Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov khoom lag luam thiab cov khoom lag luam ntawm Ceugiofur ntsiav tshuaj nyob hauv Suav teb. Txais tos rau kev lag luam wholesale loj zoo coeftiofur ntsiav tshuaj rau muag ntawm no los ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Beugiofur ntsiav tshuaj, Suav lub npe yog Ceugiofur, thiab nws cov tshuaj lom neeg lub npe yog [6R {-thia-4-oxo-4-{-thia-5-azabicyclo [4.2.0] Oct-2-en-2-carboxylic acid. Nws cov lus Askiv muaj xws li Ceftiofur dawb acid, ci ntsa iab lub hauv paus yog c19H17n5o7s3, thiab cas tus lej raug nyiag yog 80270-57-67-6. Nws yog xim dawb rau daj ntseg daj uas yog insoluble hauv dej, me ntsis soluble hauv acetone, thiab yuav luag Insoluble hauv ethanol.
Ceftiofur ntsiav tshuaj, tseem hu ua coeftiofur, yog cov ntsiav tshuaj ua los ntawm cov ntsev ua kom zoo nkauj lossis lwm yam kev zam, uas yooj yim rau cov neeg mob los ua qhov ncauj. Nws yuav yog ib qho yees duab nyias nyias yog cov ntsiav tshuaj dispersed, uas ua rau cov neeg mob los kho cov nqi kho tau raws li lawv tus mob. Hauv kev ua lag luam, muaj ntau yam tshwj xeeb, xws li cefotaxime sodium rau kev txhaj tshuaj (ua rau solotaxime hydrochloride (cefotaxime hydrochloride txhaj).
Peb Cov Khoom
Cov ntaub ntawv ntxiv ntawm kev sib txuas lus:
| Khoom npe | Beugiofur ntsiav tshuaj | Beeftiofur Txhaj |
| Khoom Yam | Ntsiav tshuaj | Kev txhaj tshuaj |
| Khoom Siv Purity | HPLC ntau dua los yog sib npaug rau 99.0% | Ntau dua los yog sib npaug rau 99% |
| Cov Khoom Qhia Khoom Khoom | Tau sib kho | Tau sib kho |
| Khoom Pob | Tau sib kho | Tau sib kho |
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Beftiofur +. coa
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Daim Ntawv Pov Thawj Kev Ntsuam Xyuas |
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Compound npe |
CoEttiofur | |
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Cas Tsis tau. |
80370-57-6 | |
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Teem nqi |
Kws Tshuaj Ntsuam Xyuas | |
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Qho ntau |
Me nyuam | |
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Ntim txheem ntim |
Me nyuam | |
| Tus tsim | Shaanxi Bloom Tech Co., Ltd. | |
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Lauj tsis tau. |
20250109001 |
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Mfg |
Jan 12th 2025 |
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Tus txeeb |
Jan 8th 2029 |
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Lub tsev |
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| Kuaj Tus Qauv | GB / T24768-2009 kev lag luam. Stnndard | |
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Yam |
Kev Lag Luam Kev Lag Luam |
Kev tsom xam tau |
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Kev tshwm sim |
Dawb lossis yuav luag dawb hmoov |
Hloov |
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Dej Cov Ntsiab Lus |
Tsawg dua los yog sib npaug rau 4.5% |
0.30% |
| Poob rau ziab |
Tsawg dua los yog sib npaug rau 1.0% |
0.15% |
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Cov hlau hnyav |
PB tsawg dua lossis sib npaug rau 0.5ppm |
N.D. |
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Tsawg tsawg dua li lossis sib npaug rau 0.5ppm |
N.D. | |
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Hg tsawg dua lossis sib npaug rau 0.5ppm |
N.D. | |
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CD tsawg dua lossis sib npaug rau 0.5ppm |
N.D. | |
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Purity (hplc) |
Ntau dua los yog sib npaug rau 99.0% |
99.5% |
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Ib Leeg Cav |
<0.8% |
0.48% |
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Residue ntawm ignition |
<0.20% |
0.064% |
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TAG NRHO LICBIAL COUNT |
Tsawg dua li lossis sib npaug rau 750cfu / g |
80 |
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E. coli |
Tsawg dua los yog sib npaug rau 2mpn / g |
N.D. |
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Tus ntses siav |
N.D. | N.D. |
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Ethanol (los ntawm gc) |
Tsawg dua los yog sib npaug rau 5000ppm |
400ppm |
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Chaw ntim khoom |
Khaws rau hauv ib qho chaw sib khi, qhov chaw tsaus thiab qhuav ntawm-20 degrees |
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Cov ntaub ntawv kho mob thiab cov tshuaj pharmasminetics
Cefuroxime tau nrawm nrawm thiab metabolized nyob rau hauv cov tsiaj, tsim cov metabolite thawj desfuroyl cefidofur (DFC) hauv Plasma. Nws cov lus qhia tawm tsam yog qhov dav dav, xws li cov kab mob tshuaj tua kab mob feem ntau Gram cov kab mob tsis zoo, ruaj khov rau cov yeeb tshuaj tiv thaiv. Nws cov nyhuv antibacterial yog tsuas yog siv tau los ntawm inhibiting synhring synthesis ntawm cov kab ntxwv ntawm cov kab ntxwv. Thaum cov kab mob nkag mus rau hauv lub cev tsiaj, lawv tau nrawm nrawm thiab metabolized, tsim cov metabolite thawj desfuroyl cefidofur (DFC) hauv Plasma. Vim yog lub nplhaib lactac nplhaib, nws cov haujlwm tshuaj tua kab mob yog ib yam nkaus li ntawm Cefotaxime. DFC tuaj yeem ua ntu zus ntxiv DFC cysteine disulfide refounds hauv cov zis, tab sis cov quav nyob hauv 24 teev tom qab txhaj tshuaj tiv thaiv 24 teev tom qab kev txhaj tshuaj.
Cov ntaub ntawv raug mob thiab kev nyab xeeb
Cefotaxime, raws li ib feem peb {{- cov kab mob tsis yooj yim, muaj qhov yooj yim- lactases, muaj qee qhov kev ua xua, thiab cov khoom seem qis hauv cov tsiaj lub cev. Hauv cov tsiaj, cefotaxime tuaj yeem siv tau ntev {{}}} kav cov txiaj ntsig tshuaj tua kab mob.
Beugiofur ntsiav tshuajyog ib feem peb {{- tiam cepharososin tshuaj tua kab mob rau cov tsiaj, siv dav hauv kev ua phem rau kws kho tsiaj. Nws cuam tshuam nrog ntau yam tshuaj. Cov hauv qab no yog kev qhia rau koj:
1. Sib Tham Nrog Glucocortiom Cov Tshuaj
Kev sib xyaw ua ke: Cefotaxime yuav tsum tsis txhob siv ua ke nrog corticosteroids xws li dexamethasone.
Mechanism ntawm Kev Ua: Cefotaxime yog oxidative thiab muaj ntau amino thiab cov pab pawg neeg sawv cev; Dexamethasone muaj kev txo qis thiab muaj ob lub vinyl bonds. Sib tov ob tus tuaj yeem ua rau redox lossis polymerization kev tawm tsam. Nyob rau tib lub sijhawm, cov qauv molecular ntawm cefotaxime muaj ib- lactam nplhaib muaj cov cawv. Nws yuav ua kom nrawm qhib kev qhib ntawm - lactam ntiv nplhaib thiab txo qhov ua tau zoo. Ib qho ntxiv, cov nyhuv ua xua ntawm dexamethasone yuav npog qee qhov kev kho mob phiv, thiab cov tshuaj glucocortoid tuaj yeem cuam tshuam lub cev lub cev.
2. Kev sib cuam tshuam nrog cov tshuaj aminoglycoside
Synergistic nyhuv: kev sib xyaw ua ke ntawm cefotaxime thiab aminoglycoside yeeb tshuaj muaj cov nyhuv synigistic, uas tuaj yeem txhim kho cov nyhuv tua kab mob.
Ceev faj: Txawm li cas los xij, kev sib xyaw ua ke ntawm ob qho nce siab, thiab ceev faj yuav tsum tau ua kom muaj kev ceev faj hauv cov neeg mob lub raum tsis sib xws. Hauv cov ntawv thov kev kho mob, rau cov tsiaj uas muaj cov tshuaj muaj zog tsis txaus, yuav tsum tau zam, thiab cov khoom siv rau cov neeg muag khoom noj tau zoo.
3. Kev cuam tshuam nrog probenecid
Mechanism ntawm Kev Ua: Cefuroxime tuaj yeem ncua lub excretion ntawm Cepetion ntawm Cepetion ntawm Cepetorins thiab nce cov kev xav ntawm Cefotaxime.
Kev saib xyuas qhov tseem ceeb: Qhov no yuav ua rau muaj kev pheej hmoo ntawm Cefotaxime, xws li siv cov tshuaj lom neeg thiab kev ua xua, thiab saib xyuas cov kev sib raug zoo ntawm cov tsiaj.
4. Kev cuam tshuam nrog Coumarin Anticoculants
Mechanism ntawm Kev Ua: Kev ua ke ntawm cefotaxime thiab coumarin anticoagulants txhim kho kev ua ub no anticoagulant kev ua haujlwm.
Cov chaw kho mob tseem ceeb: Qhov no yuav ua rau muaj kev mob ntshav, thiab lwm yam tshuaj kho mob, thiab lwm yam tshuaj kho mob Tshuaj xyuas cov txiaj ntsig kom tsis txhob muaj kev cuam tshuam loj xws li los ntshav.
5. Kev Sib Tham Nrog Cov Tshuaj Tiv Thaiv
Mechanism ntawm Kev Ua: Cefotaxime yog kev ua haujlwm fungicide, thiab cov tshuaj tua kab mob tuaj yeem cuam tshuam cov kab mob ntawm cefotaxime.
Cov chaw kuaj mob pom zoo: Hauv kev kho mob, kev sib xyaw ua ke ntawm cov tshuaj tua kab mob ctefotaxime thiab cov tshuaj tua kab mob yuav tsum zam kom muaj kev cuam tshuam ntawm Cefotaxime.
6. Kev cuam tshuam nrog Collamine
Mechanism ntawm Kev Ua: Kev sib xyaw ua ke ntawm colistin thiab cefotaxime hauv kev nqus cov zaub mov qeeb qeeb, txo cov tshuaj tiv thaiv ntshav, tab sis tsis cuam tshuam rau tag nrho cov nqus tau.
Kev ntsuas kev ua kom teb: Yog tias nws yog qhov tsim nyog los siv ob cov tshuaj no ua ke los ua ke los txo qhov cuam tshuam ntawm kev sib cuam tshuam ntawm cefotaxime.
7. Kev cuam tshuam nrog cov diuretics muaj zog
Mechanism ntawm Kev Ua: Kev sib xyaw ua ke ntawm cov khoom siv diuretics muaj zog thiab cefotaxime tuaj yeem ua exacerbate neproxicity.
Ceev faj: Rau cov tsiaj nrog kev siv tus raum tsis txaus, kev siv ib qho ntawm ob cov tshuaj no yuav tsum zam. Thaum siv, nws yog ib qho tsim nyog los ua raws Renal Functators ntawm cov tsiaj, xws li cov ntshav muaj zog, thiab lwm yam kev kho mob raum yuav tsum tau hloov kho raws sijhawm.
8. Contraindications rau kev sib raug zoo nrog lwm cov tshuaj
Beugiofur ntsiav tshuajyog tsis sib haum nrog cov tshuaj xws li oxytetracline hydrochloride, Lincium sulfate, thiab lwm yam kev sib xyaw ua ke, thiab ua kom muaj ntau yam teeb meem xws li tsiaj ua xua thiab kev lom.
Cov kev sib raug zoo thiab kev ceev faj
Tej zaum yuav ua rau kev ua xua, feem ntau yog erythema thiab urticaria, khaus, noj tshuaj kub ntsej muag, hawb pob, hawb pob, thiab hypotension thiab hypotension.
Tej zaum yuav ua rau cov tshuaj hnyuv tshuaj noj muaj zog xws li xeev siab, ntuav, thiab raws plab, thiab tej zaum kuj yuav ua rau mob plab zom mov thiab mob plab zom mov.
Serum Alanine AminotRansferase tuaj yeem yog cov tshuaj me me thiab muaj qee cov nephotoxicity.
Kev txhaj tshuaj hauv zos tuaj yeem ua rau mob hauv zos, thaum lub sijhawm txhaj tshuaj tiv thaiv tau tuaj yeem ua rau phrowsis lossis thrombophlitis.
Muaj ob peb cov kev phiv tshuaj tawm neuralological xws li mob taub hau, kiv taub hau, thiab hnov cov kev ntxhov siab.
Raws li thib peb {{- tiam kev ua haujlwm, ruaj khov rau tshuaj tua kab mob, tsis muaj kev tiv thaiv kev ua xua. Nws cov seem hauv cov tsiaj lub cev yog tsawg. Rau cov tsiaj, cefotaxime tuaj yeem siv sijhawm ntev - cov nyhuv nov. Thaum cov kab mob nkag mus rau hauv lub cev tsiaj, lawv tau nrawm nrawm thiab metabolized, tsim lub metabolized thawj zaug ua txhua qhov (DFC) hauv Plasma. Vim yog lub nplhaib lactchan ntua lactchas, nws cov haujlwm tshuaj tua kab mob yog qhov zoo ib yam li cefotaxime. DFC tuaj yeem ua ntu zus ntxiv DFC cysteine disulfide refounds hauv cov zis, tab sis cov quav nyob hauv 24 teev tom qab txhaj tshuaj tiv thaiv 24 teev tom qab kev txhaj tshuaj.
Kev Siv thiab Kev Ceev Faj
Txoj Kev Tswj Xyuas:
Cefotaxime feem ntau yog ua rau hauv soluble solts rau kev txhaj tshuaj. Kho cov tsiaj xws li nyuj, npua, thiab dev. Thaum txhaj tshuaj intramuscularly, cov tshuaj yuav tsum tau muab rau raws li cov tshuaj noj thiab kev kho mob, thiab chav kho mob yog feem ntau yog 3-5 hnub.
Cov kev sib raug zoo:
Cefotaxime yuav ua rau kev ua xua, xws li Erherhali, khaus, ua npaws kub, thiab ua npaws kub, thiab ua npaws, thiab ua npaws ntau yam zoo li kev tsaug zog thiab cov phototaxis. Thaum siv, nws raug nquahu kom tsis txhob sib faib nrog lwm cov tshuaj muaj dej haus cawv kom ntau li ntau tau kom tsis txhob ua cov tshuaj tua kab mob ntsej muag lossis cov nyom.
Kev Cia Cai Cia:
Cefotaxime yuav tsum muab cia rau hauv cov thawv ntim khoom, zam kev kub, av noo, thiab lub teeb pom kev ruaj khov thiab ua haujlwm.
Cov kev ceev faj:
Nws yog contraindicated rau cov neeg mob ua xua rau cefotaxime, siv nrog kev ceev faj rau cov tsiaj tsis muaj cov tsiaj tsis txaus. Thaum siv, cov nyom tshwm sim xws li kev ua xua, thiab photophobia, thiab photophobia yuav tsum tau saib xyuas tsis tu ncua thiab nruj me ntsis ua raws li kev kho mob,
Nyob rau hauv kev tawm tsam ntev ntawm tib neeg thiab tsiaj cov kab mob, yug ntawm cefotaxime nyob rau xyoo pua 20th thiab nws qhov chaw thov hauv ntsiav tshuaj cim tau qhov tseem ceeb tig. Qhov no tsis yog lwm qhov kev nrhiav pom ntawm cov tshuaj tua kab mob, tab sis kuj tseem yog cov tshuaj kho tsiaj dawb huv ntawm tib neeg txoj kev kho tsiaj rau cov tsiaj txhu hom.
Nyob rau xyoo 1970 thiab 1980s, cov tsiaj cov tsiaj tau txhim kho sai heev thiab ntsuas. Txawm li cas los xij, high - qhov kev sib tw ua kom nrawm nrawm, xws li cov kab mob ua pa, thiab escherichia coli hauv cov qaib, uas tau ua rau muaj kev txom nyem loj.
Xyoo 1945, Italian Tus Science rau Giuseppe Brotzu cais cov tshuaj no los ntawm Cephalosporin pwm hauv dej los ntawm Sardinia. Piv nrog cov ntsiab lus tseem ceeb ntawm lub sijhawm ntawd, Cephalosporin C ua rau muaj kev cuam tshuam ntawm {2} Taug kev tiv thaiv {2} Cov enzyme tsim los ntawm cov kab mob uas hydrolyzes tshuaj tua kab mob).
Xyoo 1970 thiab 1980s, kev tshawb fawb, kev tshawb fawb ntawm Thib Peb- tiam cepharosporins mus txog nws lub ncov. Cov yam ntxwv ntawm cov tshuaj no yog cov kev ua haujlwm tsis zoo xws li Escherichella, thiab high stabila, thiab siab stability tawm tsam {4} lactase. Lub Hnub Qub Yeeb Tshuaj xws li Cefotaxime, Ceftazide, thiab Ceftriaxone tau tawm ib qho tom qab lwm tus, ua tiav zoo hauv tib neeg tshuaj.
Cim npe nrov: CeneDiofur ntsiav tshuaj, lwm tus neeg, chaw tsim khoom, Hoobkas, lag luam Wholesale, yuav, nqe, loj, loj, rau muag