Pimobendan ntsiav tshuaj, uas yog ib hom tshuaj mob plawv tsis ua hauj lwm uas yog nyob rau hauv cov chav kawm uas tsis yog glycoside ntawm lub plawv stimulants. Nws yog ib qho siv dav thiab tshwj xeeb pharmacological tshuaj nyob rau hauv veterinary teb, feem ntau yog siv los kho cov kab mob plawv. Nws lub npe Askiv yog Pimobendan, thiab cov khoom npe yuav txawv nyob ntawm cov tuam txhab sib txawv, xws li Boehringer Ingelheim ® Tos. Hauv daim ntawv thov kev kho mob, Pimobendan feem ntau yog siv los kho mob plawv tsis ua hauj lwm hauv dev, tshwj xeeb tshaj yog lub plawv tsis ua hauj lwm thib ob rau dilated cardiomyopathy lossis mob mitral valve insufficiency. Lawv tuaj yeem txhim kho myocardial contractility, txhim kho lub plawv ua haujlwm, txhim kho lub neej zoo ntawm cov dev cuam tshuam, thiab ua kom lub neej ntev. Rau cov dev uas muaj kab mob mucinous / degenerative mitral valve, nws kuj tuaj yeem txo qis lub nra ntawm lub ventricular los ntawm mitral valve insufficiency, txhim kho kev ua haujlwm ntawm lub plawv, thiab txhim kho cov tsos mob thiab kev kuaj mob.
Txawm li cas los xij, thaum siv cov khoom, nws yog ib qho tsim nyog yuav tsum tau ua raws li cov kws kho tsiaj cov lus qhia, txiav txim siab txog kev siv tshuaj thiab kev tswj hwm raws li tus dev qhov hnyav thiab mob, thiab ua tib zoo saib xyuas tus dev cov tshuaj tiv thaiv kom ntseeg tau tias cov tshuaj muaj kev nyab xeeb thiab ua haujlwm zoo.
Cov specifications ntawmPimobendan ntsiav tshuajFeem ntau yog 1.25mg, 2.5mg, thiab 5mg. Hauv qab no yog cov lus qhia ntxaws ntxaws rau cov specifications no:
1.25mg specification
Lub hom phiaj cov neeg tuaj saib:
Haum rau cov dev nrog lub cev hnyav dua, xws li cov dev cov khoom ua si thiab cov dev me.
Kev siv thiab ntau npaum li cas: Rau cov dev uas hnyav li 5kg, muab 1.25mg chewable ntsiav tshuaj thaum sawv ntxov thiab yav tsaus ntuj.
2.5mg specification
Lub hom phiaj cov neeg tuaj saib:
Haum rau me me thiab nruab nrab - dev.
Kev siv thiab ntau npaum: Rau cov dev uas hnyav li 10kg, muab ib ntsiav tshuaj 2.5mg chewable txhua tag kis sawv ntxov thiab yav tsaus ntuj.
5mg specification
Lub hom phiaj cov neeg tuaj saib:
Haum rau nruab nrab rau cov dev loj.
Kev siv thiab ntau npaum: Rau cov dev uas hnyav li 20kg, muab 5mg chewable ntsiav tshuaj thaum sawv ntxov thiab yav tsaus ntuj.
Specification yam ntxwv thiab kev xa tshuaj yooj yooj yim
Scratch design: Chewing ntsiav tshuaj feem ntau muaj cov kab kos uas tuaj yeem tawg ua ob thiab ib nrab daim, ua kom nws yooj yim dua los kho qhov ntau npaum li cas raws li tus dev qhov hnyav.
Cov koob tshuaj ntau npaum li cas: Cov koob tshuaj txhua hnub feem ntau yog 0.2 ~ 0.6mg / kg lub cev qhov hnyav, thiab qhov koob tshuaj zoo tshaj plaws yog 0.5mg / kg lub cev hnyav.
Cia thiab hnub tas sij hawm
Cia tej yam kev mob: Nws yuav tsum tau muab kaw thiab khaws cia rau hauv qhov chaw qhuav hauv qab 25 degree.
Lub sijhawm siv tau: Lub sijhawm siv tau yog 36 lub hlis thaum tsis qhib, thiab nws yuav tsum siv li ntawm 100 hnub tom qab qhib.
Peb cov khoom
Cov ntaub ntawv ntxiv ntawm chemical compound:
| Khoom npe | Pimobendan Capsule | Pimobendan Txhaj | Pimobendan ntsiav tshuaj |
| Yam khoom | Capsule | Txhaj tshuaj | Cov ntsiav tshuaj |
| Khoom Purity | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% |
| Khoom Specifications | Customizable | Customizable | Customizable |
| Pob khoom | Customizable | Customizable | Customizable |
Peb Cov Khoom
Pimobendan+. COA
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Certificate of Analysis |
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Compound npe |
Pimobendan | |
|
CAS Nr. |
74150-27-9 | |
|
Qib |
Pharmaceutical qib | |
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Ntau |
Customized | |
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Ntim txheem |
Customized | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
|
Ntau No. |
20250109001 |
|
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MFG |
Jan 12th 2025 |
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EXP |
Jan 8th 2029 |
|
|
Qauv |
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| TEST STANDARD | GB/T24768-2009 Kev lag luam. Stnndard | |
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Yam khoom |
Enterprise txheem |
Kev txheeb xyuas qhov tshwm sim |
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Qhov tshwm sim |
Dawb los yog yuav luag dawb hmoov |
Ua raws |
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Cov ntsiab lus dej |
Tsawg dua lossis sib npaug li 4.5% |
0.30% |
| Poob rau ziab |
Tsawg dua lossis sib npaug li 1.0% |
0.15% |
|
Hnyav Hlau |
Pb Tsawg dua lossis sib npaug li 0.5ppm |
N.D. |
|
Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
|
Hg Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
|
Cd Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
|
Purity (HPLC) |
Ntau dua lossis sib npaug li 99.0% |
99.5% |
|
Ib leeg impurity |
<0.8% |
0.48% |
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Residue ntawm ignition |
<0.20% |
0.064% |
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Tag nrho microbial suav |
Tsawg dua lossis sib npaug li 750cfu / g |
80 |
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E. Coli |
Tsawg dua lossis sib npaug li 2MPN / g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (los ntawm GC) |
Tsawg dua lossis sib npaug li 5000ppm |
400ppm ua |
|
Cia |
Khaws rau hauv qhov chaw kaw, tsaus thiab qhuav ntawm -20 degrees |
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Clinical daim ntawv thov thiab indications
(1) Kev siv tib neeg
Hauv tib neeg cov tshuaj,pimobendan ntsiav tshuajFeem ntau yog siv los kho lub plawv tsis ua haujlwm los ntawm atrioventricular valve insufficiency lossis myocardial hypertrophy. Rau cov neeg mob uas tseem tsis tuaj yeem ua tiav cov txiaj ntsig kho tau zoo tom qab cov kev kho mob yooj yim xws li digitalis thiab diuretics, muaj kev xaiv kho tau zoo.
(3) Indication extension
Raws li kev tshawb fawb txuas ntxiv mus, cov lus qhia rau pimobendan tuaj yeem nthuav dav ntxiv. Piv txwv li, qee zaum, pimobendan yog siv los kho preclinical dilated cardiomyopathy lossis myxomatous mitral valve kab mob kom ncua qhov pib ntawm lub plawv tsis ua hauj lwm lossis kev tuag sai.
(2) Veterinary daim ntawv thov
Hauv kev lag luam kws kho tsiaj, pimobendan chewable ntsiav tshuaj (xws li buxinding) ®) Dav siv los kho mob plawv tsis ua hauj lwm hauv dev, tshwj xeeb tshaj yog lub plawv tsis ua hauj lwm thib ob rau dilated cardiomyopathy (DCM) lossis mob mitral valve insufficiency (CMVI). Tsis tas li ntawd, pimobendan kuj tuaj yeem siv los kho cov kab mob mucinous / degenerative mitral valve (MMVD / DMVD) hauv cov dev, txhim kho lub neej zoo thiab ua kom lub neej ntev ntawm cov dev cuam tshuam.
Pimobendan ntsiav tshuaj, raws li ib tug dav siv tshuaj rau kev kho mob ntawm cov hlab plawv cov kab mob, muaj ib tug complex thiab ntau yam mechanism ntawm kev txiav txim, nrog rau cov kev cai ntawm ntau yam physiological txheej txheem.
(1) Calcium ion rhiab heev tswj
Yuav txhim khu lub rhiab heev ntawm myocardial fibers rau calcium ions. Calcium ions ua lub luag haujlwm tseem ceeb hauv cov txheej txheem ntawm myocardial cell contraction, raws li lawv khi rau troponin thiab ua rau cov nqaij ntshiv zawv zawg, yog li ua tiav myocardial contraction. Los ntawm kev tswj cov calcium ion ntsig txog kev taw qhia txoj hauv kev hauv cov hlwb myocardial, lawv muaj peev xwm tsim kom muaj zog contractility txawm tias qis calcium ion concentrations. Cov tshuaj calcium rhiab heev no tsis tso siab rau qhov nce ntxiv ntawm calcium ion concentration, yog li nws tsis ua rau kom cov pa oxygen ntau ntxiv hauv myocardial, tsis txhob muaj kev pheej hmoo ntawm myocardial ischemia uas cov tshuaj inotropic zoo ib txwm tuaj yeem nqa tau.
Custom Notebook Solutions
(2) Phosphodiesterase III (PDE3) inhibition
Nws yog ib qho tsis xaiv phosphodiesterase III inhibitor. PDE3 yog dav nyob rau hauv cardiomyocytes thiab vascular du leeg hlwb, thiab nws lub luag haujlwm tseem ceeb yog catalyze hydrolysis ntawm cyclic adenosine monophosphate (cAMP). CAMP yog tus xa xov tseem ceeb thib ob uas ua lub luag haujlwm tseem ceeb hauv kev hloov cov teeb liab intracellular. Nws txo qis qhov degradation ntawm cAMP los ntawm inhibiting cov haujlwm ntawm PDE3, ua rau muaj kev nce hauv intracellular cAMP concentration. Qhov nce hauv cAMP concentration tuaj yeem ua kom muaj protein ntau kinase A (PKA), yog li txhawb kev tso tawm calcium ions hauv myocardial hlwb thiab txhawb nqa cov calcium ions los ntawm sarcoplasmic reticulum, txhim kho myocardial contractility. Nyob rau tib lub sijhawm, PKA tuaj yeem phosphorylate ntau cov proteins hauv cov hlwb myocardial, tswj lawv cov kev cog lus thiab so haujlwm.
(1) Vascular smooth nqaij so
Nws muaj ib tug ncaj relaxing nyhuv rau vascular du leeg hlwb. Los ntawm inhibiting PDE3 hauv vascular du leeg hlwb thiab nce intracellular cAMP concentration, cAMP tuaj yeem qhib PKA, uas ntxiv phosphorylates ntau cov proteins hauv vascular du leeg hlwb, ua rau vascular du leeg so thiab vasodilation. Cov nyhuv vasodilation no tuaj yeem txo qhov ua ntej - thiab xa khoom ntawm lub plawv, txo nws txoj haujlwm, thiab txhim kho lub plawv ua haujlwm. Rau cov neeg mob uas muaj lub plawv tsis ua haujlwm, vasodilation tuaj yeem ua rau lub plawv dhia thiab txo cov tsos mob xws li dyspnea thiab edema.
(2) Txhim kho microcirculation
Cov nyhuv vasodilatory ntawmPimobendan ntsiav tshuajtsis tas rau cov hlab ntsha loj, tab sis kuj tuaj yeem txhim kho microcirculation. Microcirculation yog qhov chaw tseem ceeb rau kev sib pauv khoom ntawm cov ntshav thiab cov ntaub so ntswg. Cov kab mob microcirculation tuaj yeem ua rau muaj ntau yam teeb meem xws li cov ntaub so ntswg hypoxia thiab cov kab mob metabolic. Los ntawm dilating microvessels, ua kom microcirculation ntshav txaus, txhim kho cov ntaub so ntswg oxygen thiab khoom noj khoom haus, thiab txhawb cov ntaub so ntswg kho thiab rov tsim dua tshiab. Microcirculatory dysfunction yog ib qho ntawm cov kev hloov pauv pathophysiological hauv cov neeg mob uas muaj lub plawv tsis ua haujlwm, thiab nws cov txiaj ntsig microcirculatory txhim kho pab txhim kho kev noj qab haus huv tag nrho ntawm cov neeg mob.
(1) Inhibit sympathetic paj hlwb excitation
Nws muaj qee yam beta receptor thaiv cov nyhuv thiab tuaj yeem cuam tshuam qhov excitation ntawm lub paj hlwb sympathetic. Thaum lub paj hlwb zoo siab heev, nws tso tawm cov neurotransmitters xws li norepinephrine, uas ua rau cov beta receptors hauv lub plawv thiab cov hlab ntsha, ua rau lub cev muaj zog xws li nce plawv dhia, txhim kho myocardial contractility, thiab vascular constriction. Nyob rau hauv cov kab mob plawv xws li lub plawv tsis ua hauj lwm, kev ua siab ntev ntawm lub paj hlwb tuaj yeem ua rau lub nra hnyav ntxiv rau lub plawv thiab txhawb txoj kev loj hlob ntawm cov kab mob. Los ntawm kev thaiv cov beta receptors, txo qhov kev ua ntawm norepinephrine, txo lub plawv dhia thiab ntshav siab, txo cov plawv dhia, thiab txhim kho plawv kev ua haujlwm.
(2) Antiarrhythmic kev kho mob
Beta receptor blockade kuj muaj cov teebmeem antiarrhythmic. Arrhythmia yog ib qho teeb meem ntawm cov kab mob plawv, thiab mob arrhythmias hnyav tuaj yeem ua rau lub neej muaj kev hem thawj xws li mob plawv. Los ntawm inhibiting receptors, txo cov autonomy thiab excitability ntawm myocardial hlwb, thiab txo cov excitation ntawm ectopic atherosclerosis cov ntsiab lus, arrhythmia tuaj yeem tiv thaiv thiab kho. Tsis tas li ntawd, beta receptor blockade tuaj yeem ua kom ntev lub sijhawm refractory zoo ntawm myocardial hlwb, txo qhov tshwm sim ntawm reentry excitation, thiab txo qhov kev pheej hmoo ntawm arrhythmia.
(1) inhibit myocardial hypertrophy
Kev kho plawv yog ib qho tseem ceeb ntawm cov txheej txheem pathophysiological hauv kev txhim kho cov kab mob plawv xws li lub plawv tsis ua haujlwm, thiab myocardial hypertrophy yog ib qho tseem ceeb ntawm kev kho plawv. Txawm hais tias myocardial hypertrophy tuaj yeem them rov qab rau qhov poob ntawm lub plawv ua haujlwm rau qee qhov, ntev -lub sij hawm myocardial hypertrophy tuaj yeem ua rau muaj qhov tshwm sim tsis zoo xws li myocardial cell apoptosis thiab fibrosis, ua rau lub plawv tsis ua haujlwm ntxiv. inhibit kev loj hlob ntawm myocardial hypertrophy los ntawm ntau lub tshuab. Ntawm qhov tod tes, nws cov txiaj ntsig zoo inotropic tuaj yeem txhim kho kev ua haujlwm ntawm lub plawv, txo cov plawv dhia, thiab yog li txo qis cov kev txhawb nqa ntawm myocardial hypertrophy; Ntawm qhov tod tes, beta receptor blockade thiab vasodilation cuam tshuam ntawm pimobendan tuaj yeem txo cov ntshav siab thiab lub plawv dhia, txo qis myocardial oxygen noj, inhibit qhov kev loj hlob thiab kev loj hlob ntawm myocardial hlwb, thiab ncua cov txheej txheem ntawm myocardial hypertrophy.
(2) Txhim kho plawv diastolic muaj nuj nqi
Diastolic dysfunction kuj yog ib qho tseem ceeb ntawm kev kho mob plawv, uas tuaj yeem ua rau lub plawv tsis ua haujlwm thiab txo cov ntshav siab. Nws tuaj yeem txhim kho cov haujlwm diastolic ntawm lub plawv. Los ntawm kev txhim kho qhov rhiab heev ntawm myocardial fibers rau calcium ions, myocardial cells tuaj yeem tso calcium ions sai dua thaum lub sijhawm diastole, txhawb kev so ntawm myocardial. Nyob rau tib lub sijhawm, cov nyhuv vasodilatory ntawm pimobendan tuaj yeem txo cov preload ntawm lub plawv, txo cov ntshav siab ntawm lub plawv, thiab pab txhawb kev so ntawm lub plawv. Kev txhim kho diastolic muaj nuj nqi tuaj yeem txhim kho kev ua haujlwm ntawm lub plawv, ua kom lub plawv tso zis, thiab txhim kho cov tsos mob ntawm tus neeg mob thiab kev kuaj mob.
(1) Kev siv ua ke nrog cov tshuaj diuretics
Hauv kev kho mob plawv tsis ua haujlwm, diuretics feem ntau siv ua ke. Diuretics tuaj yeem txo qis kev tuav dej thiab sodium hauv lub cev thiab txo qhov preload ntawm lub plawv los ntawm kev txhawb nqa cov zis tso zis.Pimobendan ntsiav tshuajntxiv txhim kho lub plawv ua haujlwm los ntawm kev txhim kho myocardial contractility thiab dilating cov hlab ntsha. Kev sib xyaw ua ke ntawm ob tuaj yeem sib koom ua ke kom txo tau lub plawv dhia, txhim kho lub plawv ua haujlwm, thiab txhim kho kev kho mob. Piv txwv li, rau preclinical myxomatous mitral valve kab mob hauv dev (asymptomatic systolic mitral valve yws thiab mob plawv), kev sib xyaw ntawm pimobendan thiab diuretics xws li furosemide tuaj yeem txhim kho lub neej zoo thiab ua kom lub neej ntev ntawm cov dev cuam tshuam.
(2) Kev siv ua ke nrog angiotensin - hloov pauv enzyme inhibitors (ACEIs) lossis angiotensin II receptor antagonists (ARBs)
ACEI thiab ARB tuaj yeem txo cov ntshav siab, txo qis kev mob plawv tom qab, thiab inhibit myocardial remodeling los ntawm inhibiting renin angiotensin aldosterone system (RAAS). Kev sib xyaw ua ke ntawm ACEI lossis ARB tuaj yeem ua rau nws cuam tshuam los ntawm cov txheej txheem sib txawv, ua ke txhim kho kev ua haujlwm ntawm lub plawv thiab ncua kev ua haujlwm ntawm lub plawv tsis ua haujlwm. Qhov kev sib xyaw ua ke no tau siv dav hauv kev kho mob thiab tau ua tiav cov txiaj ntsig zoo.
Clinical tseem ceeb ntawm lub mechanism ntawm kev txiav txim
(1) Txhim kho cov tsos mob ntawm lub plawv tsis ua hauj lwm
Los ntawm ntau yam txheej txheem hais los saum toj no, cov tsos mob ntawm cov neeg mob plawv tsis ua haujlwm tuaj yeem txhim kho tau zoo. Nws tuaj yeem ua rau lub plawv tso zis ntau ntxiv, txo qis ua ntej - thiab tom qab lub plawv dhia, txo cov tsos mob xws li mob plab, edema, thiab qaug zog, thiab txhim kho cov neeg mob lub neej zoo. Rau congestive plawv tsis ua hauj lwm nyob rau hauv cov dev, tshwj xeeb tshaj yog cov thib ob rau dilated cardiomyopathy (DCM) los yog mitral valve insufficiency (CMVI), nws muaj peev xwm txhim khu myocardial contractility, txo ua ntej - thiab postcardiac load, txhim kho plawv muaj nuj nqi, txhim khu lub neej zoo ntawm cov dev cuam tshuam, thiab ntev lub neej expectancy.
(2) ncua kev kis kab mob
Cov nyhuv inhibitory ntawm kev kho plawv tuaj yeem ncua kev loj hlob ntawm cov kab mob plawv xws li lub plawv tsis ua haujlwm. Los ntawm inhibiting myocardial hypertrophy thiab txhim kho diastolic muaj nuj nqi, nws tuaj yeem txo qis kev hloov pauv ntawm lub plawv thiab tswj nws cov qauv thiab kev ua haujlwm. Qhov no yog qhov tseem ceeb tshaj plaws rau kev txhim kho lub sijhawm ntev - kev kwv yees ntawm cov neeg mob.
(3) Txhim kho tus neeg mob ciaj sia
Cov kev tshawb fawb soj ntsuam tau pom tias kev siv pimobendan tuaj yeem txo qis kev tuag ntawm cov neeg mob plawv. Nws multifaceted mechanisms ua hauj lwm ua ke los txhim kho lub plawv muaj nuj nqi, txo qhov tshwm sim ntawm cov kab mob plawv, thiab yog li ua rau kom cov ciaj sia taus ntawm cov neeg mob. Hauv kev kho mob ntawm preclinical dilated cardiomyopathy (asymptomatic, kuaj pom los ntawm echocardiography nrog nce sab laug ventricular kawg systolic thiab kawg diastolic diameters) hauv cov dev, pimobendan tuaj yeem ncua lub hnub nyoog ntawm lub plawv tsis ua haujlwm lossis kev tuag sai sai hauv cov dev thiab ncua sijhawm lawv txoj sia nyob.
Cov lus nug nquag
Dab tsi yog tib neeg sib npaug ntawm pimobendan?
+
-
Enalapril lossis pimobendan (cov khoom xyaw nquag hauv Vetmedin®) tuaj yeem muab ua cov tshuaj ib leeg, tab sis lawv feem ntau siv ua ke los tswj kab mob plawv. Enalapril yog FDA- pom zoo rau tib neeg siv raws li hom npe Epaned® thiab Vasotec® thiab raws li generic enalapril.
Pimobendan ua dab tsi rau tus dev?
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Pimobendan yog dab tsi? Pimobendan (lub npe npe Vetmedin®) yog cov tshuaj plawv siv los kho cov dev uas muaj lub plawv tsis ua hauj lwm (CHF) feem ntau tshwm sim los ntawm dilated cardiomyopathy lossis valvular insufficiency.
Pimobendan puas ntsws ntsws?
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Pimobendan tau pom tias nce aortic flow velocity thiab fractional shortening thaum txo qis ventricular loj nyob rau hauv cov dev noj qab haus huv nrog lub ncov los ntawm 2 thiab 5 h tom qab noj qhov ncauj (16, 17).
Pimobendan puas ua rau dev nkees?
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VETMEDIN® (pimobendan) Chewable Tablets thiab VETMEDIN® Solution (pimobendan qhov ncauj tov) yog siv rau cov dev uas muaj pov thawj ntawm kev kho mob plawv nkaus xwb. Cov kev mob tshwm sim tshaj plaws uas tau tshaj tawm hauv cov kev tshawb fawb teb yog kev noj qab haus huv tsis zoo, qaug zog, raws plab, dyspnea, azotemia, tsis muaj zog, thiab ataxia.
Cim npe nrov: pimobendan ntsiav tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom