Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov khoom lag luam thiab cov chaw muag khoom ntawm Fenbendazole ntsiav tshuaj nyob hauv Suav teb. Txais tos rau kev lag luam wholesale loj zoo fenbendazole ntsiav tshuaj rau muag ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Fenbendazole tshuajyog qhov dav -} spectrum benzimidazole cov tshuaj tsis quav tshuaj tsuas yog siv rau cov tsiaj uas tsis yog. Nws yog ib txwm muaj nyob hauv cov kws kho tsiaj teb thiab tsis tau pom zoo rau kev kho mob ntawm tib neeg cov kab mob. Qhov nws tiv thaiv yog fenbendazole, nrog molecular mis formula c15h13n3o2s. Nws yog dawb lossis tawm - cov hmoov dawb, tsw thiab tsis muaj qab. Nws yog soluble nyob rau hauv Duethyl sulfoxide, me ntsis soluble hauv methanol, insoluble hauv dej, thiab solub hauv glacial acetic acid.
Fenbendazole feem ntau ua rau cov cua nab los ntawm kev sib tsoo ntawm tubulin thiab microlotuing qauv ntawm cov cabulin, inhibiting lawv kev loj hlob, thiab thaum kawg ua rau kev tuag ntawm cov cab.
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Cov ntaub ntawv ntxiv ntawm kev sib txuas lus:
Fenbendazole ntsiav tshuaj Coo
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Cov ntaub ntawv ntawm cov ntaub ntawv raw thiab cov ntaub ntawv
Kev tsim khoom ntawmFenbendazole tshuajUa ntej yuav tsum muaj cov khoom lag luam fenbendazole raw cov ntaub ntawv, nws lub npe tshuaj ntsuab yog c15} tus lej yog c15} tus lej ntawm caj ces yog 299.34 lossis 299.35. Cov khoom noj muaj txiaj ntsig ntawm Fenbendical cov khoom noj ntawm Fenbendanole feem ntau yog cov hmoov dawb lossis tsis muaj ntxhiab tsw qab, tab sis solacle hauv dimethyl sulfoxide thiab glacial acetic acid. Lub sijhawm tsim qauv txheej txheem, qee qhov kev paub ua kom xav tau, xws li cov kuab tshuaj (xws li cov hmoov txhuv nplej siab), xws li cov hmoov txhuv nplej siab (xws li cov txheej txheem ntawm cov txheej txheem tshwj xeeb thiab cov khoom lag luam zoo.
Txheej txheem ntau lawm
Cov txheej txheem ntau lawm ntawm Fenbendazole feem ntau suav nrog cov kauj ruam hauv qab no:
Qhov tseeb hnyav lub fenbendazole cov khoom siv raw thiab cov khoom yuav tsum tau ua raws li cov tshuaj piv txwv, thiab tso lawv feem hauv cov thawv huv si rau kev siv tom qab.
Muab cov khoom siv raw ntawm fenbendazole thiab qee qhov kev paub (xws li cov hmoov txhuv nplej siab, silica, thiab lwm yam. Sib tov rau lawv tusyees.
Cov ntaub ntawv muag muag tau ua los ntawm kev ntxiv cov nplaum (xws li cov hmoov txhuv nplej siab slurry).
Cov khoom muag muag tau ua rau hauv cov pellets ntub los ntawm lub tshuab viav vias.
Muab cov dej ntub nyob rau hauv cov huab cua kub cua kev cub kom qhuav thiab lub sijhawm kom paub tseeb tias cov ntsiab lus ya raws ua raws li qhov yuav tsum tau ua.
Cov granules qhuav yog granulated los ntawm granulator kom tau txais cov granules loj.
Sib tov cov granulated granules ensy nrog cov khoom seem (xws li magnesium stearate) thiab lubricants hauv tov.
Cov granules sib xyaw tau nias rau hauv cov ntsiav tshuaj los ntawm ib ntsiav tshuaj xovxwm.
Cov ntsiav tshuaj nias tau ntim rau sab hauv (xws li txhuas-}}} Yas Yas Sau Ua Yeeb Yam Zaj Duab Xis Ntim) thiab Ntim Ntim Ntim (xws li lub thawv ntim khoom).
Cov ntsiav tshuaj ntim ntim tau raug tshuaj xyuas kom zoo. Cov uas xeem tau soj ntsuam tau khaws cia hauv lub tsev rau khoom.
Cov Khoom Siv Ntau Lawm thiab Tswjhwm Zoo
Khoom Siv Ntau Lawm
Lub Tank Tank: Nws yog siv rau kev ua kom tsis muaj cov ntaub ntawv fenbendazole raw khoom thiab npaj cov nplaum.
TOV KHOOM: Nws yog siv rau kev sib xyaw ua ke cov khoom siv thiab cov ntaub ntawv tso tawm.
Viav vias granulator: nws tau siv los tig cov ntaub ntawv mos ua rau hauv cov granulub ntub.
Cov cua kub kev cub: siv rau kom qhuav ntub dej.
Granulator: siv rau granulating thiab ziab cov granules.
Ntsiav tshuaj xovxwm: nws yog siv los nias granules rau hauv ntsiav tshuaj.
Ntim tshuab: Siv rau sab hauv thiab sab nraud ntim ntawm cov ntsiav tshuaj.
Kev Tswj Xyuas Zoo
Cov khoom siv raw khoom siv raw: kev ua tau zoo kev tshuaj xyuas ntawm cov khoom xyaw ua tshuaj thiab muaj kev zam ntawm Fenbendazole kom ntseeg tau tias lawv ua tau zoo qauv.
Feem ntau cov khoom siv ntawm kev sib xyaw thiab cov ntsiav tshuaj thiab cov ntsiav tshuaj nias, thiab tag nrho cov kev faib tawm thiab cov ntsiab lus noo noo ntawm cov hais.
Cov Khoom Siv Ua tiav tsim nyog: Kev coj ua zoo kev tshuaj xyuas ntawm cov ntsiav tshuaj, suav nrog kev sib dhos, cov kev txwv tsis pub, microbator thiab lwm yam ntsuas. Tsuas yog cov ntsiav tshuaj uas ua tau raws li cov qauv zoo tuaj yeem tso tawm los ntawm lub hoobkas.
Kev ceev faj thaum lub sijhawm tsim qauv
Kev tswj hwm ib puag ncig
Kev tsim cov fenbendazole ntsiav tshuaj yuav tsum tau nqa tawm hauv ib puag ncig huv kom tsis txhob muaj microbial paug. Kev cob qhia ntau lawm yuav tsum ntxuav thiab tua kab mob, thiab cov neeg ua haujlwm yuav tsum hnav khaub ncaws ua haujlwm huv thiab hnab looj tes.
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Khoom tu thiab tu
Cov khoom siv ntau lawm yuav tsum tu ncua tsis tu ncua thiab tswj kom muaj kev ua haujlwm ib txwm muaj thiab cov khoom lag luam zoo. Equipment cleaning should follow the corresponding cleaning procedures to avoid cross-contamination.
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Txheej txheej parameter tswj
Thaum lub sijhawm cov txheej txheem tsim khoom xws li cov kev sib xyaw ua ke, ziab khaub ncaws
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Cov ntaub ntawv thiab traceability
Cov ntaub ntawv ntxaws ntxaws yuav tsum tau muab khaws cia thaum lub sijhawm tsim khoom, xws li cov ntaub ntawv siv cov lag luam uas tau tsim nyog, thiab tshawb xyuas cov haujlwm tau tsim nyog thiab tshawb xyuas thaum tsim nyog.
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Kev tiv thaiv ib puag ncig thiab kev txhim kho kom ruaj khov
Thaum lub sijhawm tsim qauv ntawmFenbendazole tshuaj, saib xyuas yuav tsum tau them rau kev tiv thaiv ib puag ncig thiab kev txhim kho kev loj hlob. Piv txwv li, ib puag ncig cov kuab tshuaj thiab kev txuag tau tuaj yeem raug coj los txo qhov cuam tshuam rau ib puag ncig. Txhim kho cov txheej txheem ntau lawm los txhim kho tus nqi ntawm cov ntaub ntawv raw thiab ua haujlwm ntawm kev siv zog siv hluav taws xob; Ntxiv dag zog rau kev kho thiab rov ua dua ntawm cov khib nyiab, thiab lwm yam.
Txoj kev rau cov ntsiab lus txiav txim siab
Kev ua kom zoo ua kua chromatography (HPLC)
Kev ua kom zoo ua kua chromatography yog lub ntsiab rau kev txiav txim siab cov ntsiab lus ntawm fenbendivity, qhov tseeb ntawm qhov tseeb thiab kev sib cais zoo thiab kev sib cais siab.
Qauv Qauv Pretreatment
Extraction: Coj tus nqi tsim nyog ntawm Fenbendazole ntsiav tshuaj, muab nws cov kuab tshuaj, co kom yaj, lim, thiab noj cov tshuaj ua haujlwm.
Kev npaj cov tshuaj: Qhov hnyav hnyav ntawm Fenbendazole siv cov khoom, yaj nws los npaj cov tshuaj tsis haum ntawm qee qhov kev xav tau.
Chromatographic mob
Chromatographic kem: feem ntau siv C18 Reversed-}} page {} 4.6mm, 3.5μm) lossis chromatographic txhua yam ntawm kev ua tau zoo.
Mobile theem: Feem ntau, methanol - dej system yog saws. Qhov kev faib ua feem yuav hloov kho raws li qhov xwm txheej tiag tiag, xws li methanol -0.5% (w / v) sodium dihydrfate (w / v) sodium dihorulfate (aws nrog phosphoric acid) (40:60), thiab lwm yam), thiab lwm yam.
Kev Tshawb Nrhiav Wavelength: Feem ntau yog ib txwm nyob ib puag ncig 290nm. Kuj tseem muaj cov lus tshaj tawm ntawm kev siv wavelengths xws li 294nM thiab 280nM rau kev kuaj pom. Qhov tshwj xeeb yoj tau xaiv raws li ultraviolet nqus cov yam ntxwv ntawm cov tshuaj.
Flow tus nqi: Feem ntau 1.0ml ib feeb.
Kab kub: feem ntau tau teeb tsa ntawm 25℃lossis 30 degree.
Kev txiav txim txoj kev
Raug ntsuas qee yam ntim ntawm cov kev ntsuas ntsuas thiab cov lus qhia daws tau, txhawm rau rau hauv cov kua chromatograph, thiab sau cov chromatogram.
Cov ntsiab lus ntawm Fenbendazole hauv cov qauv kuaj tau muab xam los ntawm qhov chaw siab tshaj raws li tus qauv sab nraud.
Ultraviolet - pa tawm pom spectrophotometry
Ultraviolet {{0 {{} pom kev pom tau zoo rau cov ntsiab lus kev txiav txim siab ntawm Fenbendazole ntsiav tshuaj, thiab kev ua haujlwm kuj yooj yim.
Qauv Qauv Pretreatment
Coj tus nqi tsim nyog ntawm fenbendazole ntsiav tshuaj, zom lawv cov nyiaj, muab cov tshuaj me me, co cov kuab tshuaj, co kom huv, thiab noj cov tshuaj ua haujlwm.
Raug ntsuas ntsuas qhov tsim nyog ntawm cov tshuaj uas tsim nyog thiab txhawb nws ntxiv nrog kev daws teeb meem los npaj kev daws teeb meem ntawm qee qhov kev xav tau.
Kev txiav txim txoj kev
Siv cov kuab tshuaj raws li qhov khoob, nqus ntawm kev ntsuas kev ntsuas yog txiav txim siab ntawm lub nthwv dej uas tau hais tseg (xws li 294nm ± 2nm).
Cov ntsiab lus ntawm Fenbendazole hauv cov qauv kuaj tau suav tau suav raws li cov coefficient (e) ntawm c15h13n3o.
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Cov hau kev rau kev tshuaj xyuas
Cov tshuaj muaj feem cuam tshuam hauvFenbendazole tshuajFeem ntau suav nrog impurity a, impurity b, etc. Cov tshuaj impurities yuav cuam tshuam qhov ua tau zoo thiab kev nyab xeeb thiab lawv yuav tsum tau tshuaj xyuas thiab tswj tau.
Kev ua kua siab ua kua chromatography
Qauv Qauv Pretrealment: Qauv ua piv txwv kev ua haujlwm hauv kev txiav txim siab ntawm tib cov ntsiab lus, npaj cov tshuaj sim.
Kev npaj ntawm kev tswj cov kev daws teeb meem: ntsuas yog qhov tsim nyog ntawm kev ntsuas daws thiab dilute los npaj kev tswj hwm ntawm qee qhov kev xav tau.
Chromatographic mob: txiav txim siab zoo ib yam, tab sis kev sib faib ntawm cov yam ntxwv ntawm cov khoom siv uas cuam tshuam los txhim kho kev daws teeb meem ntawm cov tshuaj tseem ceeb los ntawm cov khoom siv tseem ceeb.
Kev txiav txim txoj kev: ntsuas qee qhov ntim ntawm cov tshuaj ntsuas thiab siv cov chromatograph kom txog thaum lub sijhawm rov ua dua yog ob zaug lossis peb zaug. Yog tias muaj impurity peaks nyob rau hauv cov chromatogram ntawm kev ntsuas ntsuas, thaj tsam ntawm txhua qhov kev tsis sib haum xeeb yuav tsis pub tshaj ob zaug lub ntsiab ntawm cov kev daws teeb meem.
Txoj kev rau Kev Txiav Txim Siab
Kev tshem tawm tus nqi yog hais txog qhov nrawm thiab qhov uas ib qho tshuaj yaj uas dissolves los ntawm kev npaj raws li cov kev cai tshwj xeeb rau kev ntsuas cov ntsiav tshuaj zoo.
Kev Txhuam Nruab Nrab
Feem ntau siv cov lus qhia tsis sib xws yog cov tshuaj muaj roj ntsha Hydrodoric (9 → 1000), thiab lwm yam.
Cov Qauv Piav Qhia
Feem ntau, cov pob tawb txoj kev los yog lub duav tau saws, thiab kev siv nrawm yog feem ntau 50 lossis 100 lub sij hawm ib feeb.
Kev txiav txim txoj kev
Coj tus nqi tsim nyog ntawm Fenbendazole ntsiav tshuaj thiab muab lawv tso rau hauv lub pob tawb lossis lub khob sib cais ntawm cov lej sib cais. Ntxiv cov kev teev tseg ntawm kev sib cais nruab nrab thiab ua cov kev xeem sib cais ntawm qhov kub ntawm 37℃± 0.5 degree.
Cov qauv raug coj los ntawm cov ntsiab lus sijhawm (xws li 15 feeb, 30 feeb, 500 feeb, 60 feeb, 60 feeb, 60 feeb, 500 feeb los ntawm 0.8μm microstrate yog coj raws li kev ntsuas ntsuas.
Cov concentration ntawm fenbendazole hauv kev sim daws tau txiav txim siab ua kua chromatography lossis ultraviolet {{} {tus nqi ntawm txhua cov ntsiav tshuaj tau muab xam.
Cov Txheej Txheem Qhia Ntawv
Ultraviolet - pa tawm pom spectrophotometry
Qauv Qauv Pretreatment
Coj tus nqi tsim nyog ntawm fenbendazole ntsiav tshuaj, zom lawv cov nyiaj, muab cov tshuaj me me, co cov kuab tshuaj, co kom huv, thiab noj cov tshuaj ua haujlwm.
Kev txiav txim txoj kev
Qhov nqus tau ntawm cov kev ntsuas daws tau txiav txim siab ntawm wavelengths tshwj xeeb (xws li 218nm ± 2nm thiab 294nm ± ntev) siv cov kuab tshuaj raws li seem. Fenbendazole yuav tsum muaj qhov siab tshaj plaws ntawm cov wavelengths.
Tshuaj Ntsuam Xyuas Kev
Hnov mob nrog sodium hydroxide tov
Siv li 25mg ntawm cov khoom no, ntxiv 5ml ntawm cov dej, thiab poob rau hauv sodium hydrium hydroxide daws kom txog thaum nws yaj tag xwb. Tom qab ntawd ntxiv 1 mus rau 2 tee ntawm tooj liab sulfate daws, thiab cov pa roj ntsuab nag cua yuav raug tsim tam sim.
Hnov mob nrog p - dimethylaminobakalenzaldehyde daws
Siv 25mg ntawm cov khoom no, tso nws hauv kev sim tube, ntxiv 2.5ml ntawm ethanol kom yaj nws, thiab tom qab ntawd} dimosylaminaldehde kev daws teeb meem ntawm lub raj phab ntsa raj. Tam sim ntawd qhia tau Ntsuab thiab maj mam hloov liab.
Lwm txoj kev analytical
Kev txiav txim txoj kev ntawm kev ziab hnyav poob
Nqa cov khoom no thiab qhuav nws ntawm 105℃rau 3 teev. Lub cev yuag yuav tsis pub tshaj 1.0% txhawm rau tshawb xyuas cov ntsiab lus ntawm cov dej noo lossis lwm cov tshuaj uas tsis muaj zog hauv cov tshuaj.
Kev txiav txim txoj kev ntawm incineration residue
Coj tus nqi tsim nyog ntawm cov khoom lag luam no thiab ua tus xeem raws li txoj kev. Cov seem seem yuav tsum tsis pub dhau ib qho kev txwv (xws li 0.1% los xyuas cov inorganic immurities hauv cov tshuaj.
Txoj kev ntsuam xyuas hnyav hlau
Nqa cov seem sab laug hauv qab ntawm cov chaw nyob hauv nruab nrab thiab xyuas nws raws li txoj cai. Cov ntsiab lus ntawm cov hlau hnyav yuav tsum tsis pub tshaj 20 feem ib lab los ua kom muaj kev nyab xeeb ntawm cov tshuaj.
Keeb kwm ntawm Fenbendazole ntsiav tshuaj yog qhov pom tseeb thiab lub sijhawm muaj kev sib tw ntawm cov tsiaj muaj kev nyab xeeb rau hauv thaj chaw grey ntawm tib neeg kev noj qab haus huv.
Xyoo 1944, cov kws tshawb nrhiav thawj cov khoom siv tseem ceeb ntawm Benzimidazole, tab sis nws cov kev ua haujlwm muaj roj ntsha tsis to taub tag nrho.
Xyoo 1961: ib qho kev hloov pauv tseem ceeb tau tshwm sim. Cov kws tshawb fawb los ntawm merck tau pom thiab tsim cov thiebendazole, thawj zaug ua lag luam tau zoo benzimidazole tshuaj tua kab hauv keeb kwm. Nws txoj kev vam meej yog zoo li lub suab ntawm tus neeg pib, tshaj tawm rau kev lag luam thoob ntiaj teb uas Benzimidazole yog ib lub peev xwm infinations 'pharmacophore khoom siv tau Trove'. Nws tau lees paub txog qhov ua tau zoo thiab xaiv cov dej ntws los ntawm kev txhim kho cov tshuaj polymerization ntawm txhua qhov zoo sib xws hauv lub neej yav tom ntej thiab teeb tsa lub cim.
Nyob rau hauv lub xyoo 1960s, kws kho mob pib lub system tshuaj noj muaj tshuaj ntsuab hauv chav kuaj mob hoechst A hauv Tebchaws Yelemees. Lawv tau saws cov qauv classic "{- kev ua haujlwm sib raug zoo thiab 5 txoj haujlwm los hloov kho ob pawg ntawm Benzimidazole, synthesizing ntau pua ntawm derivatives.
Nyob ib ncig ntawm 1970, ib qho compound nrog cov code npe hoe 881V ua tshwj xeeb tshwj xeeb hauv cov vitro thiab hauv Vivo tshuaj ntsuam ntawm ntau tus neeg sib tw ntawm ntau tus neeg sib tw. Nws cov qauv tshuaj tau txiav txim siab los ua methyl [5 {}} (penzimidazol-2-yl] carbamate - uas tom qab ua fenbendazate.
Xyoo 1971-1973: Hemst Corporation thov rau kev tiv thaiv patent rau Fenbendazole hauv Tebchaws Meskas thiab Tebchaws Europe), tso cov kev cai lij choj thoob ntiaj teb rau nws txoj kev ua lag luam.
Xyoo 1974, Fenbendazole tau pom zoo thawj zaug kev lag luam hauv lub teb chaws Yelemees, tsuas yog siv rau kev tswj hwm cov roj ntsha xws li nyuj thiab yaj. Nws qhov kev sib tw tam sim ntawd ntes cov xim ntawm kev lag luam.
Xyoo 1975 thiab dhau: Fenbendazole nrawm nkag mus hauv lub lag luam thoob ntiaj teb. Nws tau ua pov thawj yuav ua tau zoo rau cov neeg laus, cov kab menyuam, thiab txawm tias cov qe ntawm ntau yam cab, thiab muaj kev nyab xeeb rau tus tswv tsev. Nws cov dav -} Efficiency, thiab cov tshuaj lom neeg lom zem sai sai ua nws ib qho uas nyiam cov txiv neej cov txiv neej cov tshuaj thiab tus khub tsiaj.
Thoob plaws xyoo 1980s, thaum lub sijhawm Patentent lub sijhawm ntawm Fenbendazole, Hemet corporation nyiam qhov sib faib ntawm kev ua lag luam muaj kev ua lag luam. Txhawm rau kom tau raws li cov kev xav tau sib txawv, lub tuam txhab tau tsim ntau yam tshuaj noj thiab cov tshuaj noj uas muaj tseeb, tshwj xeeb yog tsim nyog rau cov tsiaj txhu ntawm tus kheej xws li dev, miv, thiab nees. Nyob rau lub sijhawm no, Fenbendazole khov kho nws txoj hauj lwm raws li tus qauv "Kub" hauv Benzimidazole cov tshuaj.
Cim npe nrov: Fenbendazole tshuaj, lwm tus neeg, chaw tsim khoom, Hoobkas, lag luam Wholesale, yuav, nqe, loj, loj, rau muag