfilaments, as well as gastrointestinal nematodes.
(l) Ivermectin yog siv los ntawm qhov ncauj lossis subcutaneously rau nyuj thiab yaj ntawm ib koob ntawm 0.2mg / kg. Nws muaj tus nqi deworming ntawm 97% mus rau 100% tawm tsam cov neeg laus thiab theem plaub ntawm nematodes xws li hemochromatus, Oster, Gubai, Trichomonas (xws li Eisenia), roundworms, upside down nematodes, fine necked nematodes, plaub hau nematodes, esophagetic rematodes thiab nematodes. worms. Cov koob tshuaj saum toj no kuj tseem siv tau rau cov kab mob arthropods, xws li maggots (cowhide yoov, kab kab yoov, yaj yoov), mites (cov nyuj khaus mites, yaj khaus mites), thiab nab (cov nyuj palate ntshauv, nyuj cov ntshauv, thiab yaj palate ntshauv). Ivermectin muaj kev kho mob me ntsis rau cov nas tsuag (mis nyuj) thiab yaj zuam thiab yoov.
Ivermectin kuj zoo heev tiv thaiv zuam thiab yoov uas yug hauv quav. Txawm hais tias cov tshuaj tsis tuaj yeem tua cov zuam tam sim ntawd, nws tuaj yeem cuam tshuam
Noj, molting, thiab nteg qe tuaj yeem txo qhov muaj peev xwm ntawm kev ua me nyuam. Kev txhaj tshuaj subcutaneous ntawm 0.2mg / kg ib zaug lossis noj txhua hnub ntawm qhov tsis tshua muaj siab rau tsiaj
Tom qab 5 hnub ntawm kev noj tshuaj (0.01mg / kg), zuam tau pom qhov tshwm sim pom tseeb tshaj plaws uas tau hais los saum no. Kev txhaj tshuaj subcutaneous ntawm ib koob ntawm 0.2mg / kg kuj muaj qee yam kev tswj hwm ntawm yoov uas rov tsim dua hauv cov quav. Tom qab 9 hnub ntawm cov tshuaj nyob rau hauv nyuj, cov larvae ntawm lub ntsej muag yoov thiab lub caij nplooj zeeg houseflies tsis tuaj yeem loj hlob mus rau cov neeg laus hauv lawv cov quav. Tom qab lwm 5 hnub, kev yug me nyuam ntawm yoov raug txo kom tsawg vim qhov tsis zoo ntawm pupae thiab kev cuam tshuam ntawm cov neeg laus cov txheej txheem maturation. Cov koob tshuaj saum toj no yog siv rau cov ntshav yoov (cov ntshav tawm tsam yoov), thiab qhov xwm txheej zoo sib xws tom qab 4 lub lis piam.
(2) Kev tswj qhov ncauj ntawm 0.2mg / kg Ivermectin tau pom tias muaj txiaj ntsig zoo (95% txog 100%) hauv cov neeg laus thiab theem plaub ntawm cov kab mob loj thiab me me; Xws li cov kab mob loj loj (cov kab mob sib xws, cov kab nematodes nees, cov kab mob tsis muaj hniav tsis muaj hniav), cov kab mob roundworms (nema parasitic roundworms), pinworms (nees pointed tail nematodes), kab mob plab (loj lub qhov ncauj drassimus nematodes, mos nematode genus nematodes), me me intestinal nematodes. Wechsler classworms), mob ntsws nematodes (Anserinopsis net tail nematodes), thiab lwm yam. Rau peb hom nees plab maggots uas tau tsiv los yog nyob hauv plab, nrog rau cov microfilaments ntawm disc tail silk worm uas ua rau cov tawv nqaij puas tsuaj thiab lub thib peb theem larvae ntawm plab nematodes, txawm hais tias txwv tsis pub 2 mg / kg. noj tshuaj dua ntawm cov tshuaj saum toj no tom qab ib hlis.
Qhov tseem ceeb tshwj xeeb yog qhov pom zoo koob tshuaj ivermectin (0.2mg / kg) muaj qhov ua tau zoo ntawm kwv yees li 99% hauv kev kho cov hlab ntsha mesenteric los ntawm kev tsiv teb tsaws ntawm theem ntxov thiab thib plaub ntawm cov kab mob sib kis. Feem ntau, cov tsos mob tau txo qis tom qab 2 hnub ntawm cov tshuaj, thiab tag nrho cov tsos mob puas ploj tom qab li 28 hnub.
(3) Intramuscular txhaj ntawm 0.3mg / kg ivermectin muaj dav -spectrum insecticidal kev ua haujlwm hauv npua. Kev tshem tawm ntawm cov neeg laus thiab cov neeg laus tsis paub qab hau xws li npua roundworms, liab npua roundworms, orchid roundworms, npua hau taub hau nematodes, esophageal qhov ncauj nematodes, posterior roundworms, thiab toothed tail nematodes yog 94% mus rau 100%, thiab nws kuj muaj txiaj ntsig zoo rau cov hnyuv (cov nqaij mos). Txoj kev siv tshuaj saum toj no kuj muaj kev tswj xyuas zoo ntawm cov ntshav npua thiab npua kab mob mites.
Efficiency leap Precision thiab stability
(4) Muaj cov ntawv qhia tshwj xeeb rau cov dev thiab miv txawv teb chaws (ntawm koob tshuaj 6-12 μ g / kg) rau kev tiv thaiv thiab kho cov kab mob canine heartworm microfilament. Hauv Suav teb, txoj kev tswj hwm qhov ncauj ntawm 50 μ g / kg tuaj yeem siv los kho cov kab mob plawv microfilament (tsis zoo rau cov neeg laus). Cov kev sim tshuaj tau lees paub tias cov koob tshuaj ivermectin muaj txiaj ntsig zoo tiv thaiv ntau yam kab mob hauv cov dev, xws li kev txhaj tshuaj subcutaneous ntawm 50 μ g / kg tawm tsam canine hookworm, Brazilian hookworm, European hookworm, 100 μ g / kg tawm tsam canine whipworm, thiab 200 μ g / kg tiv thaiv cov neeg laus thiab plaub theem. Kev txhaj tshuaj subcutaneous ntawm ib koob ntawm 200 μ g / kg muaj kev kho mob tsuas yog 69% ntawm tus tsov ntxhuav lub arch roundworm, thaum kev tswj qhov ncauj ua tiav 95%.
Cov khoom no, thaum txhaj tshuaj subcutaneously ib zaug, kuj muaj txiaj ntsig zoo hauv kev tshem tawm cov huab cua protozoan (200 μ g / kg) thiab Osler's nematode (400 μ g / kg) uas parasitize lub ntsws ntawm cov dev. Kev txhaj tshuaj ntawm qhov ncauj lossis subcutaneous ntawm 200 μ g / kg, rov ua dua tom qab ob lub lis piam, muaj txiaj ntsig zoo ntawm 95% mus rau 100% tiv thaiv cov kab mob hauv plab hnyuv (tsis suav nrog theem thib peb larvae).
Ivermectin kuj tseem siv tau rau qee yam kab mob arthropod hauv dev thiab miv. Kev txhaj tshuaj subcutaneous ntawm 200 μ g / kg hauv cov dev thiab miv, ua raws li lwm koob ob lub lis piam tom qab, tuaj yeem tshem tawm cov kab mob ntawm pob ntseg, kab mob kab mob, thiab kab mob ntsws. Muab ob zaug (nrog rau 2 lub lis piam ib ntus) ntawm koob tshuaj 300 μ g / kg. Nws tseem muaj txiaj ntsig tiv thaiv kab mob los ntawm kab laug sab mite. Nws yog qhov zoo tshaj plaws los kho tus kab mob canine demodex los ntawm kev txhaj tshuaj subcutaneous ntawm koob tshuaj 600 μ g / kg, nrog rau lub sijhawm ntawm 7 hnub thiab 5 koob tshuaj sib law liag.
(5) Cov nqaij qaib muaj txiaj ntsig zoo tiv thaiv nematodes xws li cov kab mob sib kis thiab cov kab mob nematodes, nrog rau cov kab mob parasitic arthropods xws li hauv caug mites (mutated hauv caug mites), thaum noj tshuaj los yog subcutaneously ntawm ib koob ntawm 200-300 μ g / kg. Tab sis qhov noIvermectin stromectol ntsiav tshuajyog tsis muaj txiaj ntsig tiv thaiv qaib nematodes.
(6) Reindeer tuaj yeem kis tau Oedemagena trandi hauv lawv cov cowhide los ntawm kev txhaj tshuaj subcutaneous ntawm qhov ntau npaum li 200 μ g / kg rau nyuj.
Raw khoom npaj
Ua ntej tsim cov ntsiav tshuaj Ivermectin Stromectol, kev tshuaj xyuas nruj thiab ua ntej ntawm cov khoom xyaw nquag Ivermectin thiab ntau yam khoom ntxiv yog xav tau. Tom qab ua kom ntseeg tau tias qhov zoo ntawm cov khoom siv raw ua tau raws li cov qauv, ntau yam khoom siv raw yog hnyav rau hauv ib qho kev faib ua feem thiab sib xyaw. Cov txheej txheem sib tov yuav tsum ua kom ntseeg tau tias cov khoom sib txawv ntawm ntau yam khoom siv raw khoom kom tsis txhob muaj teeb meem ntawm cov ntsiab lus ntawm cov tshuaj tsis sib xws thaum lub sij hawm nias cov txheej txheem.
Granulation
Granulation yog txheej txheem ntawm kev ua cov khoom ntawm ib qho me me thiab cov duab los ntawm cov khoom sib xyaw. Muaj ntau txoj hauv kev ntawm granulation, feem ntau suav nrog granulation ntub thiab qhuav granulation. Hauv kev tsim cov Ivermectin Stromectol Tablets, ntub granulation feem ntau yog siv. Cov kauj ruam tshwj xeeb yog raws li nram no:
Ntxiv cov khoom sib xyaw ua ke rau hauv lub tshuab ntub dej granulation thiab ntxiv qhov tsim nyog ntawm cov nplaum (xws li polyvinylpyrrolidone tov) los tsim cov khoom ntub ntawm cov ntaub ntawv raw. Tom qab ntawd, cov agglomerates yog nyem rau hauv ib qho me me hais los ntawm lub sieve ntawm granulator. Thaum lub sij hawm granulation txheej txheem, nws yog ib qho tsim nyog los tswj cov tsis xws li tus nqi ntawm cov nplaum, nplawm nrawm, thiab lub vijtsam loj kom ntseeg tau tias qhov zoo ntawm cov khoom ua tau raws li qhov yuav tsum tau ua.
Qhuav
Cov khoom uas ua tau feem ntau muaj qee qhov dej noo thiab xav tau kev kho kom qhuav. Lub hom phiaj ntawm kev ziab yog tshem tawm cov dej noo ntawm cov khoom thiab txhim kho kev ruaj ntseg thiab compressibility ntawm cov tshuaj. Cov kev siv tshuab ziab khaub ncaws feem ntau muaj xws li cua kub kom qhuav, fluidized txaj kom qhuav, thiab lwm yam. Thaum lub sij hawm ziab, nws yog ib qho tsim nyog los tswj qhov kub thiab lub sij hawm kom tsis txhob kub dhau los yog lub sij hawm uas yuav ua rau degradation ntawm cov khoom xyaw nquag hauv cov tshuaj.
Tablet nias
Tom qab sieving thiab shaping lub qhuav hais, ib tug tsim nyog tus nqi ntawm lubricant (xws li magnesium stearate) yog ntxiv, sib tov tusyees, thiab ces compressed rau hauv ntsiav tshuaj. Cov ntsiav tshuaj nias txheej txheem yuav tsum tau siv cov ntsiav tshuaj xovxwm los compress cov hais mus rau hauv cov ntsiav tshuaj nrog ib tug tej yam zoo li, loj, thiab hardness. Thaum lub sij hawm cov ntsiav tshuaj compression txheej txheem, nws yog ib qhov tsim nyog los tswj cov tsis xws li compression siab, ntsiav tshuaj hnyav, thiab hardness kom ruaj khov ntsiav tshuaj zoo.
Txheej (yeem)
Qee zaum, cov ntsiav tshuaj yuav raug coated los txhim kho lawv cov tsos, saj, lossis ruaj khov. Cov khoom siv txheej txheej tuaj yeem yog cov txheej txheem qab zib, txheej txheej zaj duab xis nyias, thiab lwm yam. Cov txheej txheem qab zib tuaj yeem ua rau lub ntsej muag ntawm cov ntsiav tshuaj du thiab zoo nkauj, thaum npog cov ntxhiab tsw ntawm cov tshuaj; Zaj duab xis txheej tuaj yeem tswj tau qhov tso tawm ntawm cov tshuaj, txhim kho lawv cov stability thiab bioavailability. Cov txheej txheem txheej yuav tsum tau tswj tsis tau xws li cov concentration ntawm txheej txheej, txau ceev, thiab ziab kub kom ntseeg tau tias txheej txheej zoo.
Kev tswj kom zoo
Raw khoom soj ntsuam
Thaum lub sij hawm tsim khoom, kev soj ntsuam nruj nruj yuav tsum tau ua nyob rau hauv txhua pawg ntawm cov khoom siv raw. Cov khoom tshuaj ntsuam xyuas suav nrog cov ntsiab lus thiab purity ntawm cov khoom xyaw nquag, cov khoom muaj feem xyuam, thiab ntau yam kev ntsuas zoo ntawm cov khoom pabcuam. Tsuas yog tom qab dhau kev soj ntsuam cov khoom siv raw tuaj yeem muab tso rau hauv kev siv ntau lawm.
Kev soj ntsuam nruab nrab
Thaum lub sij hawm tsim cov txheej txheem ntawm granulation, ziab, thiab ntsiav tshuaj nias, nws yog ib qho tsim nyog los tshuaj xyuas txhua qhov nruab nrab. Piv txwv li, ntsuas ntsuas xws li particle loj faib, cov ntsiab lus noo noo, thiab flowability ntawm hais; Tshawb xyuas qhov sib txawv ntawm cov ntsiav tshuaj hnyav, hardness, brittleness, thiab lwm yam ntsuas ntawm cov ntsiav tshuaj. Los ntawm kev soj ntsuam nruab nrab, cov teeb meem hauv cov txheej txheem tsim khoom tuaj yeem raug txheeb xyuas raws sijhawm, thiab kev hloov kho thiab kev txhim kho tuaj yeem ua kom ntseeg tau qhov zoo ntawm cov khoom kawg.
Kev tshuaj xyuas cov khoom tiav
Kev tshuaj xyuas cov khoom tiav yog ib feem tseem ceeb ntawm kev tswj kom zoo. Yuav tsum muaj kev tshuaj ntsuam xyuas zoo rau Ivermectin Stromectol Tablet cov khoom tsim. Cov khoom tshuaj ntsuam xyuas muaj xws li cov tsos, qhov sib xws ntawm cov ntsiab lus, solubility, microbial txwv, thiab lwm yam. Cov ntsiab lus kev ntsuas qhov sib xws tuaj yeem ua kom ntseeg tau tias cov ntsiab lus tseem ceeb hauv txhua cov tshuaj ua tau raws li qhov yuav tsum tau ua; Kev soj ntsuam kev puas tsuaj tuaj yeem simulate cov txheej txheem kev sib cais ntawm cov tshuaj hauv vivo thiab ntsuas lawv cov bioavailability; Kev ntsuas microbial txwv tuaj yeem ua kom ntseeg tau tias cov tshuaj tsis muaj kab mob kis los ntawm cov kab mob hauv lub sijhawm cia thiab siv. Tsuas yog cov khoom uas dhau qhov kev soj ntsuam zaum kawg tuaj yeem nkag mus rau hauv lub khw muag khoom.
Kev ntsuas kev ruaj ntseg
Txhawm rau kom muaj kev ruaj ntseg ntawm cov tshuaj zoo thaum lub sijhawm khaws cia, kev ntsuas kev ruaj ntseg ntawm Ivermectin Stromectol Tablets yog xav tau. Kev ntsuas kev ruaj ntseg feem ntau suav nrog qhov ntev - kev ntsuas kev ruaj ntseg thiab kev ntsuas kev ruaj ntseg nrawm. Kev ntsuas kev ruaj ntseg ntev yog cov txheej txheem ntawm kev tso tshuaj nyob rau hauv cov xwm txheej khaws cia (xws li qhov kub thiab txias, av noo, thiab lwm yam) rau qee lub sijhawm, thiab tsis tu ncua sampling thiab kuaj cov kev hloov pauv ntawm cov tshuaj zoo; Kev ntsuas kev ruaj ntseg nrawm yog cov txheej txheem ntawm kev tso tshuaj nyob rau hauv qhov kub thiab txias txias rau qee lub sijhawm kom nrawm qhov hloov pauv ntawm cov tshuaj thiab kwv yees nws lub txee lub neej. Los ntawm kev soj ntsuam kev ruaj ntseg, cov xwm txheej khaws cia thiab hnub tas sij hawm ntawm cov tshuaj tuaj yeem txiav txim siab, muab kev tshawb fawb hauv paus rau kev tsim khoom, khaws cia, thiab siv tshuaj.
Cov lus nug nquag
Dab tsi yog ivermectin Ameslikas siv rau?
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Tom qab nws nrhiav tau nyob rau hauv 1975, nws thawj zaug siv nyob rau hauv veterinary tshuaj los tiv thaiv thiab kho mob plawv thiab acariasis. Kev pom zoo rau tib neeg siv xyoo 1987, nws yog siv los kho cov kab mob xws li kab mob hauv lub taub hau, kab mob scabies, dej dig muag (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis thiab lymphatic filariasis.
Leej twg tsis tuaj yeem noj ivermectin?
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Yog tias koj muaj keeb kwm ntawm qaug dab peg, nrog koj tus kws kho mob tham seb ivermectin puas muaj kev nyab xeeb rau koj. Cov tshuaj tiv thaiv tsis haum: Yog tias koj tau muaj kev fab tshuaj rau ivermectin lossis ib qho ntawm nws cov khoom xyaw, koj tus kws kho mob yuav tsis muab tshuaj ivermectin. Kev noj tshuaj tuaj yeem ua rau muaj kev fab tshuaj ntxiv.
Cov nroj tsuag twg yog ivermectin ua los ntawm?
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Ivermectin yog semisynthetic, anthelmintic tus neeg sawv cev. Nws yog ib qho avermectin, ib pawg ntawm pentacyclic kaum rau -cov tswv cuab lactones (xws li macrocyclic lactone disaccharide) muab los ntawm cov kab mob hauv av Streptomyces avermitilis. Avermectins yog cov muaj zog thiab dav -spectrum anti- cov kab mob cab.
Cov zaub mov twg muaj ivermectin?
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Txoj kev tshawb no yog thawj zaug tshawb pom ivermectin nyob rau hauv cov khoom noj ntawm bovine keeb kwm xws li mis nyuj, nqaij, thiab daim siab thiab excretions xws li tso zis thiab quav los ntawm me me - nplai ua liaj ua teb.
Puas yog neem tib yam li ivermectin?
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Yog li, Neem cog extract (Azadirachta indica A. Juss) tau siv los ua lwm txoj hauv kev los hloov Ivermectin thoob ntiaj teb.
Cim npe nrov: ivermectin stromectol ntsiav tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom